张振涛
神经病学
教授，主任医师，博士生导师，神经内一科副主任，湖北省神经精神研究所副所长
教授，主任医师，博士生导师，神经内一科副主任，湖北省神经精神研究所副所长
导师介绍
| 姓名 | 张振涛 |
| 出生年月 | 1981年10月 |
| 单位 | 武汉大学人民医院神经内科 |
| 所属学科 | 神经病学 |
| 职务、职称及头衔 | 教授，主任医师，博士生导师，神经内一科副主任，湖北省神经精神研究所副所长 |
| zhentaozhang@whu.edu.cn | |
| 联系方式 | 027-88041911转82221 |
| 研究方向 | 1.帕金森病；2.阿尔茨海默病 |
| 个人简介 | 一直致力于帕金森病和阿尔茨海默病的发病机制及治疗对策研究,主持国家重点研发计划、国家自然科学基金、湖北省杰出青年科学基金等科研项目，代表性论著包括国际顶级期刊Nature Medicine、Nature Communications、Nature Structural & Molecular Biology、Brain、Molecular Neurodegeneration、Progress in Neurobiology和Molecular Psychiatry等。目前正在培养的博士生9名，硕士生7名。 |
| 学术任职与荣誉 |
1.
“百千万人才工程”国家级人选 2. 获国家“有突出贡献中青年专家”称号 3. 国务院政府特殊津贴专家 4. 获国家“优秀青年科学基金”资助 5. 获湖北省“杰出青年科学基金”资助 6. 中国医师协会帕金森病及运动障碍学组委员 7. 中华医学会神经病学分会帕金森及运动障碍学组委员 8. 中国老年学和老年医学学会脑认知与健康分会常务委员 9. 中国老年学和老年医学学会老年脑疾病分会委员 10. 武汉医学会神经病学分会第三届帕金森病学组副主任委员 11. 湖北省神经科学学会认知科学专业委员会副主任委员 |
| 教育履历 |
2007年9月-2010年6月，华中科技大学同济医学院，博士研究生，神经病学； 2004年9月-2007年6月，华中科技大学同济医学院，硕士研究生，神经病学； 1999年9月-2004年6月，潍坊医学院医学系，本科，临床医学。 |
| 工作履历 |
2017年12月至今，武汉大学人民医院神经内科，教授，主任医师； 2016年11月至2017年11月，武汉大学人民医院神经内科，教授，副主任医师； 2015年2月至2016年10月，美国Emory大学，助理教授(Assistant professor)； 2012年2月－2015年1月，美国Emory大学，博士后； 2010年7月－2012年1月，武汉大学人民医院神经内科，主治医师。 |
| 成果获奖 | 获得中国医师协会“中国杰出神经内科医师”奖 |
| 代表性论著 |
1. Pan
L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G,
Zhang Z. Tau accelerates α-synuclein aggregation and spreading in Parkinson's
disease. Brain, 2022, awac171. 2. Zhang G, Meng L, Wang Z, Peng Q, Chen G, Xiong J, Zhang Z. Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. Mol Neurodegener, 2022, 17(1):12. 3. Meng L, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K, Zhang Z. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. Aging Cell, 2022, 21(5):e13619. 4. Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, Yu Z, Zhang Z. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease. NPJ Parkinson's Disease, 2022, 8(1):1. 5. Zhang Z, Li XG, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ, Ye K. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular Psychiatry, 2021, 26(2):586-603. 6. Xiong M, Zou L, Meng L, Zhang X, Tian Y, Zhang G, Yang J, Chen G, Xiong J, Ye K, Zhang Z. A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. Progress in Neurobiology, 2021, 203:102074. 7. Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K, Zhang Z. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Elife. 2021, 10:e65301. 8. Li Zou, Xingyu Zhang, Min Xiong, Lanxia Meng, Ye Tian, Lina Pan, Xin Yuan, Guiqin Chen, Zhihao Wang, Lihong Bu, Zhaohui Yao, Zhaohui Zhang, Keqiang Ye, Zhentao Zhang. Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease. Neurobiology of Disease, 2021, 154:105326. 9. Dai L, Zou L, Meng L, Qiang G, Yan M, Zhang Z. Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets. Mol Neurobiol, 2021, 58(5):2183-2201. 10. Jiaolong Yang, Shilin Luo, Jichun Zhang, Ting Yu, Zhihui Fu, Yongfa Zheng, Ximing Xu, Chaoyang Liu, Mingxia Fan, Zhentao Zhang. Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease. Neurobiol Dis, 2021, 148:105218. 11. Yang J, Fu Z, Zhang X, Xiong M, Meng L, Zhang Z. TREM2 Ectodomain and Its Soluble Form in Alzheimer's Disease. J Neuroinflammation, 2020, 17(1):204. 12. Zhang Z, Tian Y, Ye K. δ-secretase in Neurodegenerative Diseases: Mechanisms, Regulators and Therapeutic Opportunities. Transl Neurodegener, 2020, 9:1. 13. Tian Y, Meng L, Zhang Z. What is strain in neurodegenerative diseases? Cell Mol Life Sci, 2020, 77(4):665-676. 14. Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature Structural & Molecular Biology, 2017, 24(8):632-642. 15. Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature Communications, 2017, 8:14740. 16. Zhang Z, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE, Ping Yu S, Jia J, Levey AI, Ye K. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nature Communications, 2015, 6:8762. 17. Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI, Ye K. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature Medicine, 2014, 20, 1254-1262. |
