武汉大学人民医院湖北省人民医院

院内导航

宁金卓 泌尿外科学
医学博士，副主任医师，硕士研究生导师

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导师介绍

姓名	宁金卓
出生年月	1985年2月
单位	武汉大学人民医院泌尿外科
所属学科	临床医学-外科学
职务、职称及头衔	医学博士，副主任医师，硕士研究生导师
E-mail	1315816132@qq.com
联系方式	13855348212
研究方向	1男性生殖系统损伤2泌尿系肿瘤防治
个人简介	主持湖北省自然科学基金1项，主持湖北省卫健委基金1项，主持湖北省中医药科研项目1项，主持中央高校基本科研业务专项资金课题1项，参与国家自然科学基金3项，参与多项省市级基金。获国家实用新型专利2项，获国家外观设计专利2项。发表国内外核心期刊论文80余篇，其中以第一作者/通讯作者SCI收录20余篇，以第一作者/通讯作者发表中文统计源核心18篇。临床科研领域，在团队带领下进行了系统的“基于解剖学研究的经皮肾镜碎石取石术（PCNL）通道建立原则、基于肾脏血管解剖的安全原则与基于肾脏集合系统结构与结石分布的效率原则”研究，参编专著《超声引导经皮肾镜碎石取石术操作手册》、《坎贝尔-沃尔什泌尿外科学》。基础科研领域，长期从事男性生殖系统疾病和泌尿系肿瘤的研究，对该领域研究动态有较深入的了解，有较多的积累和较强的理论基础
学术任职与荣誉	中华医学会临床流行病学和循证医学分会青年学组委员，湖北省免疫学会泌尿外科免疫分会委员，湖北省细胞外囊泡学会理事。担任《Frontiers in Molecular Biosciences》、《Frontiers in Genetics》客座主编，担任《Drug Resistance Updates》、《Advanced Science》、《International Immunopharmacology》、《Biomedicine & Pharmacotherapy》、《Frontiers in Oncology》、《Journal of Xiangya Medicine》、《中华腔镜泌尿外科杂志》、《中华实验外科杂志》、《国际泌尿系统杂志》、《中华养生保健杂志》编委及审稿专家。
教育履历	2015.9–2018.7武汉大学泌尿外科博士 2010.9–2013.7皖南医学院泌尿外科硕士 2004.9–2010.7蚌埠医学院临床医学学士
工作履历	2020.12——至今武汉大学人民医院泌尿外科副主任医师 2018.7-2020.12武汉大学人民医院泌尿外科主治医师 2013.7-2015.7芜湖市中医医院泌尿外科住院医师
成果获奖	无
代表性论著	1 He KX, Ning JZ, Li W#, Cheng F#. Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis. Tissue Cell. 2023,82:102069. 2 Yang Du, Chuan-min Chu, Dong Zhuo, Jin-zhuo Ning#. The Inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury. International Journal of Biological Macromolecules.2022,1(209):725-736. 3 Xu LZ, He KX, Ning JZ#, Cheng F. Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation. Tissue Cell. 2022,78:101876. 4 Wei Wang, Ying He, Lu-Lu Zhai, Long-Jiang Chen, Li-Chao Yao, Lun Wu, Zhi-Gang Tang, Jin-Zhuo Ning#. m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2. Epigenetics. 2022,17(12):1738-1752. 5 Song T, He K, Ning J, Li W, Xu T, Yu W, Rao T, Cheng F. Evaluation of aliphatic acid metabolism in bladder cancer with the goal of guiding therapeutic treatment. Front Oncol. 2022,18;12:930038. 6 Zheng D, Ning J, Xia Y, Ruan Y, Cheng F. Comprehensive analysis of a homeobox family gene signature in clear cell renal cell carcinoma with regard to prognosis and immune significance. Front Oncol. 2022,31;12:1008714. 7 Xu LZ, Ning JZ, Ruan Y, Cheng F. MiR-363-3p promotes prostate cancer tumor progression by targeting Dickkopf 3. J Clin Lab Anal. 2022,18:e24360. 8 Ning JZ, Chu CM, Du Y, Zuo L. MiR-25 regulates cell proliferation and metastasis in bladder urothelial carcinoma. J Cancer. 2021,12(22):6706-6714. 