武汉大学人民医院湖北省人民医院

院内导航

郑勇斌普外
胃肠外科主任，胃肠外Ⅰ科主任、党支部书记，武汉大学人民医院（东院）胃肠外科主任

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导师介绍

姓名	郑勇斌
出生年月	1970年10月
单位	武汉大学人民医院胃肠外科
所属学科	普外科
职务、职称及头衔	武汉大学人民医院胃肠外科主任，胃肠外I科主任、党支部书记，武汉大学人民医院（东院）胃肠外科主任
E-mail	yongbinzheng@whu.edu.cn
联系方式	027-88041911转82211
研究方向	1.胃肠道肿瘤的基础与临床研究 2.结直肠癌的局部免疫研究 3.基于神经层面指引的腹腔镜直肠癌根治术研究
个人简介	郑勇斌教授，1970年10月生，现任武汉大学人民医院胃肠外科主任，博士研究生导师，University of Kentucky访问学者。长期从事胃肠道肿瘤的基础与临床研究，临床诊疗方面擅长胃肠道肿瘤在内的胃肠外科各种常见病及疑难病的微创与规范化治疗，致力于盆腔自主神经功能保护研究，在国际上首创“基于神经层面指引的直肠癌根治术”，患者术后泌尿、生殖功能保全效果得到业内同行评议一致认可。同时，在国际上首先提出胃肠发育解剖手术理念，从机理上明确胃肠手术的胚胎发育学基础，助力推动胃肠道手术的标准化与同质化在各大医疗中心的发展与优化。曾获第四届大肠癌高峰论坛视频展播第一名、第十五届世界内镜外科大会腹腔镜胃肠外科优秀临床病例选拔大赛最具风采奖、大中华结直肠腹腔外科达人训练营获优秀作品奖、广州结直肠癌高峰论坛手术视频大赛优艺奖，在“2022寻访魅力医生大型公益活动”中入选并荣获“魅力医生”荣誉称号，被武汉大学人民医院授予“医疗名家”荣誉称号，多次获评医院先进个人、优秀共产党员及优秀医务工作者等。基础研究方面，前期通过结肠干细胞体内突变构建了免疫功能正常的散发性结直肠癌小鼠模型，搭建起了结直肠癌局部免疫研究平台。同时阐明了JAK1-STAT1/GBP5/CXCL8正反馈环路促进胃癌恶性进展的分子机理，鉴定到了PUS7、NAT10等系列结直肠癌预后预测标志物。主持国家或省部级科研项目6项，担任国家级著作主编1部，以第一作者或通讯作者在国际知名期刊如Advanced science，Eur J Surg Oncol等多个杂志累计发表学术论文100余篇，累积影响因子超过100分。同时担任《中华实验外科杂志》、《腹部外科杂志》及《临床外科杂志》编委。现已完成培养博士研究生3人,硕士研究生20余人。
学术任职与荣誉	中国NOSES（Natural Orifice Specimen Extraction Surgery）联盟湖北分会副理事长中国医师协会结直肠肿瘤专业委员会第一届委员会并发症管理专业委员会委员中国研究型医院学会微创外科学专业委员会（第二届）委员中国研究型医院学会数字医学临床外科专业委员会数字化微创学组委员中国医药教育协会消化道疾病专业委员会委员中国成人教育协会医学继续教育专业委员会消化外科委员会委员湖北省微循环学会功能性胃肠外科专业委员会主任委员湖北省医学会肠外肠内营养分会委员会（第二届）ERAS学组组长湖北省医学会普通外科分会委员会（第九届）减重与代谢外科学组组员湖北省医学会结直肠肛门外科学分会委员会（第三届）副主任委员湖北省医学会腹腔镜外科分会委员会（第四届）副主任委员湖北省抗癌协会大肠癌专业委员会（第二届）副主任委员湖北省肿瘤医学质量控制中心胃癌与结直肠癌质控专家委员会（第一届）副主任委员湖北省临床肿瘤学会胃肠肿瘤外科专家委员会（第一届）委员湖北省中西医结合学会肛肠专业委员会（第三届）委员湖北省中西医结合学会普通外科专业委员会（第一届）委员湖北省医学会肠外肠内营养学分会委员会（第三届）委员武汉中西医结合学会外科专业委员会（第四届）副主任委员武汉中西医结合学会胃肠外科专业委员会（第一届）副主任委员武汉医学会腔镜外科学分会（第四届）委员武汉医学会临床营养学分会（第一届）常务委员武汉医学会机器人与腔镜外科分会（第一届）委员武汉医院协会临床营养管理专业委员会（第一届）副主任委员《中华实验外科杂志》编辑委员会（第八届）编委《腹部外科杂志》编辑委员会（第五届）编委《微循环学杂志》编辑委员会（第六届）委员《临床外科杂志》编辑委员会（第四届）编委
教育履历	1989.09-1994.07武汉大学医学院医学学士 1998.09-2001.07华中科技大学同济医学院医学硕士 2002.09-2005.07华中科技大学同济医学院医学博士
工作履历	1994.07-1998.09中国人民解放军457医院普通外科 2001.07-2002.09华中科技大学同济医学院附属协和医院急救中心 2005.07-2011.08.武汉大学人民医院胃肠外科 2011.08-2012.08 Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, university of Kentucky访问学者 2012.08 -至今武汉大学人民医院胃肠外科
成果获奖	1、广州结直肠癌高峰论坛手术视频大赛优艺奖 2、第九届中国医师协会外科医师年会中青年手术录像比赛三等奖 3、第四届大肠癌高峰论坛视频展播第一名 4、第十五届世界内镜外科大会腹腔镜胃肠外科优秀临床病例选拔大赛最具风采奖 5、中国结直肠外科医师委员会菁英风云榜结直肠手术视频大赛优艺奖 6、大中华结直肠腹腔外科达人训练营获优秀作品奖 7、"2022寻访魅力医生大型公益活动"中荣获"2022魅力医生"荣誉称号 8、第一届“中南医匠”结直肠手术视频比赛三等奖
