周本宏
药学
科室主任，教授，一级主任药师（二级岗位），博士生导师
科室主任，教授，一级主任药师（二级岗位），博士生导师
导师介绍
| 姓名 | 周本宏 |
| 出生年月 | 1964年12月 |
| 单位 | 武汉大学人民医院药学部 |
| 所属学科 | 药学 |
| 职务、职称及头衔 | 科室主任，教授，一级主任药师（二级岗位），博士生导师 |
| benhongzh@163.com | |
| 联系方式 | 027-88041911转88810、15335898431 |
| 研究方向 |
1.中药天然药物活性成分及临床代谢药理学研究（包括精神与卫生学方向）； 2.临床药学及循证药学研究 |
| 个人简介 | 主要从事中药天然药物活性成分、临床代谢药理学（包括精神与卫生学方向）、药物经济学教学与研究工作，承担国家、省部级课题10余项，获批主持国家自然科学基金6项，获批3项发明专利。承担本科生《天然药物化学》和研究生《中药现代化新技术》的主讲任务，参编教材《天然药物化学》、副主编《药学服务实务》等，在各级期刊发表论文200余篇，其中SCI论文50余篇，二区以上20篇（含一区Top 2篇，二区Top3篇）。已培养硕士100余名，在读硕士12名，博士3名。 |
| 学术任职与荣誉 |
教育部高校药学类专业教学指导委员会临床药学专业分委会委员 中国医院协会药事专业委员会委员 中国药学会药物流行病学专业委员会委员 中国中医药学会中药临床药理分会委员 湖北省药学会中药天然药物专业委员会主任委员 武汉药学会中药与天然药专业委员会主任委员 武汉药学会副理事长湖北省药学会副秘书长 湖北省药理学会治疗药物监测研究专业委员会副主委 湖北省科普作家协会医学科普创作专委会副主委 《中药材》杂志、《医药导报》杂志编委等 |
| 教育履历 |
1984.09-1988.06湖北中医药大学药学专业获学士学位 1996.09-1999.12武汉大学医学院（原湖北医科大学）药理学专业获医学硕士学位 2003.09-2007.12武汉大学有机化学专业获理学博士学位 2016.12赴美国约翰霍普金斯大学医学院短期培训学习 |
| 工作履历 |
1988.06-1994.11 湖北医科大学附属第一医院药师 1994.11-1999.11 湖北医科大学附属第一医院主管药师 1999.12-2001.03 武汉大学人民医院药学部副主任药师、副教授 2001.03-2015.04 武汉大学人民医院临床药学研究室副主任（其间：2004.12晋升为主任药师；2008.12晋升为教授） 2015.04-2020.12 武汉大学人民医院药学部副主任、临床药学研究室副主任（其间：2020.12晋升为一级主任药师） 2021.01至今 武汉大学人民医院药学部主任、药剂科主任、首义院区药剂科主任、临床药学研究室副主任 |
| 成果获奖 |
1.普通高等教育“十一五”国家级规划教材《天然药物化学》高等教育出版社，北京，2010年4月，编委 2.全国普通高等医学院校药学类专业“十四五”规划教材《药学服务实务》中国医药科技出版社，北京，2021年8月，编委 3.《湖北道地及特色药材志》湖北科学技术出版社，湖北，2021年8月，编委 2.高等学校规划教材《中药制药工艺与设计》化学工业出版社，北京，2009年8月，副主编 3.《中药经皮给药与功能性化妆品》中国医药出版社，北京，2019年5月 4.莲心碱衍生物的合成及其抗心律失常作用的定量构效关系研究2003年获湖北省科技厅鉴定，达国内领先水平 5.肾宁颗粒（无糖型）的研制及临床应用研究2010年获湖北省科技厅鉴定，达国内领先水平 6.布托啡诺术后多模式镇痛液的HPLC定量检测及在镇痛泵中稳定性2015年获湖北省科技厅鉴定，达国内领先水平 7.中药祛斑美容霜治疗色素沉着性皮肤病的实验及临床研究1997年获湖北省医药科技进步三等奖 8.《术后多模式镇痛安全合理用药体系构建与临床应用》2017年获湖北省科技进步三等奖 |
| 代表性论著 |
以第一作者或通讯作者在各级药学期刊上公开发表学术论文200余篇，其中SCI 40余篇，近三年代表论著如下： 1. Chen, P., Guo, Z.I., Chen, F.C., Wu, Y., Zhou, B.H*., Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From Ellagitannins. Frontiers in Pharmacology, 2022, 13, 917266.（IF: 5.988，2区） 2. Wu, Y., Li, K.Y., Zeng, M.L., Qiao, B.Y., Zhou, B.H*.,Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute Inflammation. Frontiers in Pharmacology, 2022, 13, 830439.