武汉大学人民医院湖北省人民医院

院内导航

肖哲曼 神经病学
科副主任，支部书记，教授，二级主任医师，博士生导师

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导师介绍

姓名	肖哲曼
出生年月	1978年6月
单位	武汉大学人民医院神经内科
所属学科	临床医学-神经病学
职务、职称及头衔	科副主任，支部书记，教授，二级主任医师，博士生导师
E-mail	zmxiao@whu.edu.cn
联系方式	027-88041911转87982
研究方向	1.发作性疾病（头痛、癫痫） 2.神经系统离子通道病
个人简介	擅长头痛性疾病、癫痫、眩晕、神经肌肉疾病及其他神经科常见病、多发病的诊断与治疗，主要研究方向为神经系统离子通道病（偏头痛、癫痫），主持包括3项国家自然科学基金、1项教育部博士点基金在内的10余项科研项目；“十三五”规划重点图书留学生教材《Neurology》第一主编，《神经疾病临床症候学》副主编，以第一作者/通讯作者发表SCI论文30余篇。
学术任职与荣誉	中华医学会神经病学分会头痛协作组副组长、中国医师协会神经内科医师分会疼痛与感觉障碍学组委员、中国卒中学会副主任委员、中国研究型医院学会神经科学分会常务委员、中国微循环学会神经变性专业青年委员会常务委员、中国抗癫痫学会药物转化专委会委员、中国生理学会转化神经科学专委会委员、中国研究型医院学会头痛与感觉障碍专业委员会委员、武汉医学会神经病学分会委员兼头痛学组组长
教育履历	1996.9-2001.6 武汉大学医学院临床医学专业本科生，获学士学位；2001.9-2006.6 武汉大学人民医院内科学博士研究生，获博士学位
工作履历	2006.09-2009.12 武汉大学人民医院神经内科，主治医师 2009.10-2012 .12 美国圣路易斯华盛顿大学医学院，博士后 2009.12-2015.12 武汉大学人民医院神经内科，副主任医师 2010.12-2017.12 武汉大学人民医院神经内科，副教授 2015.12-2021.12 武汉大学人民医院神经内科，主任医师 2017.9-2017.12 美国加州大学洛杉矶分校，访问学者 2017.12至今武汉大学人民医院神经内科，教授 2021.12至今武汉大学人民医院神经内科，二级主任医师
成果获奖

