武汉大学人民医院湖北省人民医院

院内导航

周庞虎骨外
关节外科副主任兼门诊部副主任，教授，主任医师，博士生导师

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导师介绍

姓名	周庞虎
出生年月	1981年9月
单位	武汉大学人民医院骨二科
所属学科	临床医学-外科学
职务、职称及头衔	关节外科副主任兼门诊部副主任，教授，主任医师，博士生导师
E-mail	zhoupanghu@126.com
联系方式	027-88041911转82263或13971652565
研究方向	1.骨关节病、运动医学的临床与基础研究；2.创伤骨科、骨肿瘤的临床与基础研究。
个人简介	主要从事骨关节外科、运动医学、肢体损伤、骨肿瘤及颈肩腰腿痛的综合诊治。擅长微创髋膝关节置换、运动医学、肢体损伤及腰椎间盘突出的微创治疗手术；精通髋、膝、肩、踝、腕关节及脊柱的微创修复与功能重建。主持国家自然科学基金面上项目、青年项目等省部级课题10余项，以第一作者及通讯作者发表SCI论文30余篇，目前担任国家科技部重大专项研发计划终审专家及国家自然科学基金同行评议专家。
学术任职与荣誉	2022年度获武汉大学人民医院突出核心人才奖；2017年度被评为武汉大学人民医院第五轮青年重点人才培养对象；2023年任武汉医学会机器人与腔镜外科分会委员。
教育履历	2007/11-2008/11公派德国留学，德国莱比锡大学附属医院骨外科和病理系研修学习； 2004/09-2009/06武汉大学第一临床学院，博士学位； 1999/09-2004/06武汉大学医学院，学士学位。
工作履历	2021/06至今武汉大学人民医院骨外科，教授，主任医师，博士研究生导师； 2020/12-2021/05武汉大学人民医院骨外科，教授，主任医师，硕士研究生导师； 2019/12-2020/11武汉大学人民医院骨外科，主任医师，副教授，硕士研究生导师； 2016/06-2019/11武汉大学人民医院骨外科，副主任医师，副教授，硕士研究生导师； 2015/12-2016/05武汉大学人民医院骨外科，副主任医师，副教授； 2013/12-2015/11武汉大学人民医院骨外科，副主任医师，讲师； 2010/01-2013/11武汉大学人民医院骨外科，主治医师，讲师； 2009/07-2009/12武汉大学人民医院骨外科，住院医师，助教。
成果获奖	《壳聚糖基生物材料在骨关节炎中的应用及关键技术创新》以第一完成人获2022年湖北省科技进步二等奖
代表性论著	1.Zhuang H, Ren X, Zhang Y, Jiang F, Zhou P. Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1. Food Chem Toxicol.2023;175:113726.（IF=5.572,一区） 2.Ren X, Zhuang H, Jiang F, Zhang Y, Zhou P. Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes. Int J Mol Sci. 2023;24(5):5056.（IF=6.208,二区） 3.Zhuang H, Ren X, Jiang F, Zhou P. Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis. Mol Med. 2023;29(1):17.（IF=6.376，二区） 4.Ren X#, Zhuang H, Li B, Jiang F, Zhang Y, Zhou P. Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain. Int J Mol Sci. 2023;24(4):4022.（IF=6.208,二区） 5.Zhuang H#, Li B, Xie T, Xu C, Ren X, Jiang F, Lei T, Zhou P. Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF-κB signalling pathway. Int Immunopharmacol. 2022;113(Pt A):109314.（IF=5.6,二区） 6. Ren X#, Li B#, Xu C, Zhuang H, Lei T, Jiang F, Zhou P. High expression of Piezo1 induces senescence in chondrocytes through calcium ions accumulation. Biochem Biophys Res Commun. 2022;607:138-145.（IF=3.322,三区） 7.Zhou P, Xia Z, Qi C, He M, Yu T, Shi L. Construction of chitosan/Ag nanocomposite sponges and their properties. Int J Biol Macromol. 2021 Dec 1;192:272-277.（IF=8.025,一区） 8.Xia GQ#;TR Lei#;TB Yu;PH Zhou, Nanocarrier-based activation of necroptotic cell death potentiates cancer immunotherapy. Nanoscale, 2021, 13(2): 1220-1230.