李维
麻醉学
主任医师、副教授、博士研究生导师、麻醉科副主任
主任医师、副教授、博士研究生导师、麻醉科副主任
导师介绍
| 姓名 | 李维 |
| 出生年月 | 1984年11月 |
| 单位 | 武汉大学人民医院麻醉科 |
| 所属学科 | 临床医学-麻醉学 |
| 职务、职称及头衔 | 主任医师、副教授、博士研究生导师、麻醉科副主任 |
| 150220995@qq.com | |
| 联系方式 | 18907197772 |
| 研究方向 |
1.围手术期重要脏器的损伤机理与保护 2.围手术期肾脏保护 |
| 个人简介 | 主任医师、副教授、博士研究生导师、麻醉科副主任，英国牛津大学访问学者，2022年入选“武汉英才”。擅长高龄高危患者的麻醉和围术期管理。主要研究方向为围术期脏器保护，主持国自然基金面上项目1项、青年基金项目1项、省自然基金面上项目1项、武汉市应急科研攻关项目1项、武汉大学教学研究课题1项，参与7项国家级科技项目和2项中华医学会教育研究课题。以第一/通讯作者发表SCI论文二十余篇（其中一区4篇，二区8篇）；中文核心期刊论文8篇。参编专著多部。哈佛医学院全球临床研究学者（GCSRT），主持和参与多项多中心临床药物临床试验项目。 |
| 学术任职与荣誉 | 武汉市医学会麻醉分会青年委员会副主任委员 |
| 教育履历 |
2002.09-2007.06武汉大学第一临床学院临床医学专业本科生获学士学位 2007.09-2009.06武汉大学第一临床学院临床医学硕士研究生获硕士学位 2010.10-2011.10英国牛津大学麻醉学访问学者 2011.09-2016.06武汉大学第一临床学院麻醉学博士研究生获博士学位 |
| 工作履历 |
2009.07-2012.05武汉大学人民医院住院医师 2012.05-2017.11武汉大学人民医院主治医师 2017.11-2020.11武汉大学人民医院副主任医师 2020.11-至今武汉大学人民医院主任医师 2022.11-至今武汉大学人民医院麻醉科副主任 |
| 成果获奖 |
1. “肾结石微创治疗关键技术体系构建与临床应用”获2023年湖北省科技进步一等奖 2.“围术期糖尿病肾脏再灌注损伤易损性增加的机制与防治探讨”获2017年湖北省科技进步二等奖 |
| 代表性论著 |
1.
Li W, Li W, Leng Y, Xiong Y, Xue R, Chen R, et al. Mechanism of
N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion
injury by regulating PTEN/Akt pathway through promoting DJ-1. Biosci Rep
2020; 40(6). 2. Li W, Li W, Leng Y, Xiong Y, Xia Z. Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress. DNA Cell Biol 2020; 39(2):210-225. 3. Chen R, Yu YL, Li W, Liu Y, Lu JX, Chen F, et al. Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study. Front Med (Lausanne) 2020; 7:608259. 4. Zhao S, Li W, Cheng F, Rao T, Yu W, Ruan Y, et al. High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis. Int J Mol Med 2019; 43(1):305-315. 5. Wu J, Li W, Ning J, Yu W, Rao T, Cheng F. Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition. Onco Targets Ther 2019; 12:495-508. 6. Li W, Cao Z, Yu W, Yao X, Ting R, Cheng F. Acute Kidney Injury Induced by Pneumoperitoneum Pressure Via a Mitochondrial Injury-dependent Mechanism in a Rabbit Model of Different Degrees of Hydronephrosis. Urology 2019; 127:134 e131-134 e137. 7. Zhu S, Li W, Yang X, Yu W, Rao T, Ruan Y, et al. Effects of autophagy on the spermatogonia of chronic hypoxic mice. Am J Transl Res 2018; 10(12):4119-4129. 8. Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, et al. The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele-induced rats. Exp Ther Med 2018; 15(1):433-439. 9. Li W, Zhao S, Cheng F, Rao T, Yu W, Ruan Y, et al. Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Mol Med Rep 2018; 17(5):6819-6827. 10. Li W, Ning JZ, Cheng F, Yu WM, Rao T, Ruan Y, et al. MALAT1 Promotes Cell Apoptosis and Suppresses Cell Proliferation in Testicular Ischemia-Reperfusion Injury by Sponging MiR-214 to Modulate TRPV4 Expression. Cell Physiol Biochem 2018; 46(2):802-814. 11. Ning JZ, Li W, Cheng F, Yu WM, Rao T, Ruan Y, et al. MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels. Front Physiol 2017; 8:966. 12. Meng QT, Cao C, Wu Y, Liu HM, Li W, Sun Q, et al. Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: role of Nrf2. Lab Invest 2016; 96(10):1087-1104. 13. Li W, Cao Z, Xia Z, Meng Q, Yu WM, Yao X, et al. Acute kidney injury induced by various pneumoperitoneum pressures in a rabbit model of mild and severe hydronephrosis. Urol Int 2015; 94(2):225-233. 14. Ning, Li, Cheng, et al. The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicoceleinduced rats. Experimental and Therapeutic Medicine, 2018.433-439 15. NING J Z, HE K X, CHENG F, et al. Long Non-coding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. Front Cell Dev Biol, 2021, 9: 671613. 16. SONG B F, LI B J, NING J Z, et al. Overexpression of sirtuin 1 attenuates calcium oxalate-induced kidney injury by promoting macrophage polarization. Int Immunopharmacol, 2023, 121: 110398. 17. ZHAO S, LI W, YU W, et al. Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys. Theranostics, 2021, 11(18): 8660-73. 18. HE K X, NING J Z, LI W, et al. Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis. Tissue Cell, 2023, 82: 102069. 19. YE P, LI W, HUANG X, et al. BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis. J Cell Mol Med, 2022, 26(7): 1994-2009. 20.李维,夏中元,李文远,熊永红,冷燕,赵胜,程帆.时钟基因Bmal1调控过氧化物酶体增殖物激活受体α/氧化物酶体增殖物活化受体协同刺激因子1α通路减轻移植肾缺血再灌注损伤的研究[J].中华实验外科杂志, 2019, 036(011):2078-2081. |
| Name | WEI LI |
| Date of birth | November, 1984 |
| Department | Department of anesthesiology, Renmin Hospital,Wuhan University. |
| Title | Professor, Master tutor, Vice director |
| 150220995@qq.com | |
| TEL | 18907197772 |
| Research Direction |
1.
Mechanism and protection of vital organs in perioperative period 2. Perioperative period renal protection |
| Personal Profile |
She
is a professor, master tutor, and vice director of the anesthesiology
department, visiting scholar in Oxford
University in the United Kingdom, and selected as "Wuhan Talents"
in 2022.She is expert in the anesthesia and perioperative management of
patients with senior high -risk patients and has been awarded 1 general
project of the National Natural Science Foundation of China (NSFC), 1 project of the Youth Project, and
participated in 7 NSFC projects; presided 1 item from the general project of
Hubei Provincial Health Commission; 1 item from the Emergency Scientific
Research Project of Wuhan Health Commission; 1 item from the Teaching
Research Project of Wuhan University Medical School and participated in 2
Educational Research Projects of the Chinese Medical Association. Since
taking the present position, she has published more than 20 SCI papers and 8
Chinese core journals as the first author.Participated in the compilation of
many monographs. Participated in the 2022 Harvard Medical School Global
Clinical Research Training (GCSRT) project, hosted and participated in a
number of multi-center clinical drug clinical trial projects. |
| Selected Publications |
1.
