陈志远
泌尿外科学
泌尿外Ⅰ科主任，主任医师，博士生导师
泌尿外Ⅰ科主任，主任医师，博士生导师
导师介绍
| 姓名 | 陈志远 |
| 出生年月 | 1973年5月 |
| 单位 | 武汉大学人民医院泌尿外科 |
| 所属学科 | 临床医学-外科学 |
| 职务、职称及头衔 | 泌尿外I科主任，主任医师，博士生导师 |
| chenzhiyuan163@163.com | |
| 联系方式 | 027-88041911转81101或13886000807 |
| 研究方向 |
1.急慢性肾损伤的基础与临床研究 2.人工智能在泌尿外科的应用 |
| 个人简介 | 精通泌尿系统肿瘤的微创治疗及个体化精准治疗（腹腔镜手术，机器人手术，药物综合治疗）。主持并参与国家级科研课题5项，主持湖北省科技厅、湖北省卫健委科研课题2项，个人总经费超过100万，发表高质量SCI论文70余篇，主编国家级专著1部，参编专著2部，其科研成果荣获湖北省科技进步二等奖1项。已培协助养硕士生10名，博士生4名。目前正在培养硕士生2名。 |
| 学术任职与荣誉 |
中国研究型医院学会泌尿外科专业分会青年委员 中国医疗保健国际交流促进会泌尿健康促进分会青年委员 湖北省临床肿瘤学会泌尿生殖肿瘤专委会副主任委员 湖北省医师协会泌尿外科医师分会委员 湖北省医学会泌尿外科分会委员 湖北省生物工程学会泌尿外科内镜专业委员 武汉生物医学工程学会泌尿生殖肿瘤委员会主任委员 武汉市机器人与腹腔镜外科分会委员 |
| 教育履历 |
1993.09-199.06武汉大学第一临床学院临床医学专业本科生获学士学位 2002.09-2007.06武汉大学第一临床学院外科学硕博连读研究生获博士学位 |
| 工作履历 |
1998.07-2002.09武汉市中医院泌尿外科主治医师 2009.12-2018.12武汉大学人民医院泌尿外1科副主任医师 2015.10-2016.01意大利humanitas大学访问学者 2018.12-2022.08武汉大学人民医院泌尿外1科主任医师 2022.09至今武汉大学人民医院泌尿外I科 科主任 |
| 成果获奖 | 《前列腺癌精准医疗的相关机制及临床应用》2019年获湖北省科技进步二等奖 |
| 代表性论著 |
1.
Liu Y, Jian J, Zhang Y, Wang L, Liu X, Chen Z. Construction of cancer-
associated fibroblasts related risk signature based on single-cell RNA-seq
and bulk RNA-seq data in bladder urothelial carcinoma. Front Oncol. 2023 Apr
14;13:1170893. doi: 10.3389/fonc.2023.1170893.（通讯作者） 2. Zheng Q, Yang R, Xu H, Fan J, Jiao P, Ni X, Yuan J, Wang L, Chen Z, Liu X. A Weakly Supervised Deep Learning Model and Human-Machine Fusion for Accurate Grading of Renal Cell Carcinoma from Histopathology Slides. Cancers (Basel). 2023 Jun 15;15(12):3198. doi: 10.3390/cancers15123198.（通讯作者） 3. Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomed Pharmacother. 2023 Jul 8;165:115128. doi: 10.1016/j.biopha.2023.115128.（通讯作者） 4. Xu K, Zhang Y, Yan Z, Wang Y, Li Y, Qiu Q, Du Y, Chen Z, Liu X. Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which MSH3 is a key gene during disulfidptosis. Front Immunol. 2023 Jun 23;14:1205250. doi: 10.3389/fimmu.2023.1205250.（通讯作者） 5. Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z. β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells. Int J Mol Sci. 2023 Feb 14;24(4):3851. doi: 10.3390/ijms24043851.（通讯作者） 6. Zheng Q, Jiang Z, Ni X, Yang S, Jiao P, Wu J, Xiong L, Yuan J, Wang J, Jian J, Wang L, Yang R, Chen Z, Liu X. Machine Learning Quantified Tumor-Stroma Ratio Is an Independent Prognosticator in Muscle-Invasive Bladder Cancer. Int J Mol Sci. 2023 Feb 1;24(3):2746. doi: 10.3390/ijms24032746.（通讯作者） 7. Zheng Q, Yang R, Ni X, Yang S, Jiao P, Wu J, Xiong L, Wang J, Jian J, Jiang Z, Wang L, Chen Z, Liu X. Quantitative Assessment of Tumor-Infiltrating Lymphocytes Using Machine Learning Predicts Survival in Muscle-Invasive Bladder Cancer. J Clin Med. 2022 Nov 29;11(23):7081. doi: 10.3390/jcm11237081.（通讯作者） 8. Zheng Q, Yang R, Ni X, Yang S, Xiong L, Yan D, Xia L, Yuan J, Wang J, Jiao P, Wu J, Hao Y, Wang J, Guo L, Jiang Z, Wang L, Chen Z, Liu X. Accurate Diagnosis and Survival Prediction of Bladder Cancer Using Deep Learning on Histological Slides. Cancers (Basel). 2022 Nov 25;14(23):5807. doi: 10.3390/cancers14235807.