石磊
肿瘤
副主任医师、硕士生导师、肿瘤三科党支部书记
副主任医师、硕士生导师、肿瘤三科党支部书记
导师介绍
| 姓名 | 石磊 |
| 出生年月 | 1980年6月 |
| 单位 | 武汉大学人民医院肿瘤中心 |
| 所属学科 | 临床医学-肿瘤学 |
| 职务、职称及头衔 | 副主任医师、硕士生导师、肿瘤三科党支部书记 |
| shilei19801980@126.com | |
| 联系方式 | 027-88041911转85015 |
| 研究方向 | 1.结直肠恶性肿瘤研究；2.肿瘤干细胞及肿瘤免疫研究 |
| 个人简介 | 本人长期从事肿瘤的临床、科研、教学一线工作，积攒大量临床经验对肿瘤的发病机制及相关临床研究有全面深刻的了解，对相关领域的国际、国内研究动态有及时而全面的认识。以第一作者、共同作者或通讯作者发表SCI论文18篇，从事结直肠肿瘤及干细胞研究，先后主持省市级课题9项，参与国家级课题4项。熟练掌握IMRT/SBRT等放疗技术擅长食管癌、胃癌、结直肠癌IMRT精准放疗，以及肝癌、胰腺癌SBRT大分割放疗。 |
| 学术任职与荣誉 |
湖北省抗癌协会肿瘤分子标志及医学专业委员会委员； 湖北省微循环学会肿瘤专业委员会委员； |
| 教育履历 |
1998.09-2003.06湖北省科技学院获学士学位 2003.09-2009.06武汉大学第一临床学院内科学硕博连读获博士学位 |
| 工作履历 |
2009.06-2016.11武汉大学人民医院肿瘤中心 主治医师 2011.05-2012.02美国德州A&M University 访问学者 2013.03-2014.01湖北省恩施州咸丰县人民医院副院长（湖北省博士服务团） 2016.11至今 武汉大学人民医院肿瘤中心 副主任医师 2019.01-2019.07中山大学肿瘤防治中心 放疗研修 2019.05至今 武汉大学人民医院肿瘤三科 党支部书记 |
| 成果获奖 | |
| 代表性论著 |
[1]
Xingcheng Xiong #, Juanli Xi #, Qian Liu , Cixiao Wang , Zeyou Jiang ,
Su-Yang Yue , Lei Shi*, Yuping Rong* ,
Co-expression of IL-7 and PH20 promote anti-GPC3 CAR-T tumour
suppressor activity in vivo and in vitro. Liver International, 2020 Dec 21.
Doi 10.1111/liv.14771（IF:5.175） [2] Shi L#, Xi JL#, Xu XM*, Peng B*, Zhang BH*, MiR-148a suppressed cell invasion and migration via targeting WNT10b and modulating beta-catenin signaling in cisplatin-resistant colorectal cancer cells. Biomedicine & Pharmacotherapy, 2019,109, 902-909 (IF:4.56) [3] He M#*, Zhang XJ, Yao W, Wang CS, Shi L*, Zhou PH*, Construction of alternate layered chitosanialginate composite hydrogels and their properties. Mater Lett, 2017,200, 43-46 (IF:3.20) [4] Hu W#, Shi L#, Li MY*, Zhou PH*, Qiu B*, Yin K, Zhang HH, Gao Y, Kang R, Qin SL, Ning JZ, Wang W, Zhang LJ, Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-kappaB signalling pathways. Scientific reports, 2017,7, 16479 (IF:4.0) [5] Hu W#, Shi L#, Zhou PH*, Zhang XB, Plasma concentrations of adrenomedullin and atrial and brain natriuretic peptides in patients with adrenal pheochromocytoma. Oncology letters, 2015,10, 3163-3170 (IF:2.30) [6] Shi L#, Xi JL, Zhang BH*, Application of high-throughput protein array in clinical screening for tumor markers. Int J Clin Exp Med, 2016, 9, 8529-8535 (IF:1.01) [7] Shi L#, Zhang BH*, Yu HG, Yu JP, Xi JL, Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model. Journal of perinatal medicine, 2007,35, 443-446 (IF:1.61) [8] Wang HW#, Shi L#*, Xu YP, Qin XY, Wang QZ, Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-beta1-Smad3 pathway. Renal failure, 2016, 38, 945-951 (IF:1.99) [9] Wang HW#, Shi L#*, Xu YP, Qin XY, Wang, QZ, Hesperetin alleviates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro. Experimental and therapeutic medicine, 2017,14, 3713-3719 (IF:1.79) [10] Xia ZE#, Xi JL, Shi L*, 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro. Renal failure, 2018,40, 447-454 (IF:1.99) [11] Yu HG#, Nam JO#, Miller NL#, Tanjoni I, Walsh C, Shi L, Kim L, Chen XL, Tomar A, Lim ST, D.Schlaepfer D*, p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer research, 2011,71, 360-370 (IF:9.72) [12] Yuan GJ#, Deng JJ, Cao DD, Shi L, Chen X, Lei JJ, Xu XM*, Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells. World