| Name | Zhentao Zhang |
| Date of birth | OCT, 1981 |
| Department | Department of Neurology, Renmin Hospital of Wuhan University |
| Title | Professor, Chief physician |
| zhentaozhang@whu.edu.cn | |
| TEL | 027-88041911-82221 |
| Research Direction | 1. Parkinson's disease; 2. Alzheimer's disease |
| Personal Profile | Zhentao Zhang is a professor in the Department of Neurology, Renmin Hospital of Wuhan University. He majors in the clinical and basic research of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. His group focusses on the molecular mechanisms of neuronal degeneration. He has published several papers on top journals such as Nature Medicine, Nature Structural & Molecular Biology, and Nature Communications. |
| Selected Publications |
1. Pan
L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G,
Zhang Z. Tau accelerates α-synuclein aggregation and spreading in Parkinson's
disease. Brain, 2022, awac171. 2. Zhang G, Meng L, Wang Z, Peng Q, Chen G, Xiong J, Zhang Z. Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease. Mol Neurodegener, 2022, 17(1):12. 3. Meng L, Zou L, Xiong M, Chen J, Zhang X, Yu T, Li Y, Liu C, Chen G, Wang Z, Ye K, Zhang Z. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. Aging Cell, 2022, 21(5):e13619. 4. Yan M, Xiong M, Dai L, Zhang X, Zha Y, Deng X, Yu Z, Zhang Z. Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease. NPJ Parkinson's Disease, 2022, 8(1):1. 5. Zhang Z, Li XG, Wang ZH, Song M, Yu SP, Kang SS, Liu X, Zhang Z, Xie M, Liu GP, Wang JZ, Ye K. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular Psychiatry, 2021, 26(2):586-603. 6. Xiong M, Zou L, Meng L, Zhang X, Tian Y, Zhang G, Yang J, Chen G, Xiong J, Ye K, Zhang Z. A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. Progress in Neurobiology, 2021, 203:102074. 7. Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K, Zhang Z. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Elife. 2021, 10:e65301. 8. Li Zou, Xingyu Zhang, Min Xiong, Lanxia Meng, Ye Tian, Lina Pan, Xin Yuan, Guiqin Chen, Zhihao Wang, Lihong Bu, Zhaohui Yao, Zhaohui Zhang, Keqiang Ye, Zhentao Zhang. Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease. Neurobiology of Disease, 2021, 154:105326. 9. Dai L, Zou L, Meng L, Qiang G, Yan M, Zhang Z. Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets. Mol Neurobiol, 2021, 58(5):2183-2201. 10. Jiaolong Yang, Shilin Luo, Jichun Zhang, Ting Yu, Zhihui Fu, Yongfa Zheng, Ximing Xu, Chaoyang Liu, Mingxia Fan, Zhentao Zhang. Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease. Neurobiol Dis, 2021, 148:105218. 11. Yang J, Fu Z, Zhang X, Xiong M, Meng L, Zhang Z. TREM2 Ectodomain and Its Soluble Form in Alzheimer's Disease. J Neuroinflammation, 2020, 17(1):204. 12. Zhang Z, Tian Y, Ye K. δ-secretase in Neurodegenerative Diseases: Mechanisms, Regulators and Therapeutic Opportunities. Transl Neurodegener, 2020, 9:1. 13. Tian Y, Meng L, Zhang Z. What is strain in neurodegenerative diseases? Cell Mol Life Sci, 2020, 77(4):665-676. 14. Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature Structural & Molecular Biology, 2017, 24(8):632-642. 15. Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nature Communications, 2017, 8:14740. 16. Zhang Z, Song M, Liu X, Su Kang S, Duong DM, Seyfried NT, Cao X, Cheng L, Sun YE, Ping Yu S, Jia J, Levey AI, Ye K. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nature Communications, 2015, 6:8762. 17. Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI, Ye K. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature Medicine, 2014, 20, 1254-1262. |
武汉大学人民医院
湖北省人民医院