李艳
检验
学科带头人，实验诊断学教研室，基地主任，三级教授，一级主任技师，博士生导师
学科带头人，实验诊断学教研室，基地主任，三级教授，一级主任技师，博士生导师
导师介绍
| 姓名 | 李艳 |
| 出生年月 | 1961年2月 |
| 单位 | 武汉大学人民医院检验科 |
| 所属学科 | 临床检验诊断学 |
| 职务、职称及头衔 | 学科带头人，实验诊断学教研室，基地主任，三级教授，一级主任技师，博士生导师 |
| yanlitf1120@163.com | |
| 联系方式 | 13886079252 |
| 研究方向 | “神经-内分泌-炎症”网络在冠心病发生机制中的研究 |
| 个人简介 | 从事临床检验工作40余年，在心血管疾病与激素平衡调节以及个体化医疗临床分子诊断等方面的研究与临床应用上取得一定的进展。主持国家自然科学基金、国家重大技术专项等国家及省部级课题15项，获湖北省科技发明奖二等奖1项，科技进步奖二等奖2项，三等奖4项，获国家专利16项，在《Cell Host Microbe》，《Small》等国内外重要刊物上以第一作者（或通讯作者）发表相关论文435余篇，其中中华牌期刊53篇，SCI收录84篇。培养博士后2名，博士研究生21人，硕士研究生37人。 |
| 学术任职与荣誉 | 中国老年保健医学研究会检验分会副主任委员；中国医师协会检验分会常委暨血液肿瘤个体化诊断检验医学专家委员会主任委员；中国医院管理学会临床检验管理专业委员会常委；教育部高等学校医学技术类教学指导委员会委员；《中华检验医学杂志》副总编；《微循环学杂志》主编 |
| 教育履历 |
1983.09-1989.06武汉大学医学部（原湖北医科大学）获学士学位 1996.03-1998.03日本国金沢大学获硕士学位 2001.09-2004.06武汉大学第一临床学院获博士学位 |
| 工作履历 |
1981.07-1985.06 原湖北医学院附属第一医院 中心实验室技师 1985.06-1994.10 原湖北医科大学附属第一医院 检验科技师/主管技师 1994.10-1995.10 日本国东京大学医科学研究所 访问学者 1998.03—至今 武汉大学人民医院检验科任检验科主任、副主任技师（1998）、主任技师（2001）、硕士生导师（2001年）、博士生导师（2004） |
| 成果获奖 |
1.《白血病精准医疗中分子诊断技术的研发与临床应用》2018年获得湖北省科技发明奖二等奖 2.《基于Sanger测序的个体化医疗临床分子诊断试剂盒的研制》2016年获得湖北省科技进步奖二等奖 3.《分子诊断技术快速检测临床常见病原菌及耐药基因的临床应用》2011年获得湖北省科技进步奖二等奖 4.《全细胞荧光原位杂交法快速检测B型链球菌方法的建立及其在临床中的应用》2008年获得湖北省科技进步奖三等奖 5.《冠心病新危险因子白细胞介素-1家族基因型的研究》2004年获得湖北省科技进步奖三等奖 6.《雌激素受体基因多态性与心血管疾病关系的研究》2002年获得湖北省科技进步奖三等奖 |
| 代表性论著 |
1.