（IF: 5.988，2区） 3. Zhang, Y., Liu, M.M., Zhang, Y.Y., Tian, M., Chen, P., Lan, Y., Zhou, B.H*.,Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway, 2022, Phytotherapy Research, 36(2), 984-995. (IF: 6.388，2区） 4. Chen, P., Chen, F.C., Lei, J.X., Wang, G.H., Zhou, B.H*., The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice, Frontiers in Pharmacology, 2021, 12, 768097. (IF: 5.988，2区） 5. Chen, P., Chen, F., Lei, J.X., Zhou, B.H*., Gut microbial metabolite urolithin b attenuates intestinal immunity function in vivo in aging mice and in vitro in ht29 cells by regulating oxidative stress and inflammatory signalling, 2021, Food & Function, 12(23), 11938-11955. (IF: 6.317，top1区） 6.Zhang, B.Y., Liu, M.M., Liu, G., Li, D., Zhou, B.H*., Oral absorption mechanism of the polysaccharides from Gastrodia elata Blume base on fluorescence labeling, Food research international, 2021, 144, 110342. (IF: 7.425，2区） 7.Cheng, Z.Z., Tu, J.J., Zhang, H.P., Zhang, Y., Zhou, B.H*., Urolithin A attenuates renal fibrosis by inhibiting TGF-beta 1/Smad and MAPK signaling pathways, Journal of functional foods. 2021,83: 104547.( IF: 5.223, 2区). 8.Jin, D., Zhang, B.Y., Li, Q. L., Tu, J. J., & Zhou, B. H*. Effect of punicalagin on multiple targets in streptozotocin / high-fat diet induced diabetic mice，Food & Function，2020, 11, 10617-10634.（IF: 6.317，top1区） 9. Zeng, M.L , Su, Y. , Li, K.Y , Jin, D. , Zhou, B.H*. Gallic acid inhibits bladder cancer T24 cell progression through mitochondrial dysfunction and pi3k/akt/nf-κb signaling suppression. Frontiers in Pharmacology,2020, 11, 1222.（IF: 5.988，2区） 10.Wu Y , Tian S , Rong PP , Zhang F, Chen Y, Guo XX, Zhou BH*. Sacubitril-Valsartan Compared With Enalapril for the Treatment of Heart Failure: A Decision-Analytic Markov Model Simulation in China[J]. Frontiers in Pharmacology, 2020, 11,1101.（IF: 5.988，2区） 11. Zhou B.H*, Li Q.L, Wang J, Chen P, Jiang S. Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Food and Chemical Toxicology, 2019, 123:16-27.（IF: 5.572，top2区） 12. Peng Chen, Fuchao Chen, Ben-hong Zhou. Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway. Aging us, 2019,11(18),7339-7356-11.（IF: 5.955,2区） 13. Li Qiaoling, Li Kuangyu, Cheng Zhenzhen, Zhou Benhong. Anti-renal fibrosis and anti-inflammation effect of urolithin B, ellagitannin-gut microbial-derived metabolites in unilateral ureteral obstruction rats. Journal of functional foods. 2020,65: 103748.( IF: 5.223, 2区) 14. Chen, Peng., Chen, Fuchao., Lei, Jiexin., Li, Qiaoling., Zhou, Benhong*. Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice. Neurotherapeutics, 2019 , 16 (4) , pp.1269-1282.（IF: 6.088,2区） 15. Chen P , Lei JX , Chen FC , Zhou BH*. Ameliorative effect of urolithin A on D-gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammatory and antiapoptotic properties[J]. RSC Advances, 2020, 10(14):8027-8038.