张燕
妇产科
妇Ⅰ科副主任，副教授，主任医师，硕士生导师
妇Ⅰ科副主任，副教授，主任医师，硕士生导师
导师介绍
| 姓名 | 张燕 |
| 出生年月 | 1971年2月 |
| 单位 | 武汉大学人民医院妇一科 |
| 所属学科 | 临床医学-妇产科学 |
| 职务、职称及头衔 | 妇一科副主任，教授，主任医师，硕士生导师 |
| 648434218@qq.com | |
| 联系方式 | 13307169032 |
| 研究方向 | 1.妇科肿瘤 |
| 个人简介 | 从事妇产科临床工作二十余年，经验丰富，擅长妇科良、恶性肿瘤手术及微创手术，手术技术娴熟，理念先进，率先在本院开展单孔腔镜手术，产生了良好的社会反响。在临床教学中带教本科生、研究生、留学生、进修生、规培生等临床学生，按时完成教学任务。在科研上积极进取，主持中央财政引导地方科技发展资金项目一项；湖北省自然基金面上项目一项、湖北省卫计委重点支撑项目一项、荣获湖北省科技成果推广二等奖1项、武汉大学教学成果二等奖1项、湖北省科技进步二等奖1项；荣获湖北省卫生厅2012年度“群众满意的医务人员”。发表学术论文20余篇，SCI论文10余篇；主编、副主编及编委专著3部。 |
| 学术任职与荣誉 | 《实用妇产科杂志》第五届编辑委员会编委、《中国计划生育和妇产科》杂志第五届编委、美国妇产科学杂志（AJOG）中文版青年编委、医学参考报妇产科频道青年编委、WEDA世界内镜医师协会妇科协会常务理事、中国抗癌协会妇科肿瘤专业委员会委员、中国抗癌协会第一届肿瘤内分泌专业委员会、中国优生协会妇科肿瘤防治委员会常委、中国优生科学协会肿瘤生殖学分会常委、中国妇幼保健协会妇幼微创专委会妇科阴式手术学组常委、湖北省医学会妇产科分会（第八届）委员、湖北省医学会妇科肿瘤分会（第三届）委员。 |
| 教育履历 |
1994.09-1999.07郧阳医学院医疗系临床医学专业本科生获学士学位； 2004.09-2006.06武汉大学第一临床学院妇产科学硕士研究生获硕士学位； 2010.09-2015.11武汉大学第一临床学院妇产科学博士研究生获博士学位 |
| 工作履历 |
1993.03-2004.08湖北十堰计划生育服务中心妇产科主治医师 2006.07-2014.03湖北省新华医院妇产科副主任主任医师 2014.03-2014.10湖北省荣军医院妇产科主任主任医师 2014.10-至今 武汉大学人民医院妇一科副主任主任医师 |
| 成果获奖 |
1.高危孕产妇围产期监护和母儿安全保障系统的优化；2018年中央财政引导地方科技发展资金项目，2018ZYYD014；100万，在研，主持 2.长链非编码RNA HOTAIR与蛋白转录因子STAT3在子宫颈癌肿瘤细胞迁移和侵袭过程中的协同子机制研究；2017-2018年湖北省卫生计生委重点支撑项目，WJ2017Z002，10万，在研，主持 3.EMT相关细胞因子在人卵巢癌细胞和组织中的表达及意义的研究；湖北省自然科学基金面上项目，2015CFB722，3万，2017年3月已顺利结题。主持 4.不孕症个体化诊治体系的理论及关键技术推广应用；获2015年 湖北省科技成果推广二等奖,主要完成人之一 5.生殖健康创新课程体系设计与教学模式探索；获2016年武汉大学教学成果二等奖，第一完成人之一， 6.母-胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用；获2017年湖北省科技进步二等奖。完成人之一 |
| 代表性论著 |
1.Weihong
Zeng#, Xinmei Liu#, Zhicui Liu#, Ying Zheng, Tiantian Yu, Shaliu Fu, Xiao Li,
Jing Zhang, Siming Zhang, Xiaoling Ma, Xiao-Rui Liu, Xiaoli Qin, Asma
Khanniche, Yan Zhang*, Fuju Tian*, Yi Lin*. Deep surveying of the
transcriptional and alternative splicing signatures for decidual CD8+ T cells
at the first trimester of human healthy pregnancy. Frontiers in Immunology
2018; 9:937. doi: 10.3389/fimmu.2018.00937. (IF: 5.511) 共同通讯作者 2.Fan Wu#, Fuju Tian, Weihong Zeng, Xiaorui Liu, Jianxia Fan, Yi Lin, Yan Zhang*. Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis. Cell Death and Disease 2017; 8, e2908; doi:10.1038/cddis.2017.301. (IF: 5.638) 独立通讯作者 3.Yan Zhang#, Feng Jin#, Xiao-Cui Li, Fu-Jin Shen, Xiao-Ling Ma, Fan Wu, Si-Ming Zhang, Wei-Hong Zeng, Xiao-Rui Liu, Jian-Xia Fan, Yi Lin, Fu-Ju Tian*. The YY1-HOTAIR-MMP2 signaling axis controls trophoblast invasion at the maternal-fetal interface. Molecular Therapy 2017; 25(10): 2394-2403. (IF: 7.008) 共同第一作者 4.Xiao-Rui Liu#, Yu-Na Guo#, Chuan-Mei Qin, Xiao-Li Qin, Fei Tao, Fei Su, Fu-Ju Tian, Yan Zhang*, Yi