武汉大学人民医院湖北省人民医院

院内导航

张海菊 儿科学
儿科学博士，副主任医师，硕士生导师，留美访问学者

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导师介绍

姓名	张海菊
出生年月	27/2/1981
单位	武汉大学人民医院儿科
所属学科	临床医学-儿科学
职务、职称及头衔	儿科学博士，副主任医师，硕士生导师，留美访问学者
E-mail	634326251@qq.com
联系方式	027-88041911转81543或13657281609
研究方向	1. 小儿癫痫的基础与临床 2. 小儿神经免疫性疾病的基础与临床
个人简介	主要从事儿童癫痫的发病机制、癫痫共患病及神经心理评估，神经免疫性疾病的发病机制的研究。主持国家自然科学青年基金1项，中央高校基本科研青年教师项目1项，参与国家自然基金面上及青年项目各1项，参与多项省校级课题。发表学术论文20余篇，其中SCI收录6篇。参编专著1部。荣获山东省科技进步二等奖和湖北省科技进步三等奖各1项。
学术任职与荣誉	武汉儿科学分会感染免疫学组组长湖北省医学会儿科分会小儿神经专业组委员湖北省抗癫痫协会理事湖北省罕见病医学中心儿童免疫缺陷学组委员湖北省抗癫痫协会青年委员会常务理事湖北省生物免疫协会科普分会委员中国医师协会儿科分会小儿肾脏学组青年委员
教育履历	1998.09-2003.06武汉大学第一临床学院临床医学专业本科生获学士学位 2003.09-2008.06山东大学齐鲁医院儿科学硕博连读获博士学位
工作履历	2008.07-2017.11 武汉大学人民医院儿科主治医师 2014.02-2014.08 北京大学第一医院进修小儿神经专业 2016.10-2018.10 美国东田纳西州立大学访问学者 2017.12-至今武汉大学人民医院儿科副主任医师
成果获奖	1.癫痫发病相关机制及癫痫儿童生活质量的评估》2016年获湖北省科技进步三等奖；2.齿状回颗粒细胞的神经发生在幼鼠癫癎发病机制中作用的研究》2011年或山东省科技进步二等奖
代表性论著	1. Haiju Zhang#, Shiqian Yu, Liping Xia, Xia Peng, Shun Wang, Baozhen Yao. NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice. Neurochem Res. 2022. 47(3):713-722. 2. Haiju Zhang#, Yi Caudle, Clay Wheeler, Yu Zhou, Charles Stuart, Baozhen Yao, Deling Yin. TGF-β1/Smad2/3/Foxp3 signaling is required for chronic stress-induced immune suppression. Journal of Neuroimmunology 314 (2018) :30–41. 3. Zhang H#, Caudle Y, Shaikh A, Yao B, Yin D. Inhibition of microRNA-23b prevents polymicrobial sepsis-induced cardiac dysfunction by modulating TGIF1 and PTEN. Biomed Pharmacother. 2018; 103:869-878 4. Haiju Zhang#, Baozhen Yao, Xiao Zhang, Wei Ling and Hao Yuan. Inhibition of mTOR Signal Reduces Epileptogenesis by Inhibiting Early Inflammatory Responses. Int J Drug Dev & Res. 2015, 7(4):55-61. 5. Zhang Haiju#, Sun Ruopeng*, Lei Gefei, Yang Lu, Liu Chunxi. Cyclooxygenase-2 inhibitor inhibits the hippocampal synaptic reorganization by inhibiting MAPK/ERK activity and modulating GABAergic transmission in pilocarpine-induced status epilepticus rats. Med Chem Res (2009) 18:71–90. 6. Xie, Lulu; Jiao, Zhexiao; Zhang Haiju#; Wang, Tingting;Qin, Jiaxin;Zhang, Shuai;Luo, Mingcui;Lu, Mengxi;Yao, Baozhen;Wang, Hui;Xu, Dan. Altered hippocampal GR/KCC2 signaling mediates susceptibility to convulsion in male offspring following dexamethasone exposure during pregnancy in rats. Toxicology Letters. 2022, 364(7):12-23. 7. Zhang Haiju#, Hao Suyuan, Fan Xiufang, Yang Lu, Sun Ruopeng. The combined detection of umbilical cord nucleated red blood cells and lactate: Early prediction of neonatal hypoxic ischemic encephalopathy. Journal of Perinatal Medicine. 2008, 36(3):240-247. 8. 张海菊#;余诗倩;姚宝珍. 腺苷激酶活化在幼鼠癫痫形成中的作用. 武汉大学学报：医学版. 2022, 43, 6, 908-912。 9. 张海菊#;姚宝珍;张晓;凌伟. mTOR信号抑制剂对幼鼠痫性发作后早期炎性因子的影响。武汉大学学报：医学版. 2016，37，2，209-212+217。 10. 张海菊#，姚宝珍,张晓,凌伟.睡眠中癫痫性电持续状态与注意力缺陷多动行为发病关系研究。中国儿童保健杂志,2016,24，3，302-305。 11. 张海菊#;姚宝珍;凌伟。mTOR信号在KA诱导幼鼠癎性发作后的表达变化研究。癫痫与神经电生理学杂志。2014，12. 12. 张海菊#;姚宝珍;凌伟。COX-2抑制剂抑制幼鼠癎性发作后MARK／ERK信号的活化。癫痫与神经电生理学杂志。2013，6. 13. 张海菊#;姚宝珍;凌伟。COX-2抑制剂对幼鼠海马CA1区锥体神经元钠通道的影响. 癫痫与神经电生理学杂志。2012，6. 14. 张海菊#;姚宝珍;凌伟。COX-2抑制剂对幼鼠反复痫性发作后神经发生的影响. . 癫痫与神经电生理学杂志。2011，8.

