武汉大学人民医院湖北省人民医院

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侯家保 麻醉学
副教授，副主任医师，硕士生导师

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导师介绍

姓名	侯家保
出生年月	1987年8月
单位	武汉大学人民医院麻醉科
所属学科	临床医学-麻醉学
职务、职称及头衔	副教授，副主任医师，硕士生导师
E-mail	bohrhou@whu.edu.cn
联系方式	027-88041911转81026或13407195618
研究方向	围术期神经认知障碍
个人简介	主要从事围术期神经认知障碍相关研究。主持国家自然科学基金青年项目和湖北省自然科学基金各1项。发表论文20余篇，其中以第一作者或通讯作者发表INTERNATIONAL JOURNAL OF SURGERY等SCI论文8篇，其中最高影响因子15.3。
学术任职与荣誉	中国研究型医院学会麻醉专业委员会委员、国家自然科学基金委医学科学三处评议人、武汉医学会麻醉学分会秘书，并是《Journal of Inflammation Research》、《Drug Design, Development and Therapy》、《International Journal of Molecular Medicine》等杂志审稿人。
教育履历	(1) 2016-9至2018-12,武汉大学,临床医学,博士 (2) 2005-9至2012-6,武汉大学,临床医学七年制,硕士、学士
工作履历	(1) 2020-12至今,武汉大学,人民医院,副主任医师 (1) 2015-6至2020-11,武汉大学,人民医院,主治医师 (2) 2012-7至2015-5,武汉大学,人民医院,住院医师
成果获奖	《缺血性脑损伤与免疫调控的机制与防治》湖北省科学技术进步三等奖
代表性论著	1. Chen, Guanghui;Zhou, Siqi;Chen, Qiang;Liu, Mengmeng;Dong, Meixue;Hou, Jiabao;Zhou, Benhong . Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE, 2022, 10:965697 2. J. Hou, Q. Shen, X. Wan, B. Zhao, Y. Wu, Z. Xia, REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation[J]. Behav Brain Res, 2019, 364:167-176. doi: 10.1016/j.bbr.2019.01.038.(第一作者) 3. J. Hou#, X. Wan#, Q. Shen, J. Zhu, Y. Leng, B. Zhao, Z. Xia, Y. He, Y. Wu. COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study[J]. Int J Surg, 2020. 82: 172-178. doi: 10.1016/j.ijsu.2020.08.037. (共同第一作者) 4. W. Su#, Z. Qiu#, L. Zhou#, J. Hou#, Y. Wang, F. Huang, Y. Zhang, Y. Jia, J. Zhou, D. Liu, Z. Xia, Z.Y. Xia, S. Lei. Sex differences in clinical characteristics and risk factors for mortality among severe patients with COVID-19: a retrospective study[J]. Aging (Albany NY), 2020. 12(19): 18833-18843. doi: 10.18632/aging.103793. (共同第一作者) 5. Y. Wu, J. Dou, X. Wan, Y. Leng, X. Liu, L. Chen, Q. Shen, B. Zhao, Q. Meng, J. Hou. Histone Deacetylase Inhibitor MS-275 Alleviates Postoperative Cognitive Dysfunction in Rats by Inhibiting Hippocampal Neuroinflammation[J]. Neuroscience, 2019. 417: 70-80. doi: 10.1016/j.neuroscience.2019.08.020. (通讯作者) 6.侯家保,万杏,赵博,魏晓冬,夏中元,吴洋.联合神经阻滞对急性脑梗死患者髋关节置换术后转归的影响[J],中华医学杂志, 2021. 101(25): 1968-1972. 7.侯家保,万杏,沈倩妮,刘旭珂,吴洋,宋文沁,夏中元,赵博. REV-ERBα对睡眠剥夺大鼠剖腹探查手术后工作记忆的调控作用及其机制研究[J],中华神经医学杂志, 2020. 19(3): 253-259. 8.侯家保,袁泉,万杏,刘恋,赵博,吴洋,曲古抑菌素A预处理对小鼠脑缺血再灌注损伤皮质炎症反应和凋亡的影响[J],中国现代医学杂志, 2019. 29(9):1-5. 9.侯家保,沈倩妮,万杏,赵博,吴洋,夏中元,急性睡眠剥夺对七氟烷麻醉大鼠学习记忆及海马时钟基因表达的影响[J],中华行为医学与脑科学杂志, 2018, 27 (7):577-581.（共同通讯作者）

