杨菁
妇产科
二级教授，一级主任医师，博士生导师
二级教授，一级主任医师，博士生导师
导师介绍
| 姓名 | 杨菁 |
| 出生年月 | 1958年2月 |
| 单位 | 武汉大学人民医院妇产科 |
| 所属学科 | 临床医学-妇产科学 |
| 职务、职称及头衔 | 二级教授，一级主任医师，博士生导师 |
| dryangqing@hotmail.com | |
| 联系方式 | 027-88041911转82236 |
| 研究方向 |
1.生殖内分泌疾病的诊断和治疗方向（主要研究多囊卵巢综合征、子宫内膜异位症、无排卵性不孕的治疗及发病机制） 2.辅助生殖技术方向（主要研究IVF技术的改进和优化及胚胎着床调节机制） 3.母-胎耐受的免疫机制研究方向（主要研究免疫因素在复发性流产和反复IVF失败中的作用及机制） |
| 个人简介 | 主要从事生殖内分泌及不孕不育疾病的诊治与科研工作，作为课题组长承担国家重大专项子课题2项，作为课题负责人承担5项国家自然科学基金、10余项省部级重点科研项目。参编规划教材《妇产科学（第2版）》，主讲的武汉大学通识课入选国家精品在线开放课程。在国内外核心期刊发表论文400余篇，其中SCI论文90余篇。已培养硕士生60余人，博士生27名。目前正在培养的博士生9名，硕士生14名。 |
| 学术任职与荣誉 | 中国妇幼保健协会辅助生殖技术监测与评估专业委员会常委、生育保健专业委员会生殖外科学组组长，海峡两岸医药卫生交流协会第一届不孕不育专业委员会副主任委员，中国医疗保健国际交流促进会会生殖医学分会副主任委员及妇产科专业委员会常委，中国医师协会生殖医学专业委员会常委及临床循证研究学组委员，《Human reproduction update中文版》编委，《中华生殖与避孕杂志》编委 |
| 教育履历 |
1978.09-1982.12湖北医科大学（现武汉大学医学部）医学专业本科生获学士学位 1986.09-1989.06湖北医科大学（现武汉大学医学部）妇产科学硕士研究生获硕士学位 2004.09-2007.06武汉大学第一临床学院外科学博士研究生获博士学位 |
| 工作履历 |
1982.12-1986.09 湖北省人民医院（现武汉大学人民医院）妇产科住院医师、助教 1989.07-1993.12 湖北省人民医院（现武汉大学人民医院）妇产科主治医师、讲师 1994.01-1998.12 湖北省人民医院（现武汉大学人民医院）妇产科副主任、副主任医师、副教授 1999.01-2000.03 湖北省人民医院（现武汉大学人民医院）妇产科副主任、主任医师 2000.03-2009.01 武汉大学人民医院生殖医学中心主任、主任医师、教授、硕士生导师、博士生导师（2008年起） 2009.01-2013.03 武汉大学人民医院妇产科主任，生殖医学中心主任、主任医师、教授、博士生导师 2013.03-2021.03 武汉大学人民医院妇产科主任、主任医师、教授、博士生导师 2013.03-至今 武汉大学人民医院妇产科主任医师、教授、博士生导师 |
| 成果获奖 |
1.《卵母细胞与胚胎无创评估、监测体系的研发与应用》获2020年湖北省科技进步奖二等奖 2.《MiRNAs在复发性流产病理过程中的作用及其在妊娠结局预测中的应用价值》获2019年全国妇幼健康科学技术奖科技成果奖三等奖 3.《母-胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用》获2018年中华医学科技奖二等奖 4.《创建生殖健康培养体系，引领生殖健康创新人才培养》获2018年第八届湖北省高等学校教学成果奖二等奖 5.《母-胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用》获2018年华夏医学科技奖三等奖 6.《不明原因复发性流产规范化评估治疗体系的建立及其机制研究》获2017年全国妇幼健康科学技术奖二等奖 7.《环境变迁与人类生育力改变》入选2017年国家精品在线开放课程 8.《母胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用》获2017年湖北省科技进步奖二等奖 9.《创建“生殖健康”培养体系，引领生殖健康创新人才培养》获2017年第八届湖北省高等学校教学成果奖二等奖 10.《创建“生殖健康”培养体系，引领生殖健康创新人才培养》获2017年武汉大学教学成果奖二等奖 11.《不孕症的发病基础与体外受精治疗中影响因素的研究》获2016年华夏医学科技奖三等奖 12.《生殖健康创新课程体系设计与教学模式探索》获2016年武汉大学教学成果奖二等奖 13.《不孕症的发病基础与体外受精治疗中影响因素的研究》获2015年全国妇幼健康科学技术奖二等奖 14.《不孕症个体化诊治体系的理论及关键技术推广应用》获2015年湖北省科学技术成果推广奖二等奖 15.《不孕症的发病基础与体外受精治疗中影响因素的研究》获2013年武汉市科技进步奖二等奖 16.《不孕症的发病基础与体外受精治疗中影响因素的研究》获2012年湖北省科技进步奖二等奖 |
| 代表性论著 |
1)Lan
Dong#, Lu Zhang#, Hua Liu#, Meiting Xie, Jing Gao, Xiaoyan Zhou, Qinghong
Zhao*, Silin Zhang*, Jing Yang*. Circ_0007331 knock-down suppresses the
progression of endometriosis via miR-200c-3p/HiF-1α axis. J Cell Mol
Med. 2020;Nov;24(21):12656-12666.(二区，IF4.486) 2)Luo J, Zhu H, Chang H-M, Lin Y-M, Yang J*, Leung PCK*. The regulation of IGFBP3 by BMP2 has a role in human endometrial remodeling. The FASEB Journal. 2020 Nov;34(11):15462-15479.(二区,IF：4.996) 3)Bing Qu, Qinghong Zhao, Qinglian Ma, Tian Yang, Xueyao Li, Yu Chen, Jing Yang*, Yan Zhang*. Overexpression of miR-144-3p alleviates polycystic ovaries syndrome through targeting expression of HSP-70. Gene Ther. 2020 Sep 11.（二区） 4)Jiao Chen#, Bowen Liu,# Ying Zhang#, Liangfei Ao, Zehong Li, Bing Qu, Xueyao Li, Jing Yang*. Effect of immunotherapy on patients with unexplained recurrent spontaneous abortion. Ann Palliat Med. 2020 Sep;9(5):2545-2550.