孙圣荣
普外
教授，主任医师，博士生导师
教授，主任医师，博士生导师
导师介绍
| 姓名 | 孙圣荣 |
| 出生年月 | 1957年2月 |
| 单位 | 武汉大学人民医院乳甲外科 |
| 所属学科 | 临床医学-外科学 |
| 职务、职称及头衔 | 教授，主任医师，博士生导师 |
| sun137@sina.com | |
| 联系方式 | 13707198696 |
| 研究方向 | 主要开展肿瘤微环境关键分子与乳腺癌侵袭转移的关系研究，特别是对微环境关键分子CCL5与乳腺癌侵袭转移的相互关系，以及脂肪细胞分泌外泌体与肿瘤微环境的相互作用关系进行了系列研究。 |
| 个人简介 | 从事乳腺外科临床、教学、科研工作40余年，具有丰富的临床工作经验，主持、参与多项国家及省部级科研项目并取得多项科研成果，获得国家专利3项，发表相关论文150余篇，其中SCI论文50余篇。已培养硕士生100余名，博士生60余名。目前正在培养的博士生10名，硕士生20余名。 |
| 学术任职与荣誉 | 现任中国抗癌协会遗传性肿瘤委员会常委、中国抗癌协会纳米医学委员会委员、中国抗癌协会乳腺专业委员会委员、中国研究型医院甲状腺外科专业委员会委员、湖北省抗癌协会乳腺癌专委会名誉主任委员、中国医师协会外科医师分会委员、中国医师协会甲状腺外科分会委员、湖北省生物工程乳腺甲状腺生物治疗委员会主任委员、全国“百万妇女乳腺普查工程”湖北省首席专家、湖北省农村女性“两癌”防治乳腺癌组组长被评为武汉市“人民心中的好医生”。 |
| 教育履历 |
1978.09-1983.06湖北武汉武汉大学基础医学院本科 1988.09-1991.06湖北武汉武汉大学第二临床学院研究生 2004.09-2007.06湖北武汉武汉大学第一临床学院博士 2007.06-至今湖北武汉武汉大学人民医院临床医学 2005.09-2008.06武汉大学第一临床学院内科学博士研究生获博士学位 |
| 工作履历 | 1983年6月于武汉大学临床医学专业获学士学位，就职武汉大学中南医院肿瘤科，1991年6月于武汉大学第二临床学院获肿瘤学硕士学位，后就职于武汉大学人民医院普外科，任主治医师。2007年6月或武汉大学第一临床学院外科学博士学位。2002年10月升为武汉大学人民医院乳甲外科主任医师，2009年7月评为武汉大学人民医院乳甲外科教授。 |
| 成果获奖 |
1.
CCL5对乳腺癌侵袭与转移的研究和应用，获湖北省科技进步二等奖 2. L-精氨酸对皮瓣成活影响的实验和临床研究，获湖北省科技进步三等奖 3. CCL5检测体系在乳腺癌诊治中的推广应用，获湖北省科技成果推广三等奖 |
| 代表性论著 |
1.
Wu Q, Sun S, Li Z, Yang Q, Li B, Zhu S, Wang L, Wu J, Yuan J, Yang C et al:
Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to
promote tumour progression. Molecular cancer 2018, 17(1):155.
