陈始明
耳鼻喉
东院耳鼻咽喉-头颈外2科主任，耳鼻咽喉研究所副所长；教授、主任医师、博士生导师
东院耳鼻咽喉-头颈外2科主任，耳鼻咽喉研究所副所长；教授、主任医师、博士生导师
导师介绍
| 姓名 | 陈始明 |
| 出生年月 | 1975年5月 |
| 单位 | 武汉大学人民医院东院耳鼻咽喉-头颈外2科 |
| 所属学科 | 临床医学-耳鼻咽喉科学 |
| 职务、职称及头衔 | 东院耳鼻咽喉-头颈外2科主任，耳鼻咽喉研究所副所长；教授、主任医师、博士生导师 |
| shimingchen@163.com | |
| 联系方式 | 027-88041911转83662 |
| 研究方向 |
1.鼻内镜外科学 2.鼻咽癌的发病机制 |
| 个人简介 | |||
| 主要从事鼻科及鼻颅底外科的临床诊治、教学与科研工作。2014年入选武汉市首届中青年医学骨干人才培养计划。已主持国家自然科学基金项目5项，参与国家自然科学基金项目4项。多次担任国家自然科学基金委员会一审及二审专家。获国家发明专利2项，省自然科学三等奖1项，省科技进步二等奖、三等奖各1项。发表论文100余篇，SCI收录20余篇。所发论文的杂志最高影响因子为12.6。已培养博士生7名，硕士生13名。正在培养博士6名，硕士5名。 | |||
| 学术任职与荣誉 | |||
|
中华医学会变态反应学分会鼻眼过敏性疾病学组第一届、第二届委员 中国医师协会耳鼻咽喉科医师分会第二届委员 中国中西医结合耳鼻咽喉科专业委员会颅底肿瘤专家委员会委员 中国医促会过敏科学及过敏医学分会委员 湖北省耳鼻咽喉科学会第七届、第八届委员兼秘书 《肿瘤防治研究》编委 《中国癌症防治杂志》编委 |
|||
| 教育履历 | |||
|
1995.9-2000.6江西省赣南医学院眼耳鼻喉专业学习，本科 2001.9-2006.6武汉大学医学院耳鼻咽喉专业学习，硕博连读 2010.5-2011.5澳大利亚墨尔本大学及阿德莱德大学访问学者 |
|||
| 工作履历 | |||
|
2006.07-至今 武汉大学人民医院耳鼻咽喉头颈外科主治医师、副主任医师、副教授、主任医师、教授；硕士生导师，博士生导师。 2008.01-2008.09 国家自然科学基金委员会生命科学部兼职工作。 |
|||
| 成果获奖 | |||
|
1.《阻塞性睡眠呼吸暂停低通气综合征的相关疾病及外科干预的研究》2007年获湖北省科技进步三等奖 2.《端粒酶在头颈肿瘤发生中的作用及靶向治疗价值》2012年湖北省自然科学奖三等奖 3.《过敏性鼻炎精准医疗的相关机制及临床应用》2018年湖北省科技进步二等奖 |
|||
| 代表性论著 | |||
|
1.Qi CL, Huang ML, Zou Y, Yang R, Jiang Y, Sheng
JF, Kong YG, Tao ZZ, Feng HY, Hua QQ, Bu LH (*), Chen SM (*). The
IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and
apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic
glycolysis. J Exp Clin Cancer Res. 2021,40(1):390.(IF=12.6/2021) 2.Zou Y, Yang R, Huang ML, Kong YG, Sheng JF, Tao ZZ, Gao L, Chen SM (*). NOTCH 2 negatively regulates metastasis and epithelial mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma. J Exp Clin Cancer Res, 2019, 38(1):456.(IF=12.6/2021) 3.Chen SM, Liu JP, Zhou JX, Chen C, Deng YQ, Wang Y, Tao ZZ. Suppression of the notch signapng pathway by γ-secretase inhibitor GSI inhibits human nasopharyngeal carcinoma cell propferation. Cancer Lett. 2011, 306(1):76-84.(IF=9.7/2021) 4.Zou Y, Wang BR, Sun L, Xu S, Kong YG, Shen LJ, Liang GT, Chen SM (*). The issue of recurrently positive patients who recovered from COVID-19 according to the current discharge criteria: investigation of patients from multiple medical institutions in Wuhan, China. J Infect Dis. 2020;222(11):1784-1788.(IF= 7.7/2021) 5.Jiao WE, Sun L, Xu S, Deng YQ, Qiao YL, Xi Y, Tao ZZ, Chen SM (*). Notch2 suppresses the development of allergic rhinitis by promoting FOXP3 expression and Treg cell differentiation. Life Sci. 2021, 284:119922. (IF= 6.6/2021) 6.He YQ, Qiao YL, Xu S, Jiao WE, Yang R, Kong YG, Tao ZZ, Chen SM (*). Allergen induces CD11c+ dendritic cell autophagy to aggravate allergic rhinitis through promoting immune imbalance. Int Immunopharmacol. 2022 May;106:108611.(IF=5.7/2021) 7.Xu S, Kong YG, Jiao WE, Yang R, Qiao YL, Xu Y, Tao ZZ, Chen SM (*). Tangeretin promotes regulatory T cell differentiation by inhibiting Notch1/Jagged1 signapng in allergic rhinitis. Int Immunopharmacol. 2019,72:402-412.(IF=5.7/2021) 8.Huang ML, Qi CL, Zou Y, Yang R, Jiang Y, Sheng JF, Kong YG, Tao ZZ, Chen SM (*).Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.J Cell Mol Med. 2020;24(14):7778-7788.(IF=5.3/2021) 9.Huang ML, Zou Y, Yang R, Jiang Y, Sheng JF, Han JB, Kong YG, Tao ZZ, Chen SM (*). Placenta specific 8 gene induces epithepal-mesenchymal transition of nasopharyngeal carcinoma cells via the TGF-beta/Smad pathway. Exp Cell Res. 2019,374(1). 172-180. (IF= 4.1/2021) 10.Zou JN, Sun L, Wang BR, Zou Y, Xu S, Ding YJ, Shen LJ, Huang WC, Jiang XJ, Chen SM(*). The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT. PLoS One. 2021,16(3):e0248957.(IF= 3.7/2021) 11.Jiao WE, Wei JF, Kong YG, Xu Y, Tao ZZ, Chen SM (*). Notch Signapng Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation. Int Arch Allergy Immunol. 2019,178(1):33-44 (IF= 3.7/2021) 12.Chen W, Xiao BK, pu JP, Chen SM (*), Tao ZZ(*). Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells. Cancer Science, 2010,101(8): 1769~1776(IF=6.5/2021) 13.Wang Y, Tao ZZ(*), Xiao BK, Chen SM (*), Liu JP. Apppcation of combination of short hairpin RNA segments for silencing VEGF, TERT and Bcl-xl expression in laryngeal squamous carcinoma. Cancer Biol Ther,2008,7(6):896~901(IF=4.8/2021) 14.Chen SM, Wang Y, Xiao BK, Tao ZZ. Effect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice. Cancer Biol Ther. 2008，7(5):734-9.(IF=4.8/2021) 15.Chen SM, Tao ZZ, Hua QQ, Xiao BK, Xu Y, Wang Y, Deng YQ. Inhibition of telomerase activity in cancer cells using short hairpin RNA expression vectors. Cancer Invest. 2007, 25(8):691-8(IF= 2.3/2021) 16.焦沃尔,魏金凤,续珊,孔勇刚,许昱,陶泽璋,陈始明(*). Notch1-Jagged1信号在变应性鼻炎中的表达及意义.中华耳鼻咽喉头颈外科杂志. 2018. 53(10). 733-739 |
| Name | SHI-MING CHEN |
| Date of birth | May，1975 |
| Department | Department of Otolaryngology Head and Neck Surgery，Renmin Hospital,Wuhan University. |
| Title | Director, Professor, doctoral tutor |
| shimingchen@163.com | |
| TEL | 027-88041911-83662 |
| Research Direction | |||
|
1. Nasal endoscopic surgery 2. The pathogenesis of nasopharyngeal carcinoma |
|||
| Personal Profile | |||
| He is mainly engaged in the diagnosis, treatment and research of otolaryngology-head and neck surgery, especially in the area of rhinology and nasal skull base surgery.He has been awarded 4 items for the National Natural Science Foundation, 2 items from the provincial science and Technology Department.Besides,there are more than 100 papers have been published, of which more than 20 have been included by SCI.By now, he has educated 12 masters doctors. At present, there are 6 doctors and 5 Masters studying with him. | |||
| Selected Publications | |||
|
1.Qi CL, Huang ML, Zou Y, Yang R, Jiang Y, Sheng
JF, Kong YG, Tao ZZ, Feng HY, Hua QQ, Bu LH (*), Chen SM (*). The
IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and
apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic
glycolysis. J Exp Clin Cancer Res. 2021,40(1):390.(IF=12.6/2021) 2.Zou Y, Yang R, Huang ML, Kong YG, Sheng JF, Tao ZZ, Gao L, Chen SM (*). NOTCH 2 negatively regulates metastasis and epithelial mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma. J Exp Clin Cancer Res, 2019, 38(1):456.(IF=12.6/2021) 3.Chen SM, Liu JP, Zhou JX, Chen C, Deng YQ, Wang Y, Tao ZZ. Suppression of the notch signapng pathway by γ-secretase inhibitor GSI inhibits human nasopharyngeal carcinoma cell propferation. Cancer Lett. 2011, 306(1):76-84.(IF=9.7/2021) 4.Zou Y, Wang BR, Sun L, Xu S, Kong YG, Shen LJ, Liang GT, Chen SM (*). The issue of recurrently positive patients who recovered from COVID-19 according to the current discharge criteria: investigation of patients from multiple medical institutions in Wuhan, China. J Infect Dis. 2020;222(11):1784-1788.(IF= 7.7/2021) 5.Jiao WE, Sun L, Xu S, Deng YQ, Qiao YL, Xi Y, Tao ZZ, Chen SM (*). Notch2 suppresses the development of allergic rhinitis by promoting FOXP3 expression and Treg cell differentiation. Life Sci. 2021, 284:119922. (IF= 6.6/2021) 6.He YQ, Qiao YL, Xu S, Jiao WE, Yang R, Kong YG, Tao ZZ, Chen SM (*). Allergen induces CD11c+ dendritic cell autophagy to aggravate allergic rhinitis through promoting immune imbalance. Int Immunopharmacol. 2022 May;106:108611.(IF=5.7/2021) 7.Xu S, Kong YG, Jiao WE, Yang R, Qiao YL, Xu Y, Tao ZZ, Chen SM (*). Tangeretin promotes regulatory T cell differentiation by inhibiting Notch1/Jagged1 signapng in allergic rhinitis. Int Immunopharmacol. 2019,72:402-412.(IF=5.7/2021) 8.Huang ML, Qi CL, Zou Y, Yang R, Jiang Y, Sheng JF, Kong YG, Tao ZZ, Chen SM (*).Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.J Cell Mol Med. 2020;24(14):7778-7788.(IF=5.3/2021) 9.Huang ML, Zou Y, Yang R, Jiang Y, Sheng JF, Han JB, Kong YG, Tao ZZ, Chen SM (*). Placenta specific 8 gene induces epithepal-mesenchymal transition of nasopharyngeal carcinoma cells via the TGF-beta/Smad pathway. Exp Cell Res. 2019,374(1). 172-180. (IF= 4.1/2021) 10.Zou JN, Sun L, Wang BR, Zou Y, Xu S, Ding YJ, Shen LJ, Huang WC, Jiang XJ, Chen SM(*). The characteristics and evolution of pulmonary fibrosis in COVID-19 patients as assessed by AI-assisted chest HRCT. PLoS One. 2021,16(3):e0248957.(IF= 3.7/2021) 11.Jiao WE, Wei JF, Kong YG, Xu Y, Tao ZZ, Chen SM (*). Notch Signapng Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation. Int Arch Allergy Immunol. 2019,178(1):33-44 (IF= 3.7/2021) 12.Chen W, Xiao BK, pu JP, Chen SM (*), Tao ZZ(*). Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells. Cancer Science, 2010,101(8): 1769~1776(IF=6.5/2021) 13.Wang Y, Tao ZZ(*), Xiao BK, Chen SM (*), Liu JP. Apppcation of combination of short hairpin RNA segments for silencing VEGF, TERT and Bcl-xl expression in laryngeal squamous carcinoma. Cancer Biol Ther,2008,7(6):896~901(IF=4.8/2021) 14.Chen SM, Wang Y, Xiao BK, Tao ZZ. Effect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice. Cancer Biol Ther. 2008，7(5):734-9.(IF=4.8/2021) 15.Chen SM, Tao ZZ, Hua QQ, Xiao BK, Xu Y, Wang Y, Deng YQ. Inhibition of telomerase activity in cancer cells using short hairpin RNA expression vectors. Cancer Invest. 2007, 25(8):691-8(IF= 2.3/2021) 16.焦沃尔,魏金凤,续珊,孔勇刚,许昱,陶泽璋,陈始明(*). Notch1-Jagged1信号在变应性鼻炎中的表达及意义.中华耳鼻咽喉头颈外科杂志. 2018. 53(10). 733-739 |
武汉大学人民医院
湖北省人民医院