Li D, Liu R, Wang M, et al. 3β-Hydroxysteroid dehydrogenase expressed by gut
microbes degrades testosterone and is linked to depression in males. Cell
Host Microbe. 2022;30(3):329-339.e5. doi:10.1016/j.chom.2022.01.001 2. Liu H , Huang Y , Lyu Y , et al. GDF15 as a biomarker of ageing[J]. Experimental Gerontology, 2021, 146(Suppl. 1):111228. 3. Li D , Wu Q , Tong Y , et al. Dietary beta-carotene intake is inversely associated with anxiety in US midlife women[J]. Journal of Affective Disorders, 2021, 287. 4. Wang M, Fu A, Hu B, et al. Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS-CoV-2 and Other Respiratory Viruses. Small. 2020;16(32):e2002169. 5.Li D, Zheng H, Tong Y, Li Y*. Prospective association between trans fatty acid intake and depressive symptoms: Results from the study of women's health across the nation. J Affect Disord. 2020;264:256–262. 6.Li D, Liang H, Tong Y, Zheng H, Li Y*. Association between saturated fatty acid intake and depressive symptoms in midlife women: A prospective study. J Affect Disord. 2020;267:17–22. 7.Le J, Sun T, Peng R, Li Y*, et al. LC-MS/MS determination of plasma catecholamines after selective extraction by borated zirconia. Mikrochim Acta. 2020;187(3):165. Published 2020 Feb 12. doi:10.1007/s00604-020-4145-7 8.Yuan TF, Le J, Wang ST, Li Y*. An LC-MS/MS method to analyze the steroid metabolome with high accuracy and from small serum samples [published online ahead of print, 2020 Jan 21]. J Lipid Res. 2020;jlr.D119000591. doi:10.1194/jlr.D119000591 9.Li J, Li C, Cai X, Li Y*, et al. Performance of modified carbapenem inactivation method and inhibitor-based combined disk test in the detection and distinguishing of carbapenemase producing Enterobacteriaceae. Ann Transl Med. 2019;7(20):566. doi:10.21037/atm.2019.09.43 10.Le J, Yuan TF, Geng JQ, Wang ST, Li Y*, Zhang BH. Acylation derivatization based LC-MS analysis of 25-hydroxyvitamin D from finger-prick blood. J Lipid Res. 2019 May;60(5):1058-1064. 11.Xu W, Tong Y, Li Y*. Comparison of Roche Elecsys and Sysmex HISCL immunoassays for the screening of common blood-borne pathogens. Ann Transl Med. 2019;7(14):300. doi:10.21037/atm.2019.05.83 12.Huang Y, Dai W, Yan L*. Potential associations of testosterone/estradiol ratio, leukocyte hTERT expression and PBMC telomerase activity with aging and the presence of coronary artery disease in men [J]. Exp Gerontol. 2019 Mar;117:38-44. 13.Liu H, Dai W, Cui Y, Lyu Y, Yan L*. Potential associations of circulating growth differentiation factor-15 with sex hormones in male patients with coronary artery disease [J]. Biomed Pharmacother. 2019 Mar 22;114:108792. 14.Liu H, Lyu Y, Li D, Cui Y, Huang Y, Dai W, Yan L*. Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease [J]. Cardiovasc Diabetol. 2019 Feb 28;18(1):21. 15.Yuan TF, Le J, Cui Y, Peng R, Wang ST, Yan L*. An LC-MS/MS analysis for seven sex hormones in serum [J]. J Pharm Biomed Anal. 2019 Jan 5;162:34-40. 16.Huang Y, Dai W, Li Y*. Potential associations of testosterone/estradiol ratio, leukocyte hTERT expression and PBMC telomerase activity with aging and the presence of coronary artery disease in men. Exp Gerontol. 2019;117:38–44. doi:10.1016/j.exger.2018.08.008 17.Wu W, Nie L, Zhang L, Li Y*. The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells. Cell Mol Biol Lett. 2018;23:37. Published 2018 Aug 9. doi:10.1186/s11658-018-0102-4 18.Peng R, Dai W, Yan L*. High serum levels of tenascin-C are associated with suicide attempts in depressed patients [J]. Psychiatry Res. 2018 Oct;268:60-64. 19.Le J, Yuan TF, Zhang Y, Wang ST, Yan L*. New LC-MS/MS method with single-step pretreatment analyzes fat-soluble vitamins in plasma and amniotic fluid [J]. J Lipid Res. 2018 Sep;59(9):1783-1790. 20.Peng R, Dai W, Yan L*. Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt [J]. Psychiatry Res. 2018 Aug;266:111-115. |
| Name | Li Yan |
| Date of birth | Feb. 1961 |
| Department | Laboratory Department, Renmin Hospital, Wuhan University |
| Title | Director, Professor, doctoral tutor |
| yanlitf1120@163.com | |
| TEL | 13886079252 |
| Research Direction | Nuro-Endro-Inflammation network in the development of cardiovascular disease |
| Personal Profile | She has been engaged in clinical laboratory work for more than 40 years, and has made some progress in the research and clinical application of cardiovascular diseases, hormone balance regulation and individualized medical molecular diagnosis. She presided over 15 national and provincial-level projects such as the National Natural Science Foundation and major national technology projects, won one second-class award of Hubei Science and Technology Invention Award, two second-class awards of Science and Technology Progress Award, four third-class awards, and won 16 national patents. He published more than 400 related papers by the first author (or correspondent author) in important domestic and foreign journals，such as《Cell Host Microbe》and《Small》. Among them, there are 53 Chinese Brand journals and 84 SCI journals. By now, she has educated 2 postdoctoral students, 21 doctoral students and 37 Master Students. |
| Selected Publications |
1.
