陈静
心内
心内Ⅴ科（急性心血管病救治中心）主任，主任医师、副教授、博士生导师
心内Ⅴ科（急性心血管病救治中心）主任，主任医师、副教授、博士生导师
导师介绍
| 姓名 | 陈静 |
| 出生年月 | 1982年11月 |
| 单位 | 武汉大学人民医院心血管内科 |
| 所属学科 | 临床医学-内科学 |
| 职务、职称及头衔 | 心内Ⅴ科（急性心血管病救治中心）主任，主任医师、副教授、博士生导师 |
| 364580342@qq.com | |
| 联系方式 | 027-88041911转88027；13659840327 |
| 研究方向 |
1.血管及心肌损伤修复 2.冠心病介入心脏病学 |
| 个人简介 | 擅长冠心病、高血压、心肌病、冠脉造影术和支架植入术。主持国家自然科学基金2项，承担国家自然科学基金8项，主持教育部博士点和中央高校青年教师基金各一项。发表SCI论文30余篇，参编参译论著4部。科研成果获湖北省自然科学奖和湖北省科技进步奖各一项。临床研究获第26届长城国际心脏病学会《长城青年医师奖暨CNAHA青年研究奖》二等奖；全国心血管急重症病例比赛第一名；武汉大学人民医院“医疗菁英奖”和武汉大学人民医院国家I级新技术。 |
| 学术任职与荣誉 |
1.美国心脏病学学会会员 2.亚太结构性心脏病俱乐部银级会员 3.中华医学会心血管分会急重症学组全国委员兼秘书 4.中国医师协会心血管内科医师分会第五届委员会心血管危重症学组全国委员 5.中国心衰中心联盟委员 6.中国研究型医院心力衰竭专委会委员 7.中国中部复杂冠脉介入青年委员会组长 8.中国胸痛中心现场核查专家 9.中国心胸血管麻醉学会基层心血管病分会全国委员 10.湖北省微循环学会心血管专业委员会副主任委员 11.湖北省医学会心血管内科第八届委员会委员 12.湖北省医师协会心血管内科医师分会第一届委员会委员 13.湖北省急性心血管疾病医疗救治中心秘书长兼委员 14.湖北省闭塞病变俱乐部委员兼常务秘书 |
| 教育履历 |
2000.09-2005.07 武汉大学 本科毕业 医学学士学位 2005.09-2007.07 武汉大学 硕士研究生 医学硕士学位 2008.09-2011.08 武汉大学 博士研究生 医学博士学位 2008.08-2010.06 美国美国乔治亚理工学院 访问学者 |
| 工作履历 |
2011.07-2011.12 武汉大学人民医院 住院医师 2012.01-2013.12 武汉大学人民医院 主治医师 2014.01-2019.03 武汉大学人民医院 副主任医师 2015.01-2021.07 武汉大学人民医院 副教授 2016.06-至今 武汉大学人民医院 硕士生导师 2018.06-至今 武汉大学人民医院 心内V科主任 2019.03-至今 武汉大学人民医院 主任医师 2022.07-至今 武汉大学人民医院 博士生导师 |
| 成果获奖 |
1.中国民主同盟抗击疫情先进个人 2.民盟湖北省委抗击新冠肺炎疫情先进个人 3.2020年第二届心血管病菁英抗“疫”英雄奖 4.《血管和心肌损伤及修复机制研究》2015年湖北省自然科学奖 5.《HMGB1介导血管损伤后新生内膜增生的机制及防治策略》2014年湖北省科技进步奖 6.武汉市中青年骨干人才 7.第8届武汉大学青年教师教学竞赛 8.全国介入心脏病大会IABP奖学金优秀病例 9.长城青年医师奖 |
| 代表性论著 |
1.Guo
X, Zhang BF, Zhang J, Liu G, Hu Q, Chen J. The histone demthylase KDM3A
protects the myocardium from ischemia/reperfusion injury via promotion of
ETS1 expression. Commun Biol. 2022 Mar 25;5(1):270.(Corresponding author，IF=6.548) 2.Zhang B, Zhang J, Liu G, Guo X, Liu X, Chen J. KDM3A Inhibition Ameliorates Hyperglycemia-Mediated Myocardial Injury by Epigenetic Modulation of Nuclear Factor Kappa-B/P65. Front Cardiovasc Med. 2022 Apr 29;9:870999. (Corresponding author，IF=5.846) 3.Liu X, Chen J, Liu G, Zhang B, Jin X, Wang Y. MicroRNA-17-5p, a novel endothelial cell modulator, controls vascular re-endothelialization and neointimal lesion formation. Vascular. 2021 Dec 27:17085381211067672. (Corresponding author，IF=1.105) 4.Huang B, Xu C, Liu H, Deng W, Yang Z, Wan J, Yan H, Cao G, Chen J, Jiang H. In-Hospital Management and Outcomes of Acute Myocardial Infarction Before and During the Coronavirus Disease 2019 Pandemic. J Cardiovasc Pharmacol. 2020 Nov;76(5):540-548.(Co-corresponding author，IF=3.271) 5.Liu X, Zhou J, Zhang B, Liu G, Hu Q, Chen J. Lysine demethylase 3A is a positive regulator of cardiac myofibroblast transdifferentiation that increases Smad3 phosphorylation following transforming growth factor beta1 stimulation. Mol Biol Rep. 2022 Apr;49(4):3177-3185. (Corresponding author，IF=2.742) 6.Zhang J, Yang J, Xu C, Hu Q, Hu J, Chen J, Jiang H. Down-regulation of Suv39h1 attenuates neointima formation after carotid artery injury in diabetic rats. J Cell Mol