武汉大学人民医院湖北省人民医院

院内导航

胡丹心内
楚天特聘教授，教授，主任医师，博士生导师

A+ A-

导师介绍

姓名	胡丹
出生年月	1975年7月
单位	武汉大学人民医院心血管内科
所属学科	临床医学-内科学
职务、职称及头衔	楚天特聘教授，教授，主任医师，博士生导师
E-mail	hudan0716@hotmail.com
联系方式	027-88041911
研究方向	1.临床和转化心脏病学，特别是心律失常领域； 2.心脏电生理学、心力衰竭、心律失常、心肌病、心肌梗死、心源性猝死等的流行病学、危险分层及治疗； 3.药物开发和治疗：基于动物模型，干细胞模型，细胞系和病人为基础的心脏药理学 4.以分子遗传学和突变分析研究心律失常、心肌病和心脏猝死等的基础； 5.心脏动作电位和离子通道的分子和细胞特征，心电图标记物，如J波、T波、U波、QT间期的特征和潜在机制，以及可能的治疗方法； 6.在人类和动物疾病模型中基因表达和调控； 7.干细胞和iPSC细胞
个人简介	在心血管病的发病机制、临床诊断与治疗、遗传学、药理学以及干细胞领域的研究处于国际先进水平。近年来，主持了多项国家自然科学基金项目、湖北省卫健委联合基金重点项目、武汉大学自主科研项目等。在JACC，Circulation等世界一流杂志发表学术论文/综述共140余篇（>50篇为第一，>60篇为通讯，IF>10的9篇，H-index=37，文章引用率>3900，最高影响因子为40）。指导博士硕士研究生20余位，多次指导学生在国内外比赛中获奖。
学术任职与荣誉	学术任职 2003- 中国心脏起搏与电生理协会会员， 2007- 美国生理协会会员， 2007- 美国心脏协会委员， 2007- 心脏电生理协会会员， 2010- 华裔美国心脏协会会员， 2013- 美国心律协会委员， 2014- 华裔美国心脏协会教育委员会副主席， 2015- 中国心律学会-遗传性心律失常工作委员会副主任， 2016- 美国心脏学会委员， 2016- 欧洲心律失常协会会员， 2016- 世界华人心血管医师协会委员， 2017- 亚太心律协会委员， 2019- 中国生理学会循环生理专业委员会会员， 2019- 中华医学会心血管病分会基础研究学组会员， 2019- 中国心衰中心联盟会员， 2020- Frontier in Physiology杂志副主编， 2021- 中国老年医学会心电与心功能分会委员， 2022- Frontier in Cardiovascular Medicine杂志专业主编 2022- 中国生物物理学会委员获奖与荣誉 2022年中华医师协会和中华医学会“中国心律失常领域（2019-2021年）十大原创研究 2022年在美国华裔心脏协会/恩科心血管协会/北美中华心脏病学会（CNAHA/ACRE/CAAC）联合会议会上指导学生获得“心血管研究青年学者奖-临床类第一名 2021年在第42届美国心律学会年会（HRS 2021）上指导的学生获得“心血管研究青年学者奖” 2020年武汉大学人民医院-“抗疫英雄” 2020年中华医学会“中青年心血管病学菁英” 2019年武汉大学人民医院–“教学先进个人” 2018年 Heart Rhythm杂志杰出贡献奖 2017年 HRS（心律协会）房颤意识奖 2016年 HRS（心律协会）及杂志代言人 2016年上海第十医院客座教授，武汉科技大学客座教授 2015年 ACC（美国心脏协会）年会的FIT Learning Annex的旅行奖 2014年 ACC（美国心脏协会）年会的FIT Learning Annex的旅行奖 2014年智利的de la Universidad de Valparaiso（瓦尔帕莱索大学）客座教授 2013年 ACC（美国心脏协会）青年学者奖冠军 2013年 HRS（心律协会）年会创新性摘要奖 2012年华中科技大学同济医院客座教授 2007年 CES（心脏电生理协会）的Gordon K. Moe青年学者奖 2003年武汉大学庚山奖学金（第一人）
教育履历	1993年9月-1998年6月在武汉大学攻读临床医学学士学位 1998年9月-2000年6月在武汉大学攻读内科学硕士学位 2000年9月-2003年7月在武汉大学攻读内科学博士学位
工作履历	2003.07-2004.08武汉大学人民医院心血管内科主治医师 2004.09-2018.08美国共济会研究所博士后，助教，副教授，干细胞中心SCRO主席，美国CLIA认证的基因检测实验室主任 2018.09-至今武汉大学人民医院心血管内科教授、主任医师
成果获奖	无
代表性论著	1. Hu D, Barajas-Martinez H, Zhang ZH, Duan HY, Zhao QY, Bao MW, Du YM, Burashnikov A, Monasky MM, Pappone C, Huang CX, Antzelevitch C and Jiang H. Advances in basic and translational research in atrial fibrillation. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2023;378:20220174. (第一作者+通讯作者，中科院一区，IF 6.7) 2. Chen GX, Barajas-Martínez H, Ciconte G, Wu CI, Monasky MM, Xia H, Li B, Capra JA, Guo K, Zhang ZH, Chen X, Yang B, Jiang H, Tse G, Mak CM, Aizawa Y, Gollob MH, Antzelevitch C, Wilde AAM, Pappone C and Hu D. Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome. EBioMedicine. 