王志昊
神经病学
神经退行性疾病研究中心主任，教授，博士生导师
神经退行性疾病研究中心主任，教授，博士生导师
导师介绍
| 姓名 | 王志昊 |
| 出生年月 | 1986年9月 |
| 单位 | 武汉大学人民医院神经内科 |
| 所属学科 | 临床医学-神经病学 |
| 职务、职称及头衔 | 武汉大学人民医院神经退行性疾病研究中心主任，教授，博士生导师 |
| wangzh86@whu.edu.cn | |
| 联系方式 | 027-88041911转82221 |
| 研究方向 |
1.阿尔茨海默病 2.认知障碍的环路机制 |
| 个人简介 | 主要从事阿尔茨海默病的诊治与科研工作。先后获得埃默里大学杰出博后论坛奖和国际阿尔茨海默病协会的资助。发表SCI论文40余篇，第一作者或共同第一作者研究性SCI论文13篇，总影响因子超过550，总引用次数超过1600次，h指数为24。前后五次受阿尔茨海默病协会国际会议和美国神经科学年会的邀请参会，做会议报告。目前正在培养的博士生8名，培养硕士生6名。 |
| 学术任职与荣誉 |
美国神经科学学会（SfN）会员 国际痴呆协会年会（AAIC）会员 中国神经科学学会会员 中国细胞生物学学会会员 Brain Behavior and Immunity,Life Sciences, Frontiers in Medicine等国际学术期刊审稿人 |
| 教育履历 |
2005.09-2010.06华中科技大学同济医学院临床医学专业本科生获学士学位 2010.09-2015.06华中科技大学创新研究院博士研究生获博士学位 |
| 工作履历 |
2015.01-2015.12美国埃默里大学访问学者 2016.01-2020.01美国埃默里大学博士后 2020至今 武汉大学人民医院神经内科教授 2021至今 武汉大学人民医院神经退行性疾病研究中心主任 |
| 成果获奖 |
1.《δ-分泌酶对SRPK2的翻译后修饰研究》获2018年阿尔茨海默病协会国际会议旅行奖 2.《SRPK2对δ-分泌酶的磷酸化修饰研究》获2017埃默里大学杰出博后论坛奖 |
| 代表性论著 |
1.
Wang ZH#, Xia Y#, Wu Z#, Kang SS, Zhang JC, Liu P, Liu X, Song W, Huin V,
Dhaenens CM, Yu SP, Wang XC*, Ye K*. Neuronal ApoE4 stimulates C/EBPβ
activation, promoting Alzheimer's disease pathology in a mouse model.
Progress in Neurobiology. 2022 Feb;209:102212. doi:
10.1016/j.pneurobio.2021.102212. (#共同第一作者，*通讯作者) 2. Wang ZH#, Xia Y#, Liu P, Liu X, Edgington-Mitchell L, Lei K, Yu SP, Wang XC*, Ye K*. ApoE4 Activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, Driving the Pathogenesis of Alzheimer’s Disease. Progress in Neurobiology. 2021 Jul; 202:102032. doi: 10.1016/j.pneurobio.2021.102032. (#共同第一作者，*通讯作者) 3. Xia Y#, Wang ZH#, Zhang Z, Liu X, Yu SP, Wang JZ, Wang XC*, Ye K*. Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease. Progress in Neurobiology. 2021 Jun 21:102113. doi: 10.1016/j.pneurobio.2021.102113. (#共同第一作者，*通讯作者) 4. Xia Y#, Wang ZH#, Zhang J, Liu X, Yu SP, Ye KX, Wang JZ, Ye K*, Wang XC*. C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Mol Psychiatry. 2020 Dec 18. doi: 10.1038/s41380-020-00956-4. Online ahead of print. (#共第一作者，*通讯作者) 5. Xia Y#, Wang ZH#, Liu P, Edgington-Mitchell L, Liu X, Wang XC*, Ye K*. TrkB Receptor Cleavage by Delta-Secretase Abolishes its Phosphorylation of APP, Aggravating Alzheimer's Disease Pathologies. Mol Psychiatry. 2020 Aug 11. doi: 10.1038/s41380-020-00863-8. (#共第一作者，*通讯作者) 6. Wang ZH#, Xiang J, Liu X, Yu SP, Manfredsson F, Sandoval I, Wu S, Wang JZ*, Ye K*.Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates Delta-secretase via Upregulating C/EBPβ in Alzheimer’s Disease. Cell Reports. 2019 Jul 16;28(3):655-669.e5. (#第一作者，*通讯作者) 7. Wang ZH#, Liu P, Liu X, Yu SP, Wang JZ*, Ye K*. Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. J Exp Med. 2018 Oct 29. pii: jem.20180539. doi: 10.1084/jem.20180539. (#第一作者，*通讯作者) 8. Wang ZH#, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ*, Ye K*. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. JCI Insight. 2018 Aug 23;3(16). pii: 99007. doi: 10.1172/jci.insight.99007. (#第一作者，*通讯作者) 9. Wang ZH#, Gong K#, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ*, Ye K*.C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nat Commun. 2018 May 3;9(1):1784. doi: 10.1038/s41467-018-04120-z. (#共第一作者，*通讯作者) 10. Wang ZH#, Liu P, Liu X, Manfredsson FP, Sandoval IM, Yu SP, Wang JZ, Ye K*. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Mol Cell. 2017 Sep 7;67(5):812-825.e5. doi: 10.1016/j.molcel.2017.07.018. (#第一作者，*通讯作者) 11. Yang Y#, Wang ZH#, Jin S#, Gao D, Liu N, Chen SP, Zhang S, Liu Q, Liu E, Wang X, Liang X, Wei P, Li X, Li Y, Yue C, Li HL, Wang YL, Wang Q, Ke D, Xie Q, Xu F, Wang L*, Wang JZ*. Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory. Nat Commun. 2016 Jul 14;7:11935. (#共第一作者，*通讯作者) |
| Name | ZHIHAO WANG |
| Date of birth | September，1986 |
| Department | Neurology Department，Renmin Hospital,Wuhan University. |
| Title | Director, Professor, doctoral tutor |
| wangzh86@whu.edu.cn | |
| TEL | 027-88041911-82221 |
| Research Direction |
1.
