姓名：易伟
出生年月：1973年9月
单位：武汉大学人民医院神经外科
职务、职称：主任、副教授、硕士生导师
邮箱：yiwtj@hotmail.com
联系电话：027-88041911转82079 或15377591717
研究方向：
1.脑胶质瘤的靶向治疗与分子机制：脑胶质瘤是中枢神经系统最常见的恶性肿瘤，针对胶质瘤的分子发病机制进行多靶点、多信号的靶向治疗为抗脑胶质瘤治疗提供了方向。多亮氨酸重复区免疫球蛋白样蛋白1（LRIG1）是近年发现的一种具有多受体酪氨酸激酶（RTK）抑制活性的人类细胞表面跨膜蛋白，针对LRIG1，LRIG1的胞外段（sLRIG1）以及小分子sLRIG1展开研究或许将获得脑胶质瘤靶向治疗的突破口。
个人简介：
从事神经外科疾病的临床诊治和科研工作。擅长神经外科脑肿瘤、脑神经功能相关疾病的治疗，尤其在脑胶质瘤、三叉神经痛、痉挛性斜颈、深部脑电刺激（DBS）等方面有独到见解。获2项国家自然科学基金、瑞典Lion基金、Swedish Institute、教育部博士点新教师基金、中瑞国际合作等多项基金资助，国际上首次发现LRIG1的多种生物功能及机制，发表SCI、中华等论文30余篇。任《Journal of Neurosurgical Sciences》、《British Journal of Medicine and Medical Research》、《中华实验外科杂志》等多个杂志审稿专家。
学术职务：
武汉医师协会神经外科医师协会功能神经外科学组副主任委员
中华医学会武汉市神经外科学会委员
海归医协脑血管病专业委员会委员
教育履历：
1990.09-1995.06 江西省赣南医学院临床医学专业本科生 获学士学位
1999.09-2002.07 华中科技大学同济医学院附属同济医院神经外科硕士研究生 获硕士学位
2002.09-2005.07 华中科技大学同济医学院附属同济医院神经外科博士研究生 获博士学位
2005.09-2007.08 瑞典Umea大学医院肿瘤科和神经外科 博士后研究
2008.08-2008.09 瑞典Umea大学医院肿瘤科和神经外科 访问学者
工作履历：
1995.07-1999.09 江西省赣州地区卫校病理科 助理教师
2005.9-2007.8 瑞典Umea大学医院神经外科和肿瘤科 博士后
2007.8至今 武汉大学人民医院神经外科 主治医师、副主任医师、副教授、主任医师
成果获奖：
1. 《人脑胶质瘤精准外科手术治疗及其相关发病机制》2017年湖北省科技进步一等奖
代表性论著：
1．Xiqun Zhu, Yong Han, Jing Du, Renzhong Liu, Ketao Jin, Wei Yi. Microbiota-gut-brain axis and the central nervous system. Oncotarget. 2017, 8(32): 53829-53838.
2．Zhihong Jian, Shuai Ding, Hongping Deng, Jun Wang, Wei Yi, Lei Wang, Shengmei Zhu, Lijuan Gu, Xiaoxing Xiong. Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity. Brain Research. 2016, 1643:123-129.
3．Hao Ding, Zhihong Jian, Creed M. Stary, Wei Yi and Xiaoxing Xiong. Molecular Pathogenesis of Anti-NMDAR Encephalitis. BioMed Research International. 2015, 2015:643409.
4．Wei Yi, Haitao Xu, Daofeng Tian, Liquan Wu, Shenqi Zhang, Long Wang, Baowei Ji, Xiaonan Zhu, Humphrey Okechi, Gang Liu, Qianxue Chen. Photodynamic therapy mediated by 5-aminolevulinic acid suppresses gliomas growth by decreasing the microvessels. J Huazhong Univ Sci Technol [Med Sci]. 2015, 35(2):259-264.
5．Hao Ding, Wei Liu, Xinyuan Yu, Lei Wang, Lingmin Shao, Wei Yi. Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis. Int J Clin Exp Med. 2014, 7(11): 3904-3914.
6．Wei Yi, Lin Liu, Okechi Humphrey, Qianxue Chen, Shulan Huang. Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domains (LRIG1) relates to antioxidant enzymes in human ependymoma and oligodendroglioma. Neural Regeneration Research. 2011, 6(11):860-864.
7．Wei Yi, Camilla Holmlund, Jonas Nilsson, Shigeki Inui, Ting Lei, Satoshi Itami, Roger Henriksson, Hakan Hedman. Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1. Experimental Cell Research. 2011, 317(4):504-512.
8．Wei Yi, Renzhong Liu, Jian Chen, Shengzhong Tao, Okechi Humphrey, A Tommy Bergenheim. Trauma Infant Neurologic Score Predicts the Outcome of Traumatic Brain Injury in Infants. Pediatr Neurosurg. 2010, 46:259-266.
9．Wei Yi, Hannu Haapasalo, Camilla Holmlund, Olayinka Raheem, Hakan Hedman, Roger Henriksson. Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age. Clin Neuropath. 2009,28(1),21-27.
10．Wei Yi, Kjell Ohman, Thomas Brannstrom, A Tommy Bergenheim. Percutaneous biopsy of cavernous sinus tumour via the foramen ovale. Acta Neurochir (Wien). 2009, 151(4), 401-407.
11．Camilla Holmlund, Hannu Haapasalo, Wei Yi, Olayinka Raheem, Helena Bragge, Roger Henriksson, and Hakan Hedman. Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival. Neuropathology. 2008, 10, 1440-1789.