Li W, Li W, Leng Y, Xiong Y, Xue R, Chen R, et al. Mechanism of
N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion
injury by regulating PTEN/Akt pathway through promoting DJ-1. Biosci Rep
2020; 40(6). 2. Li W, Li W, Leng Y, Xiong Y, Xia Z. Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress. DNA Cell Biol 2020; 39(2):210-225. 3. Chen R, Yu YL, Li W, Liu Y, Lu JX, Chen F, et al. Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study. Front Med (Lausanne) 2020; 7:608259. 4. Zhao S, Li W, Cheng F, Rao T, Yu W, Ruan Y, et al. High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis. Int J Mol Med 2019; 43(1):305-315. 5. Wu J, Li W, Ning J, Yu W, Rao T, Cheng F. Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition. Onco Targets Ther 2019; 12:495-508. 6. Li W, Cao Z, Yu W, Yao X, Ting R, Cheng F. Acute Kidney Injury Induced by Pneumoperitoneum Pressure Via a Mitochondrial Injury-dependent Mechanism in a Rabbit Model of Different Degrees of Hydronephrosis. Urology 2019; 127:134 e131-134 e137. 7. Zhu S, Li W, Yang X, Yu W, Rao T, Ruan Y, et al. Effects of autophagy on the spermatogonia of chronic hypoxic mice. Am J Transl Res 2018; 10(12):4119-4129. 8. Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, et al. The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele-induced rats. Exp Ther Med 2018; 15(1):433-439. 9. Li W, Zhao S, Cheng F, Rao T, Yu W, Ruan Y, et al. Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Mol Med Rep 2018; 17(5):6819-6827. 10. Li W, Ning JZ, Cheng F, Yu WM, Rao T, Ruan Y, et al. MALAT1 Promotes Cell Apoptosis and Suppresses Cell Proliferation in Testicular Ischemia-Reperfusion Injury by Sponging MiR-214 to Modulate TRPV4 Expression. Cell Physiol Biochem 2018; 46(2):802-814. 11. Ning JZ, Li W, Cheng F, Yu WM, Rao T, Ruan Y, et al. MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels. Front Physiol 2017; 8:966. 12. Meng QT, Cao C, Wu Y, Liu HM, Li W, Sun Q, et al. Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: role of Nrf2. Lab Invest 2016; 96(10):1087-1104. 13. Li W, Cao Z, Xia Z, Meng Q, Yu WM, Yao X, et al. Acute kidney injury induced by various pneumoperitoneum pressures in a rabbit model of mild and severe hydronephrosis. Urol Int 2015; 94(2):225-233. 14. Ning, Li, Cheng, et al. The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicoceleinduced rats. Experimental and Therapeutic Medicine, 2018.433-439 15. NING J Z, HE K X, CHENG F, et al. Long Non-coding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. Front Cell Dev Biol, 2021, 9: 671613. 16. SONG B F, LI B J, NING J Z, et al. Overexpression of sirtuin 1 attenuates calcium oxalate-induced kidney injury by promoting macrophage polarization. Int Immunopharmacol, 2023, 121: 110398. 17. ZHAO S, LI W, YU W, et al. Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys. Theranostics, 2021, 11(18): 8660-73. 18. HE K X, NING J Z, LI W, et al. Emodin alleviates testicular ischemia-reperfusion injury through the inhibition of NLRP3-mediated pyroptosis. Tissue Cell, 2023, 82: 102069. 19. YE P, LI W, HUANG X, et al. BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis. J Cell Mol Med, 2022, 26(7): 1994-2009. 20.李维,夏中元,李文远,熊永红,冷燕,赵胜,程帆.时钟基因Bmal1调控过氧化物酶体增殖物激活受体α/氧化物酶体增殖物活化受体协同刺激因子1α通路减轻移植肾缺血再灌注损伤的研究[J].中华实验外科杂志, 2019, 036(011):2078-2081. |
武汉大学人民医院
湖北省人民医院