(IF=15.302) 2. Wu Q, Li B, Liu L, Sun S, Sun S. Centrosome dysfunction: a link between senescence and tumor immunity. Signal Transduct Target Ther. 2020 Jun 30;5(1):107. doi: 10.1038/s41392-020-00214-7. (IF=13.493) 3. Wu Q, Li B, Li Z, Li J, Sun S, Sun S. Cancer-associated adipocytes: key players in breast cancer progression. J Hematol Oncol. 2019 Sep 10;12(1):95. doi: 10.1186/s13045-019-0778-6. (IF=11.059) 4. Wu Q, Li J, Li Z, Sun S, Zhu S, Wang L, Wu J, Yuan J, Zhang Y, Sun S et al: Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression. Journal of experimental & clinical cancer research : CR 2019, 38(1):223. (IF=7.068) 5. Wang Z, Li Z, Wu Q, Li C, Li J, Zhang Y, Wang C, Sun S, Sun S. DNER promotes epithelial-mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer. Cell Death Dis. 2020. Acceptance. (IF=6.304) 6. Zhang P, Yang F, Luo Q, Yan D, Sun S. miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2. Oncol Res. 2019 Feb 5;27(2):253-260. doi: 10.3727/096504018X15242763477504. Epub 2018 Aug 3. (IF=4.949) 7. Wu Q, Li B, Sun S, Sun S. Unraveling Adipocytes and Cancer Links: Is There a Role for Senescence? Front Cell Dev Biol. 2020 Apr 28;8:282. doi: 10.3389/fcell.2020.00282. eCollection 2020. (IF=5.201) 8. Li B, Geng R, Wu Q, Yang Q, Sun S, Zhu S, Xu Z, Sun S: Alterations in Immune-Related Genes as Potential Marker of Prognosis in Breast Cancer. Frontiers in oncology 2020, 10:333. (IF=4.848) 9. Chai CY, Song J, Tan Z, Tai IC, Zhang C, Sun S: Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway. Journal of cellular biochemistry 2019, 120(3):4057-4064. (IF=4.237) 10. Wang L, Wu Q, Li Z, Sun S, Yuan J, Li J, Zhang Y, Yu D, Wang C, Sun S. Delta/notch-like epidermal growth factor-related receptor promotes stemness to facilitate breast cancer progression. Cell Signal. 2019 Nov;63:109389. doi: 10.1016/j.cellsig.2019.109389. Epub 2019 Aug 10. (IF=3.968) 11. Zhu S, Wang Y, Liu H, Wei W, Tu Y, Chen C, Song J, Xu Z, Li J, Wang C, Sun S. Thyroxine Affects Lipopolysaccharide-Induced Macrophage Differentiation and Myocardial Cell Apoptosis via the NF- κ B p65 Pathway Both In Vitro and In Vivo. Mediators Inflamm. 2019 May 14;2019:2098972. doi: 10.1155/2019/2098972. eCollection 2019. (IF=3.758) 12. Wu Q, Sun S, Li Z, Yang Q, Li B, Zhu S, Wang L, Wu J, Yuan J, Wang C et al: Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression. Adipocyte 2019, 8(1):31-45. (IF=3.146) 13. Li Z, Tu Y, Wu Q, Wang Z, Li J, Zhang Y, Sun S. Clinical Characteristics and Outcomes of Single Versus Double Hormone Receptor-Positive Breast Cancer in 2 Large Databases. Clin Breast Cancer. 2020 Apr;20(2): e151-e163. doi: 10.1016/j.clbc.2019.07.002. Epub 2019 Aug 22. (IF=2.647) 14. Liu JH, Chen C, Li ZY, Zou ZM, Gao DC, Zhang X, Kuang XW, Sun ZH, Zheng WJ, Zhou P, Sun SR. The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways. Exp Cell Res. 2020 Jun 28;112157. doi: 10.1016/j.yexcr.2020.112157. Online ahead of print. (IF=3.383) 15. Zhu S, Wang Y, Liu H, Wei W, Tu Y, Chen C, Song J, Xu Z, Li J, Wang C, Sun S. Thyroxine Affects Lipopolysaccharide-Induced Macrophage Differentiation and Myocardial Cell Apoptosis via the NF- κ B p65 Pathway Both In Vitro and In Vivo. Mediators Inflamm. 2019 May 14;2019:2098972. doi: 10.1155/2019/2098972. eCollection 2019. (IF=3.758) |
| Name | Shengrong Sun |
| Date of birth | Feb，1957 |
| Department | Department of Breast and Thyroid Surgery，Renmin Hospital,Wuhan University. |
| Title | Professor, doctoral tutor |
| sun137@sina.com | |
| TEL | 13707198696 |
| Research Direction | Study on the relationship between key molecules of tumor microenvironment and invasion and metastasis of breast cancer, and the interaction between adipocyte secretion of exosomes and tumor microenvironment |
| Personal Profile | Engaged in breast surgery clinical, teaching, and scientific research for more than 40 years, with rich clinical work experience, presided over and participated in a number of national, provincial and ministerial-level scientific research projects and obtained a number of scientific research results, obtained 3 national patents, and published more than 100 related papers , Including more than 30 SCI papers. More than 100 master students and 60 doctoral students have been trained. Currently there are 10 doctoral students and more than 20 master students being trained. |
| Selected Publications |
1.
Wu Q, Sun S, Li Z, Yang Q, Li B, Zhu S, Wang L, Wu J, Yuan J, Yang C et al:
Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to
promote tumour progression. Molecular cancer 2018, 17(1):155.
