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    王磊 泌尿外科学
    副教授、副主任医师、硕士生导师
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    导师介绍

    姓名 王磊
    出生年月 1987年5月
    单位 武汉大学人民医院泌尿外科
    所属学科 临床医学-外科学
    职务、职称及头衔 副教授、副主任医师、硕士生导师
    E-mail drwanglei@whu.edu.cn
    联系方式 13971686877
    研究方向 1.泌尿系肿瘤的分子机制与精准治疗
    2.急慢性肾损伤（肾缺血再灌注损伤、肾纤维化）的分子机制与临床研究
    个人简介 武汉大学—美国宾夕法尼亚大学联培博士。长期从事泌尿系肿瘤（肾癌、膀胱癌、前列腺癌）及急慢性肾损伤的基础与临床研究，擅长泌尿外科常见疾病的微创治疗。长期担任科研秘书，目前主持国家自然科学基金青年项目、湖北省自然科学基金青年项目、武汉市青年科技晨光计划、中央高校青年教师资助项目、武汉大学教学研究项目、武汉大学医学部创新种子基金培育项目、武汉大学人民医院引导基金共7项。以第一、共一、通讯、共同通讯作者发表SCI论文30余篇，总影响因子超过150分。以第一作者在中华、核心期刊上发表论著10余篇。授权国家发明专利1项，实用新型专利2项，副主编专著1部，获得湖北省科学技术进步奖二等奖1项，多次被评为武汉大学人民医院优秀党员、先进工作者、医德医风先进个人。在美国宾夕法尼亚大学留学期间以co-author在Cancer Cell（IF=31.7）、Cancer Research（IF=12.7）、Leukemia（IF=11.5）发表高质量SCI论文3篇。已协助培养硕士生5名，博士生4名，其中2名博士获得武汉大学学术创新二等奖。目前正在培养硕士生2名。
    学术任职与荣誉 获武汉大学人民医院中国医师节医疗春苗奖，担任湖北省医师协会泌尿外科医师分会秘书、湖北省临床肿瘤学会泌尿生殖肿瘤专委会委员、武汉生物医学工程学会泌尿生殖肿瘤专委会委员兼秘书，以及多个SCI期刊的通讯编委，包括Frontiers in Genetics、Molecular and Cellular Endocrinology、Amino Acids、Renal Failure、Frontiers in Oncology、Journal of International Medical Research、Frontiers in Pharmacology、Frontiers in Immunology、Andrologia、International Braz J Urol等。
    教育履历 2006.09-2011.06湖北医药学院第一临床学院临床医学专业本科生获学士学位
    2011.09-2016.06武汉大学第一临床学院外科学硕博连读获博士学位
    2014.08-2016.02美国宾夕法尼亚大学医学院联培博士
    工作履历 2016.07-2016.11武汉大学人民医院泌尿外科住院医师
    2016.12-2019.11武汉大学人民医院泌尿外科主治医师
    2019.12-2020.11武汉大学人民医院泌尿外科副主任医师
    2020.12-至今武汉大学人民医院泌尿外科副教授、副主任医师
    成果获奖 1.《前列腺癌精准医疗的相关机制与临床应用》2019年获湖北省科技进步二等奖
    代表性论著 1. Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.Biomed Pharmacother. 2023 Jul 8;165:115128.（中科院2区,通讯作者,IF=7.5）
    2. Zheng Q, Jian J, Wang J, Wang K, Fan J, Xu H, Ni X, Yang S, Yuan J, Wu J, Jiao P, Yang R, Chen Z, Liu X, Wang L. Predicting Lymph Node Metastasis Status from Primary Muscle-Invasive Bladder Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter Study.Cancers (Basel). 2023 May 31;15(11):3000.（中科院2区,通讯作者,IF=5.2）
    3. Zhang Y, Mao H, Li Y, Xiong Y, Liu X,Wang L, Chen Z. β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells. Int J Mol Sci. 2023 Feb 14;24(4):3851.（中科院2区,通讯作者,IF=5.6）
    4. Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X. Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.Oxid Med Cell Longev. 2022 Oct 10;2022:5992436.（中科院2区,通讯作者,IF=7.3）
    5. Mao H, Zhang Y, Xiong Y, Zhu Z, Wang L, Liu X. Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion. Oxid Med Cell Longev. 2022 Sep 20;2022:2213503.（中科院2区,通讯作者,IF=7.3）
    6. Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice.Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, Chen Z, Chen H, Liu X, Wang L, Weng X. J Cell Mol Med. 2022 Aug;26(15):4254-4267.（中科院2区,通讯作者,IF=5.3）