Lin*. Transcriptomic insights into the response of placenta and decidua basalis to the CpG oligodeoxynucleotide stimulation in non-obese diabetic mice and wild-type controls. International Journal of Molecular Sciences 2016; 17, 1281; doi:10.3390/ijms17081281 (IF: 3.226) 共同通讯作者 5.Weihong Zeng#, Zhicui Liu, Siming Zhang, Jiabin Ren, Xiaoling Ma, Chuanmei Qin, Fuju Tian, Yan Zhang*, Yi Lin*. Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage induced abortion. Scientific Reports 2016; 6:36560. DOI: 10.1038/srep36560. (IF: 4.259) 共同通讯作者 6.Yan Zhang, Xiaoling Cheng, Hua Liang, Zhenzhen Jin,∗Zhang Y1, Cheng X2, Liang H1, Jin Z3. Long non-coding RNA HOTAIR and STAT3 synergistically regulate the cervical cancer cell migration and invasion. Chemico-biological interactions. 2018 Apr 25;286:106-110. doi: 10.1016/j.cbi.2018.03.010. Epub 2018 Mar 20. 第一作者 7.Xiaoli Qin, Yan Liang, Yuna Guo, Xiaorui Liu, Weihong Zeng, Fan Wu, Yi Lin and Yan Zhang. Eukaryotic initiation factor 5A and Ca2+/calmodulin-dependent protein kinase 1D modulate trophoblast cell function. Am J Reprod Immunol. 2018 Jul;80(1):e12845. doi: 10.1111/aji.12845. Epub 2018 Mar 13.共同通讯作者 8.Yan Zhang1，Min Hu，Liu Liu，Xiao-Ling Cheng，Jing Cai，Tao Wang*. Anticancer effects of Rosmarinic acid in OVCAR-3 ovarian cancer cells are mediated via induction of apoptosis, suppression of cell migration and modulation of lncRNA MALAT-1 expression. J BUON. 2018 May-Jun;23(3):763-768.第一作者 9.Yan Zhang1, Nina Fan2, Jing Yang1.Expression and clinical significance of HIF-1α, Snail and E-cadherin in human ovarian cancer cell line. Molecular Medicine Reports, Thursday, May 14, 2015 (DOI: 10.3892/mmr.2015.3786). 第一作者 10.Zhang Y1，Wang T, Huang HQ, Li W, Cheng XL, Yang J. Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration. J BUON. 2015 Nov-Dec;20(6):1497-503. 第一作者 11.Jing Cai1, Tao Wang2, Mingzhe Li2, Xiaoling Cheng3, Yan Zhang4* .Isolated proteinuria in chinese pregnant women with pre-eclampsia：Results of retrospective observational syudy. Biomedical Research.Apr 25,2017.通讯作者 12.Yan Zhang1, Min Hu1, Liu Liu1, Xiao-Ling Cheng2, Jing Cai3, Tao Wang4*. Involvement of reproductive system related autoantibodies in Chinese patients with infertility: A reproductive immunology study. Biomedical Research 2017; 28 (3): ISSN 0970-938X www.biomedres.info第一作者 13.蔡静，张丹，张燕。香芹酚拮抗大鼠卵巢储备化疗损伤的功能。2017 (11) :904-909 中华生殖与避孕杂志。 Chin J Reprod Contracep, November 2017, Vol.37, No.11。通讯作者 14.Xiao Li, Xiao‐Ling Ma,Fu‐Ju Tian,Fan Wu, Jing Zhang, Wei‐Hong Zeng, Yi Lin, Yan Zhang*. Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage. Am J Reprod Immunol. 