（通讯作者） 9. Zheng Q, Yang R, Ni X, Yang S, Jiang Z, Wang L, Chen Z, Liu X. Development and validation of a deep learning-based laparoscopic system for improving video quality. Int J Comput Assist Radiol Surg. 2023 Feb;18(2):257-268. doi: 10.1007/s11548-022-02777-y.（通讯作者） 10. Li Y, Zhang Y, Qiu Q, Wang L, Mao H, Hu J, Chen Z, Du Y, Liu X. Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer. Oxid Med Cell Longev. 2022 Oct 4;2022:2353115. doi: 10.1155/2022/2353115.（通讯作者） 11. Zhang Y, Li Y, Qiu Q, Chen Z, Du Y, Liu X. MITD1 Deficiency Suppresses Clear Cell Renal Cell Carcinoma Growth and Migration by Inducing Ferroptosis through the TAZ/SLC7A11 Pathway. Oxid Med Cell Longev. 2022 Aug 22;2022:7560569. doi: 10.1155/2022/7560569.（通讯作者） 12. Du Y, Yang R, Chen Z, Wang L, Weng X, Liu X. A deep learning network-assisted bladder tumour recognition under cystoscopy based on Caffe deep learning framework and EasyDL platform. Int J Med Robot. 2021 Feb;17(1):1-8. doi: 10.1002/rcs.2169.（通讯作者） 13. Wang L, Chen Z, Liu Y, Du Y, Liu X. Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway. Drug Des Devel Ther. 2018 May 21;12:1293-1301. doi: 10.2147/DDDT.S164927.（通讯作者） 14. Chen ZY, Du Y, Wang L, Liu XH, Guo J, Weng XD. MiR-543 promotes cell proliferation and metastasis of renal cell carcinoma by targeting Dickkopf 1 through the Wnt/β-catenin signaling pathway. J Cancer. 2018 Sep 8;9(20):3660-3668. doi: 10.7150/jca.27124.（第一作者） 15. Wang L, Chen Z, Weng X, Wang M, Du Y, Liu X. Combined Ischemic Postconditioning and Ozone Postconditioning Provides Synergistic Protection Against Renal Ischemia and Reperfusion Injury Through Inhibiting Pyroptosis. Urology. 2019 Jan;123:296.e1-296.e8. doi: 10.1016/j.urology.2018.10.015.（通讯作者） 16. Chen Z, Du Y, Liu X, Chen H, Weng X, Guo J, Wang M, Wang X, Wang L. EZH2 inhibition suppresses bladder cancer cell growth and metastasis via the JAK2/STAT3 signaling pathway. Oncol Lett. 2019 Jul;18(1):907-915. doi: 10.3892/ol.2019.10359. Epub 2019 May 14.（第一作者） 17. Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X. Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress. Redox Biol. 2019 Jun;24:101195. doi: 10.1016/j.redox.2019.101195. Epub 2019 Apr 11.（通讯作者） 18. Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L. Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model. FASEB J. 2020 Jan;34(1):835-852. doi: 10.1096/fj.201901816R. Epub 2019 Nov 27. PMID: 31914694.（共同第一作者） 19. Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z. Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats. Mol Med Rep. 2020 Feb;21(2):695-704. doi: 10.3892/mmr.2019.10893. Epub 2019 Dec 18.（通讯作者） 20. Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L. Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury. Oxid Med Cell Longev. 2019 Nov 25;2019:2345658. doi: 10.1155/2019/2345658.（共同第一作者） |
| Name | Zhiyuan Chen |
| Date of birth | May，1973 |
| Department | Department of Urology,，Renmin Hospital,Wuhan University. |
| Title | Director, Professor, doctoral tutor |
| chenzhiyuan163@163.com | |
| TEL | 027-88041911转81101或13886000807 |
| Research Direction |
1.Basic
and clinical study of acute and chronic renal injury 2. Application of artificial intelligence in urology |
