武汉大学人民医院湖北省人民医院

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田道锋神外

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导师介绍

姓名：田道锋

出生年月：1975年8月

单位：武汉大学人民医院神经外科

职务、职称：支部书记、副主任、主任医师、硕士生导师

邮箱：tiandaofeng@hotmail.com

联系电话：13971668815或者027-88041919-82237

研究方向：显微神经外科和胶质瘤的基础研究

个人简介：

主要从事神经外科疾病的诊治和科研工作，主持省自然科学基金等5项，参与国家自然科学基金6项；第一作者发表论文30余篇；获湖北省科技进步一等奖1项、二等奖1项、三等奖1项，武汉市科技进步三等奖1项。擅长颅脑肿瘤、脑血管病、脑膜瘤、胶质瘤、垂体瘤、听神经瘤及脑动脉瘤的诊断和显微手术治疗，特别是颅神经疾病治疗，如面肌痉挛、三叉神经痛、舌咽神经痛的微血管减压手术治疗；致力于颅底解剖结构及颅底肿瘤的手术研究。

学术职务：

中国中西医结合学会神经外科专业委员会委员

湖北省医师协会神经外科专业委员会委员

湖北省病理生理协会颅脑外伤及重症专业委员会副主任委员

湖北省抗癌协会青年委员会委员

湖北省医学会神经外科分会秘书

湖北省抗癌协会神经肿瘤专业委员会秘书

《中华实验外科杂志》特约审稿专家

教育履历：

1992.09-1997.07 湖北医科大学（武汉大学医学院）临床医学专业，学士

1997.09-2000.07 湖北医科大学（武汉大学医学院）外科学专业，硕士

2003.09-2007.09 武汉大学医学院外科学专业，研究生，博士

2014.09-2015.09 美国耶鲁大学医学院神经外科访问学者

工作履历：

2000.07－2002.09 武汉大学人民医院神经外科，住院医生

2002.09－2007.11 武汉大学人民医院神经外科，主治医师

2007.12-2012．11 武汉大学人民医院神经外科，副主任医师

2012.12-至今武汉大学人民医院神经外科，主任医师

成果获奖：

1. 人脑胶质瘤精准外科手术治疗及其相关发病机制 2017年湖北省科技进步一等奖

2. 脑胶质瘤的外科干预策略及侵袭性分子机制研究 2009年湖北省科技进步二等奖

3. 脑胶质瘤的外科干预策略及侵袭性分子机制研究 2008年武汉市科技进步三等奖

4. 套式双腔管的研制及其在神经外科的应用研究 2002年湖北省科技进步三等奖

论文代表作：

1.Baohui Liu, Daofeng Tian, Wei Yi, Liquan Wu, Qiang Cai, Huimin Dong, Heng Shen, Baowei Ji, Long Wang, Shenqi Zhang, Dong Ruan, Qianxue Chen. Effect of Bone Morphogenetic Protein 4 in the Human Brain Glioma Cell Line U251. Cell Biochem Biophys, 2010, 11,58(2):91~96.（IF:3.337）

2.Zesheng Peng, Tingfeng Wu, Yuntao Li, Zhou Xu, Shenqi Zhang, Baohui Liu, Qianxue Chen,Daofeng Tian. MicroRNA-370-3p inhibits human glioma cell proliferation and induces cell cycle arrest via directly targeting β-catenin. Brain research. 2016，1644：53-61

3.Zesheng Peng, Daofeng Tian, Shenqi Zhang, Baohui Liu, Zhou Xu, Liquan Wu, Qianxue Chen. Cerebral Syphilitic GummaMimicking Malignant Brain Tumour in a Human Immunodeficiency Virus. Int J Clin Exp Med. 2016;9(3): 6720-6723.

4.Zesheng Peng, Daofeng Tian, Qianxue Chen, Shenqi Zhang, Baohui Liu, Baowei Ji. Telomerase reverse transcriptase (TERT) rs2736100 polymorphism contributes to increased risk of glioma: evidence from a meta-analysis. Int J Clin Exp Med. 2015, 8(1): 422-430.

