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    张申起 神外
    科研处副处长，副教授，副主任医师，硕士生导师
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    导师介绍

    姓名 张申起
    出生年月 1985年10月
    单位 武汉大学人民医院神经外科
    所属学科 临床医学-外科学
    职务、职称及头衔 科研处副处长，副教授，副主任医师，硕士生导师
    E-mail shenqiz@whu.edu.cn
    联系方式 027-88041911转82237或13476851266
    研究方向 1.脑血管病基础与临床研究
    2.纳米医学与神经系统疾病交叉转化研究
    个人简介 主要从事脑血管病的诊治与科研工作，担任中国科技部专家库专家，曾在美国耶鲁大学医学院神经外科中心从事博士后研究。近5年，以第一作者/通讯作者发表SCI论文16篇，总影响因子162.672分，其中一区TOP期刊8篇，发表于Advanced Functional Materials, Bioactive Materials, Advanced Science, Small, Cancer Research, Stroke, Theranostics, JCI insight等国际权威期刊。主持国家自然科学基金及省部级项目10项，副主编神经外科专著2部，参编参译专著各1部，获中国专利9项，美国专利1项，获湖北省科技进步一等奖，二等奖。
    学术任职与荣誉 1.中国科技部专家库专家；
    2.中国研究型医院协会脑血管病专业委员会青年委员；
    3.中国老年保健协会神经外科学创新与转化分会委员；
    4.湖北省微循环协会神经外科专业委员会委员；
    5.湖北省病理生理学会脑血管疾病专业委员会委员；
    6.武汉市医学会神经外科专业委员会委员；
    7.欧美同学会医师协会脑血管病分会会员；
    教育履历 2003.09-2010.06武汉大学第一临床学院临床医学七年制获学士、硕士学位
    2012.09-2014.06武汉大学第一临床学院外科学博士研究生获博士学位
    2017.09-2019.12美国耶鲁大学神经外科中心博士后获博士后证书
    工作履历 2010.07-2019.11武汉大学人民医院神经外科主治医师
    2017.09-2019.12美国耶鲁大学神经外科中心博士后
    2019.12-至今武汉大学人民医院神经外科副主任医师
    2020.12-至今武汉大学人民医院神经外科副教授
    成果获奖 1.《人脑胶质瘤精准外科手术治疗及其相关发病机制》2017年获湖北省科技进步一等奖
    2.《脑卒中神经保护的相关分子机制及精准治疗》2021年获湖北省科技进步二等奖
    代表性论著 1. Shenqi Zhang#, Gang Deng#, Fuyao Liu, Bin Peng, Youmei Bao, Fengyi Du, Ann T. Chen, Jun Liu, Zeming Chen, Junning Ma, Xiangjun Tang, Wendy C. Sheu, Qianxue Chen*, Jiangbing Zhou*. Autocatalytic Delivery of Brain Tumor-targeting, Size-shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases. Advanced Functional Materials. 2020, 30(14): 1910651.（一区TOP，IF: 19.924）
    2. Shenqi Zhang#, Bin Peng#, Zeming Chen, Jiang Yu, Gang Deng, Youmei Bao, Chao Ma, Fengyi Du, Wendy C. Sheu, W. Taylor Kimberly, J. Marc Simard, Daniel Coman, Qianxue Chen, Fahmeed Hyder, Jiangbing Zhou*, Kevin N. Sheth*. Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery. Bioactive Materials. 2022, 02, 033. (一区TOP，IF:18.900)
    3. Yu Zhou#, Shenqi Zhang#, Zeming Chen, Youmei Bao, Ann T. Chen, Wendy C. Sheu, Fuyao Liu, Zhaozhong Jiang*, Jiangbing Zhou*. Targeted Delivery of Secretory Promelittin via Novel Poly (lactone-co-β-amino ester) Nanoparticles for Treatment of Breast Cancer Brain Metastases. Advanced Science. 2020, 7(5): 1901866.（一区TOP，IF: 17.521）
    4. Junning Ma#, Shenqi Zhang#, Jun Liu, Fuyao Liu, Ann T. Chen, Youmei Bao, Gang Deng, Yu Zhou, Peng Wu, Kevin Sheth, Haijun Wang*, Jiangbing Zhou*. Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells. Small. 2019, 15(35): 1902011.（一区TOP，IF: 15.153）
    5. Shenqi Zhang#, Christopher May, Anupama Shirali, Valentina Dubljevic, James A. Campbell, Jiangbing Zhou, James E. Hansen*. Deoxymab: A targeted biologic that is synthetically lethal to TNBC brain metastases. Cancer Research. 2019, 79(13 Suppl): 393.（一区TOP，IF: 13.312）
    6. Gang Deng#, Chao Ma#, Haitian Zhao#, Shenqi Zhang#, Jun Liu, Fuyao Liu, Zeming Chen, Ann T. Chen, Xin Yang, Jonathan Avery, Pan Zou, Fengyi Du, Keun-poong Lim, Daniel Holden, Songye Li, Richard E. Carson, Yiyun Huang, Qianxue Chen, W. Taylor Kimberly, J. Marc Simard, Kevin N. Sheth*, Jiangbing Zhou*. Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles. Theranostics，2019, 9(23): 6991-7002.（一区TOP，IF:11.600）