代表性论著	[1] Li S, Wang X, Yan Z, Wang T, Chen Z, Song H, Zheng Y. Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing. Adv Sci (Weinh). 2023 May 18:e2300576. doi: 10.1002/advs.202300576. Epub ahead of print. PMID: 37202594. [2] Zeng J, Li K, Cao F, Zheng Y. Development and validation of survival prediction model for gastric adenocarcinoma patients using deep learning: A SEER-based study. Front Oncol. 2023 Mar 7;13:1131859. doi: 10.3389/fonc.2023.1131859. PMID: 36959782; PMCID: PMC10029996. [3] Li K, Zeng J, Pang P, Cheng H, He X, Cao F, Luo Q, Tong S, Zheng Y. Significance of Nerve Plane for Inferior Mesenteric Plexus Preservation in Laparoscopic Rectal Cancer Surgery. Front Oncol. 2022 Apr 22;12:853662. doi: 10.3389/fonc.2022.853662. PMID: 35530321; PMCID: PMC9072964. [4] Yang C, Cao F, Huang S, Zheng Y. Follistatin-Like 3 Correlates With Lymph Node Metastasis and Serves as a Biomarker of Extracellular Matrix Remodeling in Colorectal Cancer. Front Immunol. 2021 Jul 16;12:717505. doi: 10.3389/fimmu.2021.717505. PMID: 34335633; PMCID: PMC8322704. [5] Huang X, Zhang J, Zheng Y. ANTXR1 Is a Prognostic Biomarker and Correlates With Stromal and Immune Cell Infiltration in Gastric Cancer. Front Mol Biosci. 2020 Dec 15;7:598221. doi: 10.3389/fmolb.2020.598221. PMID: 33385012; PMCID: PMC7770144. [6] Cao FY, Wang CH, Li X, Ma MZ, Tao GC, Yang C, Li K, He XB, Tong SL, Zhao QC, Su S, Song D, Zheng YB. Guanylate binding protein 5 accelerates gastric cancer progression via the JAK1-STAT1/GBP5/CXCL8 positive feedback loop. Am J Cancer Res. 2023 Apr 15;13(4):1310-1328. PMID: 37168340; PMCID: PMC10164808. [7] Li J, Yang C, Zheng Y. Identification of a tissue resident memory CD8 T cell-related risk score signature for colorectal cancer, the association with TME landscapes and therapeutic responses. Front Genet. 2023 Jan 4;13:1088230. doi: 10.3389/fgene.2022.1088230. PMID: 36685946; PMCID: PMC9845416. [8] Li K, Pang P, Cheng H, Zeng J, He X, Cao F, Luo Q, Tong S, Zheng Y. Protective effect of laparoscopic functional total mesorectal excision on urinary and sexual functions in male patients with mid-low rectal cancer. Asian J Surg. 2023 Jan;46(1):236-243. doi: 10.1016/j.asjsur.2022.03.050. Epub 2022 Mar 29. PMID: 35361550. [9] Li X, Song D, Su S, He X, Cao F, Yang C, Li K, Huang S, Li C, Wang C, Zhang A, Pang P, Zheng Y. Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response. Front Genet. 