    7. The LINC01929/miR-6875-5p/ADAMTS12 Axis in the ceRNA Network Regulates the Development of Advanced Bladder Cancer. Xiong Y, Pang M, Du Y, Yu X, Yuan J, Liu W, Wang L, Liu X. Front Oncol. 2022 May 12;12:856560. doi: 10.3389/fonc.2022.856560. eCollection 2022.PMID: 35646642（中科院2区,通讯作者,IF=5.7）
    8. Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury. Mao H, Wang L, Xiong Y, Jiang G, Liu X. Oxid Med Cell Longev. 2022 Jan 28;2022:7444430. doi: 10.1155/2022/7444430. eCollection 2022.PMID: 35126819（中科院2区,共同第一作者,IF=7.3）
    9. Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway. Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, Chen ZY, Wang L, Liu XH. Drug Des Devel Ther. 2021 Dec 10;15:4973-4983. doi: 10.2147/DDDT.S333372. eCollection 2021.PMID: 34916780（中科院3区,通讯作者,IF=4.3）
    10. RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2. Zhang J, Chen H, Weng X, Liu H, Chen Z, Huang Q, Wang L, Liu X. Cell Death Discov. 2021 Oct 27;7(1):317. doi: 10.1038/s41420-021-00713-8.PMID: 34707090（中科院2区,通讯作者,IF=7.1）
    11. The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury. Zhao X, Wang D, Wan S, Liu X, Wang W, Wang L. Oxid Med Cell Longev. 2021 Jul 30;2021:1313847. doi: 10.1155/2021/1313847. eCollection 2021.PMID: 34373763（中科院2区,通讯作者,IF=7.3）
    12. Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5. Li RG, Deng H, Liu XH, Chen ZY, Wan SS, Wang L. Oxid Med Cell Longev. 2021 Jul 13;2021:6650781. doi: 10.1155/2021/6650781. eCollection 2021.PMID: 34336110（中科院2区,通讯作者,IF=7.3）
    13. The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1. Liu H, Wang W, Weng X, Chen H, Chen Z, Du Y, Liu X, Wang L. Free Radic Biol Med. 2021 Jun 5;172:123-135. doi: 0.1016/j.freeradbiomed.2021.06.002.（中科院2区,通讯作者,IF=8.1）
    14. TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway. Yu X, Li S, Pang M, Du Y, Xu T, Bai T, Yang K, Hu J, Zhu S, Wang L, Liu X.
    Front Oncol. 2021 Jan 8;10:613869. doi: 10.3389/fonc.2020.613869.（中科院2区,共同通讯作者,IF=5.7）
    15. CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway. Zhang Y, Zhang JJ, Liu XH, Wang L. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1531-F1538. doi: 10.1152/ajprenal.00088.2020. Epub 2020 May 11.（中科院3区,通讯作者,IF=4.1）
    16. Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats. Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z. Mol Med Rep. 2020 Feb;21(2):695-704. doi: 10.3892/mmr.2019.10893. Epub 2019 Dec 18.（中科院3区,共同第一作者,IF=3.4）
    17. Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model. Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L. FASEB J. 2020 Jan;34(1):835-852. doi: 10.1096/fj.201901816R. Epub 2019 Nov 27.（中科院2区,通讯作者,IF=5.8）
    18. Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury.
    Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L. Oxid Med Cell Longev. 2019 Nov 25;2019:2345658. doi: 10.1155/2019/2345658. eCollection 2019.（中科院2区,通讯作者,IF=7.3）
    19. Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy. Yang YY, Gong DJ, Zhang JJ, Liu XH, Wang L. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F852-F864. doi: 10.1152/ajprenal.00181.2019. Epub 2019 Aug 7.（中科院3区,通讯作者,IF=4.1）
    20. Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress. Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X. Redox Biol. 2019 Jun;24:101195. doi: 10.1016/j.redox.2019.101195. Epub 2019 Apr 11.（中科院1区,共同第一作者,IF=11.7）
    Name LEI WANG
    Date of birth May，1987
    Department Department of Urology, Renmin Hospital of Wuhan University
    Title Associated Professor, Master tutor
    Email drwanglei@whu.edu.cn
    TEL 13971686877
    Research Direction 1. Molecular mechanism and precise treatment of urinary tract tumors
    2. Molecular mechanism and clinical study of acute and chronic renal injury (renal ischemia reperfusion injury, renal fibrosis)
    Personal Profile He has studied in University of Pennsylvania for two years during PhD degree. He is engaged in the basic and clinical research of urinary tract tumors (kidney cancer, bladder cancer, prostate cancer) and acute and chronic kidney injury. He is good at the minimally invasive treatment of common urological diseases.He is the secretary of scientific research at deparment of urology. Now he is responsible for the National Natural Science Foundation of China, Hubei Province Natural Science Foundation, Youth Science and Technology Program of Wuhan Morning Plan, The central Young Teacher Program of Wuhan University, Teaching Research Project of Wuhan University, Innovation project of Wuhan University Medical School, the Guidance Fund of Renmin Hospital of Wuhan University. He has published more than 30 SCI papers as the first or corresponding author, with a total impact factor of more than 150 points. As the first author, he has published more than 10 articles on Chinese and Core journals.He has applied for three national patents and won the second prize of Hubei Provincial Science and Technology Progress Award. He has been awarded as Outstanding Party Member, Advanced Worker and Advanced Individual of Medical Ethics in Renmin Hospital of Wuhan University for many times.During his study in the University of Pennsylvania, he published three high-quality SCI papers as co-authors on Cancer Cell (IF=31.7), Cancer Research (IF=12.7) and Leukemia (IF=11.5). He has assisted in training 5 master's students and 4 PhD students, and 2 of them won the second prize of academic innovation of Wuhan University. Now he is training 2 master's students by himself.
    Selected Publications 1. Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.Biomed Pharmacother. 2023 Jul 8;165:115128.（中科院2区,通讯作者,IF=7.5）
    2. Zheng Q, Jian J, Wang J, Wang K, Fan J, Xu H, Ni X, Yang S, Yuan J, Wu J, Jiao P, Yang R, Chen Z, Liu X, Wang L. Predicting Lymph Node Metastasis Status from Primary Muscle-Invasive Bladder Cancer Histology Slides Using Deep Learning: A Retrospective Multicenter Study.Cancers (Basel). 2023 May 31;15(11):3000.（中科院2区,通讯作者,IF=5.2）
    3. Zhang Y, Mao H, Li Y, Xiong Y, Liu X,Wang L, Chen Z. β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells. Int J Mol Sci. 2023 Feb 14;24(4):3851.（中科院2区,通讯作者,IF=5.6）
    4. Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X. Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.Oxid Med Cell Longev. 2022 Oct 10;2022:5992436.（中科院2区,通讯作者,IF=7.3）
    5. Mao H, Zhang Y, Xiong Y, Zhu Z, Wang L, Liu X. Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion. Oxid Med Cell Longev. 2022 Sep 20;2022:2213503.（中科院2区,通讯作者,IF=7.3）