5.Zesheng Peng, Daofeng Tian, Hongliu Wang, Derek Kai Kong, Shenqi Zhang, Baohui Liu, Gang Deng, Zhou Xu, Liquan Wu, Baowei Ji, Long Wang, Qiang Cai, Mingchang Li, Junmin Wang, Aimin Zhang, Qianxue Chen. Epistaxis and pituitary apoplexy due to ruptured internal carotid artery aneurysm embedded within pituitary adenoma. Int J Clin Exp Pathol. 2015, 8(11): 14189-14197.

6.彭泽生，张申起，朱晓楠，陈谦学，田道锋.微小RNA-370-3P对胶质瘤细胞U251增殖的影响及机制. 中华实验外科杂志. 2017, 34(8): 1267-1270.

7.MircoRNA-370-3p对胶质母细胞瘤细胞株U87-MG增殖能力的影响及机制的初探讨. 中国临床神经外科杂志. 2016, 21(4): 226-229.

8.经岩骨乙状窦前入路显微手术治疗岩斜区脑膜瘤. 中国临床神经外科杂志. 2014, (03): 135-137.

9.田道锋, 陈谦学, 吴立权, 冀保卫, 张申起, 刘宝辉, 王龙, 陈治标, 蔡强. 转染人β干扰素基因的骨髓间充质干细胞治疗大鼠颅内胶质瘤. 中华实验外科杂志, 2010, 27(10): 1384-1387.

10.田道锋, 陈谦学, 吴立权, 蔡强, 陈治标, 袁先厚. 人β干扰素基因重组腺病毒载体的构建及在骨髓间充质干细胞的表达. 中华实验外科杂志, 2009， 26（2）: 216-218.

11.田道锋,陈谦学,刘仁忠, 等. 儿童鼻内型脑膜脑膨出的临床特征及手术治疗.中华小儿外科杂志. 2006, 27(5): 234-236.

12.田道锋,陈谦学,刘仁忠,等. 内镜辅助听神经瘤切除术以减少术后脑脊液漏. 中华神经外科杂志.2006, 22(9): 536-537.

13.田道锋，陈谦学，陈治标，等. 颅面穿通性损伤的临床分型及救治. 中华急诊医学杂志. 2006, 15(3): 206-208.

14.田道锋, 陈谦学, 刘仁忠, 等. 颞肌的解剖研究及翼点开颅术后颞肌萎缩的防治. 中华神经外科杂志. 2006, 22(4): 239-241.

15.田道锋，刘仁忠，陈谦学，等. 老年人颅内动脉瘤的锁孔手术治疗. 中华老年医学杂志. 2005，24（10）：764－765.

16.田道锋，邹瑛，王军民，等. 儿童颅骨生长性骨折(附13例报告). 中华小儿外科杂志. 2005，26（3）：161－162.

17.田道锋，陈谦学，刘仁忠，等. 无菌开颅术后硬膜外区域感染的原因及治疗. 中华神经外科疾病研究杂志. 2006, 5(2):175-176.

CURRICULUM VITAE

Name Daofeng Tian

Education: (From his CV)

2003—2007 Wuhan University, Wuhan

Received the degree of doctor of Medicine in 2007

1997—2000 Wuhan University, Wuhan

Received Master’s degree in Medicine in 2000

1992—1997 Hubei Medical University (which was incorporated into Wuhan University in 2000), Wuhan

Received Bachelor’s degree in Medicine in 1997

Career/Academic appointment in his country-- From his CV

2012-present senior surgeon

Neurosurgery Department, Renmin Hospital of Wuhan University, Wuhan

2007-2012 Associate senior surgeon

Neurosurgery Department, Renmin Hospital of Wuhan University, Wuhan

2000-2007 Resident, Attending

Neurosurgery Department, Renmin Hospital of Wuhan University, Wuhan

PUBLICATIONS

First author:

6.Daofeng Tian, Shenqi Zhang, Qianxue Chen, et al. [Keyhole surgery for large cerebellopontine angle tumors and intraoperative preservation of neural function]. Journal of Clinical Surgery, 2011, 19(6): 402-404. Chinese.

7.Daofeng Tian, Qianxue Chen, Liquan Wu, et al. [Studies of regional subdural pressure measurement during supratentorial craniotomy]. Chinese Journal of Clinical Neurosurgery, 2011, 16(2): 109-110. Chinese.