(二区IF：1.681) 5)Jun Liu，Jinli Ding，Bing Qu，Jiuying Liu，Xiaojie Song，Qingli Suo，Aifen Zhou，Jing Yang*. CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2020 Aug 17;24(18):11001-11011. (二区，IF4.486) 6)Yanting Wu #, Chen Liu #, Lan Dong #, Chenjie Zhang , Yang Chen , Jun Liu , Chen Zhang , Chenchi Duan, Hanqiu Zhang, Ben W Mol, Cindy-Lee Dennis , Tailang Yin*, Jing Yang*, Hefeng Huang*. Coronavirus Disease 2019 Among Pregnant Chinese Women: Case Series Data on the Safety of Vaginal Birth and Breastfeeding. BJOG. 2020 Aug; 127(9): 1109–1115. (二区IF:5.040) 7)Jinli Ding, Chaogang Yang , Yanxiang Cheng, Jiayu Wang, Sainan Zhang, Sisi Yan , Fan He, Tailang Yin, Jing Yang* . Trophoblast-derived IL-6 serves as an important factor for normal pregnancy by activating Stat3-mediated M2 macrophages polarization Int Immunopharmacol. 2020 Jul 24;106788.(二区，IF：3.943) 8)Yan-Ting Wu, Jun Liu, Jing-Jing Xu, Yan-Fen Chen, Wen Yang, Yang Chen, Cheng Li, Yu Wang, Han Liu, Chen Zhang, Ling Jiang, Zhao-Xia Qian, Andrew Kawai, Ben Willem Mol, Cindy-Lee Dennis, Guo-Ping Xiong, Bi-Heng Cheng, Jing Yang*, He-Feng Huang*. Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. PLOS MEDICINE. 2020 Jul 28;17(7):e1003195. (一区，IF10.5) 9)Bing Qu, Jing Yang*. Monologue of a physician who tested persistently positive for COVID-19. Clin Infect Dis. 2020, May 11;ciaa551.(一区Top，IF:8.313) 10)Gengxiang Wu, Zhe Yang, Yajie Chen, Xiaoling Li, Jing Yang*, Tailang Yin*. Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome. Mol Cell Endocrinol. 2020 Apr 15;506:110760. doi: 10.1016/j.mce.2020.110760.（二区，IF3.871） 11)Lan Dong, Jinhua Tian, Songming He, Chuchao Zhu, Jian Wang, Chen Liu*, Jing Yang*. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020 Mar 26;323(18):1846-1848. doi: 10.1001/jama.2020.4621.（一区，IF45.54） 12)X. Wang, ,X. Tian, . Ye , Y. Zhang, C. Li, . Liao, . Zou, S. Zhang, Y. Zhu, J. Yang* and L. Ma*. Gaseous pollutant exposure affects semen quality in central China: a cross-sectional study. Andrology, 2020 Jan;8(1):117-124. doi: 10.1111/andr.12655.（二区；IF：3.106） 13)Jinli Ding, Yanxiang Cheng, Yi Zhang, Shujie Liao*, Tailang Yin*, Jing Yang*. The miR-27a-3p/USP25 axis participates in the pathogenesis of recurrent miscarriage by inhibiting trophoblast migration and invasion. J Cell Physiol, 2019 Nov;234(11):19951-19963.（二区，IF 4.522） 14)Yuan Ni, Dan Xu, Feng Lv, Yang Wan, Guanlan Fan, Wen Zou, Yunxi Chen, Linguo Pei, Jing Yang, Hui Wang. Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency. Journal of Endocrinology, 2019,243(1):43-58.（二区，IF 4.381） 15)Lingyan Liu, TailangYin, Yu Chen, Yinghuan Li, Lu Yin, Jinli Ding, Jing Yang*, HuaiL Feng*. Follicular dynamics of glycerophospholipid and sphingolipid metabolisms in polycystic ovary syndrome patients. J Steroid Biochem Mol Biol, 2019 Jan;185:142-149.(二区，IF 3.785) 16)Mu Y, Yin TL, Yin L, Hu X, Yang J.CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice. Clin Sci (Lond). 2018 Apr 30;132(8):883-899.(二区，IF 5.22) 17)Li S, Zhou D, Yin T, Xu W, Xie Q, Cheng D, Yang J. Dual trigger of triptorelin and HCG optimizes clinical outcome for high ovarian responder in GnRH-antagonist protocols. Oncotarget. 2018 Jan 4;9(4):5337-5343.(二区，IF 4.73) |