Li D, Liu R, Wang M, et al. 3β-Hydroxysteroid dehydrogenase expressed by gut
microbes degrades testosterone and is linked to depression in males. Cell
Host Microbe. 2022;30(3):329-339.e5. doi:10.1016/j.chom.2022.01.001 2. Liu H , Huang Y , Lyu Y , et al. GDF15 as a biomarker of ageing[J]. Experimental Gerontology, 2021, 146(Suppl. 1):111228. 3. Li D , Wu Q , Tong Y , et al. Dietary beta-carotene intake is inversely associated with anxiety in US midlife women[J]. Journal of Affective Disorders, 2021, 287. 4. Wang M, Fu A, Hu B, et al. Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS-CoV-2 and Other Respiratory Viruses. Small. 2020;16(32):e2002169. 5.Li D, Zheng H, Tong Y, Li Y*. Prospective association between trans fatty acid intake and depressive symptoms: Results from the study of women's health across the nation. J Affect Disord. 2020;264:256–262. 6.Li D, Liang H, Tong Y, Zheng H, Li Y*. Association between saturated fatty acid intake and depressive symptoms in midlife women: A prospective study. J Affect Disord. 2020;267:17–22. 7.Le J, Sun T, Peng R, Li Y*, et al. LC-MS/MS determination of plasma catecholamines after selective extraction by borated zirconia. Mikrochim Acta. 2020;187(3):165. Published 2020 Feb 12. doi:10.1007/s00604-020-4145-7 8.Yuan TF, Le J, Wang ST, Li Y*. An LC-MS/MS method to analyze the steroid metabolome with high accuracy and from small serum samples [published online ahead of print, 2020 Jan 21]. J Lipid Res. 2020;jlr.D119000591. doi:10.1194/jlr.D119000591 9.Li J, Li C, Cai X, Li Y*, et al. Performance of modified carbapenem inactivation method and inhibitor-based combined disk test in the detection and distinguishing of carbapenemase producing Enterobacteriaceae. Ann Transl Med. 2019;7(20):566. doi:10.21037/atm.2019.09.43 10.Le J, Yuan TF, Geng JQ, Wang ST, Li Y*, Zhang BH. Acylation derivatization based LC-MS analysis of 25-hydroxyvitamin D from finger-prick blood. J Lipid Res. 2019 May;60(5):1058-1064. 11.Xu W, Tong Y, Li Y*. Comparison of Roche Elecsys and Sysmex HISCL immunoassays for the screening of common blood-borne pathogens. Ann Transl Med. 2019;7(14):300. doi:10.21037/atm.2019.05.83 12.Huang Y, Dai W, Yan L*. Potential associations of testosterone/estradiol ratio, leukocyte hTERT expression and PBMC telomerase activity with aging and the presence of coronary artery disease in men [J]. Exp Gerontol. 2019 Mar;117:38-44. 13.Liu H, Dai W, Cui Y, Lyu Y, Yan L*. Potential associations of circulating growth differentiation factor-15 with sex hormones in male patients with coronary artery disease [J]. Biomed Pharmacother. 2019 Mar 22;114:108792. 14.Liu H, Lyu Y, Li D, Cui Y, Huang Y, Dai W, Yan L*. Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease [J]. Cardiovasc Diabetol. 2019 Feb 28;18(1):21. 15.Yuan TF, Le J, Cui Y, Peng R, Wang ST, Yan L*. An LC-MS/MS analysis for seven sex hormones in serum [J]. J Pharm Biomed Anal. 2019 Jan 5;162:34-40. 16.Huang Y, Dai W, Li Y*. Potential associations of testosterone/estradiol ratio, leukocyte hTERT expression and PBMC telomerase activity with aging and the presence of coronary artery disease in men. Exp Gerontol. 2019;117:38–44. doi:10.1016/j.exger.2018.08.008 17.Wu W, Nie L, Zhang L, Li Y*. The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells. Cell Mol Biol Lett. 2018;23:37. Published 2018 Aug 9. doi:10.1186/s11658-018-0102-4 18.Peng R, Dai W, Yan L*. High serum levels of tenascin-C are associated with suicide attempts in depressed patients [J]. Psychiatry Res. 2018 Oct;268:60-64. 19.Le J, Yuan TF, Zhang Y, Wang ST, Yan L*. New LC-MS/MS method with single-step pretreatment analyzes fat-soluble vitamins in plasma and amniotic fluid [J]. J Lipid Res. 2018 Sep;59(9):1783-1790. 20.Peng R, Dai W, Yan L*. Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt [J]. Psychiatry Res. 2018 Aug;266:111-115. |
武汉大学人民医院
湖北省人民医院