2022 Sep 30;13:984615. doi: 10.3389/fgene.2022.984615. PMID: 36246628; PMCID: PMC9561824. [10] Li K, He X, Tong S, Zheng Y. Risk factors for sexual dysfunction after rectal cancer surgery in 948 consecutive patients: A prospective cohort study. Eur J Surg Oncol. 2021 Aug;47(8):2087-2092. doi: 10.1016/j.ejso.2021.03.251. Epub 2021 Mar 29. PMID: 33832775. [11] Xiao Z, Zheng YB, Dao WX, Luo JF, Deng WH, Yan RC, Liu JS. MicroRNA-328-3p facilitates the progression of gastric cancer via KEAP1/NRF2 axis. Free Radic Res. 2021 Jun;55(6):720-730. doi: 10.1080/10715762.2021.1923705. Epub 2021 Jun 23. PMID: 34160338. [12] Li K, He X, Zheng Y. An Optimal Surgical Plane for Laparoscopic Functional Total Mesorectal Excision in Rectal Cancer. J Gastrointest Surg. 2021 Oct;25(10):2726-2727. doi: 10.1007/s11605-021-05035-9. Epub 2021 Jun 9. PMID: 34109532. [13] Yang C, Huang S, Cao F, Zheng Y. A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma. BMC Cancer. 2021 Nov 5;21(1):1182. doi: 10.1186/s12885-021-08902-5. PMID: 34740325; PMCID: PMC8571885. [14] Li H, Yang C, Cheng H, Huang S, Zheng Y. CAR-T cells for Colorectal Cancer: Target-selection and strategies for improved activity and safety. J Cancer. 2021 Jan 21;12(6):1804-1814. doi: 10.7150/jca.50509. PMID: 33613769; PMCID: PMC7890323. [15] Yang C, Huang S, Cao F, Zheng Y. Role of ferroptosis-related genes in prognostic prediction and tumor immune microenvironment in colorectal carcinoma. PeerJ. 2021 Jul 14;9:e11745. doi: 10.7717/peerj.11745. PMID: 34316400; PMCID: PMC8286063. [16] Yang C, Yang Y, Huang X, Li H, Cheng H, Tong S, Zheng Y. A Nomogram Based on Clinicopathologic Features and Preoperative Hematology Parameters to Predict Occult Peritoneal Metastasis of Gastric Cancer: A Single-Center Retrospective Study. Dis Markers. 2020 Dec 9;2020:1418978. doi: 10.1155/2020/1418978. PMID: 33376558; PMCID: PMC7746455. [17] Li K, He X, Tong S, Zheng Y. Nerve plane: An optimal surgical plane for laparoscopic rectal cancer surgery? Med Hypotheses. 2021 Sep;154:110657. doi: 10.1016/j.mehy.2021.110657. Epub 2021 Aug 5. PMID: 34388537. [18] Huang X, Yang Y, Yang C, Li H, Cheng H, Zheng Y. Overexpression of LBX2 associated with tumor progression and poor prognosis in colorectal cancer. Oncol Lett. 2020 Jun;19(6):3751-3760. doi: 10.3892/ol.2020.11489. Epub 2020 Mar 27. PMID: 32382328; PMCID: PMC7202318.

