武汉大学人民医院湖北省人民医院

院内导航

龚作炯传染
教研室主任，教授，主任医师，博士生导师

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导师介绍

姓名	龚作炯
出生年月	1962年12月
单位	武汉大学人民医院感染科
所属学科	临床医学-内科学
职务、职称及头衔	教研室主任，教授，主任医师，博士生导师
E-mail	zjgong@163.com
联系方式	027-88041911转82273 or 13971687857
研究方向	1. 慢性肝病的基础与临床：主要研究内容为HBV感染慢性化的机制、肝衰竭发病的炎症机制及其临床救治。 2. 病毒性疾病的基础与临床：主要研究内容为病毒感染的免疫学机制，及抑制病毒复制的基因治疗策略。
个人简介	从事传染病学临床医疗、科研及教学工作。主持国家自然科学科学基金6项、国家教育部、国家人事部、湖北省科技攻关、湖北省卫生厅重点课题4项。近年来在国内、外学术刊物上发表论文300余篇，其中50余篇论文被SCI收录（Hepatology, J.Hepatology, J.Viral Hepatitis）。主编或参编专著10部。7次获得年湖北省自然科学奖及科技进步奖。已培养博士生29名，硕士生48名。目前正在培养的博士生5名，硕士生7名。
学术任职与荣誉	中华医学会感染病学会第5-8届委员会全国委员中国中西医结合传染病专业委员会第1-2届全国常委中国医师协会感染病医师分会第二届全国常委中国医促会肝胆疾病委员会全国常委湖北省感染病学会第5-7届副主任委员湖北省肝病学会第1-3届副主任委员武汉市感染病学会第十六届主任委员《World Journal of Hepatology》、《Hepatobiliary & Pancreatic Diseases International》、《International Journal of Molecular Science》、《Molecular Science Reports》、《Nutrition》、《Cytokines》、《International Journal of Hepatology》特邀审稿人《中华传染病杂志》、《中华临床感染病杂志》、《中国肝脏病杂志》（电子版）、《中西医结合肝病杂志》、《世界感染杂志》、《武汉大学学报（医学版）》、《实用肝脏病杂志》、《临床肝胆病杂志》等杂志编委
教育履历	1984.09-1987.07武汉大学第一临床医学院传染病学专业硕士研究生获硕士学位 1993.10-1998.05比利时鲁汶天主教大学医学院博士研究生获博士学位 1998.05-1998.12比利时鲁汶天主教大学医学院博士后
工作履历	1988.05-1991.09武汉大学人民医院感染科主治医师 1991.10-1993.09武汉大学人民医院感染科副教授 1999.01-1999.12武汉大学人民医院感染科教授 2000.01-至今武汉大学人民医院感染科博士生导师
成果获奖	1.《乙型肝炎病毒受体研究》2002年获湖北省自然科学三等奖 2.《乙型肝炎病毒体外感染模型的建立及抗病毒药物的评价》2003年获湖北省自然科学三等奖 3.《中药金三莪抗肝纤维化的实验和临床研究》2006年获湖北省科技进步三等奖 4.《湖北地区HIV-1的分子流行病学调查》2011年获湖北省科技进步三等奖 5.《甲基供体（S-腺苷蛋氨酸及甜菜碱）治疗慢性肝病的基础及临床探讨》2014年获湖北省科技进步三等奖 6.《抗肝纤维化治疗的实验及临床探讨》2015年获湖北省科技进步三等奖 7.《肝衰竭关键诊疗技术创新及临床应用》2022年获湖北省科技进步二等奖
代表性论著	1. Cao P, Chen Q, Shi C, Pei M, Wang L, Gong Z. Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo. Eur J Pharmacol. 2022 Jan 15; 915:174610. 2. Cao P, Chen Q, Shi CX, Wang LW, Gong ZJ. Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species via hypoxia inducible factor 1α. World J Gastroenterol. 2022 May 7; 28(17):1798-1813. 3. Cao P, Chen Q, Shi C, Wang L, Gong Z. Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD+ salvage metabolic pathway. Gut Pathog. 2022 Jun 28; 14(1):29. 4. Shi C, Pei M, Wang Y, Chen Q, Cao P, Zhang L, Guo J, Deng W, Wang L, Li X, Gong Z. Changes of flavin-containing monooxygenases and trimethylamine- N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine. Biochem Biophys Res Commun. 2022 Feb 26; 594:1-7. 5. Shi C, Jiao F, Wang Y, Chen Q, Wang L, Gong Z. SIRT3 inhibitor 3-TYP exacerbates thioacetamide-induced hepatic injury in mice. Front Physiol. 2022 Jul 18;13:915193. 6. Chen Q, Zhang Q, Cao P, Shi C, Zhang L, Wang L, Gong Z. NOD2-mediated HDAC6/NF-κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure. J Cell Mol Med. 2022 Nov;26(21):5528-5538. 