武汉大学人民医院湖北省人民医院

院内导航

周建林骨外
关节外科副主任，主持医院疫情防控指挥部工作，主任医师，副教授，硕士生导师

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导师介绍

姓名	周建林
出生年月	1980年2月
单位	武汉大学人民医院关节外科
所属学科	临床医学-外科学
职务、职称及头衔	关节外科副主任，主持医院疫情防控指挥部工作，主任医师，副教授，硕士生导师。
E-mail	13659880625@163.cpm
联系方式	13659880625
研究方向	1.骨关节炎发病机理 2.骨肿瘤的诊疗
个人简介	主持及参与国家自然科学基金5项，教育部、湖北省、中央高校、武汉市课题7项，参与湖北省重点研发项目1项，获得国家专利4项，获湖北省科技进步奖1项，发表论文40余篇，SCI论文20余篇.精通复杂膝、髋关节置换，肩、膝、踝关节关节镜治疗，骨盆、脊柱骨折微创手术，脊柱矫形、腰椎间盘突出症等手术治疗，手术快，麻醉时间短，患者康复快，2020年率先在业界内提出OHO(一小时手术)和GOP(绿色手术)理念。目前正在培养的硕士生2名。
学术任职与荣誉	中国研究型医院协会骨科创新与转化专业委员会委员，中国康复医学会修复重建外科委员，湖北省医学会骨科分会委员，湖北省医师协会骨科分会青年委员，湖北省微循环学会理事，湖北省运动人体科学研究会委员，湖北省生物医学工程学会骨生物材料与组织工程专业委员会青年委员，湖北省生物医学工程学会颈肩腰腿痛生物治疗专业委员会青年委员，武汉市生物医学工程学会颈肩腰腿痛生物治疗专业委员会常委，亚太足踝外科医师协会委员，湖北省足踝工作委员会常委，医学参考报常务编委，武汉市机器人与腔镜外科分会第一届骨科学组委员，中华临床医师杂志，临床外科杂志编委，中国组织工程研究组织审稿专家。
教育履历	2000.09-2005.06武汉大学第一临床学院临床医学专业本科生获学士学位 2005.09-2007.06武汉大学第一临床学院外科学硕士研究生获硕士学位 2007.09-2010.06武汉大学第一临床学院外科学博士研究生获博士学位
工作履历	2010.7-2011.12武汉大学人民医院骨外科住院医师 2011.12-2015.12武汉大学人民医院骨科主治医师 2015.10-2015.12河南省固始县中医院技术指导专家 2015.12-2016.8武汉大学人民医院骨科副主任医师 2016.8-2019.6武汉大学人民医院松滋医院副院长 2019.6-2022.12武汉大学人民医院骨科关节外科副主任副主任医师 2022.4-2022.6武汉大学人民医院第二批援沪医疗队领队 2022.9-至今武汉大学人民医院疫情防控指挥部办公室主持工作 2022.12-至今武汉大学人民医院骨科关节外科副主任主任医师
成果获奖	《股骨头坏死发病机制与快速康复关键技术》2019年获湖北省科技进步二等奖
代表性论著	1.Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway. Chem Biol Interact. 2023 Jun 9;382:110602. 2.CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9. Int Immunopharmacol. 2022 Sep;110:109064. 3.Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.PeerJ.2022;10:e13319. 4.Dexamethasone induces ferroptosis via P53/SLC7A11/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head. Biochem Biophys Res Commun. 2022;602:149-155. 5.Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation. J Cell Mol Med. 2021;25(1):120-131 6.Identification of Disease-Specific Hub Biomarkers and Immune Infiltration in Osteoarthritis and Rheumatoid Arthritis Synovial Tissues by Bioinformatics Analysis. Dis Markers. 2021:9911184 7.Protective Effect of Human Umbilical Cord Mesenchymal Stem Cells in Glucocorticoid-induced Osteonecrosis of Femoral Head. Curr Med Sci. 2021;41(5):909-915. 8.MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression. PPAR Res. 2020:6633022 9.Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway.Biomed Pharmacother. 2019;109(1):2335-2341 10.Local intraarticular injection of vascular endothelial growth factor accelerates articular cartilage degeneration in rat osteoarthritis model. Molecular medicine reports.2018，17, 6311-6318 11.The Relationship between HIF-2a and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee.Yonsei Med J. 2016;57(3):735-40. 12.PKCa Agonists Enhance the Protective Effect of Hyaluronic Acid on Nitric Oxide-Induced Apoptosis of Articular Chondrocytes in Vitro. Iranian Journal of Basic Medical Sciences.2013;16(12):1276-81. 13.Hyaluronic Acid Inhibits Nitric Oxide-induced Apoptosis and Dedifferentiation of Articular Chondrocytes in Vitro. Inflamm Res. 2010; 59（7）：519-530. 14.Effects of hyaluronan on vascular endothelial growth factor and receptor-2 expression in a rabbit osteoarthritis model. J Orthop Sci. 2009; 14(3):313-319. 15.The protective effect of sodium hyaluronate on the cartilage of rabbit osteoarthritis by inhibiting Peroxisome Proliferator-Activated Receptor-Gamma mRNA expression. Yonsei Med J. 2009; 50(6):832-837. 16.血管内皮生长因子在骨关节炎软骨钙化层重构中的作用.微循环学杂志，2017,27(2):67-70. 17.Local intra-articular injection of sodium hyaluronate delays articular cartilage degeneration after traumatic osteoarthritis.中国组织工程研究. 2015; 19 (33): 5295-5300. 18.血管内皮生长因子和缺氧诱导因子对软骨细胞凋亡的作用[J].中国组织工程研究，2015，19(29):4705-4709. 19.自体、异体骨软骨移植及组织工程材料修复的关节软骨损伤[J].中国组织工程研究，2015，19(34):5530-5535. 20.透明质酸钠对兔骨关节炎软骨VEGF及其受体-2mRNA表达的影响.武汉大学学报.2013;34(2):178-182