(IF=15.302) 2. Wu Q, Li B, Liu L, Sun S, Sun S. Centrosome dysfunction: a link between senescence and tumor immunity. Signal Transduct Target Ther. 2020 Jun 30;5(1):107. doi: 10.1038/s41392-020-00214-7. (IF=13.493) 3. Wu Q, Li B, Li Z, Li J, Sun S, Sun S. Cancer-associated adipocytes: key players in breast cancer progression. J Hematol Oncol. 2019 Sep 10;12(1):95. doi: 10.1186/s13045-019-0778-6. (IF=11.059) 4. Wu Q, Li J, Li Z, Sun S, Zhu S, Wang L, Wu J, Yuan J, Zhang Y, Sun S et al: Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression. Journal of experimental & clinical cancer research : CR 2019, 38(1):223. (IF=7.068) 5. Wang Z, Li Z, Wu Q, Li C, Li J, Zhang Y, Wang C, Sun S, Sun S. DNER promotes epithelial-mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer. Cell Death Dis. 2020. Acceptance. (IF=6.304) 6. Zhang P, Yang F, Luo Q, Yan D, Sun S. miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2. Oncol Res. 2019 Feb 5;27(2):253-260. doi: 10.3727/096504018X15242763477504. Epub 2018 Aug 3. (IF=4.949) 7. Wu Q, Li B, Sun S, Sun S. Unraveling Adipocytes and Cancer Links: Is There a Role for Senescence? Front Cell Dev Biol. 2020 Apr 28;8:282. doi: 10.3389/fcell.2020.00282. eCollection 2020. (IF=5.201) 8. Li B, Geng R, Wu Q, Yang Q, Sun S, Zhu S, Xu Z, Sun S: Alterations in Immune-Related Genes as Potential Marker of Prognosis in Breast Cancer. Frontiers in oncology 2020, 10:333. (IF=4.848) 9. Chai CY, Song J, Tan Z, Tai IC, Zhang C, Sun S: Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway. Journal of cellular biochemistry 2019, 120(3):4057-4064. (IF=4.237) 10. Wang L, Wu Q, Li Z, Sun S, Yuan J, Li J, Zhang Y, Yu D, Wang C, Sun S. Delta/notch-like epidermal growth factor-related receptor promotes stemness to facilitate breast cancer progression. Cell Signal. 2019 Nov;63:109389. doi: 10.1016/j.cellsig.2019.109389. Epub 2019 Aug 10. (IF=3.968) 11. Zhu S, Wang Y, Liu H, Wei W, Tu Y, Chen C, Song J, Xu Z, Li J, Wang C, Sun S. Thyroxine Affects Lipopolysaccharide-Induced Macrophage Differentiation and Myocardial Cell Apoptosis via the NF- κ B p65 Pathway Both In Vitro and In Vivo. Mediators Inflamm. 2019 May 14;2019:2098972. doi: 10.1155/2019/2098972. eCollection 2019. (IF=3.758) 12. Wu Q, Sun S, Li Z, Yang Q, Li B, Zhu S, Wang L, Wu J, Yuan J, Wang C et al: Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression. Adipocyte 2019, 8(1):31-45. (IF=3.146) 13. Li Z, Tu Y, Wu Q, Wang Z, Li J, Zhang Y, Sun S. Clinical Characteristics and Outcomes of Single Versus Double Hormone Receptor-Positive Breast Cancer in 2 Large Databases. Clin Breast Cancer. 2020 Apr;20(2): e151-e163. doi: 10.1016/j.clbc.2019.07.002. Epub 2019 Aug 22. (IF=2.647) 14. Liu JH, Chen C, Li ZY, Zou ZM, Gao DC, Zhang X, Kuang XW, Sun ZH, Zheng WJ, Zhou P, Sun SR. The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways. Exp Cell Res. 2020 Jun 28;112157. doi: 10.1016/j.yexcr.2020.112157. Online ahead of print. (IF=3.383) 15. Zhu S, Wang Y, Liu H, Wei W, Tu Y, Chen C, Song J, Xu Z, Li J, Wang C, Sun S. Thyroxine Affects Lipopolysaccharide-Induced Macrophage Differentiation and Myocardial Cell Apoptosis via the NF- κ B p65 Pathway Both In Vitro and In Vivo. Mediators Inflamm. 2019 May 14;2019:2098972. doi: 10.1155/2019/2098972. eCollection 2019. (IF=3.758) |
武汉大学人民医院
湖北省人民医院