7、Guo J, Shi CX, Zhang QQ, Deng W, Zhang LY, Chen Q, Zhang DM, Gong ZJ. Interventions for non-alcoholic liver disease: a gut microbial metabolites perspective. Therap Adv Gastroenterol. 2022 Dec 6;15:17562848221138676. 8. Li X, Hong J, Wang Y, Pei M, Wang L, Gong Z. Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD. Front Mol Biosci. 2021 Oct 1;8:733507. 9. Jiao F, Wang Y, Chen Q, Cao P, Shi C, Pei M, Wang L, Gong Z. Role of SIRT1 in Hepatic Encephalopathy: In Vivo and In Vitro Studies Focusing on the NLRP3 Inflammasome. Oxid Med Cell Longev. 2021 Oct 12;2021:5522708. 10. Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z. Histone Deacetylase 6 Regulates the Activation of M1 Macrophages by the Glycolytic Pathway During Acute Liver Failure. J Inflamm Res. 2021 Apr 15;14:1473-1485. 11. Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z. The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients. J Med Virol. 2021 Nov;93(11):6229-6235. doi: 12. Wang Y, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z. Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site. Cell Death Dis. 2021 Jan 11;12(1):55. 13. Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, Wang L, Gong Z. HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway. J Cell Mol Med. 2021 Aug;25(15):7218-7228. 14. Shi CX, Wang Y, Jiao FZ, Chen Q, Cao P, Pei MH, Zhang LY, Guo J, Deng W, Wang LW, Gong ZJ. Epigenetic Regulation of Hepatic Stellate Cell Activation and Macrophage in Chronic Liver Inflammation. Front Physiol. 2021 Jul 1;12:683526. 15. Wang Y, Zhang HY, Chen Q, Jiao FZ, Shi CX, Pei MH, Lv J, Zhang H, Wang LW, Gong ZJ. TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury. Cell Prolif. Cell 2020 Jun; 53(6): e12829. 16. Wang Y, Wang L, Li X, Gong Z. Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers. Curr Infect Dis Rep. 2020; 22(11): 30. 17. Chen Q, Wang Y, Jiao FZ, Shi CX, Pei MH, Wang LW, Gong ZJ. Histone Deacetylase 6 Inhibitor ACY1215 Ameliorates Mitochondrial Dynamic and Function Injury in Hepatocytes by Activating AMPK Signaling Pathway in Acute Liver Failure Mice. Histol Histopathol. 2020 Jun 23;18237. 18. Chen Q, Wang Y, Jiao F, Shi C, Pei M, Wang L, Gong Z. Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice. Sci Rep. 2020 Dec 14;10(1):21850. 19. Shi CX, Wang Y, Chen Q, Jiao FZ, Pei MH, Gong ZJ. Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways. Front Cell Infect Microbiol, 2020, 10:196. 20. Wang L, Li X, Chen H, Yan S, Li D, Li Y, Gong Z. Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. Am J Nephrol. 2020;51(5):343-348.