2019;00:e13144.)DOI: 10.1111/aji.13144. 通讯作者 15.Ren J, Zeng W, Tian F, Zhang S, Wu F, Qin X, Zhang Y*, Lin Y*. Myeloid-derived suppressor cells depletion may cause pregnancy loss via upregulating the cytotoxicity of decidual natural killer cells. Am J Reprod Immunol. 2019 Apr;81(4):e13099. doi: 10.1111/aji.13099.共同通讯 16.Mo HQ , Tian FJ, Li X, Zhang J, Ma XL, Zeng WH, Lin Y , Zhang Y* ANXA7 regulates trophoblast proliferation and apoptosis in preeclampsia. Am J Reprod Immunol. 2019 Aug 25:e13183. doi: 10.1111/aji.13183.通讯作者 17.Yan Zhang，Xiao-Ying He，Shi Qin，Hui-Qin Mo，Xiao Li，Fan Wu，Jing Zhang，Xing Li，Lin Mao，Ya-Qing Peng，Yu-Na Guo，Yi Lin，Fu-Ju Tian*. Upregulation of Pumilio 1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol Ther. 2019 Dec 6. pii: S1525-0016(19)30551-9. doi: 10.1016/j.ymthe.2019.11.025.第一作者 18.Zhang Y, Li X, Zhang J, Liang H. Natural Killer T Cell Cytotoxic Activity in Cervical Cancer Is Facilitated by the LINC00240/microRNA-124-3p/STAT3/MICA Axis. Cancer Lett. 2020 Jan 2. pii: S0304-3835(19)30660-3. doi: 10.1016/j. canlet.2019.12.038. 第一作者 19.Zhang Yan ，Luo Ruoyu，Li Xing，Liang Hua，ZhangYi，Peng Yaqin，Wang Wei，Tan Aili，Zhao Yuzi，Mao Lin，Tan Huiping* Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest. Archives of Biochemistry and biophysics. 2020 Feb 24:108320. doi: 10.1016/j.abb.2020.108320.第一作者 20.张珺，彭澎，李星，查云飞，向阳，张国楠，张燕*。妇科恶性肿瘤伴发新型冠状病毒肺炎三例临床分析及其管理对策探讨。中华妇产科杂志2020年4月第55卷第4期。April2020,Vol.55,No.4。通讯作者 |
| Name | YAN ZHANG |
| Date of birth | February，1978 |
| Department | Gynaecology Department，Renmin Hospital,Wuhan University. |
| Title | Deputy Director, Professor, master tutor |
| 648434218@qq.com | |
| TEL | 13307169032 |
| Research Direction | 1.gynecologic oncology |
| Personal Profile | She has been engaged in clinical work of obstetrics and gynaecology for more than 20 years, with rich experience. She is good at gynecological surgery and minimally invasive surgery for benign and malignant tumors. With skilled surgical techniques and advanced concepts, she took the lead in carrying out single-port endoscopic surgery in our hospital, which has generated good social response. In clinical teaching, she teaches undergraduate students, graduate students, international students, advanced students, regular trainees and other clinical students, and completes the teaching tasks on time.Besides she has published more than 20 academic papers and more than 10 SCI papers. And there are 3 monographs by she served as chief editor, deputy editor and editors. |
| Selected Publications |
