陈创
普外
科副主任，副主任医师，副教授，硕士生导师
科副主任，副主任医师，副教授，硕士生导师
导师介绍
| 姓名 | 陈创 |
| 出生年月 | 1982年7月 |
| 单位 | 武汉大学人民医院乳腺甲状腺中心 |
| 所属学科 | 临床医学-外科学 |
| 职务、职称及头衔 | 科副主任，副主任医师，副教授，硕士生导师 |
| chenc2469@163.com | |
| 联系方式 | 13476064785 |
| 研究方向 |
1.乳腺癌导管内干预诊疗的基础及临床研究 2.纳米多功能探针成像技术的临床应用基础研究 3.难治性乳腺炎的基础与临床研究 |
| 个人简介 | 主要从事乳腺甲状腺疾病的诊疗与科研工作，美国约翰霍普金斯大学医学院访问学者，武汉大学人民医院第四轮青年重点人才，武汉市中青年医学骨干人才。主持、参与国家级、省部级项目10余项。已发表科研论文90余篇，第一作者及通讯作者SCI论文20余篇，专利2项。已协助培养硕士生10名，博士生6名。目前正在协助培养的博士生4名，硕士生5名。 |
| 学术任职与荣誉 | 中国医师协会外科医师分会乳腺外科医师委员会青年委员,湖北省临床肿瘤学会乳腺癌专家委员会副秘书长、湖北省抗癌协会乳腺癌青年委员会副主任委员，湖北省抗癌协会甲状腺癌青年委员会副主任委员，中国抗癌协会肿瘤标志物专业委员会甲状腺癌标志物协作组委员，武汉医师协会甲乳外科医师分会常务委员 |
| 教育履历 |
2001.09-2006.06武汉大学第二临床学院临床医学专业本科生获学士学位 2006.09-2011.12武汉大学第二临床学院肿瘤学专业硕博连读获博士学位 |
| 工作履历 |
2011.07-2015.12 武汉大学人民医院乳腺甲状腺中心主治医师 2015.06-2016.06 美国约翰霍普金斯大学医学院访问学者 2016.01-至今 武汉大学人民医院乳腺甲状腺中心副教授、副主任医师 |
| 成果获奖 | 2018年湖北省科学技术成果推广三等奖. |
| 代表性论著 |
1.Chen
D#, Chen C#, Huang C, Chen T, Liu Z. Injectable Hydrogel for NIR-II
Photo-Thermal Tumor Therapy and Dihydroartemisinin-Mediated Chemodynamic
Therapy. Front. Chem. 2020, 8:251. doi: 10.3389/fchem.2020.00251 2.Liu JH#, Chen C#, Li ZY, Zou ZM, Gao DC, Zhang X, Kuang XW, Sun ZH, Zheng WJ, Zhou P, Sun SR. The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways. Exp Cell Res, 2020:112157. DOI: 10.1016/j.yexcr.2020.112157. 3.Liu Hanqing#, Yang Dan# , Li Lingrui, Tu Yi , Chen Chuang*, Sun Shengrong*. Appraisal of radioiodine refractory thyroid cancer: advances and challenges. Am J Cancer Res, 2020; in press. 4.Li JJ#, Santa-Maria CA#, Feng HF, Wang LC W, Zhang PC, Xu YB, Tan YY, Liu ZC, Du B, Lan M, Yang QF, Yao F, Tu Y, Sun SR, Li XR*, Chen C*. Patient-reported Outcomes of Patients With Breast Cancer During the COVID-19 Outbreak in the Epicenter of China: A Cross-sectional Survey Study. Clin Breast Cancer, 2020,DOI: 10.1016/j.clbc.2020.06.003. 5.Kuang XW, Liu JH, Sun ZH, Sukumar S, Sun SR, Chen C*. Intraductal Therapy in Breast Cancer: Current Status and Future Prospective. J Mammary Gland Biol Neoplasia, 2020,DOI: 10.1007/s10911-020-09453-4. 6.Downs B, Mercado-Rodriguez C, Cimino-Mathews A, Chen C, Yuan J, Van Den Berg EJ, Cope L, Schmitt F, Tse GM, Ali SZ, Meir-Levi D, Sood R, Li J, Richardson AL, Mosunjac M, Rizzo M, Tulac S, Kocmond K, de Guzman TN, Lai EW, Rhees B, Bates M, Wolff AC, Gabrielson E, Harvey S, Umbricht CB, Visvanathan K, Fackler MJ, Sukumar S. DNA Methylation Markers for Breast Cancer Detection in the Developing World. Clin Cancer Res, 2019,25(21):6357-6367. DOI: 10.1158/1078-0432.CCR-18-3277. 7.Wang G#, Chen C#, Pai P, Korangath P, Sun S, Merino VF, Yuan J, Li S, Nie G, Stearns V, Sukumar S. Intraductal fulvestrant for Therapy of ERα-positive Ductal Carcinoma in Situ (DCIS) of the breast- a Preclinical Study. Carcinogenesis, 2019, 40(7):903-913. DOI: 10.1093/carcin/bgz084. 8.Zhu YY, Chen C*, Li JJ, Sun SR. The prognostic value of quantitative analysis of CCL5 and collagen IV in luminal B (HER2-) subtype breast cancer by quantum-dot-based molecular imaging. Int J Nanomed, 2018, 13:3795-3803. 9.Cao Tian-Ze#, Chen Chuang#, Han Xiu-Hua, Sun Si, Yuan Jing-Ping, Wang Yao-Huai, Li Juan-Juan, Sun Jin-Zhong, Sun Shengrong*. Breast cancer characteristics of Mongolian and disparities of ethnicities among Chinese patients. Int J Clin Exp Med, 2017, 10(3):5046-5053. 