| Name | JING YANG |
| Date of birth | February，1958 |
| Department | Obstetrics and Gynecology,Renmin Hospital,Wuhan University. |
| Title | Professor, doctoral tutor |
| dryangqing@hotmail.com | |
| TEL | 027-88041911-82236 |
| Research Direction |
1.Diagnosis
and treatment of Reproductive Endocrine Disorders (mainly focused on the
pathogenesis and treatment of Polycystic Ovary Syndrome, Endometriosis and
Anovulatory Infertility) 2.Assisted Reproductive Technology (mainly focused on the improvement and optimization of in vitro fertilization and embryo transfer, and the regulatory mechanism of embryo implantation) 3.The immunologic mechanism of the maternal-fetal immune tolerance (mainly focused on the effect and mechanisms of immunological factors on recurrent spontaneous abortion) |
| Personal Profile | She is mainly engaged in the diagnosis and treatment of reproductive endocrine and infertility diseases, and has been awarded 2 subproject for the National Key Research and Development Program of China, 5 items for the National Natural Science Foundation, 10 items for the provincial and ministerial key scientific research programs. She has also involved in compiling the planning teaching material Obstetrics and Gynecology (Second Edition). One course in general education of Wuhan University taught by her has been officially selected as the national selected premium quality online open course. Besides, there are more than 400 articles published in domestic and foreign core journals, of which 90 papers indexed by SCI. By now, she has educated more than 60 masters and 27 doctors. At present, there are 9 doctors and 14 masters studying with her. |
| Selected Publications |
1)Lan
Dong#, Lu Zhang#, Hua Liu#, Meiting Xie, Jing Gao, Xiaoyan Zhou, Qinghong
Zhao*, Silin Zhang*, Jing Yang*. Circ_0007331 knock-down suppresses the
progression of endometriosis via miR-200c-3p/HiF-1α axis. J Cell Mol
Med. 2020;Nov;24(21):12656-12666.(二区，IF4.486) 2)Luo J, Zhu H, Chang H-M, Lin Y-M, Yang J*, Leung PCK*. The regulation of IGFBP3 by BMP2 has a role in human endometrial remodeling. The FASEB Journal. 2020 Nov;34(11):15462-15479.(二区,IF：4.996) 3)Bing Qu, Qinghong Zhao, Qinglian Ma, Tian Yang, Xueyao Li, Yu Chen, Jing Yang*, Yan Zhang*. Overexpression of miR-144-3p alleviates polycystic ovaries syndrome through targeting expression of HSP-70. Gene Ther. 2020 Sep 11.（二区） 4)Jiao Chen#, Bowen Liu,# Ying Zhang#, Liangfei Ao, Zehong Li, Bing Qu, Xueyao Li, Jing Yang*. Effect of immunotherapy on patients with unexplained recurrent spontaneous abortion. Ann Palliat Med. 2020 Sep;9(5):2545-2550.