journal of gastroenterology, 2017,23, 5530-5537 (IF:3.67) [13] Zhou PH#*, Ma BL#, Shi L, Xie T, Qiu B, Inhibition of interleukin-1beta-stimulated matrix metalloproteinases via the controlled release of interleukin-1Ra from chitosan microspheres in chondrocytes. Molecular medicine reports, 2015, 11, 555-560 (IF:2.10) [14] Zhou PH#, Shi L#, Hu W*, Zhang XB, Wang W, Zhang LJ, Changes of adrenomedullin and natriuretic peptides in patients with adrenal medullary hyperplasia prior to and following pharmacological therapy and adrenalectomy. Experimental and therapeutic medicine, 2016,12, 864-872 (IF:1.79) [15] Zhou PH#, Shi L#, Qiu B*, Protective effect of controlled release of cytokine response modifier A from chitosan microspheres on rat chondrocytes from interleukin-1beta induced inflammation and apoptosis. Experimental and therapeutic medicine, 2017,14, 3170-3178 (IF:1.79) [16] Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu CD, Zhou BY, A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation, 2012,125, 2892-2903 (IF:23.60) [17] He M#*, Shi L#, Wang GZ, Cheng ZH, Han L, Zhang XJ, Wang CS, Wang JS, Zhou PH*, Wang GZ*, Biocompatible and biodegradable chitosan/sodium polyacrylate polyelectrolyte complex hydrogels with smart responsiveness. International Journal of Biological Macromolecules, 2020,155, 1245-1251. (IF:5.16) [18] Li MY#, Zhu XL#, Zhao BX#, Shi L, Wang W, Hu Wei*, Qin SL*, Chen BH*, Zhou PH, Qiu B, Gao Y, Liu BL, Adrenomedullin alleviates the pyroptosis of leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis. Cell Death & Disease, 2019,10,489. (IF:6.30) |
| Name | LEI SHI |
| Date of birth | JUNE, 1980 |
| Department | Department of Oncology，Renmin Hospital of Wuhan University. |
| Title | Associate Chief Physician, Master tutor |
| shilei19801980@126.com | |
| TEL | 027-88041911-85015 |
| Research Direction | 1.Research on colorectal malignancy; 2.Research on tumor stem cells and tumor immunity |
| Personal Profile | I have been engaged in the front-line work of clinical, scientific research and teaching of cancer for a long time, accumulated a lot of clinical experience to have a comprehensive and profound understanding of the pathogenesis of cancer and related clinical research, and have a timely and comprehensive understanding of the international and domestic research trends in relevant fields. I have published 18 SCI papers as the first author, co-author or corresponding author, and am engaged in colorectal cancer and stem cell research. I have presided over 9 provincial and municipal projects and participated in 4 national projects. Proficient in IMRT/SBRT and other radiotherapy techniques. Proficient in IMRT precision radiotherapy for esophageal cancer, gastric cancer and colorectal cancer, as well as SBRT large fraction radiotherapy for liver cancer and pancreatic cancer. |
| Selected Publications |
[1]
Xingcheng Xiong #, Juanli Xi #, Qian Liu , Cixiao Wang , Zeyou Jiang ,
Su-Yang Yue , Lei Shi*, Yuping Rong* ,
Co-expression of IL-7 and PH20 promote anti-GPC3 CAR-T tumour
suppressor activity in vivo and in vitro. Liver International, 2020 Dec 21.