10.Song Jun-Long#, Chen Chuang #, Yuan Jing-Ping , Li Juan-Juan, Sun Sheng-Rong(*). Family history of cancer other than breast or ovarian cancer in first-degree relatives is associated with poor breast cancer prognosis. The Breast, 2017, 32: 130-134. 11.Song Jun-Long#, Chen Chuang#, Yuan Jing-Ping, Sun Sheng-Rong*.The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis. Familial Cancer, 2017, 2017,16(3):339-349. 12.Zheng Hongmei, Li Xiang, Chen Chuang, Chen Jian, Sun Jinzhong, Sun Si, Jin Liting, Li Juanjuan, Sun Shengrong*, Wu Xinhong*. Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2Aand prognostic value in triple-negative breast cancer. Int J Nanomed, 11, 5519-5529, 2016. 13.Song Jun-Long#, Chen Chuang#, Yuan Jing-Ping, Sun Sheng-Rong*. Progress in the clinical detection of heterogeneity in breast cancer. Cancer Med, 2016, 5(12):3475-3488. DOI: 10.1002/cam4.943. 14.Cheng YX, Chen GT, Chen C*, Zhang QF, Pan F, Hu M, Li BS. MicroRNA_x001e_200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE. Molecular Medicine Reports, 2016, 13(4): 3139-3146. DOI: 10.3892/mmr.2016.4933. 15.Chen C#, Sun S#, Yuan JP, Wang YH, Cao TZ, Zheng HM, Jiang XQ, Gong YP, Tu Y, Yao F, Hu M, Li JJ, Sun SR, Wei W*. Characteristics of breast cancer in Central China, literature review and comparison with USA. Breast, 2016, 30:208-213. 16.Zheng HM#, Chen C#, Wu XH, Chen J, Sun S, Sun JZ, Wang MW, Sun SR*. Quantum dot-based in situ simultaneous molecular imaging and quantitative analysis of EGFR and collagen IV and identification of their prognostic value in triple-negative breast cancer. Tumour Biol, 2016, 37(2):2509-2518. |
| Name | CHUANG CHEN |
| Date of birth | July, 1982 |
| Department | Department of Breast and Thyroid Surgery, Renmin Hospital, Wuhan University. |
| Title | Deputy director, associate professor, master's tutor |
| chenc2469@163.com | |
| TEL | 13476064785 |
| Research Direction |
1.Intraductal
intervention for breast cancer diagnosis and treatment; 2.Nano multi-function probe based imaging technique for breast cancer diagnosis and treatment; 3.Basic and clinical study for refractory mastitis |
| Personal Profile | He is mainly engaged in the diagnosis and treatment of breast and thyroid diseases, and has been awarded 10 items for the National Natural Science Foundation and provincial science and Technology Department, the Provincial Education Commission and the Provincial Health Department. He has published more than 20 SCI papers published by the first author or corresponding author with more than 100 influencing factors. By now, he has educated 10 masters and 6 doctors. At present, there are 4 doctors and 5 Masters studying with him. |
| Selected Publications |
1.Chen
D#, Chen C#, Huang C, Chen T, Liu Z. Injectable Hydrogel for NIR-II
Photo-Thermal Tumor Therapy and Dihydroartemisinin-Mediated Chemodynamic
Therapy. Front. Chem. 2020, 8:251. doi: 10.3389/fchem.2020.00251 2.Liu JH#, Chen C#, Li ZY, Zou ZM, Gao DC, Zhang X, Kuang XW, Sun ZH, Zheng WJ, Zhou P, Sun SR. The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways. Exp Cell Res, 2020:112157. DOI: 10.1016/j.yexcr.2020.112157. 3.Liu Hanqing#, Yang Dan# , Li Lingrui, Tu Yi , Chen Chuang*, Sun Shengrong*. Appraisal of radioiodine refractory thyroid cancer: advances and challenges. Am J Cancer Res, 2020; in press. 