    7. Shenqi Zhang#, Zeming Chen, Gang Deng, W T Kimberly, J Marc Simard, Jiangbing Zhou*, Kevin N Sheth*. Targeted Drug Delivery Via Acid-triggered Release Antioxidant Nanoparticles Improves Efficacy of NA1 for Stroke Treatment. Stroke. 2021, 3, 52. 10.1161/str.52.suppl_1.65.（一区TOP，IF: 10.17）
    8. Zahra Rattray#, Gang Deng#, Shenqi Zhang#, Anupama Shirali, Christopher K. May, Xiaoyong Chen, Benedette J. Cuffari, Jun Liu, Pan Zou, Nicholas J.W. Rattray, Caroline H. Johnson, Valentina Dubljevic, James A. Campbell, Anita Huttner, Joachim M. Baehring, Jiangbing Zhou*, James E. Hansen*. JCI Insight. 2021, 6(14):e145875.（一区TOP，IF: 9.484）
    9. Zhang Ye#, Lun Gao#, Jiayang Cai, Yixuan Wang, Yong Li, Shiao Tong, Tengfeng Yan, Qian Sun, Yangzhi Qi, Yang Xu, Hongxiang Jiang, Si Zhang, Linyao Zhao, Shenqi Zhang*, Qianxue Chen*. Esterase-responsive and size-optimized prodrug nanoparticles for effective intracranial drug delivery and glioblastoma treatment. Nanomedicine: Nanotechnology, Biology, and Medicine, 2022, 44: 102581.（二区，IF: 6.458）
    10. Jiayang Cai#, Zhang Ye#, Yuanyuan Hu#, Ji’an Yang, Liquan Wu, Fanen Yuan, Li Zhang, Qianxue Chen, Shenqi Zhang*. Identification of immunogenic cell death-related gene classification patterns and immune infiltration characterization in ischemic stroke based on machine learning. Front Cell Neurosci. 2022 Dec 19;16: 1094500.（二区，IF: 6.147）
    11. Bin Peng#, Shenqi Zhang#, Haoan Wu, Farrah S. Mohammed, Fuyao Liu, Wendy C. Sheu, Kevin N. Sheth, Jiangbing Zhou*. Oral delivery of NA1 via sumaresinolic acid nanoparticles for effective treatment of ischemic stroke. ACS Applied Materials & Interfaces, 2022, 9. (Accepted)（一区，IF: 10.383）
    12. Shenqi Zhang#, Bin Peng, Creed M. Stary, Baohui Liu, Qianxue Chen, Xiaoxing Xiong*. Serum prealbumin as an effective prognostic indicator for determining clinical status and prognosis in patients with hemorrhagic stroke. Neural Regeneration Research, 2017,7,12 (7): 1097-1102.（二区，IF: 6.058）
    13. Xiangjun Tang#, Shenqi Zhang#, Rui Fu, Li Zhang, Kuanming Huang, Hao Peng, Longjun Dai, Qianxue Chen*. Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma. Front. Oncol. 2019, 9: 1208.（二区，IF: 5.738）
    14. Zhang Ye#, Shenqi Zhang#, Jiayang Cai, Liguo Ye, Lun Gao, Yixuan Wang, Shiao Tong, Qian Sun, Yu Wu, Xiaoxing Xiong*, Qianxue Chen*. Development and validation of cuproptosis-associated prognostic signatures in WHO 2/3 glioma. Front. Oncol, 2022, 12: 967159.（二区，IF: 5.738）
    15. Fanen Yuan#, Qian Sun, Si Zhang, Liguo Ye, Yang Xu, Zhou Xu, Baohui Liu, Shenqi Zhang*, Qianxue Chen*. HSP27 protects against ferroptosis of glioblastoma cells. Human Cell. 2021, 1, 35(1):238-249.（三区，IF: 4.374）
    16. Lun Gao#, Zhang Ye#, Junhui Liu, Jian Yang, Yong Li, Jiayang Cai, Yixuan Wang, Shiao Tong, Gang Deng, Shenqi Zhang*, Qiaxue Chen*. TMCO1 expression promotes cell proliferation and induces epithelial-mesenchymal transformation in human gliomas. Med Oncol. 2022,15, 39(5):90.（三区，IF: 3.738）
    Name SHENQI ZHANG
    Date of birth Oct，1985
    Department Neurosurgery Department，Renmin Hospital,Wuhan University.