    6. Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice.Feng R, Xiong Y, Lei Y, Huang Q, Liu H, Zhao X, Chen Z, Chen H, Liu X, Wang L, Weng X. J Cell Mol Med. 2022 Aug;26(15):4254-4267.（中科院2区,通讯作者,IF=5.3）
    7. The LINC01929/miR-6875-5p/ADAMTS12 Axis in the ceRNA Network Regulates the Development of Advanced Bladder Cancer. Xiong Y, Pang M, Du Y, Yu X, Yuan J, Liu W, Wang L, Liu X. Front Oncol. 2022 May 12;12:856560. doi: 10.3389/fonc.2022.856560. eCollection 2022.PMID: 35646642（中科院2区,通讯作者,IF=5.7）
    8. Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury. Mao H, Wang L, Xiong Y, Jiang G, Liu X. Oxid Med Cell Longev. 2022 Jan 28;2022:7444430. doi: 10.1155/2022/7444430. eCollection 2022.PMID: 35126819（中科院2区,共同第一作者,IF=7.3）
    9. Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway. Zhang BH, Liu H, Yuan Y, Weng XD, Du Y, Chen H, Chen ZY, Wang L, Liu XH. Drug Des Devel Ther. 2021 Dec 10;15:4973-4983. doi: 10.2147/DDDT.S333372. eCollection 2021.PMID: 34916780（中科院3区,通讯作者,IF=4.3）
    10. RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2. Zhang J, Chen H, Weng X, Liu H, Chen Z, Huang Q, Wang L, Liu X. Cell Death Discov. 2021 Oct 27;7(1):317. doi: 10.1038/s41420-021-00713-8.PMID: 34707090（中科院2区,通讯作者,IF=7.1）
    11. The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury. Zhao X, Wang D, Wan S, Liu X, Wang W, Wang L. Oxid Med Cell Longev. 2021 Jul 30;2021:1313847. doi: 10.1155/2021/1313847. eCollection 2021.PMID: 34373763（中科院2区,通讯作者,IF=7.3）
    12. Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5. Li RG, Deng H, Liu XH, Chen ZY, Wan SS, Wang L. Oxid Med Cell Longev. 2021 Jul 13;2021:6650781. doi: 10.1155/2021/6650781. eCollection 2021.PMID: 34336110（中科院2区,通讯作者,IF=7.3）
    13. The H3K9 histone methyltransferase G9a modulates renal ischemia reperfusion injury by targeting Sirt1. Liu H, Wang W, Weng X, Chen H, Chen Z, Du Y, Liu X, Wang L. Free Radic Biol Med. 2021 Jun 5;172:123-135. doi: 0.1016/j.freeradbiomed.2021.06.002.（中科院2区,通讯作者,IF=8.1）
    14. TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway. Yu X, Li S, Pang M, Du Y, Xu T, Bai T, Yang K, Hu J, Zhu S, Wang L, Liu X.
    Front Oncol. 2021 Jan 8;10:613869. doi: 10.3389/fonc.2020.613869.（中科院2区,共同通讯作者,IF=5.7）
    15. CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway. Zhang Y, Zhang JJ, Liu XH, Wang L. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1531-F1538. doi: 10.1152/ajprenal.00088.2020. Epub 2020 May 11.（中科院3区,通讯作者,IF=4.1）
    16. Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats. Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z. Mol Med Rep. 2020 Feb;21(2):695-704. doi: 10.3892/mmr.2019.10893. Epub 2019 Dec 18.（中科院3区,共同第一作者,IF=3.4）
    17. Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model. Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L. FASEB J. 2020 Jan;34(1):835-852. doi: 10.1096/fj.201901816R. Epub 2019 Nov 27.（中科院2区,通讯作者,IF=5.8）
    18. Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury.
    Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L. Oxid Med Cell Longev. 2019 Nov 25;2019:2345658. doi: 10.1155/2019/2345658. eCollection 2019.（中科院2区,通讯作者,IF=7.3）
    19. Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy. Yang YY, Gong DJ, Zhang JJ, Liu XH, Wang L. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F852-F864. doi: 10.1152/ajprenal.00181.2019. Epub 2019 Aug 7.（中科院3区,通讯作者,IF=4.1）
    20. Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress. Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X. Redox Biol. 2019 Jun;24:101195. doi: 10.1016/j.redox.2019.101195. Epub 2019 Apr 11.（中科院1区,共同第一作者,IF=11.7）



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