Name	HAIJU ZHANG
Date of birth	Feburary，1981
Department	Pediatrics Department，Renmin Hospital,Wuhan University.
Title	Ph.D, associate chief physician, supervisor of postgraduate, research scholar in the U.S.A
Email	634326251@qq.com
TEL	027-88041911-81543 or 13657281609
Research Direction	1. The mechanism and clinic manifestation of epilepsy in children 2. The fundamentals and clinical manifestations of neuroimmune diseases in children
Personal Profile	She is mainly engaged in the diagnosis and treatment of neural system diseases in children,and has been awarded the National Natural Science Foundation, and one basic scientific research project of the central university for young teacher in Wuhan University.There are more than 20 articles by the first author, including 7 SCI papers. She won the second prize of Shandong Province Science and technology progress and the third prize of Hubei Province Science and technology progress.
Selected Publications	1. Haiju Zhang#, Shiqian Yu, Liping Xia, Xia Peng, Shun Wang, Baozhen Yao. NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice. Neurochem Res. 2022. 47(3):713-722. 2. Haiju Zhang#, Yi Caudle, Clay Wheeler, Yu Zhou, Charles Stuart, Baozhen Yao, Deling Yin. TGF-β1/Smad2/3/Foxp3 signaling is required for chronic stress-induced immune suppression. Journal of Neuroimmunology 314 (2018) :30–41. 3. Zhang H#, Caudle Y, Shaikh A, Yao B, Yin D. Inhibition of microRNA-23b prevents polymicrobial sepsis-induced cardiac dysfunction by modulating TGIF1 and PTEN. Biomed Pharmacother. 2018; 103:869-878 4. Haiju Zhang#, Baozhen Yao, Xiao Zhang, Wei Ling and Hao Yuan. Inhibition of mTOR Signal Reduces Epileptogenesis by Inhibiting Early Inflammatory Responses. Int J Drug Dev & Res. 2015, 7(4):55-61. 5. Zhang Haiju#, Sun Ruopeng*, Lei Gefei, Yang Lu, Liu Chunxi. Cyclooxygenase-2 inhibitor inhibits the hippocampal synaptic reorganization by inhibiting MAPK/ERK activity and modulating GABAergic transmission in pilocarpine-induced status epilepticus rats. Med Chem Res (2009) 18:71–90. 6. Xie, Lulu; Jiao, Zhexiao; Zhang Haiju#; Wang, Tingting;Qin, Jiaxin;Zhang, Shuai;Luo, Mingcui;Lu, Mengxi;Yao, Baozhen;Wang, Hui;Xu, Dan. Altered hippocampal GR/KCC2 signaling mediates susceptibility to convulsion in male offspring following dexamethasone exposure during pregnancy in rats. Toxicology Letters. 2022, 364(7):12-23. 7. Zhang Haiju#, Hao Suyuan, Fan Xiufang, Yang Lu, Sun Ruopeng. The combined detection of umbilical cord nucleated red blood cells and lactate: Early prediction of neonatal hypoxic ischemic encephalopathy. Journal of Perinatal Medicine. 2008, 36(3):240-247. 8. 张海菊#;余诗倩;姚宝珍. 腺苷激酶活化在幼鼠癫痫形成中的作用. 武汉大学学报：医学版. 2022, 43, 6, 908-912。 9. 张海菊#;姚宝珍;张晓;凌伟. mTOR信号抑制剂对幼鼠痫性发作后早期炎性因子的影响。武汉大学学报：医学版. 2016，37，2，209-212+217。 10. 张海菊#，姚宝珍,张晓,凌伟.睡眠中癫痫性电持续状态与注意力缺陷多动行为发病关系研究。中国儿童保健杂志,2016,24，3，302-305。 11. 张海菊#;姚宝珍;凌伟。mTOR信号在KA诱导幼鼠癎性发作后的表达变化研究。癫痫与神经电生理学杂志。2014，12. 12. 张海菊#;姚宝珍;凌伟。COX-2抑制剂抑制幼鼠癎性发作后MARK／ERK信号的活化。癫痫与神经电生理学杂志。2013，6. 13. 张海菊#;姚宝珍;凌伟。COX-2抑制剂对幼鼠海马CA1区锥体神经元钠通道的影响. 癫痫与神经电生理学杂志。2012，6. 14. 张海菊#;姚宝珍;凌伟。COX-2抑制剂对幼鼠反复痫性发作后神经发生的影响. . 癫痫与神经电生理学杂志。2011，8.