Alzheimer's disease 2. Neuronal circuit dysfunction in cognitive impairment |
| Personal Profile | Prof. Wang experts in basic, clinical and translational research on Alzheimer's disease. He was awarded the "2017 Distinguished Postdoc Symposium Award" in Emory University, and supported by Alzheimer’s Association. He has more than 30 publications on top journals including Molecular Cell, Nature Communications, Molecular Psychiatry, Journal of Experimental Medicine, Progress in Neurobiology, PNAS, Cell Reports, JCI insight, etc. Currently, he is mentoring 8 PHD candidate and mentoring 6 Master candidate. |
| Selected Publications |
1.
Wang ZH#, Xia Y#, Wu Z#, Kang SS, Zhang JC, Liu P, Liu X, Song W, Huin V,
Dhaenens CM, Yu SP, Wang XC*, Ye K*. Neuronal ApoE4 stimulates C/EBPβ
activation, promoting Alzheimer's disease pathology in a mouse model.
Progress in Neurobiology. 2022 Feb;209:102212. doi:
10.1016/j.pneurobio.2021.102212. (#共同第一作者，*通讯作者) 2. Wang ZH#, Xia Y#, Liu P, Liu X, Edgington-Mitchell L, Lei K, Yu SP, Wang XC*, Ye K*. ApoE4 Activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, Driving the Pathogenesis of Alzheimer’s Disease. Progress in Neurobiology. 2021 Jul; 202:102032. doi: 10.1016/j.pneurobio.2021.102032. (#共同第一作者，*通讯作者) 3. Xia Y#, Wang ZH#, Zhang Z, Liu X, Yu SP, Wang JZ, Wang XC*, Ye K*. Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease. Progress in Neurobiology. 2021 Jun 21:102113. doi: 10.1016/j.pneurobio.2021.102113. (#共同第一作者，*通讯作者) 4. Xia Y#, Wang ZH#, Zhang J, Liu X, Yu SP, Ye KX, Wang JZ, Ye K*, Wang XC*. C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Mol Psychiatry. 2020 Dec 18. doi: 10.1038/s41380-020-00956-4. Online ahead of print. (#共第一作者，*通讯作者) 5. Xia Y#, Wang ZH#, Liu P, Edgington-Mitchell L, Liu X, Wang XC*, Ye K*. TrkB Receptor Cleavage by Delta-Secretase Abolishes its Phosphorylation of APP, Aggravating Alzheimer's Disease Pathologies. Mol Psychiatry. 2020 Aug 11. doi: 10.1038/s41380-020-00863-8. (#共第一作者，*通讯作者) 6. Wang ZH#, Xiang J, Liu X, Yu SP, Manfredsson F, Sandoval I, Wu S, Wang JZ*, Ye K*.Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates Delta-secretase via Upregulating C/EBPβ in Alzheimer’s Disease. Cell Reports. 2019 Jul 16;28(3):655-669.e5. (#第一作者，*通讯作者) 7. Wang ZH#, Liu P, Liu X, Yu SP, Wang JZ*, Ye K*. Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. J Exp Med. 2018 Oct 29. pii: jem.20180539. doi: 10.1084/jem.20180539. (#第一作者，*通讯作者) 8. Wang ZH#, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ*, Ye K*. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. JCI Insight. 2018 Aug 23;3(16). pii: 99007. doi: 10.1172/jci.insight.99007. (#第一作者，*通讯作者) 9. Wang ZH#, Gong K#, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ*, Ye K*.C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nat Commun. 2018 May 3;9(1):1784. doi: 10.1038/s41467-018-04120-z. (#共第一作者，*通讯作者) 10. Wang ZH#, Liu P, Liu X, Manfredsson FP, Sandoval IM, Yu SP, Wang JZ, Ye K*. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Mol Cell. 2017 Sep 7;67(5):812-825.e5. doi: 10.1016/j.molcel.2017.07.018. (#第一作者，*通讯作者) 11. Yang Y#, Wang ZH#, Jin S#, Gao D, Liu N, Chen SP, Zhang S, Liu Q, Liu E, Wang X, Liang X, Wei P, Li X, Li Y, Yue C, Li HL, Wang YL, Wang Q, Ke D, Xie Q, Xu F, Wang L*, Wang JZ*. Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory. Nat Commun. 2016 Jul 14;7:11935. (#共第一作者，*通讯作者) |
武汉大学人民医院
湖北省人民医院