| Personal Profile | He is proficient in minimally invasive treatment of urinary system tumors and individualized precision treatment (laparoscopic surgery, robotic surgery, drug combination therapy). Presided over and participated in 5 national scientific research projects, presided over 2 scientific research projects of Hubei Provincial Science and Technology Department and Hubei Provincial Health Commission, with a total personal fund of more than 1 million yuan, published more than 70 high-quality SCI papers, edited 1 national monograph, participated in editing 2 monographs, and won 1 second prize of Hubei Provincial Science and Technology Progress Award for his scientific research achievements. He has trained and assisted 10 master students and 4 doctoral students. Currently, he is training 2 master students. |
| Selected Publications |
1.
Liu Y, Jian J, Zhang Y, Wang L, Liu X, Chen Z. Construction of cancer-
associated fibroblasts related risk signature based on single-cell RNA-seq
and bulk RNA-seq data in bladder urothelial carcinoma. Front Oncol. 2023 Apr
14;13:1170893. doi: 10.3389/fonc.2023.1170893.（通讯作者） 2. Zheng Q, Yang R, Xu H, Fan J, Jiao P, Ni X, Yuan J, Wang L, Chen Z, Liu X. A Weakly Supervised Deep Learning Model and Human-Machine Fusion for Accurate Grading of Renal Cell Carcinoma from Histopathology Slides. Cancers (Basel). 2023 Jun 15;15(12):3198. doi: 10.3390/cancers15123198.（通讯作者） 3. Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L. Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury. Biomed Pharmacother. 2023 Jul 8;165:115128. doi: 10.1016/j.biopha.2023.115128.（通讯作者） 4. Xu K, Zhang Y, Yan Z, Wang Y, Li Y, Qiu Q, Du Y, Chen Z, Liu X. Identification of disulfidptosis related subtypes, characterization of tumor microenvironment infiltration, and development of DRG prognostic prediction model in RCC, in which MSH3 is a key gene during disulfidptosis. Front Immunol. 2023 Jun 23;14:1205250. doi: 10.3389/fimmu.2023.1205250.（通讯作者） 5. Zhang Y, Mao H, Li Y, Xiong Y, Liu X, Wang L, Chen Z. β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells. Int J Mol Sci. 2023 Feb 14;24(4):3851. doi: 10.3390/ijms24043851.（通讯作者） 6. Zheng Q, Jiang Z, Ni X, Yang S, Jiao P, Wu J, Xiong L, Yuan J, Wang J, Jian J, Wang L, Yang R, Chen Z, Liu X. Machine Learning Quantified Tumor-Stroma Ratio Is an Independent Prognosticator in Muscle-Invasive Bladder Cancer. Int J Mol Sci. 2023 Feb 1;24(3):2746. doi: 10.3390/ijms24032746.（通讯作者） 7. Zheng Q, Yang R, Ni X, Yang S, Jiao P, Wu J, Xiong L, Wang J, Jian J, Jiang Z, Wang L, Chen Z, Liu X. Quantitative Assessment of Tumor-Infiltrating Lymphocytes Using Machine Learning Predicts Survival in Muscle-Invasive Bladder Cancer. J Clin Med. 2022 Nov 29;11(23):7081. doi: 10.3390/jcm11237081.（通讯作者） 8. Zheng Q, Yang R, Ni X, Yang S, Xiong L, Yan D, Xia L, Yuan J, Wang J, Jiao P, Wu J, Hao Y, Wang J, Guo L, Jiang Z, Wang L, Chen Z, Liu X. Accurate Diagnosis and Survival Prediction of Bladder Cancer Using Deep Learning on Histological Slides. Cancers (Basel). 