（IF=8.307,二区TOP） 9.He M#;L Shi#;G Wang;Z Cheng;L Han;X Zhang;C Wang;J Wang;P Zhou;G Wang, Biocompatible and biodegradable chitosan/sodium polyacrylate polyelectrolyte complex hydrogels with smart responsiveness. Int J Biol Macromol, 2020, 155: 1245-1251（IF=8.025,一区） 10.Deng RH#, Zou MZ#, Zheng DW, Peng SY, Liu WL, Bai XF, Chen HS, Sun YX, Zhou PH, and Zhang XZ, Nanoparticles from Cuttlefish Ink Inhibit Tumor Growth by Synergizing Immunotherapy and Photothermal Therapy. ACS Nano, 2019. 13(8).（IF=18.027,一区TOP） 11.Qiu B, Xu XF, Deng RH, Xia GQ, Shang XF, and Zhou PH, Construction of chitosan/ZnO nanocomposite film by in situ precipitation. Int J Biol Macromol, 2019. 122.（IF=8.025,一区） 12.Qiu B, Xu XF, Deng RH, Xia GQ, Shang XF, and Zhou PH, Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1beta induced inflammation in synoviocytes in vitro. Int J Mol Med, 2019, 43(2): 1076-1084.（IF=5.314,三区） 13.Deng RH, Qiu B, and Zhou PH, Chitosan/hyaluronic acid/plasmid-DNA nanoparticles encoding interleukin-1 receptor antagonist attenuate inflammation in synoviocytes induced by interleukin-1 beta. Journal of Materials Science-Materials in Medicine, 2018. 29(10).（IF=4.727,三区） 14.He M, Hao C, Zhang X, Wang C, Cheng Xu, Xue YT, Wang JS, Zhou PH ,Qing XZ. Construction of novel cellulose/chitosan composite hydrogels and films and their applications. Cellulose 2018;25:1987-96.（IF=6.123,二区） 15.He M, Zhang X, Yao W, Wang C, Shi L, Zhou PH. Construction of alternate layered chitosan/alginate composite hydrogels and their properties. Mater Lett. 2017;200:43-6.（IF=3.574,三区） 16.Zhou PH#, Shi L#, Qiu B. Protective effect of controlled release of cytokine response modifier A from chitosan microspheres on rat chondrocytes from interleukin-1beta induced inflammation and apoptosis. Exp Ther Med. 2017;14(4):3170-8.（IF=2.751,四区） 17.Wang W#, Zhou PH#, Xu CG, Zhou XJ, Hu W, Zhang J. Baicalein ameliorates renal interstitial fibrosis by inducing myofibroblast apoptosis in vivo and in vitro. BJU Int. 2016;118(1):145-52.（IF=5.929,二区） 18.Qiu B, Gong M, He QT, Zhou PH. Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1beta-Induced Inflammation and Apoptosis in Chondrocytes. Biomed Res Int. 2016;2016:6290957.（IF=3.246,三区） 19.Zhang T#, Zhou PH#, Zhan Y, Shi X, Lin J, Du Y, Li X, Deng H. Pectin/lysozyme bilayers layer-by-layer deposited cellulose nanofibrous mats for antibacterial application. Carbohydr Polym. 2015;117:687-93.（IF=10.723,一区TOP） 20.Zhou PH#, Ma BL#, Shi L, Xie T, Qiu B. Inhibition of interleukin-1beta-stimulated matrix metalloproteinases via the controlled release of interleukin-1Ra from chitosan microspheres in chondrocytes. Mol Med Rep. 2015;11(1):555-60.（IF=3.423,四区）