（IF: 4.036，3区） 16. Li Qiaoling, Tu Jie, Zhou Benhong*. The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo. Journal of functional foods, 2019. 57:361-372. (IF: 5.223,2区) 17. Chen,Peng ; Chen,Fuchao; Zhou,Benhong*.Systematic review and meta-analysis of prevalence of dermatological toxicities associated withvemurafenib treatment in patients with melanoma. Clinical and experimental dermatology, 2019, 44(3):243-251.（IF: 4.481,4区） 18. Chen,Peng., Lei, Jiexin., Zhou, Benhong*. Letter: decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers. Alimentary Pharmacology & Therapeutics, 2019,50(8):973-974.（9.524, IF: 1区top） 19.周本宏,涂晶晶,章柏钰,吴杰.基于序贯代谢模型研究地榆鞣质在大鼠体内的代谢作用[J].中国医院药学杂志,2020,40(16):1705-1709. 20.周本宏,章柏钰,李妍,程珍珍,刘刚.院内制剂消炎抗菌片的UPLC-LTQ-Orbitrap HRMS分析[J].中国医院药学杂志,2020,40(08):902-908. |
| Name | BENHONG ZHOU |
| Date of birth | Dec, 1964 |
| Department | Department of Pharmacy, Renmin Hospital, Wuhan University. |
| Title | Director, Chief pharmacist, Professor, doctoral tutor |
| benhongzh@163.com | |
| TEL | 027-88041911-88810 or 15335898431 |
| Research Direction |
1.
Research on the active ingredients of Traditional Chinese Medicine and
natural medicine and clinical metabolism pharmacology (spirit and hygiene)
. 2. Clinical Pharmacy and Evidence based pharmaceutical research. |
| Personal Profile | Prof. Zhou is mainly engaged in the research of natural product chemistry, metabolic pharmacology, clinical pharmacy, evidence based pharmaceutical research and pharmacoeconomics. He has undertaken more than 10 national, provincial and ministerial level projects and has been approved to preside over 6 National Natural Science Funds. He has been granted 3 patents for invention. He is responsible for the teaching of "Natural Medicine Chemistry" in undergraduates and "New Technology of Modern Chinese Medicine" in postgraduates. He has involved in compiling the planning teaching material “Natural Medicine Chemistry”, and he is deputy editor in"Pharmaceutical care practice". As the first and the corresponding author, He has published more than 200 papers academic papers, including more than 50 SCI papers, 20 papers above the second region (including 2 papers of the top first region, 3 papers of the top second region). By now, he has educated more than 100 masters. At present, there are12 postgraduates and 3 doctor studying with him. |
| Selected Publications |
1.