2023;87:104388. (通讯作者，中科院一区，IF 11.2) 3. Zeng B, Zhang X, Schimpf R, Powers A, Glikson M, Antzelevitch C, Hu D and Barajas-Martinez H. Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2023;378:20220286. (第一作者+通讯作者，中科院一区，IF 6.7) 4. Huang Y, Ding HS, Song T, Chen YT, Wang T, Tang YH, Barajas-Martinez H, Huang CX and Hu D. Abrogation of CC Chemokine Receptor 9 Ameliorates Ventricular Electrical Remodeling in Mice After Myocardial Infarction. Frontiers in cardiovascular medicine. 2021;8:716219. 5. Chen X, Barajas-Martínez H, Xia H, Zhang Z, Chen G, Yang B, Jiang H, Antzelevitch C and Hu D. Clinical and Functional Genetic Characterization of the Role of Cardiac Calcium Channel Variants in the Early Repolarization Syndrome. Frontiers in cardiovascular medicine. 2021;8:680819. 6. Huang Y, Hu Z, Hu D, Quan Z, Zhou X, Fan G, Chen X, Liu X, Zhang Z, Chen G, Wu Y, Zhang F, Mao C, Xia H, Liang J, Yang B, Jiang H, Huang C, Barajas-Martínez H and Hu D. Clinical characteristics, risk factors, and cardiac manifestations of cancer patients with COVID-19. Journal of applied physiology (Bethesda, Md : 1985). 2021;131:966-976. 7. Huang Y, Chen XM, Barajas-Martinez H, Jiang H, Antzelevitch C and Hu D. Common variants in SCN10A gene associated with Brugada syndrome. Human molecular genetics. 2021;31:157-165. 8. Zhang ZH, Barajas-Martínez H, Xia H, Li B, Capra JA, Clatot J, Chen GX, Chen X, Yang B, Jiang H, Tse G, Aizawa Y, Gollob MH, Scheinman M, Antzelevitch C and Hu D. Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants. Journal of the American College of Cardiology. 2021;78:1603-1617. (通讯作者，中科院一区，IF 27.2) 9. Hu D, Hu D, Liu L, Barr D, Liu Y, Balderrabano-Saucedo N, Wang B, Zhu F, Xue Y, Wu S, Song B, McManus H, Murphy K, Loes K, Adler A, Monserrat L, Antzelevitch C, Gollob MH, Elliott PM and Barajas-Martinez H. Identification, clinical manifestation and structural mechanisms of mutations in AMPK associated cardiac glycogen storage disease. EBioMedicine. 2020;54:102723. (第一作者+通讯作者，中科院一区，IF 11.2) 10. Liu X, Qu C, Shi S, Ye T, Wang L, Liu S, Zhang C, Liang J, Hu D and Yang B. The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism. Frontiers in physiology. 2019;10:1346. 11. Hu D, Barajas-Martínez H, Pfeiffer R, Dezi F, Pfeiffer J, Buch T, Betzenhauser MJ, Belardinelli L, Kahlig KM, Rajamani S, DeAntonio HJ, Myerburg RJ, Ito H, Deshmukh P, Marieb M, Nam GB, Bhatia A, Hasdemir C, Haïssaguerre M, Veltmann C, Schimpf R, Borggrefe M, Viskin S and Antzelevitch C. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. Journal of the American College of Cardiology. 2014;64:66-79. (第一作者，中科院一区，IF 27.2) 12.张想,黄燕,曾彬,胡丹.导致J波综合征的CACNA1C基因的热点突变.武汉大学学报（医学版）,2023,44(4):387-392..(通讯作者.核心期刊) 13.黄燕,胡丹.三磷酸腺苷敏感性钾通道基因突变与心血管疾病[J].中国心脏起搏与心电生理杂志, 2020, v.34(06):78-80.(通讯作者.核心期刊) 14.张中和,陈甘潇,夏豪,杨波,江洪,胡丹.合并新冠感染的遗传性和获得性心律失常综合征患者的处理原则.中华心血管病杂志,2020,48 (09): 799-804.(通讯作者.中华期刊) 14.（书）张春祥,杜杰,周翔宇,谭晓秋,段大跃,王瑛,徐勇,胡丹.现代心血管研究热点：百名杰出专家共画.专著.科学技术文献出版社.2021.编委. 15.（书）刘丽文,葛均波,张远,周晓东,张军,David H.Hsi,葛舒平,刘兵,刘金成,胡丹.Liwen术式治疗肥厚性心肌病：从基础到临床应用实践.专著.科学出版社.2021.编委.

Name	Dan Hu
Date of birth	Jul，1975
Department	Cardiovascular Department，Renmin Hospital,Wuhan University.
Title	Director, Professor, doctoral tutor
Email	hudan0716@hotmail.com
TEL	027-88041911
Research Direction	1. Clinical and translational cardiology, specifically in the area of electrophysiology and arrhythmia, such as inherited arrhythmogenic cardiac syndromes. 2. Cardiac electrobiology, epidemiology, risk stratification, and treatment of heart failure, arrhythmia, cardiomyopathy, myocardial infarction, and sudden cardiac death, et al. 3. Drug development and therapy. Cardiac pharmacology in animal model, stem cell model, cell lines, and patients. Device implantation and ablation of arrhythmia. 4. Molecular genetics and mutation analysis of the basis for cardiac arrhythmias, cardiomyopathy, and sudden cardiac death. 5. Molecular and cellular characteristics of action potential and ion channels in heart, and the characteristics and underlying mechanism of ECG markers, such as J wave, T wave, U wave and QT interval, and possible therapy. 6. Gene expression and modulation in human and animal models with cardiac arrhythmias. 7. Stem cells and iPSC cells.
Personal Profile	She is mainly engaged in pathogenesis, clinical diagnosis and treatment, genetics, pharmacology, and stem cells in cardiovascular diseases. In recent years, she has presided over two National Natural Science Foundation of China projects, key projects of Hubei Provincial Health Commission joint fund, Wuhan University independent research projects, etc. She has published over 140 academic papers/reviews (with over 40 as first author and over 50 as corresponding author) in world-leading journals such as JACC, Circulation, etc., including 9 papers with IF>10. Her H-index is 37, citations over 3900, and highest IF of 40. She has supervised over 20 doctoral and master students, and has repeatedly guided students to win awards in domestic and international competitions.