2022 Nov 25;14(23):5807. doi: 10.3390/cancers14235807.（通讯作者） 9. Zheng Q, Yang R, Ni X, Yang S, Jiang Z, Wang L, Chen Z, Liu X. Development and validation of a deep learning-based laparoscopic system for improving video quality. Int J Comput Assist Radiol Surg. 2023 Feb;18(2):257-268. doi: 10.1007/s11548-022-02777-y.（通讯作者） 10. Li Y, Zhang Y, Qiu Q, Wang L, Mao H, Hu J, Chen Z, Du Y, Liu X. Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer. Oxid Med Cell Longev. 2022 Oct 4;2022:2353115. doi: 10.1155/2022/2353115.（通讯作者） 11. Zhang Y, Li Y, Qiu Q, Chen Z, Du Y, Liu X. MITD1 Deficiency Suppresses Clear Cell Renal Cell Carcinoma Growth and Migration by Inducing Ferroptosis through the TAZ/SLC7A11 Pathway. Oxid Med Cell Longev. 2022 Aug 22;2022:7560569. doi: 10.1155/2022/7560569.（通讯作者） 12. Du Y, Yang R, Chen Z, Wang L, Weng X, Liu X. A deep learning network-assisted bladder tumour recognition under cystoscopy based on Caffe deep learning framework and EasyDL platform. Int J Med Robot. 2021 Feb;17(1):1-8. doi: 10.1002/rcs.2169.（通讯作者） 13. Wang L, Chen Z, Liu Y, Du Y, Liu X. Ozone oxidative postconditioning inhibits oxidative stress and apoptosis in renal ischemia and reperfusion injury through inhibition of MAPK signaling pathway. Drug Des Devel Ther. 2018 May 21;12:1293-1301. doi: 10.2147/DDDT.S164927.（通讯作者） 14. Chen ZY, Du Y, Wang L, Liu XH, Guo J, Weng XD. MiR-543 promotes cell proliferation and metastasis of renal cell carcinoma by targeting Dickkopf 1 through the Wnt/β-catenin signaling pathway. J Cancer. 2018 Sep 8;9(20):3660-3668. doi: 10.7150/jca.27124.（第一作者） 15. Wang L, Chen Z, Weng X, Wang M, Du Y, Liu X. Combined Ischemic Postconditioning and Ozone Postconditioning Provides Synergistic Protection Against Renal Ischemia and Reperfusion Injury Through Inhibiting Pyroptosis. Urology. 2019 Jan;123:296.e1-296.e8. doi: 10.1016/j.urology.2018.10.015.（通讯作者） 16. Chen Z, Du Y, Liu X, Chen H, Weng X, Guo J, Wang M, Wang X, Wang L. EZH2 inhibition suppresses bladder cancer cell growth and metastasis via the JAK2/STAT3 signaling pathway. Oncol Lett. 2019 Jul;18(1):907-915. doi: 10.3892/ol.2019.10359. Epub 2019 May 14.（第一作者） 17. Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z, Liu X. Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress. Redox Biol. 2019 Jun;24:101195. doi: 10.1016/j.redox.2019.101195. Epub 2019 Apr 11.（通讯作者） 18. Liu H, Chen Z, Weng X, Chen H, Du Y, Diao C, Liu X, Wang L. Enhancer of zeste homolog 2 modulates oxidative stress-mediated pyroptosis in vitro and in a mouse kidney ischemia-reperfusion injury model. FASEB J. 2020 Jan;34(1):835-852. doi: 10.1096/fj.201901816R. Epub 2019 Nov 27. PMID: 31914694.（共同第一作者） 19. Zhang J, Wang L, Gong D, Yang Y, Liu X, Chen Z. Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats. Mol Med Rep. 2020 Feb;21(2):695-704. doi: 10.3892/mmr.2019.10893. Epub 2019 Dec 18.（通讯作者） 20. Diao C, Chen Z, Qiu T, Liu H, Yang Y, Liu X, Wu J, Wang L. Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury. Oxid Med Cell Longev. 2019 Nov 25;2019:2345658. doi: 10.1155/2019/2345658.（共同第一作者） |
武汉大学人民医院
湖北省人民医院