12．朱锡群,易伟.硬脑膜动静脉瘘临床表现与治疗策略.疑难病杂志,2017,16(4):411-414.
13．朱锡群,简志宏,刘宝辉,易伟.多亮氨酸重复区免疫球蛋白样蛋白1对U251胶质瘤细胞基因表达的影响.医学研究杂志,45(12):24-26,2016.
14．周志伟,易伟,刘仁忠.桥脑海绵状血管瘤的显微外科治疗.中国临床神经外科杂志, 21(7): 398-400, 2016.
15．刘伟,简志宏,易伟.sLRIG1与脑胶质瘤耐药细胞株化疗敏感性的关系.中国临床神经外科杂志, 21(8): 476-478, 2016.
16．刘伟,易伟.LRIG1在人脑胶质瘤中作用的研究进展.中国临床神经外科杂志2016-12-25.
17．周志伟,易伟,吴英亮.溶瘤病毒治疗恶性胶质瘤的研究进展.国际神经病学神经外科学杂志,42(5):450-454,2015.
18．丁昊,周志伟,易伟,雷霆,简志宏,刘仁忠. LRIG1相关功能片段对EGFR活性和胶质瘤细胞增殖的影响.中国临床神经外科杂志,20(9):544-546,2015.
19．朱锡群,易伟,熊晓星.巨噬细胞和缺血性脑卒中.国际神经病学神经外科学杂志,42(4):362-365,2015.
20．余信远,易伟,刘仁忠,简志宏,冯艳萍.海绵窦海绵状血管瘤的临床诊断及显微外科治疗.华中科技大学学报(医学版),44(02):226-228,234,2015.
Name：WEI YI
Date of birth：Sep，1973
Department：Department of Neurosurgery，Renmin Hospital, Wuhan University.
Title：Director, Vice-professor, postgraduate tutor
Email：yiwtj@hotmail.com
TEL：027-88041911-82076 or 15377591717
Research Direction：
1. Molecular target treatment for human glioma：Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a recently discovered negative endogenous regulator for multiple receptor tyrosine kinases (RTK). LRIG1 and its extracellular part of LRIG1 (also soluble LRIG1, so called sLRIG1) have been found to inhibit cell proliferation, negate multiple RTK signals, and sensitize chemotherapy in human gliomas. Research on LRIG1, sLRIG1 and their small fragment may be useful for target therapeutics for human gliomas.
Personal Profile:
He is mainly engaged in the diagnosis and treatment of neurosurgical diseases. He has obtained two research grants from the National Natural Science Foundation. He has published above 30 international papers and most are on Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) and human glioma. He also partly works as reviews for Journal of Neurosurgical Sciences, British Journal of Medicine and Medical Research and some Chinese journals like the Journal of Chinese Experimental Surgery.
Selected Publications:
1．Xiqun Zhu, Yong Han, Jing Du, Renzhong Liu, Ketao Jin, Wei Yi. Microbiota-gut-brain axis and the central nervous system. Oncotarget. 2017, 8(32): 53829-53838.
2．Zhihong Jian, Shuai Ding, Hongping Deng, Jun Wang, Wei Yi, Lei Wang, Shengmei Zhu, Lijuan Gu, Xiaoxing Xiong. Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity. Brain Research. 2016, 1643:123-129.
3．Hao Ding, Zhihong Jian, Creed M. Stary, Wei Yi and Xiaoxing Xiong. Molecular Pathogenesis of Anti-NMDAR Encephalitis. BioMed Research International. 2015, 2015:643409.
4．Wei Yi, Haitao Xu, Daofeng Tian, Liquan Wu, Shenqi Zhang, Long Wang, Baowei Ji, Xiaonan Zhu, Humphrey Okechi, Gang Liu, Qianxue Chen. Photodynamic therapy mediated by 5-aminolevulinic acid suppresses gliomas growth by decreasing the microvessels. J Huazhong Univ Sci Technol [Med Sci]. 2015, 35(2):259-264.
5．Hao Ding, Wei Liu, Xinyuan Yu, Lei Wang, Lingmin Shao, Wei Yi. Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis. Int J Clin Exp Med. 2014, 7(11): 3904-3914.
6．Wei Yi, Lin Liu, Okechi Humphrey, Qianxue Chen, Shulan Huang. Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domains (LRIG1) relates to antioxidant enzymes in human ependymoma and oligodendroglioma. Neural Regeneration Research. 2011, 6(11):860-864.
7．Wei Yi, Camilla Holmlund, Jonas Nilsson, Shigeki Inui, Ting Lei, Satoshi Itami, Roger Henriksson, Hakan Hedman. Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1. Experimental Cell Research. 2011, 317(4):504-512.
8．Wei Yi, Renzhong Liu, Jian Chen, Shengzhong Tao, Okechi Humphrey, A Tommy Bergenheim. Trauma Infant Neurologic Score Predicts the Outcome of Traumatic Brain Injury in Infants. Pediatr Neurosurg. 2010, 46:259-266.
9．Wei Yi, Hannu Haapasalo, Camilla Holmlund, Olayinka Raheem, Hakan Hedman, Roger Henriksson. Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age. Clin Neuropath. 2009,28(1),21-27.
10．Wei Yi, Kjell Ohman, Thomas Brannstrom, A Tommy Bergenheim. Percutaneous biopsy of cavernous sinus tumour via the foramen ovale. Acta Neurochir (Wien). 2009, 151(4), 401-407.
11．Camilla Holmlund, Hannu Haapasalo, Wei Yi, Olayinka Raheem, Helena Bragge, Roger Henriksson, and Hakan Hedman. Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival. Neuropathology. 2008, 10, 1440-1789.
武汉大学人民医院
湖北省人民医院