Name	YONG BIN ZHENG
Date of birth	October，1970
Department	Gastrointestinal Surgery Department，Renmin Hospital,Wuhan University.
Title	Director, Professor, doctoral tutor
Email	yongbinzheng@whu.edu.cn
TEL	027-88041911-82211
Research Direction	1. The basic and clinical study of gastrointestinal tumors 2.The research of local immunity of colorectal cancer 3.The research of nerve plane-oriented laparoscopic total mesorectal excision(NPO+LTME)
Personal Profile	Professor Zheng is mainly engaged in basic research and clinical treatment of gastrointestinal tumors, with rich clinical experiences and excellent surgical skills. He is proficient in minimally invasive and standardized treatment of gastrointestinal tumors as well as conventional and laparoscopic radical resection of colorectal cancer. He built a special team and develop standardized processes for operating gastrointestinal tumors patients with 2D and 3D laparoscopic radical resectiona. In recent years, He applied Ta-TME operation and ISR+Ta-TME in anus preserving operation for low and ultra-low rectal cancer and gained a lot of experience and achievements in the study of ultra low rectal cancer surgery and pelvicautonomic nerve preservation. He proposed the nerve plane-oriented radical rectal cancer resection for the first time at home and abroad. He has been awarded 1 items for the National Natural Science Foundation, 1 items for Wu JiePing Medical Foundation, 1 items for Chen XiaoPing Foundation for the Development of Science and Technology. He also took charge and participated in the research of Hubei Natural Science Foundation and Hubei science and technology tackling key project. Besides, he published more than 100 academic papers.
Selected Publications	[1] Li S, Wang X, Yan Z, Wang T, Chen Z, Song H, Zheng Y. Microneedle Patches with Antimicrobial and Immunomodulating Properties for Infected Wound Healing. Adv Sci (Weinh). 2023 May 18:e2300576. doi: 10.1002/advs.202300576. Epub ahead of print. PMID: 37202594. [2] Zeng J, Li K, Cao F, Zheng Y. Development and validation of survival prediction model for gastric adenocarcinoma patients using deep learning: A SEER-based study. Front Oncol. 2023 Mar 7;13:1131859. doi: 10.3389/fonc.2023.1131859. PMID: 36959782; PMCID: PMC10029996. [3] Li K, Zeng J, Pang P, Cheng H, He X, Cao F, Luo Q, Tong S, Zheng Y. Significance of Nerve Plane for Inferior Mesenteric Plexus Preservation in Laparoscopic Rectal Cancer Surgery. Front Oncol. 2022 Apr 22;12:853662. doi: 10.3389/fonc.2022.853662. PMID: 35530321; PMCID: PMC9072964. [4] Yang C, Cao F, Huang S, Zheng Y. Follistatin-Like 3 Correlates With Lymph Node Metastasis and Serves as a Biomarker of Extracellular Matrix Remodeling in Colorectal Cancer. Front Immunol. 2021 Jul 16;12:717505. doi: 10.3389/fimmu.2021.717505. PMID: 34335633; PMCID: PMC8322704. [5] Huang X, Zhang J, Zheng Y. ANTXR1 Is a Prognostic Biomarker and Correlates With Stromal and Immune Cell Infiltration in Gastric Cancer. Front Mol Biosci. 