吴晓静
麻醉学
科副主任，副教授，主任医师，硕士生导师
科副主任，副教授，主任医师，硕士生导师
导师介绍
| 姓名 | 吴晓静 |
| 出生年月 | 1982年8月 |
| 单位 | 武汉大学人民医院麻醉科 |
| 所属学科 | 临床医学-麻醉学 |
| 职务、职称及头衔 | 科副主任，副教授，主任医师，硕士生导师 |
| wxj164@163.com | |
| 联系方式 | 18062059782 |
| 研究方向 |
1.脓毒症 2.急性肺损伤 |
| 个人简介 | |
| 主要从事脓毒症及肺损伤相关的诊治与科研工作，获国家自然科学基金2项、省科技厅课题2项、中央高校基本业务基金1项和武汉大学人民医院院内基金1项。以第一作者和通讯作者发表论文30余篇，其中SCI论文16篇，《中华麻醉学杂志》论文12篇，教学论文2篇。目前正在培养硕士生3名，协助培养博士研究生8名。 | |
| 学术任职与荣誉 | |
|
中国病理生理学会休克专业委员会委员；《中华麻醉学杂志》特邀审稿人 |
|
| 教育履历 | |
| 2008.09-2013.06 武汉大学第一临床学院麻醉学/外科学 硕士/博士研究生 获博士学位 | |
| 工作履历 | |
|
2013.07-2013.11武汉大学人民医院麻醉科住院医师 2013.12-2017.11武汉大学人民医院麻醉科主治医师 2014.11-2015.11美国University of Illinois at Chicago访问学者 2017.12-2022.11武汉大学人民医院麻醉科副主任医师 2019.12-至今 武汉大学人民医院麻醉科副教授 2022.11-至今 武汉大学人民医院麻醉科副主任 2022.12-至今 武汉大学人民医院麻醉科主任医师 |
|
| 成果获奖 | |
| 无 | |
| 代表性论著 | |
|
1. Ning Li, Rui Xiong, Guorui Li, Tinglv Fu,
Donghang Li, Chenzhen Xu, Xiaojing Wu, Qing Geng. A novel mechanism for the
protection against acute lung injury by melatonin mitochondrial quality
control of lung epithelial cells is preserved through SIRT3‑dependent
deacetylation of SOD2. Cell Mol Life Sci. 2022Nov;30,79(12):610. 2. Guoqing Jing, Jing Zuo, Qing Fang, Min Yuan, Yun Xia, Qiyan Jin, Yuping Liu, Yanlin Wang, Zongze Zhang, Wanhong Liu, Xiaojing Wu, Xuemin Song. Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis. J Neuroinflammation. 2022 Sep;28,19(1):237. 3. Tingqian Ming, Mingyou Dong, Xuemin Song, Xingqiao Li, Qian Kong, Qing Fang, Jie Wang, Xiaojing Wu, Zhongyuan Xia. Integrated Analysis of Gene Co-Expression Network and Prediction Model Indicates Immune-Related Roles of the Identified Biomarkers in Sepsis and Sepsis-Induced Acute Respiratory Distress Syndrome. Front Immunol. 2022 Jun;30,13:897390. 4. Ning Li, Wenyang Jiang, Wei Wang, Rui Xiong, Xiaojing Wu, Qing Geng. Ferroptosis and its emerging roles in cardiovascular diseases. Pharmacol Res. 2021; 3;166:105466. 5. Xiaojing Wu, Xutao Yan, Xuming Yang, Ying Zhang, Hongyu Wang, Huan Luo, Qing Fang, Hui Li, Xinyi Li, K Chen, Yanlin Wang, Zongze Zhang, Xuemin Song. GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice. Cytokine. 2020; 128: 155019. 6. Xinyi Li, Rui Li, Qing Fang, Jamal M, Chengyao Wang, Yanlin Wang, Zongze Zhang Z, Xiaojing Wu*, Xuemin Song. Oxycodone attenuates vascular leak and lung inflammation in a clinically relevant two-hit rat model of acute lung injury. Cytokine. 2021 Feb;138:155346. 7. Qian Kong, Min Yuan, Tingqian Ming, Qing Fang, Xiaojing Wu*, Xuemin Song. Expression and regulation of tumor necrosis factor-α-induced protein-8-like 2 is associated with acute lung injury induced by myocardial ischemia reperfusion in diabetic rats. Microvasc Res. 2020; 130: 104009. 8. Tingqian Ming , Min Yuan, Qian Kong, Qin Huang, Zhongyuan Xia, Xiaojing Wu*. Mol Med Rep. Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock‑resuscitation‑induced acute lung injury through inhibiting the NLRP3 inflammasome. 2020;22(3): 2507-2515. 