Name	ZUOJIONG GONG
Date of birth	December, 1962
Department	Department of Infectious Diseases，Renmin Hospital of Wuhan University
Title	Director, Professor, doctoral tutor
Email	xzhang@whu.edu.cn
TEL	027-88041911-82273 or 13971687857
Research Direction	1. The basic and clinical study on chronic liver disease: the main studies on mechanism of the chronicity of HBV infection, inflammatory response and the pathogenesis of liver failure and its clinical treatments. 2. The basic and clinical study on viral diseases: the main studies on immunological mechanism of viral infection and the gene therapy strategy to inhibition of viral replication.
Personal Profile	He is mainly engaged in clinical medicine, research and teaching work of infectious diseases, and has been awarded 6 items for the National Natural Science Foundation of China, 7 items from the National Ministry of Education, the National Ministry of Personnel, the Hubei Provincial Science and Technology Department and the Hubei Provincial Health Department. In recent years, more than 300 papers have been published in academic journals at home and abroad, of which more than 50 papers have been published in SCI journals (Hepatology, J.Hepatology, J.Viral Hepatitis). He wrote 10 academic books as a chief editor or an editor. He won the Hubei Provincial Natural Science Award and the Science and Technology Progress Award for the 6 times. By now, he has educated 29 doctors and 48 masters. At present, there are 5 doctors and 7 Masters studying with him.
Selected Publications	1. Cao P, Chen Q, Shi C, Pei M, Wang L, Gong Z. Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo. Eur J Pharmacol. 2022 Jan 15; 915:174610. 2. Cao P, Chen Q, Shi CX, Wang LW, Gong ZJ. Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species via hypoxia inducible factor 1α. World J Gastroenterol. 2022 May 7; 28(17):1798-1813. 3. Cao P, Chen Q, Shi C, Wang L, Gong Z. Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD+ salvage metabolic pathway. Gut Pathog. 2022 Jun 28; 14(1):29. 4. Shi C, Pei M, Wang Y, Chen Q, Cao P, Zhang L, Guo J, Deng W, Wang L, Li X, Gong Z. Changes of flavin-containing monooxygenases and trimethylamine- N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine. Biochem Biophys Res Commun. 2022 Feb 26; 594:1-7. 5. Shi C, Jiao F, Wang Y, Chen Q, Wang L, Gong Z. SIRT3 inhibitor 3-TYP exacerbates thioacetamide-induced hepatic injury in mice. Front Physiol. 2022 Jul 18;13:915193. 6. Chen Q, Zhang Q, Cao P, Shi C, Zhang L, Wang L, Gong Z. NOD2-mediated HDAC6/NF-κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure. J Cell Mol Med. 2022 Nov;26(21):5528-5538. 7、Guo J, Shi CX, Zhang QQ, Deng W, Zhang LY, Chen Q, Zhang DM, Gong ZJ. Interventions for non-alcoholic liver disease: a gut microbial metabolites perspective. Therap Adv Gastroenterol. 2022 Dec 6;15:17562848221138676. 8. Li X, Hong J, Wang Y, Pei M, Wang L, Gong Z. Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD. Front Mol Biosci. 2021 Oct 1;8:733507. 9. Jiao F, Wang Y, Chen Q, Cao P, Shi C, Pei M, Wang L, Gong Z. Role of SIRT1 in Hepatic Encephalopathy: In Vivo and In Vitro Studies Focusing on the NLRP3 Inflammasome. Oxid Med Cell Longev. 2021 Oct 12;2021:5522708. 10. Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z. Histone Deacetylase 6 Regulates the Activation of M1 Macrophages by the Glycolytic Pathway During Acute Liver Failure. J Inflamm Res. 2021 Apr 15;14:1473-1485. 11. Wang Y, Li X, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z. The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients. J Med Virol. 2021 Nov;93(11):6229-6235. doi: 12. Wang Y, Chen Q, Jiao F, Shi C, Pei M, Wang L, Gong Z. Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site. Cell Death Dis. 2021 Jan 11;12(1):55. 13. Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, Wang L, Gong Z. HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway. J Cell Mol Med. 2021 Aug;25(15):7218-7228. 14. Shi CX, Wang Y, Jiao FZ, Chen Q, Cao P, Pei MH, Zhang LY, Guo J, Deng W, Wang LW, Gong ZJ. Epigenetic Regulation of Hepatic Stellate Cell Activation and Macrophage in Chronic Liver Inflammation. Front Physiol. 2021 Jul 1;12:683526. 15. Wang Y, Zhang HY, Chen Q, Jiao FZ, Shi CX, Pei MH, Lv J, Zhang H, Wang LW, Gong ZJ. TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury. Cell Prolif. Cell 2020 Jun; 53(6): e12829. 16. Wang Y, Wang L, Li X, Gong Z. Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers. Curr Infect Dis Rep. 2020; 22(11): 30. 17. Chen Q, Wang Y, Jiao FZ, Shi CX, Pei MH, Wang LW, Gong ZJ. Histone Deacetylase 6 Inhibitor ACY1215 Ameliorates Mitochondrial Dynamic and Function Injury in Hepatocytes by Activating AMPK Signaling Pathway in Acute Liver Failure Mice. Histol Histopathol. 2020 Jun 23;18237. 18. Chen Q, Wang Y, Jiao F, Shi C, Pei M, Wang L, Gong Z. Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice. Sci Rep. 2020 Dec 14;10(1):21850. 19. Shi CX, Wang Y, Chen Q, Jiao FZ, Pei MH, Gong ZJ. Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways. Front Cell Infect Microbiol, 2020, 10:196. 20. Wang L, Li X, Chen H, Yan S, Li D, Li Y, Gong Z. Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. Am J Nephrol. 2020;51(5):343-348.