Med. 2020; 24(1): 973-983. (Co-corresponding author，IF=4.486) 7.Zhang BF, Jiang H, Chen J, Hu Q, Yang S, Liu XP, Liu G. LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodeling by regulating KDM3A. J Cell Mol Med. 2020; 24(1):1099-1115. (Co-corresponding author，IF=4.486) 8.Zhang BF, Jiang H, Chen J, Hu Q, Yang S, Liu XP. Silica-coated magnetic nanoparticles labeled endothelial progenitor cells alleviate ischemic myocardial injury and improve long-term cardiac function with magnetic field guidance in rats with myocardial infarction. J Cell Physiol. 2019; 234(10): 18544-18559. (Co-corresponding author，IF=5.546) 9.Zhang BF, Jiang H, Chen J, Guo X, Li Y, Hu Q, Yang S. Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway. Int Immunopharmacol. 2019; 73:98-107. (Co-corresponding author，IF=3.943) 5. Zhang BF, Chen J, Jiang H. LncRNA H19 ameliorates myocardial ischemia-reperfusion injury by targeting miR-22-3P. Int J Cardiol. 2019; 278:224. (Co-corresponding author，IF=3.223) 10.Liu X, Chen J, Zhang B, Liu G, Zhao H, Hu Q. KDM3A inhibition modulates macrophage polarization to aggravate post-MI injuries and accelerates adverse ventricular remodeling via an IRF4 signaling pathway. Cell Signal. 2019; 64:109415. (Corresponding author，IF=3.968) 11.Yu G, Chen J, Li S, Pu P, Huang W, Zhao Y, Peng X, Wang R, Lei H. RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo. Life Sci. 2018; 208: 325-332. (co-first author，IF=3.647) 12.Guo X, Hu S, Chen J, Jiang H. JDP2: A novel therapeutic thought in cardiac remodeling. Int J Cardiol. 2018; 257: 229. (Co-corresponding author，IF=3.223) 13. Chen J, Zhang J, Yang J, Xu L, Hu Q, Xu C, Yang S, Jiang H. Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats. Atherosclerosis. 2017; 257:152-163. (IF=3.919) 14.Guo X, Zhang BF, Chen J, Jiang H. DPP-4 inhibition as a therapeutic strategy to ameliorate diabetic metabolic memory. Int J Cardiol. 2017; 247: 40. (Co-corresponding author，IF=3.223) 15. Guo X, Jiang H, Chen J. RP105-PI3K-Akt axis: A potential therapeutic approach for ameliorating myocardial ischemia/reperfusion injury. Int J Cardiol. 2016; 206: 95-96. (Co-corresponding author，IF=3.223) 16. Chen J, Xu L, Hu Q, Yang S, Zhang B, Jiang H. MiR-17-5p as circulating biomarkers for the severity of coronary atherosclerosis in coronary artery disease. Int J Cardiol. 2015; 197: 123-124. (co-first author，IF=3.223) 17. Chen J, Jiang H, Yang J, Chen SS, Xu L. Down-regulation of CREB-binding protein expression blocks thrombin-mediated endothelial activation by inhibiting acetylation of NF-κB. Int J Cardiol. 2012; 154(2): 147-152. (IF=3.223) 18. Chen J, Zhang J, Xu L, Xu C, Chen S, Yang J, Jiang H. Inhibition of neointimal hyperplasia in the rat carotid artery injury model by a HMGB1 inhibitor. Atherosclerosis. 2012; 224(2): 332-339. (co-first author，IF=3.919) 19. Chen J, Wang L, Matyunina LV, Hill CG, McDonald JF. Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. Gynecol Oncol. 2011; 121(1):200-205. (IF=4.623) 20. Guo Xin, Chen Jing, Jiang Hong, Zhang Bo-fang, Hu Qi, and Yang Shuo. Abstract 19689: Kdm3a Protects Myocardium From Ischemia/reperfusion Injury Through Targeting Akt-dependent Signaling Pathways. Circulation. 2017;136:A19689.（American Heart Association，2017，IF=23.603） |