Doi 10.1111/liv.14771（IF:5.175） [2] Shi L#, Xi JL#, Xu XM*, Peng B*, Zhang BH*, MiR-148a suppressed cell invasion and migration via targeting WNT10b and modulating beta-catenin signaling in cisplatin-resistant colorectal cancer cells. Biomedicine & Pharmacotherapy, 2019,109, 902-909 (IF:4.56) [3] He M#*, Zhang XJ, Yao W, Wang CS, Shi L*, Zhou PH*, Construction of alternate layered chitosanialginate composite hydrogels and their properties. Mater Lett, 2017,200, 43-46 (IF:3.20) [4] Hu W#, Shi L#, Li MY*, Zhou PH*, Qiu B*, Yin K, Zhang HH, Gao Y, Kang R, Qin SL, Ning JZ, Wang W, Zhang LJ, Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-kappaB signalling pathways. Scientific reports, 2017,7, 16479 (IF:4.0) [5] Hu W#, Shi L#, Zhou PH*, Zhang XB, Plasma concentrations of adrenomedullin and atrial and brain natriuretic peptides in patients with adrenal pheochromocytoma. Oncology letters, 2015,10, 3163-3170 (IF:2.30) [6] Shi L#, Xi JL, Zhang BH*, Application of high-throughput protein array in clinical screening for tumor markers. Int J Clin Exp Med, 2016, 9, 8529-8535 (IF:1.01) [7] Shi L#, Zhang BH*, Yu HG, Yu JP, Xi JL, Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model. Journal of perinatal medicine, 2007,35, 443-446 (IF:1.61) [8] Wang HW#, Shi L#*, Xu YP, Qin XY, Wang QZ, Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-beta1-Smad3 pathway. Renal failure, 2016, 38, 945-951 (IF:1.99) [9] Wang HW#, Shi L#*, Xu YP, Qin XY, Wang, QZ, Hesperetin alleviates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro. Experimental and therapeutic medicine, 2017,14, 3713-3719 (IF:1.79) [10] Xia ZE#, Xi JL, Shi L*, 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro. Renal failure, 2018,40, 447-454 (IF:1.99) [11] Yu HG#, Nam JO#, Miller NL#, Tanjoni I, Walsh C, Shi L, Kim L, Chen XL, Tomar A, Lim ST, D.Schlaepfer D*, p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer research, 2011,71, 360-370 (IF:9.72) [12] Yuan GJ#, Deng JJ, Cao DD, Shi L, Chen X, Lei JJ, Xu XM*, Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells. World journal of gastroenterology, 2017,23, 5530-5537 (IF:3.67) [13] Zhou PH#*, Ma BL#, Shi L, Xie T, Qiu B, Inhibition of interleukin-1beta-stimulated matrix metalloproteinases via the controlled release of interleukin-1Ra from chitosan microspheres in chondrocytes. Molecular medicine reports, 2015, 11, 555-560 (IF:2.10) [14] Zhou PH#, Shi L#, Hu W*, Zhang XB, Wang W, Zhang LJ, Changes of adrenomedullin and natriuretic peptides in patients with adrenal medullary hyperplasia prior to and following pharmacological therapy and adrenalectomy. Experimental and therapeutic medicine, 2016,12, 864-872 (IF:1.79) [15] Zhou PH#, Shi L#, Qiu B*, Protective effect of controlled release of cytokine response modifier A from chitosan microspheres on rat chondrocytes from interleukin-1beta induced inflammation and apoptosis. Experimental and therapeutic medicine, 2017,14, 3170-3178 (IF:1.79) [16] Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu CD, Zhou BY, A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation, 2012,125, 2892-2903 (IF:23.60) [17] He M#*, Shi L#, Wang GZ, Cheng ZH, Han L, Zhang XJ, Wang CS, Wang JS, Zhou PH*, Wang GZ*, Biocompatible and biodegradable chitosan/sodium polyacrylate polyelectrolyte complex hydrogels with smart responsiveness. International Journal of Biological Macromolecules, 2020,155, 1245-1251. (IF:5.16) [18] Li MY#, Zhu XL#, Zhao BX#, Shi L, Wang W, Hu Wei*, Qin SL*, Chen BH*, Zhou PH, Qiu B, Gao Y, Liu BL, Adrenomedullin alleviates the pyroptosis of leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis. Cell Death & Disease, 2019,10,489. (IF:6.30) |
武汉大学人民医院
湖北省人民医院