    Title Deputy Director of Scientific Research Dept; Associate Professor; Deputy Chief Physician; Master's Degree Tutor
    Email shenqiz@whu.edu.cn
    TEL 027-88041911-82237 or 13476851266
    Research Direction 1. Basic and Clinical Research on Cerebrovascular Disease;
    2. Translational research at the intersection of nanomedicine and neurological disorders;
    Personal Profile He is mainly engaged in the diagnosis and treatment of cerebrovascular diseases and scientific research, and serves as an expert in the expert pool of the Ministry of Science and Technology of China. He was a postdoctoral fellow in the Center for Neurosurgery, Yale University School of Medicine, USA. In the past 5 years, he has published 16 SCI papers as the first author/corresponding author, with a total impact factor of 162.672, including 8 papers in top journals of Region I. He has been published in Advanced Functional Materials, Bioactive Materials, Advanced Science, Small, Cancer He has published in Advanced Functional Materials, Bioactive Materials, Advanced Science, Small, Cancer, Research, Stroke, Theranostics, JCI insight and other international authoritative journals. He has presided over 10 projects of National Natural Science Foundation of China and provincial and ministerial level projects, co-edited 2 neurosurgery monographs, co-edited and translated 1 monograph each, and was awarded 9 Chinese patents, 1 US patent, and won the first and second prizes of Hubei Provincial Scientific and Technological Progress.
    Selected Publications 1. Shenqi Zhang#, Gang Deng#, Fuyao Liu, Bin Peng, Youmei Bao, Fengyi Du, Ann T. Chen, Jun Liu, Zeming Chen, Junning Ma, Xiangjun Tang, Wendy C. Sheu, Qianxue Chen*, Jiangbing Zhou*. Autocatalytic Delivery of Brain Tumor-targeting, Size-shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases. Advanced Functional Materials. 2020, 30(14): 1910651.（一区TOP，IF: 19.924）
    2. Shenqi Zhang#, Bin Peng#, Zeming Chen, Jiang Yu, Gang Deng, Youmei Bao, Chao Ma, Fengyi Du, Wendy C. Sheu, W. Taylor Kimberly, J. Marc Simard, Daniel Coman, Qianxue Chen, Fahmeed Hyder, Jiangbing Zhou*, Kevin N. Sheth*. Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery. Bioactive Materials. 2022, 02, 033. (一区TOP，IF:18.900)
    3. Yu Zhou#, Shenqi Zhang#, Zeming Chen, Youmei Bao, Ann T. Chen, Wendy C. Sheu, Fuyao Liu, Zhaozhong Jiang*, Jiangbing Zhou*. Targeted Delivery of Secretory Promelittin via Novel Poly (lactone-co-β-amino ester) Nanoparticles for Treatment of Breast Cancer Brain Metastases. Advanced Science. 2020, 7(5): 1901866.（一区TOP，IF: 17.521）
    4. Junning Ma#, Shenqi Zhang#, Jun Liu, Fuyao Liu, Ann T. Chen, Youmei Bao, Gang Deng, Yu Zhou, Peng Wu, Kevin Sheth, Haijun Wang*, Jiangbing Zhou*. Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells. Small. 2019, 15(35): 1902011.（一区TOP，IF: 15.153）
    5. Shenqi Zhang#, Christopher May, Anupama Shirali, Valentina Dubljevic, James A. Campbell, Jiangbing Zhou, James E. Hansen*. Deoxymab: A targeted biologic that is synthetically lethal to TNBC brain metastases. Cancer Research. 2019, 79(13 Suppl): 393.（一区TOP，IF: 13.312）
