武汉大学人民医院湖北省人民医院

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范国华 心胸外
副教授，副主任医师，硕士生导师

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导师介绍

姓名	范国华
出生年月	1970年6月
单位	武汉大学人民医院胸外科
所属学科	临床医学-外科学
职务、职称及头衔	副教授，副主任医师，硕士生导师
E-mail	fanguohuade@163.com
联系方式	027-88041911转82240或13971146716
研究方向	肺及食管肿瘤基础与临床研究
个人简介	主要从事胸外科疾病的诊治与科研工作，普胸外科肺，食管，纵隔等良恶性疾病的诊断和治疗，特别擅长胸腔镜外科治疗肺，食管等疾病，对复合食管癌的诊治有丰富临床经验。以第一或通讯作者发表SCI及中文核心期刊论文30余篇，承担湖北省自然科学基金2项，参与国家自然科学基金项目3项。主编和参编专著各2部。
学术任职与荣誉	湖北省医学会胸心外科分委会食管癌专委会委员；湖北省抗癌协会食管癌专业委员会委员；武汉市医学会胸外科分委员会委员；湖北省临床肿瘤学会肺癌专业委员会委员；湖北省生物医学工程学会微创胸外科专委会副主任委员
教育履历	1991.09-1996.06武汉大学第一临床学院临床医学专业本科生获学士学位 2000.09-2005.07武汉大学第一临床学院外科学硕士研究生获硕士学位及博士学位（硕博连读）
工作履历	1996.07-2000.09湖北省宜昌市葛洲坝中心医院主治医师 2000.09-2005.07武汉大学第一临床学院外科学硕士研究生获硕士学位及博士学位（硕博连读） 2005.07-2010.12武汉大学人民医院胸外科主治医师 2010.12-至今武汉大学人民医院胸外科副主任医师
成果获奖	结肠代食管手术技术创新和临床推广应用(2017T-017-2-005-005-R8)，湖北省人民政府，湖北省科技成果推广奖，二等奖，2017
代表性论著	1．Guohua F, Tieyuan Z, Xinping M, Juan X. Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner. Ecotoxicol Environ Saf. 2021 Oct 15;223:112588. 2. Fan GH, Zhu TY, Huang J. FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1. Cell Signal. 2020 Aug;72:109665. 3. Guohua F, Tieyuan Z, Rui W, Juan X. Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1-Dependent Manner. Oxid Med Cell Longev. 2021 Aug 4;2021:6878026. 4.Zhongyin Z, Wei W, Juan X, Guohua F. Isoliquiritin apioside relieves intestinal ischemia/reperfusion-induced acute lung injury by blocking Hif-1α-mediated ferroptosis. Int Immunopharmacol. 2022 Jul;108:108852. 5. Hui Z, Jie H, Fan GH*. Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway. Med Sci Monit. 2021 Apr 3;27:e930429. 6. Zhongyin Z, Wei W, Juan X, Guohua F. Epigallocatechin Gallate Relieved PM2.5-Induced Lung Fibrosis by Inhibiting Oxidative Damage and Epithelial-Mesenchymal Transition through AKT/mTOR Pathway. Oxid Med Cell Longev. 2022 Jun 6;2022:7291774.28. 7.Fan G , Jie H , Fan X , et al. Enhanced oxidation and detection of toxic clenbuterol on the surface of acetylene black nanoparticle-modified electrode[J]. Journal of Molecular Liquids, 2012, 169(none):102–105.

Name	GUOHUA FAN
Date of birth	JUN，1970
Department	Department of thoracic surgery，Renmin Hospital,Wuhan University.
Title	Associate Professor, Associate Chief Physician, master‘s tutor
Email	fanguohuade@163.com
TEL	027-88041911-82240 or 13971146716
Research Direction	Basic and clinical research on Lung and esophageal cancer
Personal Profile	He is mainly engaged in the diagnosis and treatment of chest diseases,and general thoracic department of lung, esophagus, mediastinum and other benign and malignant diseases diagnosis and treatment, especially skilled in thoracoscopic surgical treatment of lung, esophagus and other diseases, the diagnosis and treatment of complex esophageal cancer has rich clinical experience.He has published more than 30 papers in SCI and Chinese core journals as the first or corresponding author. He has undertaken 2 natural science foundation projects of Hubei Province and 3 national Natural Science Foundation projects. Two monographs were edited and edited respectively.
Selected Publications	1．Guohua F, Tieyuan Z, Xinping M, Juan X. Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner. Ecotoxicol Environ Saf. 2021 Oct 15;223:112588. 2. Fan GH, Zhu TY, Huang J. FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1. Cell Signal. 2020 Aug;72:109665. 3. Guohua F, Tieyuan Z, Rui W, Juan X. Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1-Dependent Manner. Oxid Med Cell Longev. 2021 Aug 4;2021:6878026. 4.Zhongyin Z, Wei W, Juan X, Guohua F. Isoliquiritin apioside relieves intestinal ischemia/reperfusion-induced acute lung injury by blocking Hif-1α-mediated ferroptosis. Int Immunopharmacol. 2022 Jul;108:108852. 5. Hui Z, Jie H, Fan GH*. Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway. Med Sci Monit. 2021 Apr 3;27:e930429. 6. Zhongyin Z, Wei W, Juan X, Guohua F. Epigallocatechin Gallate Relieved PM2.5-Induced Lung Fibrosis by Inhibiting Oxidative Damage and Epithelial-Mesenchymal Transition through AKT/mTOR Pathway. Oxid Med Cell Longev. 2022 Jun 6;2022:7291774.28. 7.Fan G , Jie H , Fan X , et al. Enhanced oxidation and detection of toxic clenbuterol on the surface of acetylene black nanoparticle-modified electrode[J]. Journal of Molecular Liquids, 2012, 169(none):102–105.