2020 Dec 15;7:598221. doi: 10.3389/fmolb.2020.598221. PMID: 33385012; PMCID: PMC7770144. [6] Cao FY, Wang CH, Li X, Ma MZ, Tao GC, Yang C, Li K, He XB, Tong SL, Zhao QC, Su S, Song D, Zheng YB. Guanylate binding protein 5 accelerates gastric cancer progression via the JAK1-STAT1/GBP5/CXCL8 positive feedback loop. Am J Cancer Res. 2023 Apr 15;13(4):1310-1328. PMID: 37168340; PMCID: PMC10164808. [7] Li J, Yang C, Zheng Y. Identification of a tissue resident memory CD8 T cell-related risk score signature for colorectal cancer, the association with TME landscapes and therapeutic responses. Front Genet. 2023 Jan 4;13:1088230. doi: 10.3389/fgene.2022.1088230. PMID: 36685946; PMCID: PMC9845416. [8] Li K, Pang P, Cheng H, Zeng J, He X, Cao F, Luo Q, Tong S, Zheng Y. Protective effect of laparoscopic functional total mesorectal excision on urinary and sexual functions in male patients with mid-low rectal cancer. Asian J Surg. 2023 Jan;46(1):236-243. doi: 10.1016/j.asjsur.2022.03.050. Epub 2022 Mar 29. PMID: 35361550. [9] Li X, Song D, Su S, He X, Cao F, Yang C, Li K, Huang S, Li C, Wang C, Zhang A, Pang P, Zheng Y. Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response. Front Genet. 2022 Sep 30;13:984615. doi: 10.3389/fgene.2022.984615. PMID: 36246628; PMCID: PMC9561824. [10] Li K, He X, Tong S, Zheng Y. Risk factors for sexual dysfunction after rectal cancer surgery in 948 consecutive patients: A prospective cohort study. Eur J Surg Oncol. 2021 Aug;47(8):2087-2092. doi: 10.1016/j.ejso.2021.03.251. Epub 2021 Mar 29. PMID: 33832775. [11] Xiao Z, Zheng YB, Dao WX, Luo JF, Deng WH, Yan RC, Liu JS. MicroRNA-328-3p facilitates the progression of gastric cancer via KEAP1/NRF2 axis. Free Radic Res. 2021 Jun;55(6):720-730. doi: 10.1080/10715762.2021.1923705. Epub 2021 Jun 23. PMID: 34160338. [12] Li K, He X, Zheng Y. An Optimal Surgical Plane for Laparoscopic Functional Total Mesorectal Excision in Rectal Cancer. J Gastrointest Surg. 2021 Oct;25(10):2726-2727. doi: 10.1007/s11605-021-05035-9. Epub 2021 Jun 9. PMID: 34109532. [13] Yang C, Huang S, Cao F, Zheng Y. A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma. BMC Cancer. 2021 Nov 5;21(1):1182. doi: 10.1186/s12885-021-08902-5. PMID: 34740325; PMCID: PMC8571885. [14] Li H, Yang C, Cheng H, Huang S, Zheng Y. CAR-T cells for Colorectal Cancer: Target-selection and strategies for improved activity and safety. J Cancer. 2021 Jan 21;12(6):1804-1814. doi: 10.7150/jca.50509. PMID: 33613769; PMCID: PMC7890323. [15] Yang C, Huang S, Cao F, Zheng Y. Role of ferroptosis-related genes in prognostic prediction and tumor immune microenvironment in colorectal carcinoma. PeerJ. 2021 Jul 14;9:e11745. doi: 10.7717/peerj.11745. PMID: 34316400; PMCID: PMC8286063. [16] Yang C, Yang Y, Huang X, Li H, Cheng H, Tong S, Zheng Y. A Nomogram Based on Clinicopathologic Features and Preoperative Hematology Parameters to Predict Occult Peritoneal Metastasis of Gastric Cancer: A Single-Center Retrospective Study. Dis Markers. 2020 Dec 9;2020:1418978. doi: 10.1155/2020/1418978. PMID: 33376558; PMCID: PMC7746455. [17] Li K, He X, Tong S, Zheng Y. Nerve plane: An optimal surgical plane for laparoscopic rectal cancer surgery? Med Hypotheses. 2021 Sep;154:110657. doi: 10.1016/j.mehy.2021.110657. Epub 2021 Aug 5. PMID: 34388537. [18] Huang X, Yang Y, Yang C, Li H, Cheng H, Zheng Y. Overexpression of LBX2 associated with tumor progression and poor prognosis in colorectal cancer. Oncol Lett. 2020 Jun;19(6):3751-3760. doi: 10.3892/ol.2020.11489. Epub 2020 Mar 27. PMID: 32382328; PMCID: PMC7202318.