武汉大学人民医院湖北省人民医院

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陈震 眼科学
东院眼科主任，主任医师，硕士生导师

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导师介绍

姓名	陈震
出生年月	1976年7月
单位	武汉大学人民医院东院眼科
所属学科	临床医学-眼科学
职务、职称及头衔	东院眼科主任，主任医师，硕士生导师
E-mail	hchenzhen@163.com
联系方式	13871025806
研究方向	1.玻璃体视网膜疾病 2.复杂眼外伤 3.葡萄膜炎
个人简介	主要从事玻璃体视网膜疾病、复杂眼外伤及葡萄膜炎的诊治与科研工作，参与国家自然科学基金项目2项，主持省教委、省卫生厅、省卫健委课题5项。发表论文50余篇，其中SCI论文30余篇。已培养硕士生8名，目前正在培养的硕士生3名。
学术任职与荣誉	湖北省防盲专家组成员、办公室副主任湖北省眼科质控中心办公室主任中华医学会眼科分会眼外伤学组委员湖北省生物医学工程学会眼生物材料专业委员会委员湖北省医师协会眼科医师分会委员兼秘书武汉医师协会眼科医师分会委员
教育履历	1993.09-1998.06华中科技大学，临床医学，获学士学位 2000.09-2003.06武汉大学第一临床学院内科学硕士研究生获硕士学位 2005.09-2008.06华中科技大学博士研究生获博士学位
工作履历	1998.06-2005.09黄石市中心医院、主治医师 2008.10-2010.12武汉大学博士后流动站、博士后 2010.01-2013.03武汉大学人民医院眼科中心、主治医师 2013.03-2019.11武汉大学人民医院眼科中心、副主任医师 2019.11-至今武汉大学人民医院东院眼科、主任医师
成果获奖	1.连续5年获得我院杰出核心人才奖 2. 2018年获湖北省科技进步二等奖
代表性论著	1.Zhou YY, Duan CY, Zeng YY, Tong YQ, Nie YH, Yang Y, Chen Z, Chen CZ. Ocular findings and proportion with conjunctival SARS-COV-2 in COVID-19 patients. Opthalmology 2020, 127(7):982-983. 2.Li F, Xia QY, Ren L, Nie YH, Ren H, Guo XY，Yu JQ, Xing YQ, Chen Z. GSDME increases chemotherapeutic drug sensitivity by inducing pyroptosis in retinoblastoma cells. Oxid Med Cell Longev 2022,2022(2371807). 3.Gu JS, Xu YS, Hua DH, Chen Z. Role of artesunate in autoimmune disease and signaling pathways. Immunotheray 2023, Jul 11. 4.Xia QY, Lyu CJ, Li F, Pang BB, Guo XY, Ren H, Xing YQ, Chen Z. Candidate drugs screening for Behcet’s disease based on bioinformatics analysis and mouse experiments. Front Immunol 2022,13,895869 5.Guo XY, Yu X, Li F, Xia QY, Ren H, Chen Z, Xing YQ. Identification of survival-related metabolic genes and a novel gene signature predicting the overall survival for patients with uveal melanoma. Ophthalmic Res.2022 Apr 7. 6.Ren H, Guo XY, Li F, Xia QY, Chen Z, Xing YQ. Four Autophagy-Related Long Noncoding RNAs Provide Coexpression and ceRNA Mechanisms in Retinoblastoma through Bioinformatics and Experimental Evidence. ACS Omega. 2021 Nov 29;6(49):33976-33984. 7.Xu AM, Sun GP, Duan CY, Chen Z, Chen CZ. Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA. DIAGNOSTICS.2021, 11(11): 1948-1948. 8.Hua DH, Xu YS, Heiduschka P, Zhang WL, Zhang X, Zeng XB, Zhu XX, He T, Zheng HM, Xiao X, Xing YQ, Chen Z, Chen CZ. Retina Vascular Perfusion Dynamics During Exercise With and Without Face Masks in Healthy Young Adults: An OCT Angiography Study. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY.2021, 10(3): 1-9. 9.Nie YH, Zhang Y, Li F, Wang Q, Xu AM, Chen Z. Incidence of and Risk Factors for Postoperative Hyphema After 23-Gauge Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy, INTERNATIONAL JOURNAL OF GENERAL MEDICINE. 2021, 2021(14): 7277-7284. 10.Chen Z, Yang HX, Li Z, Xia QY, Nie YH. Temsirolimus as a dual inhibitor of retinoblastoma and angiogenesis via targeting mTOR sigballing. Biochem Biophys Res Commun.2019 Aug 27;516(3):726-732. 11.Chen Z, Yang HX, Nie YH, Xing YQ. miR-145 regulates the proliferation and apoptosis of Y79 human retinoblastoma cells by targeting IGF-1R. Int J Clin Exp Pathol. 2018, 11(9): 4331-4338. 12.Wang P, Xing Y, Chen C, Chen Z, Qian Z. Advanced glycation end-product (AGE) induces apoptosis in human retinal ARPE-19 cells via promoting mitochondrial dysfunction and activating the Fas-FasL signaling. Biosci Biotechnol Biochem.2016;80(2):250-6.(1.255). 13.Li Z, He T, Du K, Xing YQ, Yan Y, Chen Z, Zhang H, Shen Y. Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression. Mol Vis. 2012;18:2847-59. 14.Chen Z, Yang AH, Xu C, Xing YQ , Gong WR, Li JP. c-Jun N-terminal Kinase is Involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells. Graefe's Archive for Clinical and Experimental Ophthalmology. 2011; 249:1399-1407. 15.Chen Z, Chen CZ, Gong WR, Li JP, Xing YQ. Integrin-α5 Mediates Epidermal Growth Factor-Induced Retinal Pigment Epithelial Cells Proliferation and Migration. Pathobiology.2010; 77: 88-95.