Chen, P., Guo, Z.I., Chen, F.C., Wu, Y., Zhou, B.H*., Recent Advances and
Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural
Product Derived From Ellagitannins. Frontiers in Pharmacology, 2022, 13,
917266.（IF: 5.988，2区） 2. Wu, Y., Li, K.Y., Zeng, M.L., Qiao, B.Y., Zhou, B.H*.,Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute Inflammation. Frontiers in Pharmacology, 2022, 13, 830439.（IF: 5.988，2区） 3. Zhang, Y., Liu, M.M., Zhang, Y.Y., Tian, M., Chen, P., Lan, Y., Zhou, B.H*.,Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway, 2022, Phytotherapy Research, 36(2), 984-995. (IF: 6.388，2区） 4. Chen, P., Chen, F.C., Lei, J.X., Wang, G.H., Zhou, B.H*., The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice, Frontiers in Pharmacology, 2021, 12, 768097. (IF: 5.988，2区） 5. Chen, P., Chen, F., Lei, J.X., Zhou, B.H*., Gut microbial metabolite urolithin b attenuates intestinal immunity function in vivo in aging mice and in vitro in ht29 cells by regulating oxidative stress and inflammatory signalling, 2021, Food & Function, 12(23), 11938-11955. (IF: 6.317，top1区） 6.Zhang, B.Y., Liu, M.M., Liu, G., Li, D., Zhou, B.H*., Oral absorption mechanism of the polysaccharides from Gastrodia elata Blume base on fluorescence labeling, Food research international, 2021, 144, 110342. (IF: 7.425，2区） 7.Cheng, Z.Z., Tu, J.J., Zhang, H.P., Zhang, Y., Zhou, B.H*., Urolithin A attenuates renal fibrosis by inhibiting TGF-beta 1/Smad and MAPK signaling pathways, Journal of functional foods. 2021,83: 104547.( IF: 5.223, 2区). 8.Jin, D., Zhang, B.Y., Li, Q. L., Tu, J. J., & Zhou, B. H*. Effect of punicalagin on multiple targets in streptozotocin / high-fat diet induced diabetic mice，Food & Function，2020, 11, 10617-10634.（IF: 6.317，top1区） 9. Zeng, M.L , Su, Y. , Li, K.Y , Jin, D. , Zhou, B.H*. Gallic acid inhibits bladder cancer T24 cell progression through mitochondrial dysfunction and pi3k/akt/nf-κb signaling suppression. Frontiers in Pharmacology,2020, 11, 1222.（IF: 5.988，2区） 10.Wu Y , Tian S , Rong PP , Zhang F, Chen Y, Guo XX, Zhou BH*. Sacubitril-Valsartan Compared With Enalapril for the Treatment of Heart Failure: A Decision-Analytic Markov Model Simulation in China[J]. Frontiers in Pharmacology, 2020, 11,1101.（IF: 5.988，2区） 11. Zhou B.H*, Li Q.L, Wang J, Chen P, Jiang S. Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Food and Chemical Toxicology, 2019, 123:16-27.（IF: 5.572，top2区） 12. Peng Chen, Fuchao Chen, Ben-hong Zhou. Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway. Aging us, 2019,11(18),7339-7356-11.（IF: 5.955,2区） 13. Li Qiaoling, Li Kuangyu, Cheng Zhenzhen, Zhou Benhong. Anti-renal fibrosis and anti-inflammation effect of urolithin B, ellagitannin-gut microbial-derived metabolites in unilateral ureteral obstruction rats. Journal of functional foods. 2020,65: 103748.( IF: 5.223, 2区) 14. Chen, Peng., Chen, Fuchao., Lei, Jiexin., Li, Qiaoling., Zhou, Benhong*. Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice. Neurotherapeutics, 2019 , 16 (4) , pp.1269-1282.（IF: 6.088,2区） 15. Chen P , Lei JX , Chen FC , Zhou BH*. Ameliorative effect of urolithin A on D-gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammatory and antiapoptotic properties[J]. RSC Advances, 2020, 10(14):8027-8038.（IF: 4.036，3区） 16. Li Qiaoling, Tu Jie, Zhou Benhong*. The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo. Journal of functional foods, 2019. 57:361-372. (IF: 5.223,2区) 17. Chen,Peng ; Chen,Fuchao; Zhou,Benhong*.Systematic review and meta-analysis of prevalence of dermatological toxicities associated withvemurafenib treatment in patients with melanoma. Clinical and experimental dermatology, 2019, 44(3):243-251.（IF: 4.481,4区） 18. Chen,Peng., Lei, Jiexin., Zhou, Benhong*. Letter: decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers. Alimentary Pharmacology & Therapeutics, 2019,50(8):973-974.（9.524, IF: 1区top） |
武汉大学人民医院
湖北省人民医院