9 Li ML, Ning JZ, Huang HB, Jiang SC, Zhuo D. Allicin protects against renal ischemia-reperfusion injury by attenuating oxidative stress and apoptosis. INTERNATIONAL UROLOGY AND NEPHROLOGY. 2021 Nov 25. 10 Ning JZ, He KX,Cheng F, Li W, Yu WM, Li HY, Rao T, Ruan Y. Long noncoding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. FRONT CELL AND DEVELOPMENTAL BIOLOGY.2021,(18)9: 671613. 11 Du Y, Ning JZ#. MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3.UROLOGIA INTERNATIONALIS. Urol Int. 2021,105(7-8):687-696. 12 Chen LJ, Ning JZ, Cheng F, Rao T, Yu WM, Ruan Y, Wu JF, Li RG, Geng RX. Comparison of Intraperitoneal and Intratesticular GYY4137 Therapy for the Treatment of Testicular Ischemia Reperfusion Injury in Rats. Curr Med Sci. 2020, 40(2):332-338. 13 Wang W, Ning JZ, Tang ZG, He Y, Yao LC, Ye L, Wu L. MicroRNA-23a acts as an oncogene in pancreatic carcinoma by targeting TFPI-2. Exp Ther Med. 2020, 20(5):53. 14 Wang W, Ning JZ, He Y, Zhai LL, Xiang F, Yao LC, Ye L,Wu L, Ji T, Tang ZG. Unveiling the mechanism of Astragalus membranaceus in the treatment of gastrointestinal cancers based on network pharmacology. European Journal of Integrative Medicine. 2020, 40:101249. 15 Ning JZ, Yu WM, Cheng F, Rao T, Ruan Y. MiR-425 Promotes Migration and Invasion in Bladder Cancer by Targeting Dickkopf 3. J Cancer. 2020, 11(12):3424-3432. 16 Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, Yuan R, Zhang XB, Du Y, Xiao CC. The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele-induced rats. Exp Ther Med. 2018, 15(1):433-439. 17 Li W, Ning JZ, Cheng F, Yu WM, Rao T, Ruan Y, Yuan R, Zhang XB, Zhuo D, Du Y, Xiao CC. MALAT1 promotes cell apoptosis and suppresses cell proliferation in testicular ischemia-reperfusion injury by sponging miR-214 to modulate TRPV4 expression. Cell Physiol Biochem. 2018, 46(2):802-814. 18 Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, Yuan R, Zhu SM, Zhang XB, Du Y, Xiao CC. The protective effects of GYY4137 on testicular torsion/detorsion injury in rats. Int J Clin Exp Med. 2018, 11(4):3387-3395. 19 Ning JZ, Li W, Cheng F, Yu WM, Rao T, Ruan Y, Yuan R, Zhang XB, Zhuo D, Du Y, Xiao CC. MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels. Front Physiol. 2017, 8:966. 20 Ning JZ, Rao T, Cheng F, Yu WM, Ruan Y, Yuan R, Zhu SM, Du Y, Xiao CC. Effect of varicocelectomy treatment on spermatogenesis and apoptosis via the induction of heat shock protein 70 in varicocele-induced rats. Mol Med Rep. 2017, 6(4):5406-5412.