1.Weihong
Zeng#, Xinmei Liu#, Zhicui Liu#, Ying Zheng, Tiantian Yu, Shaliu Fu, Xiao Li,
Jing Zhang, Siming Zhang, Xiaoling Ma, Xiao-Rui Liu, Xiaoli Qin, Asma
Khanniche, Yan Zhang*, Fuju Tian*, Yi Lin*. Deep surveying of the
transcriptional and alternative splicing signatures for decidual CD8+ T cells
at the first trimester of human healthy pregnancy. Frontiers in Immunology
2018; 9:937. doi: 10.3389/fimmu.2018.00937. (IF: 5.511)共同通讯作者 2.Fan Wu#, Fuju Tian, Weihong Zeng, Xiaorui Liu, Jianxia Fan, Yi Lin, Yan Zhang*. Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis. Cell Death and Disease 2017; 8, e2908; doi:10.1038/cddis.2017.301. (IF: 5.638)独立通讯作者 3.Yan Zhang#, Feng Jin#, Xiao-Cui Li, Fu-Jin Shen, Xiao-Ling Ma, Fan Wu, Si-Ming Zhang, Wei-Hong Zeng, Xiao-Rui Liu, Jian-Xia Fan, Yi Lin, Fu-Ju Tian*. The YY1-HOTAIR-MMP2 signaling axis controls trophoblast invasion at the maternal-fetal interface. Molecular Therapy 2017; 25(10): 2394-2403. (IF: 7.008)共同第一作者 4.Xiao-Rui Liu#, Yu-Na Guo#, Chuan-Mei Qin, Xiao-Li Qin, Fei Tao, Fei Su, Fu-Ju Tian, Yan Zhang*, Yi Lin*. Transcriptomic insights into the response of placenta and decidua basalis to the CpG oligodeoxynucleotide stimulation in non-obese diabetic mice and wild-type controls. International Journal of Molecular Sciences 2016; 17, 1281; doi:10.3390/ijms17081281 (IF: 3.226) 共同通讯作者 5.Weihong Zeng#, Zhicui Liu, Siming Zhang, Jiabin Ren, Xiaoling Ma, Chuanmei Qin, Fuju Tian, Yan Zhang*, Yi Lin*. Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage induced abortion. Scientific Reports 2016; 6:36560. DOI: 10.1038/srep36560. (IF: 4.259)共同通讯作者 6.Yan Zhang, Xiaoling Cheng, Hua Liang, Zhenzhen Jin,∗Zhang Y1, Cheng X2, Liang H1, Jin Z3. Long non-coding RNA HOTAIR and STAT3 synergistically regulate the cervical cancer cell migration and invasion. Chemico-biological interactions. 2018 Apr 25;286:106-110. doi: 10.1016/j.cbi.2018.03.010. Epub 2018 Mar 20.第一作者 7.Xiaoli Qin, Yan Liang, Yuna Guo, Xiaorui Liu, Weihong Zeng, Fan Wu, Yi Lin and Yan Zhang. Eukaryotic initiation factor 5A and Ca2+/calmodulin-dependent protein kinase 1D modulate trophoblast cell function. Am J Reprod Immunol. 2018 Jul;80(1):e12845. doi: 10.1111/aji.12845. Epub 2018 Mar 13.共同通讯作者 8.Yan Zhang1，Min Hu，Liu Liu，Xiao-Ling Cheng，Jing Cai，Tao Wang*. Anticancer effects of Rosmarinic acid in OVCAR-3 ovarian cancer cells are mediated via induction of apoptosis, suppression of cell migration and modulation of lncRNA MALAT-1 expression. J BUON. 2018 May-Jun;23(3):763-768.