Name	JIAN-LIN ZHOU
Date of birth	Feb，1980
Department	Orthopedics Department，Renmin Hospital,Wuhan University.
Title	deputy director, master tutor
Email	13659880625@163.cpm
TEL	13659880625
Research Direction	1. Pathogenesis of osteoarthritis 2. Diagnosis and treatment of bone tumors
Personal Profile	He presided over and participated in 5 items from the National Natural Science Foundation, 1 item from the Ministry of Education, 1 item from the Natural Science Foundation of Hubei Province, 1 item from the Central University Research Project, 4 items from municipal scientific research projects, 1 item from key research and development projects in Hubei Province, 4 national patents, 1 Hubei Science and Technology Progress Besides,there are more than 40 papers published, including more than 20 international SCI papers.Professional expertise : proficient in complex knee and hip replacement, shoulder, knee and ankle arthroscopic minimally invasive treatment, pelvic and spinal fracture minimally invasive surgery, spinal orthopedics, lumbar disc herniation, lumbar spondylolisthesis and other surgical treatment, to carry out a number of new technologies and new business. In 2020, the concept of OHO ( one-hour surgery ) and GOP ( green surgery ) was first proposed in the industry. At present, there are 2 Masters studying with him.
Selected Publications	1.Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway. Chem Biol Interact. 2023 Jun 9;382:110602. 2.CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9. Int Immunopharmacol. 2022 Sep;110:109064. 3.Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.PeerJ.2022;10:e13319. 4.Dexamethasone induces ferroptosis via P53/SLC7A11/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head. Biochem Biophys Res Commun. 2022;602:149-155. 5.Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation. J Cell Mol Med. 2021;25(1):120-131 6.Identification of Disease-Specific Hub Biomarkers and Immune Infiltration in Osteoarthritis and Rheumatoid Arthritis Synovial Tissues by Bioinformatics Analysis. Dis Markers. 2021:9911184 7.Protective Effect of Human Umbilical Cord Mesenchymal Stem Cells in Glucocorticoid-induced Osteonecrosis of Femoral Head. Curr Med Sci. 2021;41(5):909-915. 8.MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression. PPAR Res. 2020:6633022 9.Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway.Biomed Pharmacother. 2019;109(1):2335-2341 10.Local intraarticular injection of vascular endothelial growth factor accelerates articular cartilage degeneration in rat osteoarthritis model. Molecular medicine reports.2018，17, 6311-6318 11.The Relationship between HIF-2a and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee.Yonsei Med J. 2016;57(3):735-40. 12.PKCa Agonists Enhance the Protective Effect of Hyaluronic Acid on Nitric Oxide-Induced Apoptosis of Articular Chondrocytes in Vitro. Iranian Journal of Basic Medical Sciences.2013;16(12):1276-81. 13.Hyaluronic Acid Inhibits Nitric Oxide-induced Apoptosis and Dedifferentiation of Articular Chondrocytes in Vitro. Inflamm Res. 2010; 59（7）：519-530. 14.Effects of hyaluronan on vascular endothelial growth factor and receptor-2 expression in a rabbit osteoarthritis model. J Orthop Sci. 2009; 14(3):313-319. 15.The protective effect of sodium hyaluronate on the cartilage of rabbit osteoarthritis by inhibiting Peroxisome Proliferator-Activated Receptor-Gamma mRNA expression. Yonsei Med J. 2009; 50(6):832-837. 16.血管内皮生长因子在骨关节炎软骨钙化层重构中的作用.微循环学杂志，2017,27(2):67-70. 17.Local intra-articular injection of sodium hyaluronate delays articular cartilage degeneration after traumatic osteoarthritis.中国组织工程研究. 2015; 19 (33): 5295-5300. 18.血管内皮生长因子和缺氧诱导因子对软骨细胞凋亡的作用[J].中国组织工程研究，2015，19(29):4705-4709. 19.自体、异体骨软骨移植及组织工程材料修复的关节软骨损伤[J].中国组织工程研究，2015，19(34):5530-5535. 20.透明质酸钠对兔骨关节炎软骨VEGF及其受体-2mRNA表达的影响.武汉大学学报.2013;34(2):178-182