9. Qian Kong#, Xiaojing Wu#, ZhenQiu, Qin Huang, Zhongyuan Xia,Xuemin Song. Protective effect of dexmedetomidine on acute lung injury via the upregulation of tumour necrosis factor-α-induced protein-8-like 2 in septic mice inflammation. 2020;43(3): 833-846. 10. Xiaojing Wu, Qian Kong, LiyingZhan, Zhen Qiu, Qin Huang , Xuemin Song. TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury. Inflamm Res. 2019;68(11): 981-992. 11. Xiaojing Wu, Qian Kong, Zhongyuan Xia, Liying Zhan, WeinaDuan, Xuemin Song. Penehyclidine hydrochloride alleviates lipopolysaccharide induced acute lung injury in rats: Potential role of caveolin 1 expression upregulation. Int J Mol Med. 2019;43(5): 2064-2074. 12. Qian Kong#, Xiaojing Wu#, WeinaDuan, Liying Zhan, Xuemin Song. Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway. Exp Ther Med. 2019;17(5): 3598-3606. 13. Xiaojing Wu, Hui Liang, Ying Zhang, Xuming Yang, Hongyu Wang, Hui Li, Xinyi Li, Kai Chen,Yanlin Wang, Jianguo Li, Zongze Zhang, Xuemin Song. Muramyl dipeptide enhances thermal injury-induced autophagy and inflammatory cytokine response of lungs via activation of Nod2/Rick signaling pathway in rats. Shock. 2018;50(5): 606-612. 14. Xiaojing Wu, Humin Liu, Xuemin Song, Bo Zhao, Yan Leng, Eyou Wang, Liying Zhan, QingtaoMeng, Zhongyuan Xia*. Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats. Mol Med Rep. 2018;17(5): 6327-6336. 15. Xiaojing Wu, Xuming Yang, Xuemin Song, Yang Xu, Jianguo Li, Yanlin Wang, Zongze Zhang, Linli Le, Hui Liang, Ying Zhang. Protective effects of dexmedetomidine on blunt chest trauma-induced pulmonary contusion in rats. Shock. 2017;47(5): 653-657. |
| Name | XIAOJING WU |
| Date of birth | August,1982 |
| Department | Anesthesiology Department，Renmin Hospital,Wuhan University. |
| Title | Vice director, Professor, Master tutor |
| wxj164@163.com | |
| TEL | 18062059782 |
| Research Direction | |
|
1. Sepsis 2. Acute Lung Injury |
|
| Personal Profile | |
| She is mainly engaged in the diagnosis and treatment of Sepsis/ALI diseases,and has been awarded 2 items for the National Natural Science Foundation, 2 items from the provincial science and Technology Department. Besides,there are more than 30 papers published by the first author and corresponding author, including 16 SCI papers. At present, there is 3 Master studying with her. | |
| Selected Publications | |
|
1. Ning Li, Rui Xiong, Guorui Li, Tinglv Fu,
Donghang Li, Chenzhen Xu, Xiaojing Wu, Qing Geng. A novel mechanism for the
protection against acute lung injury by melatonin mitochondrial quality
control of lung epithelial cells is preserved through SIRT3‑dependent
deacetylation of SOD2. Cell Mol Life Sci. 2022Nov;30,79(12):610. 2. Guoqing Jing, Jing Zuo, Qing Fang, Min Yuan, Yun Xia, Qiyan Jin, Yuping Liu, Yanlin Wang, Zongze Zhang, Wanhong Liu, Xiaojing Wu, Xuemin Song. Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis. J Neuroinflammation. 2022 Sep;28,19(1):237. 3. Tingqian Ming, Mingyou Dong, Xuemin Song, Xingqiao Li, Qian Kong, Qing Fang, Jie Wang, Xiaojing Wu, Zhongyuan Xia. Integrated Analysis of Gene Co-Expression Network and Prediction Model Indicates Immune-Related Roles of the Identified Biomarkers in Sepsis and Sepsis-Induced Acute Respiratory Distress Syndrome. Front Immunol. 