8.Daofeng Tian, Qianxue Chen, Shenqi Zhang, et al. [Clinical characteristics and surgical treatment of distal posterior inferior cerebellar artery aneurysms]. Chinese Journal of Clinical Neurosurgery, 2011, 16(1): 1-3. Chinese.

9.Daofeng Tian, Qianxue Chen, Liquan Wu, et al. [Gene therapy of rat intracranial glioma by Mesenchymal Stem Cells (MSCs) transfected with the beta-interferon gene]. Chinese Journal of Experimental Surgery. 2010, 27(10): 1384-1387. Chinese.

10.Daofeng Tian, Qianxue Chen, Liquan Wu, et al. [Construction of recombinant adenovirus vector containing human beta-interferon gene and its expression in bone mesenchymal stem cells]. Chinese Journal of Experimental Surgery. 2009, 26（2）: 216-218. Chinese.

11.Daofeng Tian, Qianxue Chen, Liquan Wu, et al. [C6 glioma cells were inhibited by mesenchymal stem cells(MSCs) transfected with the Beta-interferon gene in vitro]. Stroke and Nervous Diseases, 2010, 17(4): 225-228. Chinese.

12.Daofeng Tian, Ying Zou, Qianxue Chen, et al. [The clinical classification, diagnosis and treatment of craniofacial penetrating injuries in children]. Journal of Clinical Surgery, 2008, (10): 676-677. Chinese.

13.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [The reason and treatment of epidural region infection after asepsis craniotomy]. Chinese Journal of Neurosurgical Disease Research, 2006, 5(2): 175-176. Chinese.

14.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [The clinical feature and treatment of intranasal encephalomeningocele in children]. Chinese Journal of Pediatric Surgery, 2006, 27(5): 234-236. Chinese.

15.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [The reason and treatment of delayed scalp infection after asepsis craniotomy]. Chinese Journal of Clinical Neurosurgery, 2006, 11(6): 356-357. Chinese.

16.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [Endoscopically assisted prevention of cerebrospinal fluid leak after microsurgical removal of acoustic neuroma]. Chinese Journal of Neurosurgery, 2006, 22(9): 536-537. Chinese.

17.Daofeng Tian, Qianxue Chen, Zhibiao Chen, et al. [The clinical classification, diagnosis and treatment of penetrating craniofacial injuries]. Chinese Journal of Emergency Medicine, 2006, 15(3): 206-208. Chinese.

18.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [The anatomy of temporal muscle and surgical preservation of temporal muscle in pterional craniotomy]. Chinese Journal of Neurosurgery, 2006, 22(4): 239-241. Chinese.

19.Daofeng Tian, Renzhong Liu, Qianxue Chen, et al. [Keyhole approach in surgical treatment for elderly patients with intracranial aneurysms]. Chinese Journal of Geriatrics, 2005, 24（10）: 764-765. Chinese.

20.Daofeng Tian, Ying Zou, Junmin Wang, et al. [Growing skull fracture(GSF) in childhood (presentation of 13 cases)]. Chinese Journal of Pediatric Surgery, 2005, 26（3）: 161-162. Chinese.

21.Daofeng Tian, Yinghu Ye, Qianxue Chen, et al. [Significance of changes of intramucosal PH after hypertensive cerebral hemorrhage]. Stroke and Nervous Diseases, 2005, 12（5）: 291-293. Chinese.

22.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [Cerebrospinal fluid leak after microsurgical removal of vestibular schwannomas]. Chinese Journal of Clinical Neurosurgery, 2005, 10（5）: 373-375. Chinese.

23.Daofeng Tian, Ying Zou, Qianxue Chen, et al. [Spontaneous intracranial hemorrhage in children( A report of 29 cases )]. Chinese Pediatric Emergency Medicine, 2005, 12（2）: 138-139. Chinese.

24.Daofeng Tian, Ying Zou, Junmin Wang, et al. [Monitoring of gastric intramucosal PH in patients with severe craniocerebral injury and its clinical significance]. Chinese Journal of Gastroenterology, 2005, 10(4): 227-229. Chinese.

25.Daofeng Tian, Hongguo Wang, Qianxue Chen, et al. [The causes and treatment for cerebrospinal fluid leak after microsurgical removal of vestibular schwannomas]. Journal of Chinese Physician, 2005, 7（10）: 1302-1304. Chinese.