Name	JINZHUO,NING
Date of birth	February，1985
Department	Uology Department，Renmin Hospital,Wuhan University.
Title	Doctor of Medicine, Associate Chief physician, Master Supervisor
Email	1315816132@qq.com
TEL	13855348212
Research Direction	1. Injury of Male reproductive system 2. Prevention and treatment of urinary tumor
Personal Profile	Led one project of the Hubei Provincial Natural Science Foundation, one project of the Hubei Provincial Health Commission Foundation, one project of traditional Chinese medicine research in Hubei Province, one project of special funding for basic scientific research business in central universities, participated in three projects of the National Natural Science Foundation, and participated in multiple provincial and municipal level funds. Received 2 national utility model patents and 2 national design patents. Published over 80 core journal papers both domestically and internationally, including more than 20 papers indexed by the first author/corresponding author SCI, and 18 core Chinese statistical source papers published by the first author/corresponding author. In the field of clinical scientific research, under the leadership of the team, the team carried out a systematic study on "the principles of establishing channels for percutaneous nephrolithotomy (PCNL) based on anatomical research, the safety principles based on renal vascular anatomy, and the efficiency principles based on the structure of the kidney assembly system and the distribution of stones", and participated in the compilation of monographs "Operation Manual of Ultrasound Guided Percutaneous Nephrolithotomy" and "Campbell Walsh Urology". Basic scientific research field, has been engaged in the research of Male reproductive system diseases and urinary system tumors for a long time, has a deeper understanding of research trends in this field, has more accumulation and strong theoretical basis
Selected Publications	1 He KX, Ning JZ, Li W#, Cheng F#. Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis. Tissue Cell. 2023,82:102069. 2 Yang Du, Chuan-min Chu, Dong Zhuo, Jin-zhuo Ning#. The Inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury. International Journal of Biological Macromolecules.2022,1(209):725-736. 3 Xu LZ, He KX, Ning JZ#, Cheng F. Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation. Tissue Cell. 2022,78:101876. 4 Wei Wang, Ying He, Lu-Lu Zhai, Long-Jiang Chen, Li-Chao Yao, Lun Wu, Zhi-Gang Tang, Jin-Zhuo Ning#. m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2. Epigenetics. 2022,17(12):1738-1752. 5 Song T, He K, Ning J, Li W, Xu T, Yu W, Rao T, Cheng F. Evaluation of aliphatic acid metabolism in bladder cancer with the goal of guiding therapeutic treatment. Front Oncol. 2022,18;12:930038. 6 Zheng D, Ning J, Xia Y, Ruan Y, Cheng F. Comprehensive analysis of a homeobox family gene signature in clear cell renal cell carcinoma with regard to prognosis and immune significance. Front Oncol. 2022,31;12:1008714. 7 Xu LZ, Ning JZ, Ruan Y, Cheng F. MiR-363-3p promotes prostate cancer tumor progression by targeting Dickkopf 3. J Clin Lab Anal. 2022,18:e24360. 8 Ning JZ, Chu CM, Du Y, Zuo L. MiR-25 regulates cell proliferation and metastasis in bladder urothelial carcinoma. J Cancer. 2021,12(22):6706-6714. 9 Li ML, Ning JZ, Huang HB, Jiang SC, Zhuo D. Allicin protects against renal ischemia-reperfusion injury by attenuating oxidative stress and apoptosis. INTERNATIONAL UROLOGY AND NEPHROLOGY. 2021 Nov 25. 10 Ning JZ, He KX,Cheng F, Li W, Yu WM, Li HY, Rao T, Ruan Y. Long noncoding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. FRONT CELL AND DEVELOPMENTAL BIOLOGY.2021,(18)9: 671613. 11 Du Y, Ning JZ#. MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3.UROLOGIA INTERNATIONALIS. Urol Int. 2021,105(7-8):687-696. 12 Chen LJ, Ning JZ, Cheng F, Rao T, Yu WM, Ruan Y, Wu JF, Li RG, Geng RX. Comparison of Intraperitoneal and Intratesticular GYY4137 Therapy for the Treatment of Testicular Ischemia Reperfusion Injury in Rats. Curr Med Sci. 2020, 40(2):332-338. 13 Wang W, Ning JZ, Tang ZG, He Y, Yao LC, Ye L, Wu L. MicroRNA-23a acts as an oncogene in pancreatic carcinoma by targeting TFPI-2. Exp Ther Med. 2020, 20(5):53. 14 Wang W, Ning JZ, He Y, Zhai LL, Xiang F, Yao LC, Ye L,Wu L, Ji T, Tang ZG. Unveiling the mechanism of Astragalus membranaceus in the treatment of gastrointestinal cancers based on network pharmacology. European Journal of Integrative Medicine. 2020, 40:101249. 15 Ning JZ, Yu WM, Cheng F, Rao T, Ruan Y. MiR-425 Promotes Migration and Invasion in Bladder Cancer by Targeting Dickkopf 3. J Cancer. 2020, 11(12):3424-3432. 16 Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, Yuan R, Zhang XB, Du Y, Xiao CC. The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele-induced rats. Exp Ther Med. 2018, 15(1):433-439. 17 Li W, Ning JZ, Cheng F, Yu WM, Rao T, Ruan Y, Yuan R, Zhang XB, Zhuo D, Du Y, Xiao CC. MALAT1 promotes cell apoptosis and suppresses cell proliferation in testicular ischemia-reperfusion injury by sponging miR-214 to modulate TRPV4 expression. Cell Physiol Biochem. 2018, 46(2):802-814. 18 Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, Yuan R, Zhu SM, Zhang XB, Du Y, Xiao CC. The protective effects of GYY4137 on testicular torsion/detorsion injury in rats. Int J Clin Exp Med. 2018, 11(4):3387-3395. 19 Ning JZ, Li W, Cheng F, Yu WM, Rao T, Ruan Y, Yuan R, Zhang XB, Zhuo D, Du Y, Xiao CC. MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels. Front Physiol. 2017, 8:966. 20 Ning JZ, Rao T, Cheng F, Yu WM, Ruan Y, Yuan R, Zhu SM, Du Y, Xiao CC. Effect of varicocelectomy treatment on spermatogenesis and apoptosis via the induction of heat shock protein 70 in varicocele-induced rats. Mol Med Rep. 2017, 6(4):5406-5412.