| Name | JING CHEN |
| Date of birth | November，1982 |
| Department | Cardiovascular Department，Renmin Hospital,Wuhan University. |
| Title | Director of Cardiology V Department (Acute Cardiovascular Disease Treatment Center), Chief physician，Associate professor, doctoral tutor |
| 364580342@qq.com | |
| TEL | 027-88041911-88027 or 13659840327 |
| Research Direction |
1.
Vascular and myocardial repair mechanism 2. Interventional cardiology |
| Personal Profile | Major research direction is focused on basic and clinical research on coronary heart disease, repair of vascular injury, mechanism of heart failure. More than 30 SCI papers have been published and Several National Natural Science Foundations of China have been supported by Chinese Government. |
| Selected Publications |
1.Guo
X, Zhang BF, Zhang J, Liu G, Hu Q, Chen J. The histone demthylase KDM3A
protects the myocardium from ischemia/reperfusion injury via promotion of
ETS1 expression. Commun Biol. 2022 Mar 25;5(1):270.(Corresponding author，IF=6.548) 2.Zhang B, Zhang J, Liu G, Guo X, Liu X, Chen J. KDM3A Inhibition Ameliorates Hyperglycemia-Mediated Myocardial Injury by Epigenetic Modulation of Nuclear Factor Kappa-B/P65. Front Cardiovasc Med. 2022 Apr 29;9:870999. (Corresponding author，IF=5.846) 3.Liu X, Chen J, Liu G, Zhang B, Jin X, Wang Y. MicroRNA-17-5p, a novel endothelial cell modulator, controls vascular re-endothelialization and neointimal lesion formation. Vascular. 2021 Dec 27:17085381211067672. (Corresponding author，IF=1.105) 4.Huang B, Xu C, Liu H, Deng W, Yang Z, Wan J, Yan H, Cao G, Chen J, Jiang H. In-Hospital Management and Outcomes of Acute Myocardial Infarction Before and During the Coronavirus Disease 2019 Pandemic. J Cardiovasc Pharmacol. 2020 Nov;76(5):540-548.(Co-corresponding author，IF=3.271) 5.Liu X, Zhou J, Zhang B, Liu G, Hu Q, Chen J. Lysine demethylase 3A is a positive regulator of cardiac myofibroblast transdifferentiation that increases Smad3 phosphorylation following transforming growth factor beta1 stimulation. Mol Biol Rep. 2022 Apr;49(4):3177-3185. (Corresponding author，IF=2.742) 6.Zhang J, Yang J, Xu C, Hu Q, Hu J, Chen J, Jiang H. Down-regulation of Suv39h1 attenuates neointima formation after carotid artery injury in diabetic rats. J Cell Mol Med. 2020; 24(1): 973-983. (Co-corresponding author，IF=4.486) 7.Zhang BF, Jiang H, Chen J, Hu Q, Yang S, Liu XP, Liu G. LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodeling by regulating KDM3A. J Cell Mol Med. 2020; 24(1):1099-1115. (Co-corresponding author，IF=4.486) 8.Zhang BF, Jiang H, Chen J, Hu Q, Yang S, Liu XP. Silica-coated magnetic nanoparticles labeled endothelial progenitor cells alleviate ischemic myocardial injury and improve long-term cardiac function with magnetic field guidance in rats with myocardial infarction. J Cell Physiol. 