(二区IF：1.681) 5)Jun Liu，Jinli Ding，Bing Qu，Jiuying Liu，Xiaojie Song，Qingli Suo，Aifen Zhou，Jing Yang*. CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2020 Aug 17;24(18):11001-11011. (二区，IF4.486) 6)Yanting Wu #, Chen Liu #, Lan Dong #, Chenjie Zhang , Yang Chen , Jun Liu , Chen Zhang , Chenchi Duan, Hanqiu Zhang, Ben W Mol, Cindy-Lee Dennis , Tailang Yin*, Jing Yang*, Hefeng Huang*. Coronavirus Disease 2019 Among Pregnant Chinese Women: Case Series Data on the Safety of Vaginal Birth and Breastfeeding. BJOG. 2020 Aug; 127(9): 1109–1115. (二区IF:5.040) 7)Jinli Ding, Chaogang Yang , Yanxiang Cheng, Jiayu Wang, Sainan Zhang, Sisi Yan , Fan He, Tailang Yin, Jing Yang* . Trophoblast-derived IL-6 serves as an important factor for normal pregnancy by activating Stat3-mediated M2 macrophages polarization Int Immunopharmacol. 2020 Jul 24;106788.(二区，IF：3.943) 8)Yan-Ting Wu, Jun Liu, Jing-Jing Xu, Yan-Fen Chen, Wen Yang, Yang Chen, Cheng Li, Yu Wang, Han Liu, Chen Zhang, Ling Jiang, Zhao-Xia Qian, Andrew Kawai, Ben Willem Mol, Cindy-Lee Dennis, Guo-Ping Xiong, Bi-Heng Cheng, Jing Yang*, He-Feng Huang*. Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China. PLOS MEDICINE. 2020 Jul 28;17(7):e1003195. (一区，IF10.5) 9)Bing Qu, Jing Yang*. Monologue of a physician who tested persistently positive for COVID-19. Clin Infect Dis. 2020, May 11;ciaa551.(一区Top，IF:8.313) 10)Gengxiang Wu, Zhe Yang, Yajie Chen, Xiaoling Li, Jing Yang*, Tailang Yin*. Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome. Mol Cell Endocrinol. 2020 Apr 15;506:110760. doi: 10.1016/j.mce.2020.110760.（二区，IF3.871） 11)Lan Dong, Jinhua Tian, Songming He, Chuchao Zhu, Jian Wang, Chen Liu*, Jing Yang*. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020 Mar 26;323(18):1846-1848. doi: 10.1001/jama.2020.4621.（一区，IF45.54） 12)X. Wang, ,X. Tian, . Ye , Y. Zhang, C. Li, . Liao, . Zou, S. Zhang, Y. Zhu, J. Yang* and L. Ma*. Gaseous pollutant exposure affects semen quality in central China: a cross-sectional study. Andrology, 2020 Jan;8(1):117-124. doi: 10.1111/andr.12655.（二区；IF：3.106） 13)Jinli Ding, Yanxiang Cheng, Yi Zhang, Shujie Liao*, Tailang Yin*, Jing Yang*. The miR-27a-3p/USP25 axis participates in the pathogenesis of recurrent miscarriage by inhibiting trophoblast migration and invasion. J Cell Physiol, 2019 Nov;234(11):19951-19963.（二区，IF 4.522） 14)Yuan Ni, Dan Xu, Feng Lv, Yang Wan, Guanlan Fan, Wen Zou, Yunxi Chen, Linguo Pei, Jing Yang, Hui Wang. Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency. Journal of Endocrinology, 2019,243(1):43-58.（二区，IF 4.381） 15)Lingyan Liu, TailangYin, Yu Chen, Yinghuan Li, Lu Yin, Jinli Ding, Jing Yang*, HuaiL Feng*. Follicular dynamics of glycerophospholipid and sphingolipid metabolisms in polycystic ovary syndrome patients. J Steroid Biochem Mol Biol, 2019 Jan;185:142-149.(二区，IF 3.785) 16)Mu Y, Yin TL, Yin L, Hu X, Yang J.CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice. Clin Sci (Lond). 2018 Apr 30;132(8):883-899.(二区，IF 5.22) 17)Li S, Zhou D, Yin T, Xu W, Xie Q, Cheng D, Yang J. Dual trigger of triptorelin and HCG optimizes clinical outcome for high ovarian responder in GnRH-antagonist protocols. Oncotarget. 2018 Jan 4;9(4):5337-5343.(二区，IF 4.73) |
武汉大学人民医院
湖北省人民医院