Name	PANGHU ZHOU
Date of birth	Sep,1981
Department	Department of Orthopedics, Renmin Hospital, Wuhan University.
Title	Professor; Chief physician; Doctoral tutor
Email	zhoupanghu@126.com
TEL	027-88041911-82263, 13971652565
Research Direction	1. Hip and knee surgery, Trauma surgery, Sports medcine; 2. Orthopaedic oncology.
Personal Profile	I am mainly engaged in the diagnosis and treatment of orthopaedic diseases, and have been awarded 2 items for the National Natural Science Foundation, 1 items for sub-project of key research and development projects in Hubei Province, 2 items from the Natural Science Foundation of Hubei Province, 1 items for Young Scientists Foundation of Health Department of Hubei Province, 1 items for Wuhan University Original Frontier Cultivation Program, 1 items for Cross-Innovation Talent Program of Renmin Hospital of Wuhan University. I have been awarded the Second Prize of Hubei Provincial Scientific and Technological Progress as the first complete author, and have published more than 30 SCI papers as the first author or corresponding author.
Selected Publications	1.Zhuang H, Ren X, Zhang Y, Jiang F, Zhou P. Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1. Food Chem Toxicol.2023;175:113726.（IF=5.572,一区） 2.Ren X, Zhuang H, Jiang F, Zhang Y, Zhou P. Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes. Int J Mol Sci. 2023;24(5):5056.（IF=6.208,二区） 3.Zhuang H, Ren X, Jiang F, Zhou P. Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis. Mol Med. 2023;29(1):17.（IF=6.376，二区） 4.Ren X#, Zhuang H, Li B, Jiang F, Zhang Y, Zhou P. Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain. Int J Mol Sci. 2023;24(4):4022.（IF=6.208,二区） 5.Zhuang H#, Li B, Xie T, Xu C, Ren X, Jiang F, Lei T, Zhou P. Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF-κB signalling pathway. Int Immunopharmacol. 2022;113(Pt A):109314.（IF=5.6,二区） 6. Ren X#, Li B#, Xu C, Zhuang H, Lei T, Jiang F, Zhou P. High expression of Piezo1 induces senescence in chondrocytes through calcium ions accumulation. Biochem Biophys Res Commun. 2022;607:138-145.（IF=3.322,三区） 7.Zhou P, Xia Z, Qi C, He M, Yu T, Shi L. Construction of chitosan/Ag nanocomposite sponges and their properties. Int J Biol Macromol. 2021 Dec 1;192:272-277.（IF=8.025,一区） 8.Xia GQ#;TR Lei#;TB Yu;PH Zhou, Nanocarrier-based activation of necroptotic cell death potentiates cancer immunotherapy. Nanoscale, 2021, 13(2): 1220-1230.（IF=8.307,二区TOP） 9.He M#;L Shi#;G Wang;Z Cheng;L Han;X Zhang;C Wang;J Wang;P Zhou;G Wang, Biocompatible and biodegradable chitosan/sodium polyacrylate polyelectrolyte complex hydrogels with smart responsiveness. Int J Biol Macromol, 2020, 155: 1245-1251（IF=8.025,一区） 10.Deng RH#, Zou MZ#, Zheng DW, Peng SY, Liu WL, Bai XF, Chen HS, Sun YX, Zhou PH, and Zhang XZ, Nanoparticles from Cuttlefish Ink Inhibit Tumor Growth by Synergizing Immunotherapy and Photothermal Therapy. ACS Nano, 2019. 13(8).（IF=18.027,一区TOP） 11.Qiu B, Xu XF, Deng RH, Xia GQ, Shang XF, and Zhou PH, Construction of chitosan/ZnO nanocomposite film by in situ precipitation. Int J Biol Macromol, 2019. 122.（IF=8.025,一区） 12.Qiu B, Xu XF, Deng RH, Xia GQ, Shang XF, and Zhou PH, Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1beta induced inflammation in synoviocytes in vitro. Int J Mol Med, 2019, 43(2): 1076-1084.（IF=5.314,三区） 13.Deng RH, Qiu B, and Zhou PH, Chitosan/hyaluronic acid/plasmid-DNA nanoparticles encoding interleukin-1 receptor antagonist attenuate inflammation in synoviocytes induced by interleukin-1 beta. Journal of Materials Science-Materials in Medicine, 2018. 29(10).（IF=4.727,三区） 14.He M, Hao C, Zhang X, Wang C, Cheng Xu, Xue YT, Wang JS, Zhou PH ,Qing XZ. Construction of novel cellulose/chitosan composite hydrogels and films and their applications. Cellulose 2018;25:1987-96.（IF=6.123,二区） 15.He M, Zhang X, Yao W, Wang C, Shi L, Zhou PH. Construction of alternate layered chitosan/alginate composite hydrogels and their properties. Mater Lett. 2017;200:43-6.（IF=3.574,三区） 16.Zhou PH#, Shi L#, Qiu B. Protective effect of controlled release of cytokine response modifier A from chitosan microspheres on rat chondrocytes from interleukin-1beta induced inflammation and apoptosis. Exp Ther Med. 2017;14(4):3170-8.（IF=2.751,四区） 17.Wang W#, Zhou PH#, Xu CG, Zhou XJ, Hu W, Zhang J. Baicalein ameliorates renal interstitial fibrosis by inducing myofibroblast apoptosis in vivo and in vitro. BJU Int. 2016;118(1):145-52.（IF=5.929,二区） 18.Qiu B, Gong M, He QT, Zhou PH. Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1beta-Induced Inflammation and Apoptosis in Chondrocytes. Biomed Res Int. 2016;2016:6290957.（IF=3.246,三区） 19.Zhang T#, Zhou PH#, Zhan Y, Shi X, Lin J, Du Y, Li X, Deng H. Pectin/lysozyme bilayers layer-by-layer deposited cellulose nanofibrous mats for antibacterial application. Carbohydr Polym. 2015;117:687-93.（IF=10.723,一区TOP） 20.Zhou PH#, Ma BL#, Shi L, Xie T, Qiu B. Inhibition of interleukin-1beta-stimulated matrix metalloproteinases via the controlled release of interleukin-1Ra from chitosan microspheres in chondrocytes. Mol Med Rep. 2015;11(1):555-60.（IF=3.423,四区）