2019; 234(10): 18544-18559. (Co-corresponding author，IF=5.546) 9.Zhang BF, Jiang H, Chen J, Guo X, Li Y, Hu Q, Yang S. Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway. Int Immunopharmacol. 2019; 73:98-107. (Co-corresponding author，IF=3.943) 5. Zhang BF, Chen J, Jiang H. LncRNA H19 ameliorates myocardial ischemia-reperfusion injury by targeting miR-22-3P. Int J Cardiol. 2019; 278:224. (Co-corresponding author，IF=3.223) 10.Liu X, Chen J, Zhang B, Liu G, Zhao H, Hu Q. KDM3A inhibition modulates macrophage polarization to aggravate post-MI injuries and accelerates adverse ventricular remodeling via an IRF4 signaling pathway. Cell Signal. 2019; 64:109415. (Corresponding author，IF=3.968) 11.Yu G, Chen J, Li S, Pu P, Huang W, Zhao Y, Peng X, Wang R, Lei H. RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo. Life Sci. 2018; 208: 325-332. (co-first author，IF=3.647) 12.Guo X, Hu S, Chen J, Jiang H. JDP2: A novel therapeutic thought in cardiac remodeling. Int J Cardiol. 2018; 257: 229. (Co-corresponding author，IF=3.223) 13. Chen J, Zhang J, Yang J, Xu L, Hu Q, Xu C, Yang S, Jiang H. Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats. Atherosclerosis. 2017; 257:152-163. (IF=3.919) 14.Guo X, Zhang BF, Chen J, Jiang H. DPP-4 inhibition as a therapeutic strategy to ameliorate diabetic metabolic memory. Int J Cardiol. 2017; 247: 40. (Co-corresponding author，IF=3.223) 15. Guo X, Jiang H, Chen J. RP105-PI3K-Akt axis: A potential therapeutic approach for ameliorating myocardial ischemia/reperfusion injury. Int J Cardiol. 2016; 206: 95-96. (Co-corresponding author，IF=3.223) 16. Chen J, Xu L, Hu Q, Yang S, Zhang B, Jiang H. MiR-17-5p as circulating biomarkers for the severity of coronary atherosclerosis in coronary artery disease. Int J Cardiol. 2015; 197: 123-124. (co-first author，IF=3.223) 17. Chen J, Jiang H, Yang J, Chen SS, Xu L. Down-regulation of CREB-binding protein expression blocks thrombin-mediated endothelial activation by inhibiting acetylation of NF-κB. Int J Cardiol. 2012; 154(2): 147-152. (IF=3.223) 18. Chen J, Zhang J, Xu L, Xu C, Chen S, Yang J, Jiang H. Inhibition of neointimal hyperplasia in the rat carotid artery injury model by a HMGB1 inhibitor. Atherosclerosis. 2012; 224(2): 332-339. (co-first author，IF=3.919) 19. Chen J, Wang L, Matyunina LV, Hill CG, McDonald JF. Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. Gynecol Oncol. 2011; 121(1):200-205. (IF=4.623) 20. Guo Xin, Chen Jing, Jiang Hong, Zhang Bo-fang, Hu Qi, and Yang Shuo. Abstract 19689: Kdm3a Protects Myocardium From Ischemia/reperfusion Injury Through Targeting Akt-dependent Signaling Pathways. Circulation. 2017;136:A19689.（American Heart Association，2017，IF=23.603） |
武汉大学人民医院
湖北省人民医院