武汉大学人民医院湖北省人民医院

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周炎骨外
副主任医师，副教授，硕士生导师

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导师介绍

姓名	周炎
出生年月	1984年8月
单位	武汉大学人民医院骨科
所属学科	临床医学-外科学
职务、职称及头衔	副主任医师，副教授，硕士生导师
E-mail	yanzhou0827@whu.edu.cn
联系方式	13545089307，微信号13581275171
研究方向	1.骨与关节退行性疾病的基础研究 2.脊柱脊髓损伤的基础及临床研究
个人简介	主要从事骨与关节退行性变、脊柱脊髓损伤疾病的临床诊治与科研工作。主持国家自然科学基金2项、湖北省自然科学基金面上项目1项、中央高校科研专项基金1项、武汉大学人民医院引导基金1项、武汉大学医学部教学课题1项。主编专著《临床骨科学研究》，获得国家发明专利1项，实用新型专利1项。以第一作者及通讯作者在《中华创伤杂志》、《中华创伤骨科杂志》等杂志上发表论文40余篇，其中SCI论文15篇，影响因子超过50。目前正在培养的硕士生3名。
学术任职与荣誉	武汉生物医学工程学会颈肩腰腿痛专委会常委兼秘书 AO Spine国际会员湖北省骨生物材料与组织工程专业委员会青年委员湖北省中医师协会骨伤专业委员会委员湖北省颈肩腰腿痛生物治疗专业委员会青年委员全国颈肩腰腿痛研究会理事湖北省中西医结合学会颈肩腰腿痛学术委员会秘书湖北省运动人体科学研究会骨科专业委员会委员中国残疾人康复协会肢残康复专业委员会骨质疏松防治基地委员全国研究生教育评估监测专家库专家湖北省医保基金专家监督员国际SCI杂志《Cell Death and Disease》（1区）《Journal of Controlled Release》（1区）《International Immunopharmacology》（2区）《Journal of Biomedical Nanotechnology》（2区）特约审稿人
教育履历	2021年04月~2021年07月北京大学第三医院脊柱外科访问学者 2013年09月~ 2016年06月武汉大学第一临床学院博士 2015年08月~ 2015年11月纽约州立大学上州医院外科系访问学者 2006年09月~ 2009年06月湖北中医药大学硕士 2002年09月~ 2006年06月湖北民族大学医学院学士
工作履历	2021年5月~至今武汉大学人民医院骨科副教授 2019年10月~至今武汉大学人民医院骨科副主任医师 2016年07月~ 2019年10月武汉大学人民医院骨科主治医师 2015年08月~ 2015年11月纽约州立大学上州医院外科系访问学者
成果获奖	1. 2023年武汉大学人民医院优秀共产党员 2. 2021年武汉大学人民医院“人民抗议英雄”称号 3. 2020年中国医师协会骨科医师风采大赛中区总决赛优胜奖 4. 2019年中国医师协会骨科医师风采大赛湖北总决赛三等奖励 5. 2018年武汉大学第一临床学院青年教师演讲比赛三等奖 6.《踝背伸位桥式钢丝夹板外固定治疗小儿股骨干骨折的临床研究》2013年获国内领先技术 7.《踝背伸位桥式钢丝夹板外固定治疗小儿股骨干骨折的临床研究》2015年黄冈市科技进步三等奖
代表性论著	1. Jiang H, Zhang Y, Hu G, Shang X, Ming J, Deng M, Li Y, Ma Y, Liu S,Zhou Y. Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling. Front Immunol, 2022, 13:913901 (IF: 8.786，2区). 2.Zhou Yan#, Ming Jianghua, Li Yaming, Li Bochun, Deng Ming, Ma Yonggang, Chen Zhonghui, Zhang Yubiao, Li Jia, Liu Shiqing. Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis. Cell Death Discov, 2021, 7(1):37. (IF:7.109，2区) 3.Zhou Yan#, Ming Jianghua, Liu Shiqing. Epidemiologic characteristics and double-buffered strategy for patients in orthopedic surgery during the novel coronavirus outbreak: Wuhan's experience. Eur J Med Res. 2021,26(1):39. (IF:4.981，4区) 4.Zhou Yan#, Ming Jianghua, Deng Ming, Li Yaming, Li Bochun, Li Jia, Ma Yonggang, Chen Zhonghui, Liu Shiqing. Berberine-mediated up-regulation of surfactant protein D facilitates cartilage repair by modulating immune responses via the inhibition of TLR4/NF-ĸB signaling. Pharmacol Res, 2020, 155:104690. (IF:10.334，1区) 5.Zhou Yan#, Ming Jianghua, Deng Ming, Li Yaming, Li Bochun, Li Jia, Ma Yonggang, Chen Zhonghui, Wang Guirong, Liu Shiqing. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl), 2020, 98(10):1479-1491. (IF:5.606,2区) 6. Chen Zhonghui#, Zhang Weibing, Deng Ming, Li Yaming,Zhou Yan. CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging (Albany NY), 2020, 12(21):21971-21991. (IF:5.955，2区) 7.Zhou Yan#, Ming Jianghua, Li Yaming, Deng Ming, Chen Qing, Ma Yonggang, Chen Zhonghui, Zhang Yubiao, Liu Shiqing. Ligustilide attenuates nitric oxide- induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways. J Cell Mol Med, 2019, 23:3357-3368.(IF:5.31，2区) 8.Zhou Yan#, Ming Jianghua, Li Yaming, Du Xianjin, Deng Ming, He Bin, Zhou Jianlin, Wang Guirong, Liu Shiqing. Surfactant Protein D attenuates nitric oxide-stimulated apoptosis in rat chondrocyte by suppressing p38 MAPK signaling. Biochem Biophys Res Commun, 2018, 495(1):526-532. (IF:3.322，3区) 9.Zhou Yan#, Liu Shiqing, Ming Jianghua, Li Yaming, Deng Ming, He Bin. Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture. Drug Dev Ind Pharm, 2017, 43(10): 1703-1714. (IF:3.727,3区) 10.Zhou Yan#, Tao Haiying, Li Yaming, Deng Ming, He Bin, Xia Shaoqiang, Zhang Chun, Liu Shiqing. Berberine promotes proliferation of sodium nitroprusside- stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/β-catenin pathway. Eur J Pharmacol, 2016, 789: 109-118. (IF:5.195，3区) 11.周炎，李亚明，明江华，刘世清，陈庆，马永刚，胡戈亮，邓明，廖琦，陈忠辉，汪喆，彭昊.新型冠状病毒肺炎疫情期间双缓冲诊疗模式处理骨科急症的效果.中华创伤杂志，2021，36(3):193-196. 12.周炎，明江华，李亚明，陈庆，马永刚，邓明，刘世清.颈、腰椎多节段椎管狭窄症的临床特点及手术治疗.生物骨科材料与临床研究，2019，16(2): 25-30. 13.周炎，刘世清，明江华，李亚明，陈庆，邓明.骨水泥强化椎弓根螺钉固定后并发混合型渗漏的治疗.中华创伤杂志，2017，33(4): 379-382.

Name	YAN ZHOU
Date of birth	August，1984
Department	Department of Orthopedics，Renmin Hospital,Wuhan University.
Title	Associate Chief Physician, Master Tutor
Email	yanzhou0827@whu.edu.cn
TEL	13545089307，WeChat ID：13581275171
Research Direction	1. Degenerative diseases of bone and joints 2. Spinal cord injury
Personal Profile	He is mainly engaged in the diagnosis, treatment and scientific research of bone and joint degenerative changes, spinal cord injury diseases. He has presided over 2 projects of National Natural Science Foundation, 1 project of Hubei Natural Science Foundation, 1 project of Central University Special Research Fund, 1 Guiding fund of Wuhan University People's Hospital, and 1 teaching project of Wuhan University Medical Science Center. He has published more than 40 papers in Chinese Journal of Trauma and Chinese Journal of Trauma and Orthopedics, including nearly 15 SCI papers with impact factors of over 50. Currently, I am training 3 master's degree student.