第一作者 9.Yan Zhang1, Nina Fan2, Jing Yang1.Expression and clinical significance of HIF-1α, Snail and E-cadherin in human ovarian cancer cell line. Molecular Medicine Reports, Thursday, May 14, 2015 (DOI: 10.3892/mmr.2015.3786).第一作者 10.Zhang Y1，Wang T, Huang HQ, Li W, Cheng XL, Yang J. Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration. J BUON. 2015 Nov-Dec;20(6):1497-503.第一作者 11.Jing Cai1, Tao Wang2, Mingzhe Li2, Xiaoling Cheng3, Yan Zhang4* .Isolated proteinuria in chinese pregnant women with pre-eclampsia：Results of retrospective observational syudy. Biomedical Research.Apr 25,2017.通讯作者 12.Yan Zhang1, Min Hu1, Liu Liu1, Xiao-Ling Cheng2, Jing Cai3, Tao Wang4*. Involvement of reproductive system related autoantibodies in Chinese patients with infertility: A reproductive immunology study. Biomedical Research 2017; 28 (3): ISSN 0970-938X www.biomedres.info第一作者 13.蔡静，张丹，张燕。香芹酚拮抗大鼠卵巢储备化疗损伤的功能。2017 (11) :904-909中华生殖与避孕杂志。Chin J Reprod Contracep, November 2017, Vol.37, No.11。通讯作者 14.Xiao Li, Xiao‐Ling Ma,Fu‐Ju Tian,Fan Wu, Jing Zhang, Wei‐Hong Zeng, Yi Lin, Yan Zhang*. Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage. Am J Reprod Immunol. 2019;00:e13144.)DOI: 10.1111/aji.13144.通讯作者 15.Ren J, Zeng W, Tian F, Zhang S, Wu F, Qin X, Zhang Y*, Lin Y*. Myeloid-derived suppressor cells depletion may cause pregnancy loss via upregulating the cytotoxicity of decidual natural killer cells. Am J Reprod Immunol. 2019 Apr;81(4):e13099. doi: 10.1111/aji.13099.共同通讯 16.Mo HQ , Tian FJ, Li X, Zhang J, Ma XL, Zeng WH, Lin Y , Zhang Y* ANXA7 regulates trophoblast proliferation and apoptosis in preeclampsia. Am J Reprod Immunol. 2019 Aug 25:e13183. doi: 10.1111/aji.13183.通讯作者 17.Yan Zhang，Xiao-Ying He，Shi Qin，Hui-Qin Mo，Xiao Li，Fan Wu，Jing Zhang，Xing Li，Lin Mao，Ya-Qing Peng，Yu-Na Guo，Yi Lin，Fu-Ju Tian*. Upregulation of Pumilio 1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol Ther. 2019 Dec 6. pii: S1525-0016(19)30551-9. doi: 10.1016/j.ymthe.2019.11.025.第一作者 18.Zhang Y, Li X, Zhang J, Liang H. Natural Killer T Cell Cytotoxic Activity in Cervical Cancer Is Facilitated by the LINC00240/microRNA-124-3p/STAT3/MICA Axis. Cancer Lett. 2020 Jan 2. pii: S0304-3835(19)30660-3. doi: 10.1016/j. canlet.2019.12.038.第一作者 19.Zhang Yan，Luo Ruoyu，Li Xing，Liang Hua，ZhangYi，Peng Yaqin，Wang Wei，Tan Aili，Zhao Yuzi，Mao Lin，Tan Huiping* Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest. Archives of Biochemistry and biophysics. 2020 Feb 24:108320. doi: 10.1016/j.abb.2020.108320.第一作者 20.张珺，彭澎，李星，查云飞，向阳，张国楠，张燕*。妇科恶性肿瘤伴发新型冠状病毒肺炎三例临床分析及其管理对策探讨。中华妇产科杂志2020年4月第55卷第4期。April2020,Vol.55,No.4。通讯作者 |
武汉大学人民医院
湖北省人民医院