26.Daofeng Tian, Ying Zou, Qianxue Chen, et al. [The treatment of craniofacial penetrating injuries in children]. Journal of Applied Clinical Pediatrics, 2005, 20(12): 1254-1255. Chinese.

27.Daofeng Tian, Qianxue Chen, Renzhong Liu, et al. [Causes and prevention of postoperative atrophy of temporal muscle in pterional craniotomy]. Chinese Journal of Minimally Invasive Neurosurgery, 2004, 9（11）: 493-494. Chinese.

28.Daofeng Tian, Xuebin Hu, Renzhong Liu, et al. [Endonasal transsphenoidal endoscopic pituitary surgery]. Cancer Research on Prevention and Treatment, 2003, 30（4）: 316-317. Chinese.

29.Daofeng Tian, Biquan Zheng, Zhihong Jian, et al. [26 cases of ruptured cerebral vascular malformation in children]. Journal of Applied Clinical Pediatrics, 2003，18（5）: 396-397. Chinese.

30.Daofeng Tian, Guoan Wang. [Endonasal transsphenoidal endoscopic pituitary surgery(review)]. Chinese Journal of Clinical Neurosurgery. 2002，7（5）：318-320. Chinese.

31.Daofeng Tian, Yinghu Ye, Guoan Wang. [Apoptosis and bcl-2, p53 Protein expression in meningiomas]. The Practical Journal of Cancer, 2001, 16（3）: 256-258. Chinese.

32.Daofeng Tian. [Study on molecular biology of meningioma]. Chinese Journal of Clinical Neurosurgery, 2000, 5（3）: 191-193. Chinese.

Co-author:

2.Baohui Liu, Qianxue Chen, Daofeng Tian, Liquan Wu, Junmin Wang, Qiang Cai, Heng Shen, Baowei Ji, Long Wang, Shenqi Zhang, Dong Ruan, Xiaonan Zhu, Zhentao Guo, Huimin Dong, Mingmin Yan. Increased leucine-rich repeats and immunoglobulin- like domains 1 expression enhances chemosensitivity in glioma. Neural Regen Res. 2011;6(32):2516-2520.

3.Liquan Wu, Mingcan Wu, Daofeng Tian, Shijie Chen, Baohui Liu, Qianxue Chen,Junmin Wang, Qiang Cai, Baowei Ji,Long Wang, Shenqi Zhang, et al. Clinical and Imaging Characteristics of Cerebral Schistosomiasis. Cell Biochem Biophys, 2012, 62: 289–295.

4.Liu B,Chen Q,Tian D,Wu L,Dong H,Wang J,Ji B,Zhu X,Cai Q,Wang L,Zhang S. BMP4 reverses multidrug resistance through modulation of BCL-2 and GDNF in glioblastoma. Brain Res, 2013, 1507:115-124.

5.BaoweiJi,Qianxue Chen, Baohui Liu, Liquan Wu, Daofeng Tian, Zhentao Guo, Wei Yi. Glioma stem cell-targeted dendritic cells as a tumor vaccine against human malignant glioma. Yonsei Med J, 2013, 54(1):92-100.

PATENT

Grants

1President: Natural Science Foundation of Hubei Province, China. Project Name: Experimental study on treatment of glioma cells by bone marrow mesenchymal stem transfected by LRIG1. funds: 20,000 RMB.

2President: Natural Science Foundation of The health department of Hubei Province, China. Project Name: the relationship and mechanism between glioma stem cell chemosensitivity and interferon beta gene. Funds: 30,000 RMB.

3Participant: National Science Foundation of China. Project Name : Experimental study on anti-glioma with siRNA mediated by human foamy retrovirus(30670099). Funds: 300,000 RMB.

4Participant: National Science Foundation of China. Project Name : the functions of SARS coronavirus nonstructural protein Nsp16 and its RNA capping mechanism (30670450). Funds: 300,000 RMB.

5Participant: National Science Foundation of China. Project Name : Experimental study on the effect and the mechanism of dendritic cell vaccine targeted by cancer stem cells in the treatment of malignant gliomas (30772223). Funds: 300,000 RMB.

Committees and Academic Achievements

The research of glioma surgical intervention strategy and raiding molecular mechanism. Hubei Pronvince Scientific and Technological Progress, P.R.C. 2009.09, Second prize, Seventh Ranked.