Name	ZHEN CHEN
Date of birth	July，1976
Department	Ophthalmology Department，Renmin Hospital,Wuhan University.
Title	Director, Associate Professor, Master tutor
Email	hchenzhen@163.com
TEL	13871025806
Research Direction	1. Viteroretinal disease 2. Complex ocular trauma 3. uveitis
Personal Profile	He is mainly engaged in the diagnosis, treatment and scientific research of vitreoretinal diseases, complex ocular trauma and uveitis. He has participated in 2 projects of the National Natural Science Foundation of China, hosted over 5 projects from the Provincial Science and Technology Department, the Provincial Education Commission, the Provincial Health Department and tthe Provincial Health Commission. He has published more than 50 papers, including 30 SCI papers. By now, he has educated 8 masters. At present , there are 3 masters studing with him.
Selected Publications	1.Zhou YY, Duan CY, Zeng YY, Tong YQ, Nie YH, Yang Y, Chen Z, Chen CZ. Ocular findings and proportion with conjunctival SARS-COV-2 in COVID-19 patients. Opthalmology 2020, 127(7):982-983. 2.Li F, Xia QY, Ren L, Nie YH, Ren H, Guo XY，Yu JQ, Xing YQ, Chen Z. GSDME increases chemotherapeutic drug sensitivity by inducing pyroptosis in retinoblastoma cells. Oxid Med Cell Longev 2022,2022(2371807). 3.Gu JS, Xu YS, Hua DH, Chen Z. Role of artesunate in autoimmune disease and signaling pathways. Immunotheray 2023, Jul 11. 4.Xia QY, Lyu CJ, Li F, Pang BB, Guo XY, Ren H, Xing YQ, Chen Z. Candidate drugs screening for Behcet’s disease based on bioinformatics analysis and mouse experiments. Front Immunol 2022,13,895869 5.Guo XY, Yu X, Li F, Xia QY, Ren H, Chen Z, Xing YQ. Identification of survival-related metabolic genes and a novel gene signature predicting the overall survival for patients with uveal melanoma. Ophthalmic Res.2022 Apr 7. 6.Ren H, Guo XY, Li F, Xia QY, Chen Z, Xing YQ. Four Autophagy-Related Long Noncoding RNAs Provide Coexpression and ceRNA Mechanisms in Retinoblastoma through Bioinformatics and Experimental Evidence. ACS Omega. 2021 Nov 29;6(49):33976-33984. 7.Xu AM, Sun GP, Duan CY, Chen Z, Chen CZ. Quantitative Assessment of Three-Dimensional Choroidal Vascularity and Choriocapillaris Flow Signal Voids in Myopic Patients Using SS-OCTA. DIAGNOSTICS.2021, 11(11): 1948-1948. 8.Hua DH, Xu YS, Heiduschka P, Zhang WL, Zhang X, Zeng XB, Zhu XX, He T, Zheng HM, Xiao X, Xing YQ, Chen Z, Chen CZ. Retina Vascular Perfusion Dynamics During Exercise With and Without Face Masks in Healthy Young Adults: An OCT Angiography Study. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY.2021, 10(3): 1-9. 9.Nie YH, Zhang Y, Li F, Wang Q, Xu AM, Chen Z. Incidence of and Risk Factors for Postoperative Hyphema After 23-Gauge Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy, INTERNATIONAL JOURNAL OF GENERAL MEDICINE. 2021, 2021(14): 7277-7284. 10.Chen Z, Yang HX, Li Z, Xia QY, Nie YH. Temsirolimus as a dual inhibitor of retinoblastoma and angiogenesis via targeting mTOR sigballing. Biochem Biophys Res Commun.2019 Aug 27;516(3):726-732. 11.Chen Z, Yang HX, Nie YH, Xing YQ. miR-145 regulates the proliferation and apoptosis of Y79 human retinoblastoma cells by targeting IGF-1R. Int J Clin Exp Pathol. 2018, 11(9): 4331-4338. 12.Wang P, Xing Y, Chen C, Chen Z, Qian Z. Advanced glycation end-product (AGE) induces apoptosis in human retinal ARPE-19 cells via promoting mitochondrial dysfunction and activating the Fas-FasL signaling. Biosci Biotechnol Biochem.2016;80(2):250-6.(1.255). 13.Li Z, He T, Du K, Xing YQ, Yan Y, Chen Z, Zhang H, Shen Y. Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression. Mol Vis. 2012;18:2847-59. 14.Chen Z, Yang AH, Xu C, Xing YQ , Gong WR, Li JP. c-Jun N-terminal Kinase is Involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells. Graefe's Archive for Clinical and Experimental Ophthalmology. 2011; 249:1399-1407. 15.Chen Z, Chen CZ, Gong WR, Li JP, Xing YQ. Integrin-α5 Mediates Epidermal Growth Factor-Induced Retinal Pigment Epithelial Cells Proliferation and Migration. Pathobiology.2010; 77: 88-95.