代表性论著	1) Wang Y, Liang J, Fang Y, Yao D, Zhang L, Zhou Y, Wang Y, Hu L, Lu Z, Wang Y, and Xiao Z. The burden of common neurological diseases in Asian countries from 1990 to 2019: an analysis for the Global Burden of Disease Study 2019. Neurology. 2023; 100(21):e2141-e2154. 2) Zhang L, Zhou Y, Yang L, Wang Y, Xiao Z. PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine. J Headache Pain. 2023; 24(1):66. 3) Shan Z, Wang Y, Qiu T, Zhou Y, Zhang Y, Hu L, Zhang L, Liang J, Ding M, Fan S, Xiao Z. SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop. J Headache Pain. 2023; 24(1):65. 4) Zhang, L, Zhou, Y, Wang, Y, Yang, L, Wang, Y, Shan, Z, Liang, J, Xiao, Z. Inhibiting PAC1 receptor internalization and endosomal ERK pathway activation may ameliorate hyperalgesia in a chronic migraine rat model. Cephalalgia. 2023；3(4):3331024231163131. 5) Wang Y, Shan Z, Zhang L, Fan S, Zhou Y, Hu L, Wang Y, Li W, XiaoZ. P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine.J Headache Pain 2022 Jul 02;23(1) (correspondence) 6) Zhou Y, Zhang L, Hao Y, Yang L, Fan S, Xiao Z. FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats. J Headache Pain 2022 Apr 05;23(1)(correspondence) 7) Wang Y, Wang S, Qiu T, Xiao Z. Photophobia in headache disorders: characteristics and potential mechanisms. J Neurol. 2022; 269(8):4055-4067.(correspondence) 8) Gong Q, Lin Y, Lu Z, Xiao Z. Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine. Neuroscience 451 (2020) 207-215. (correspondence) 9) Liu S#, Xiao Z#, Lou M, et al. Guillain-Barré syndrome in southern China: retrospective analysis of hospitalised patients from 14 provinces in the area south of the Huaihe River. J Neurol Neurosurg Psychiatry. 2018; 89(6): 618-626. (Equal-first) 10) Liu P#, Xiao Z#, Ren F#, Guo Z, Chen Z, Zhao H, Cao YQ. Functional analysis of a migraine-associated TRESK K+ channel mutation. J Neurosci. 2013; 33(31): 12810-12824. (Equal-first)
Name	Zheman XIAO
Date of birth	June, 1978
Department	Department of neurology，Renmin Hospital,Wuhan University.
Title	Associated director, Professor,chief physicion, doctoral tutor
Email	zmxiao@whu.edu.cn
TEL	027-88041911-87982
Research Direction	1 Paroxysmal disease (headache and epilepsy) 2 Ion channel disease of nervous system
Personal Profile	She is good at diagnosis and treatment of headache disease, epilepsy, vertigo, neuromuscular disease. Her main research direction is nervous system ion channel disease (migraine and epilepsy). She finished her postdoctoral training in Washington University in St. Louis (USA). She has presided over more than 10 scientific research projects including 3 National Natural Science Foundation and 1 Doctoral Program Fund of the Ministry of education. She is the first chief editor of textbook of Neurology in "the Series key books of the 13th five-year plan" (in editing), the deputy editor in chief of clinical syndromes of neurological diseases. She has published 20+ SCI papers and more than 50 other papers as the first author / corresponding author.
Selected Publications	1) Wang Y, Liang J, Fang Y, Yao D, Zhang L, Zhou Y, Wang Y, Hu L, Lu Z, Wang Y, and Xiao Z. The burden of common neurological diseases in Asian countries from 1990 to 2019: an analysis for the Global Burden of Disease Study 2019. Neurology. 2023; 100(21):e2141-e2154. 2) Zhang L, Zhou Y, Yang L, Wang Y, Xiao Z. PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine. J Headache Pain. 2023; 24(1):66. 3) Shan Z, Wang Y, Qiu T, Zhou Y, Zhang Y, Hu L, Zhang L, Liang J, Ding M, Fan S, Xiao Z. SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop. J Headache Pain. 2023; 24(1):65. 4) Zhang, L, Zhou, Y, Wang, Y, Yang, L, Wang, Y, Shan, Z, Liang, J, Xiao, Z. Inhibiting PAC1 receptor internalization and endosomal ERK pathway activation may ameliorate hyperalgesia in a chronic migraine rat model. Cephalalgia. 2023；3(4):3331024231163131. 5) Wang Y, Shan Z, Zhang L, Fan S, Zhou Y, Hu L, Wang Y, Li W, XiaoZ. P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine.J Headache Pain 2022 Jul 02;23(1) (correspondence) 6) Zhou Y, Zhang L, Hao Y, Yang L, Fan S, Xiao Z. FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats. J Headache Pain 2022 Apr 05;23(1)(correspondence) 7) Wang Y, Wang S, Qiu T, Xiao Z. Photophobia in headache disorders: characteristics and potential mechanisms. J Neurol. 2022; 269(8):4055-4067.(correspondence) 8) Gong Q, Lin Y, Lu Z, Xiao Z. Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine. Neuroscience 451 (2020) 207-215. (correspondence) 9) Liu S#, Xiao Z#, Lou M, et al. Guillain-Barré syndrome in southern China: retrospective analysis of hospitalised patients from 14 provinces in the area south of the Huaihe River. J Neurol Neurosurg Psychiatry. 2018; 89(6): 618-626. (Equal-first) 10) Liu P#, Xiao Z#, Ren F#, Guo Z, Chen Z, Zhao H, Cao YQ. Functional analysis of a migraine-associated TRESK K+ channel mutation. J Neurosci. 2013; 33(31): 12810-12824. (Equal-first)