    6. Gang Deng#, Chao Ma#, Haitian Zhao#, Shenqi Zhang#, Jun Liu, Fuyao Liu, Zeming Chen, Ann T. Chen, Xin Yang, Jonathan Avery, Pan Zou, Fengyi Du, Keun-poong Lim, Daniel Holden, Songye Li, Richard E. Carson, Yiyun Huang, Qianxue Chen, W. Taylor Kimberly, J. Marc Simard, Kevin N. Sheth*, Jiangbing Zhou*. Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles. Theranostics，2019, 9(23): 6991-7002.（一区TOP，IF:11.600）
    7. Shenqi Zhang#, Zeming Chen, Gang Deng, W T Kimberly, J Marc Simard, Jiangbing Zhou*, Kevin N Sheth*. Targeted Drug Delivery Via Acid-triggered Release Antioxidant Nanoparticles Improves Efficacy of NA1 for Stroke Treatment. Stroke. 2021, 3, 52. 10.1161/str.52.suppl_1.65.（一区TOP，IF: 10.17）
    8. Zahra Rattray#, Gang Deng#, Shenqi Zhang#, Anupama Shirali, Christopher K. May, Xiaoyong Chen, Benedette J. Cuffari, Jun Liu, Pan Zou, Nicholas J.W. Rattray, Caroline H. Johnson, Valentina Dubljevic, James A. Campbell, Anita Huttner, Joachim M. Baehring, Jiangbing Zhou*, James E. Hansen*. JCI Insight. 2021, 6(14):e145875.（一区TOP，IF: 9.484）
    9. Zhang Ye#, Lun Gao#, Jiayang Cai, Yixuan Wang, Yong Li, Shiao Tong, Tengfeng Yan, Qian Sun, Yangzhi Qi, Yang Xu, Hongxiang Jiang, Si Zhang, Linyao Zhao, Shenqi Zhang*, Qianxue Chen*. Esterase-responsive and size-optimized prodrug nanoparticles for effective intracranial drug delivery and glioblastoma treatment. Nanomedicine: Nanotechnology, Biology, and Medicine, 2022, 44: 102581.（二区，IF: 6.458）
    10. Jiayang Cai#, Zhang Ye#, Yuanyuan Hu#, Ji’an Yang, Liquan Wu, Fanen Yuan, Li Zhang, Qianxue Chen, Shenqi Zhang*. Identification of immunogenic cell death-related gene classification patterns and immune infiltration characterization in ischemic stroke based on machine learning. Front Cell Neurosci. 2022 Dec 19;16: 1094500.（二区，IF: 6.147）
    11. Bin Peng#, Shenqi Zhang#, Haoan Wu, Farrah S. Mohammed, Fuyao Liu, Wendy C. Sheu, Kevin N. Sheth, Jiangbing Zhou*. Oral delivery of NA1 via sumaresinolic acid nanoparticles for effective treatment of ischemic stroke. ACS Applied Materials & Interfaces, 2022, 9. (Accepted)（一区，IF: 10.383）
    12. Shenqi Zhang#, Bin Peng, Creed M. Stary, Baohui Liu, Qianxue Chen, Xiaoxing Xiong*. Serum prealbumin as an effective prognostic indicator for determining clinical status and prognosis in patients with hemorrhagic stroke. Neural Regeneration Research, 2017,7,12 (7): 1097-1102.（二区，IF: 6.058）
    13. Xiangjun Tang#, Shenqi Zhang#, Rui Fu, Li Zhang, Kuanming Huang, Hao Peng, Longjun Dai, Qianxue Chen*. Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma. Front. Oncol. 2019, 9: 1208.（二区，IF: 5.738）
    14. Zhang Ye#, Shenqi Zhang#, Jiayang Cai, Liguo Ye, Lun Gao, Yixuan Wang, Shiao Tong, Qian Sun, Yu Wu, Xiaoxing Xiong*, Qianxue Chen*. Development and validation of cuproptosis-associated prognostic signatures in WHO 2/3 glioma. Front. Oncol, 2022, 12: 967159.（二区，IF: 5.738）
    15. Fanen Yuan#, Qian Sun, Si Zhang, Liguo Ye, Yang Xu, Zhou Xu, Baohui Liu, Shenqi Zhang*, Qianxue Chen*. HSP27 protects against ferroptosis of glioblastoma cells. Human Cell. 2021, 1, 35(1):238-249.（三区，IF: 4.374）
    16. Lun Gao#, Zhang Ye#, Junhui Liu, Jian Yang, Yong Li, Jiayang Cai, Yixuan Wang, Shiao Tong, Gang Deng, Shenqi Zhang*, Qiaxue Chen*. TMCO1 expression promotes cell proliferation and induces epithelial-mesenchymal transformation in human gliomas. Med Oncol. 2022,15, 39(5):90.（三区，IF: 3.738）



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