Selected Publications	1. Hu D, Barajas-Martinez H, Zhang ZH, Duan HY, Zhao QY, Bao MW, Du YM, Burashnikov A, Monasky MM, Pappone C, Huang CX, Antzelevitch C and Jiang H. Advances in basic and translational research in atrial fibrillation. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2023;378:20220174. (First author + corresponding author,IF 6.7) 2. Chen GX, Barajas-Martínez H, Ciconte G, Wu CI, Monasky MM, Xia H, Li B, Capra JA, Guo K, Zhang ZH, Chen X, Yang B, Jiang H, Tse G, Mak CM, Aizawa Y, Gollob MH, Antzelevitch C, Wilde AAM, Pappone C and Hu D. Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome. EBioMedicine. 2023;87:104388. (Corresponding author,IF 11.2) 3. Zeng B, Zhang X, Schimpf R, Powers A, Glikson M, Antzelevitch C, Hu D and Barajas-Martinez H. Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes. Philosophical transactions of the Royal Society of London Series B, Biological sciences. 2023;378:20220286. (First author + corresponding author,IF 6.7) 4. Huang Y, Ding HS, Song T, Chen YT, Wang T, Tang YH, Barajas-Martinez H, Huang CX and Hu D. Abrogation of CC Chemokine Receptor 9 Ameliorates Ventricular Electrical Remodeling in Mice After Myocardial Infarction. Frontiers in cardiovascular medicine. 2021;8:716219. 5. Chen X, Barajas-Martínez H, Xia H, Zhang Z, Chen G, Yang B, Jiang H, Antzelevitch C and Hu D. Clinical and Functional Genetic Characterization of the Role of Cardiac Calcium Channel Variants in the Early Repolarization Syndrome. Frontiers in cardiovascular medicine. 2021;8:680819. 6. Huang Y, Hu Z, Hu D, Quan Z, Zhou X, Fan G, Chen X, Liu X, Zhang Z, Chen G, Wu Y, Zhang F, Mao C, Xia H, Liang J, Yang B, Jiang H, Huang C, Barajas-Martínez H and Hu D. Clinical characteristics, risk factors, and cardiac manifestations of cancer patients with COVID-19. Journal of applied physiology (Bethesda, Md : 1985). 2021;131:966-976. 7. Huang Y, Chen XM, Barajas-Martinez H, Jiang H, Antzelevitch C and Hu D. Common variants in SCN10A gene associated with Brugada syndrome. Human molecular genetics. 2021;31:157-165. 8. Zhang ZH, Barajas-Martínez H, Xia H, Li B, Capra JA, Clatot J, Chen GX, Chen X, Yang B, Jiang H, Tse G, Aizawa Y, Gollob MH, Scheinman M, Antzelevitch C and Hu D. Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants. Journal of the American College of Cardiology. 2021;78:1603-1617. (Corresponding author,IF 27.2) 9. Hu D, Hu D, Liu L, Barr D, Liu Y, Balderrabano-Saucedo N, Wang B, Zhu F, Xue Y, Wu S, Song B, McManus H, Murphy K, Loes K, Adler A, Monserrat L, Antzelevitch C, Gollob MH, Elliott PM and Barajas-Martinez H. Identification, clinical manifestation and structural mechanisms of mutations in AMPK associated cardiac glycogen storage disease. EBioMedicine. 2020;54:102723. (First author + corresponding author,IF 11.2) 10. Liu X, Qu C, Shi S, Ye T, Wang L, Liu S, Zhang C, Liang J, Hu D and Yang B. The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism. Frontiers in physiology. 2019;10:1346. 11. Hu D, Barajas-Martínez H, Pfeiffer R, Dezi F, Pfeiffer J, Buch T, Betzenhauser MJ, Belardinelli L, Kahlig KM, Rajamani S, DeAntonio HJ, Myerburg RJ, Ito H, Deshmukh P, Marieb M, Nam GB, Bhatia A, Hasdemir C, Haïssaguerre M, Veltmann C, Schimpf R, Borggrefe M, Viskin S and Antzelevitch C. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. Journal of the American College of Cardiology. 2014;64:66-79. (First Author,IF 27.2) 12.Zhang X, Huang Y, Zeng B, Hu D.Hot spot mutation of CACNA1C gene causing J-wave syndrome.Medical Journal of Wuhan University,2023,44(4):387-392..(Corresponding author. Core journal) 13. Huang Y, Hu D.Adenosine triphosphate sensitive potassium channel gene mutation and cardiovascular disease.Chinese Journal of Cardiac Pacing and Electrophysiology, 2020, v.34(06):78-80.(Corresponding author. Core journal) 14.Zhang ZH, Chen GX, Xia H, Yang B, Jiang H, HU D.Principle of management among patients withinherited and acquired arrhythmic syndrome complicating with COVID-19 infection. Chinese Journal of Cardiology,2020,48 (09): 799-804.(Corresponding author. Chinese Medical Associationjournal) 14.（书）张春祥,杜杰,周翔宇,谭晓秋,段大跃,王瑛,徐勇,胡丹.现代心血管研究热点：百名杰出专家共画.专著.科学技术文献出版社.2021.编委. 15.（书）刘丽文,葛均波,张远,周晓东,张军,David H.Hsi,葛舒平,刘兵,刘金成,胡丹.Liwen术式治疗肥厚性心肌病：从基础到临床应用实践.专著.科学出版社.2021.编委.