Selected Publications	1. Jiang H, Zhang Y, Hu G, Shang X, Ming J, Deng M, Li Y, Ma Y, Liu S,Zhou Y. Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling. Front Immunol, 2022, 13:913901 (IF: 8.786，2区). 2.Zhou Yan#, Ming Jianghua, Li Yaming, Li Bochun, Deng Ming, Ma Yonggang, Chen Zhonghui, Zhang Yubiao, Li Jia, Liu Shiqing. Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis. Cell Death Discov, 2021, 7(1):37. (IF:7.109，2区) 3.Zhou Yan#, Ming Jianghua, Liu Shiqing. Epidemiologic characteristics and double-buffered strategy for patients in orthopedic surgery during the novel coronavirus outbreak: Wuhan's experience. Eur J Med Res. 2021,26(1):39. (IF:4.981，4区) 4.Zhou Yan#, Ming Jianghua, Deng Ming, Li Yaming, Li Bochun, Li Jia, Ma Yonggang, Chen Zhonghui, Liu Shiqing. Berberine-mediated up-regulation of surfactant protein D facilitates cartilage repair by modulating immune responses via the inhibition of TLR4/NF-ĸB signaling. Pharmacol Res, 2020, 155:104690. (IF:10.334，1区) 5.Zhou Yan#, Ming Jianghua, Deng Ming, Li Yaming, Li Bochun, Li Jia, Ma Yonggang, Chen Zhonghui, Wang Guirong, Liu Shiqing. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl), 2020, 98(10):1479-1491. (IF:5.606,2区) 6. Chen Zhonghui#, Zhang Weibing, Deng Ming, Li Yaming,Zhou Yan. CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging (Albany NY), 2020, 12(21):21971-21991. (IF:5.955，2区) 7.Zhou Yan#, Ming Jianghua, Li Yaming, Deng Ming, Chen Qing, Ma Yonggang, Chen Zhonghui, Zhang Yubiao, Liu Shiqing. Ligustilide attenuates nitric oxide- induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways. J Cell Mol Med, 2019, 23:3357-3368.(IF:5.31，2区) 8.Zhou Yan#, Ming Jianghua, Li Yaming, Du Xianjin, Deng Ming, He Bin, Zhou Jianlin, Wang Guirong, Liu Shiqing. Surfactant Protein D attenuates nitric oxide-stimulated apoptosis in rat chondrocyte by suppressing p38 MAPK signaling. Biochem Biophys Res Commun, 2018, 495(1):526-532. (IF:3.322，3区) 9.Zhou Yan#, Liu Shiqing, Ming Jianghua, Li Yaming, Deng Ming, He Bin. Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture. Drug Dev Ind Pharm, 2017, 43(10): 1703-1714. (IF:3.727,3区) 10.Zhou Yan#, Tao Haiying, Li Yaming, Deng Ming, He Bin, Xia Shaoqiang, Zhang Chun, Liu Shiqing. Berberine promotes proliferation of sodium nitroprusside- stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/β-catenin pathway. Eur J Pharmacol, 2016, 789: 109-118. (IF:5.195，3区) 11.周炎，李亚明，明江华，刘世清，陈庆，马永刚，胡戈亮，邓明，廖琦，陈忠辉，汪喆，彭昊.新型冠状病毒肺炎疫情期间双缓冲诊疗模式处理骨科急症的效果.中华创伤杂志，2021，36(3):193-196. 12.周炎，明江华，李亚明，陈庆，马永刚，邓明，刘世清.颈、腰椎多节段椎管狭窄症的临床特点及手术治疗.生物骨科材料与临床研究，2019，16(2): 25-30. 13.周炎，刘世清，明江华，李亚明，陈庆，邓明.骨水泥强化椎弓根螺钉固定后并发混合型渗漏的治疗.中华创伤杂志，2017，33(4): 379-382.