Name	Hou Jiabao
Date of birth	Aug，1987
Department	Anesthesiology Department，Renmin Hospital,Wuhan University.
Title	Associate professor, Master tutor
Email	Bohrhou@whu.edu.cn
TEL	027-88041911-81026 or 13407195618
Research Direction	perioperative neurocognitive disorders,PND
Personal Profile	He is mainly engaged in perioperative neurocognitive impairment. he has hosted one National Natural Science Foundation Youth Program and one Hubei Provincial Natural Science Foundation, and as the first author or corresponding author has published over 20 papers, including 8 SCI papers such as INTERNATIONAL JOURNAL OF SURGERY , with the highest impact factor of 15.3.
Selected Publications	1. Chen, Guanghui;Zhou, Siqi;Chen, Qiang;Liu, Mengmeng;Dong, Meixue;Hou, Jiabao;Zhou, Benhong . Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE, 2022, 10:965697（共同通讯作者） 2. J. Hou, Q. Shen, X. Wan, B. Zhao, Y. Wu, Z. Xia, REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation[J]. Behav Brain Res, 2019, 364:167-176. doi: 10.1016/j.bbr.2019.01.038.(第一作者) 3. J. Hou#, X. Wan#, Q. Shen, J. Zhu, Y. Leng, B. Zhao, Z. Xia, Y. He, Y. Wu. COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study[J]. Int J Surg, 2020. 82: 172-178. doi: 10.1016/j.ijsu.2020.08.037. (共同第一作者) 4. W. Su#, Z. Qiu#, L. Zhou#, J. Hou#, Y. Wang, F. Huang, Y. Zhang, Y. Jia, J. Zhou, D. Liu, Z. Xia, Z.Y. Xia, S. Lei. Sex differences in clinical characteristics and risk factors for mortality among severe patients with COVID-19: a retrospective study[J]. Aging (Albany NY), 2020. 12(19): 18833-18843. doi: 10.18632/aging.103793. (共同第一作者) 5. Y. Wu, J. Dou, X. Wan, Y. Leng, X. Liu, L. Chen, Q. Shen, B. Zhao, Q. Meng, J. Hou. Histone Deacetylase Inhibitor MS-275 Alleviates Postoperative Cognitive Dysfunction in Rats by Inhibiting Hippocampal Neuroinflammation[J]. Neuroscience, 2019. 417: 70-80. doi: 10.1016/j.neuroscience.2019.08.020. (通讯作者) 6.侯家保,万杏,赵博,魏晓冬,夏中元,吴洋.联合神经阻滞对急性脑梗死患者髋关节置换术后转归的影响[J],中华医学杂志, 2021. 101(25): 1968-1972. 7.侯家保,万杏,沈倩妮,刘旭珂,吴洋,宋文沁,夏中元,赵博. REV-ERBα对睡眠剥夺大鼠剖腹探查手术后工作记忆的调控作用及其机制研究[J],中华神经医学杂志, 2020. 19(3): 253-259. 8.侯家保,袁泉,万杏,刘恋,赵博,吴洋,曲古抑菌素A预处理对小鼠脑缺血再灌注损伤皮质炎症反应和凋亡的影响[J],中国现代医学杂志, 2019. 29(9):1-5. 9.侯家保,沈倩妮,万杏,赵博,吴洋,夏中元,急性睡眠剥夺对七氟烷麻醉大鼠学习记忆及海马时钟基因表达的影响[J],中华行为医学与脑科学杂志, 2018, 27 (7):577-581.