4.Li JJ#, Santa-Maria CA#, Feng HF, Wang LC W, Zhang PC, Xu YB, Tan YY, Liu ZC, Du B, Lan M, Yang QF, Yao F, Tu Y, Sun SR, Li XR*, Chen C*. Patient-reported Outcomes of Patients With Breast Cancer During the COVID-19 Outbreak in the Epicenter of China: A Cross-sectional Survey Study. Clin Breast Cancer, 2020,DOI: 10.1016/j.clbc.2020.06.003. 5.Kuang XW, Liu JH, Sun ZH, Sukumar S, Sun SR, Chen C*. Intraductal Therapy in Breast Cancer: Current Status and Future Prospective. J Mammary Gland Biol Neoplasia, 2020,DOI: 10.1007/s10911-020-09453-4. 6.Downs B, Mercado-Rodriguez C, Cimino-Mathews A, Chen C, Yuan J, Van Den Berg EJ, Cope L, Schmitt F, Tse GM, Ali SZ, Meir-Levi D, Sood R, Li J, Richardson AL, Mosunjac M, Rizzo M, Tulac S, Kocmond K, de Guzman TN, Lai EW, Rhees B, Bates M, Wolff AC, Gabrielson E, Harvey S, Umbricht CB, Visvanathan K, Fackler MJ, Sukumar S. DNA Methylation Markers for Breast Cancer Detection in the Developing World. Clin Cancer Res, 2019,25(21):6357-6367. DOI: 10.1158/1078-0432.CCR-18-3277. 7.Wang G#, Chen C#, Pai P, Korangath P, Sun S, Merino VF, Yuan J, Li S, Nie G, Stearns V, Sukumar S. Intraductal fulvestrant for Therapy of ERα-positive Ductal Carcinoma in Situ (DCIS) of the breast- a Preclinical Study. Carcinogenesis, 2019, 40(7):903-913. DOI: 10.1093/carcin/bgz084. 8.Zhu YY, Chen C*, Li JJ, Sun SR. The prognostic value of quantitative analysis of CCL5 and collagen IV in luminal B (HER2-) subtype breast cancer by quantum-dot-based molecular imaging. Int J Nanomed, 2018, 13:3795-3803. 9.Cao Tian-Ze#, Chen Chuang#, Han Xiu-Hua, Sun Si, Yuan Jing-Ping, Wang Yao-Huai, Li Juan-Juan, Sun Jin-Zhong, Sun Shengrong*. Breast cancer characteristics of Mongolian and disparities of ethnicities among Chinese patients. Int J Clin Exp Med, 2017, 10(3):5046-5053. 10.Song Jun-Long#, Chen Chuang #, Yuan Jing-Ping , Li Juan-Juan, Sun Sheng-Rong(*). Family history of cancer other than breast or ovarian cancer in first-degree relatives is associated with poor breast cancer prognosis. The Breast, 2017, 32: 130-134. 11.Song Jun-Long#, Chen Chuang#, Yuan Jing-Ping, Sun Sheng-Rong*.The association between prognosis of breast cancer and first-degree family history of breast or ovarian cancer: a systematic review and meta-analysis. Familial Cancer, 2017, 2017,16(3):339-349. 12.Zheng Hongmei, Li Xiang, Chen Chuang, Chen Jian, Sun Jinzhong, Sun Si, Jin Liting, Li Juanjuan, Sun Shengrong*, Wu Xinhong*. Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2Aand prognostic value in triple-negative breast cancer. Int J Nanomed, 11, 5519-5529, 2016. 13.Song Jun-Long#, Chen Chuang#, Yuan Jing-Ping, Sun Sheng-Rong*. Progress in the clinical detection of heterogeneity in breast cancer. Cancer Med, 2016, 5(12):3475-3488. DOI: 10.1002/cam4.943. 14.Cheng YX, Chen GT, Chen C*, Zhang QF, Pan F, Hu M, Li BS. MicroRNA_x001e_200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE. Molecular Medicine Reports, 2016, 13(4): 3139-3146. DOI: 10.3892/mmr.2016.4933. 15.Chen C#, Sun S#, Yuan JP, Wang YH, Cao TZ, Zheng HM, Jiang XQ, Gong YP, Tu Y, Yao F, Hu M, Li JJ, Sun SR, Wei W*. Characteristics of breast cancer in Central China, literature review and comparison with USA. Breast, 2016, 30:208-213. 16.Zheng HM#, Chen C#, Wu XH, Chen J, Sun S, Sun JZ, Wang MW, Sun SR*. Quantum dot-based in situ simultaneous molecular imaging and quantitative analysis of EGFR and collagen IV and identification of their prognostic value in triple-negative breast cancer. Tumour Biol, 2016, 37(2):2509-2518. |
武汉大学人民医院
湖北省人民医院