2022 Jun;30,13:897390. 4. Ning Li, Wenyang Jiang, Wei Wang, Rui Xiong, Xiaojing Wu, Qing Geng. Ferroptosis and its emerging roles in cardiovascular diseases. Pharmacol Res. 2021; 3;166:105466. 5. Xiaojing Wu, Xutao Yan, Xuming Yang, Ying Zhang, Hongyu Wang, Huan Luo, Qing Fang, Hui Li, Xinyi Li, K Chen, Yanlin Wang, Zongze Zhang, Xuemin Song. GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice. Cytokine. 2020; 128: 155019. 6. Xinyi Li, Rui Li, Qing Fang, Jamal M, Chengyao Wang, Yanlin Wang, Zongze Zhang Z, Xiaojing Wu*, Xuemin Song. Oxycodone attenuates vascular leak and lung inflammation in a clinically relevant two-hit rat model of acute lung injury. Cytokine. 2021 Feb;138:155346. 7. Qian Kong, Min Yuan, Tingqian Ming, Qing Fang, Xiaojing Wu*, Xuemin Song. Expression and regulation of tumor necrosis factor-α-induced protein-8-like 2 is associated with acute lung injury induced by myocardial ischemia reperfusion in diabetic rats. Microvasc Res. 2020; 130: 104009. 8. Tingqian Ming , Min Yuan, Qian Kong, Qin Huang, Zhongyuan Xia, Xiaojing Wu*. Mol Med Rep. Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock‑resuscitation‑induced acute lung injury through inhibiting the NLRP3 inflammasome. 2020;22(3): 2507-2515. 9. Qian Kong#, Xiaojing Wu#, ZhenQiu, Qin Huang, Zhongyuan Xia,Xuemin Song. Protective effect of dexmedetomidine on acute lung injury via the upregulation of tumour necrosis factor-α-induced protein-8-like 2 in septic mice inflammation. 2020;43(3): 833-846. 10. Xiaojing Wu, Qian Kong, LiyingZhan, Zhen Qiu, Qin Huang , Xuemin Song. TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury. Inflamm Res. 2019;68(11): 981-992. 11. Xiaojing Wu, Qian Kong, Zhongyuan Xia, Liying Zhan, WeinaDuan, Xuemin Song. Penehyclidine hydrochloride alleviates lipopolysaccharide induced acute lung injury in rats: Potential role of caveolin 1 expression upregulation. Int J Mol Med. 2019;43(5): 2064-2074. 12. Qian Kong#, Xiaojing Wu#, WeinaDuan, Liying Zhan, Xuemin Song. Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway. Exp Ther Med. 2019;17(5): 3598-3606. 13. Xiaojing Wu, Hui Liang, Ying Zhang, Xuming Yang, Hongyu Wang, Hui Li, Xinyi Li, Kai Chen,Yanlin Wang, Jianguo Li, Zongze Zhang, Xuemin Song. Muramyl dipeptide enhances thermal injury-induced autophagy and inflammatory cytokine response of lungs via activation of Nod2/Rick signaling pathway in rats. Shock. 2018;50(5): 606-612. 14. Xiaojing Wu, Humin Liu, Xuemin Song, Bo Zhao, Yan Leng, Eyou Wang, Liying Zhan, QingtaoMeng, Zhongyuan Xia*. Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats. Mol Med Rep. 2018;17(5): 6327-6336. 15. Xiaojing Wu, Xuming Yang, Xuemin Song, Yang Xu, Jianguo Li, Yanlin Wang, Zongze Zhang, Linli Le, Hui Liang, Ying Zhang. Protective effects of dexmedetomidine on blunt chest trauma-induced pulmonary contusion in rats. Shock. 2017;47(5): 653-657. |
武汉大学人民医院
湖北省人民医院