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  • 陈明锴 消化
    消化内Ⅱ科主任、消化内科与感染科分党委党总支副书记、二级主任医师、教授、博士生导师
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    导师介绍

    姓名 陈明锴
    出生年月 1974年3月
    单位 武汉大学人民医院消化内科
    所属学科 临床医学-内科学
    职务、职称及头衔 消化内Ⅱ科主任、消化内科与感染科分党委党总支副书记、二级主任医师、教授、博士生导师
    E-mail kaimingchen@163.com
    联系方式 027-88041911转81396或13720330580
    研究方向 1.多种原因所致肝硬化门脉高压食管胃底静脉曲张的内镜下治疗,门脉高压的介入诊疗;
    2.胃肠道肿瘤的早期诊断与治疗;
    3.消化系统疾病的人工智能诊疗;
    4.胃肠动力学与离子通道
    个人简介
    主要从事肝硬化门脉高压内镜介入治疗与临床研究,创新性的提出超声内镜下弹簧圈置入的治疗方式,作为主要负责人建立了食管胃静脉曲张的MDT团队;主持(或承担)国家自然科学基金3项、省卫计委项目1项、省科技厅项目1项、省自然科学基金2项目、武大自主青年项目1项、市晨光计划1项、医学部种子基金1项、主编《微生物油脂发酵与加工技术》,以第一作者或通讯作者发表SCI10余篇,在《中华消化内镜杂志》、《中华实验外科学杂志》、《中华消化杂志》等以第一作者或通讯作者发表论文70余篇,已培养研究生30名,目前正在培养博士研究生1名,硕士研究生8名。
    学术任职与荣誉
    1.学术任职:中华医学会肝病学分会肝病相关消化疾病协作组委员;北京健康促进会第一届超级微创专业委员会副主任委员;海峡两岸医药卫生交流协会消化内镜学分会第一届消化道出血学组副组长;中国抗癌协会肿瘤内镜学专业委员会第一届消化道癌前病变内镜诊治学组委员;中国医药教育协会消化内镜专业委员会常务委员;中华医学会消化内镜学分会第八届委员会食管胃静脉曲张内镜诊断与治疗学组委员;中华医学会消化内镜学分会第八届委员会微创减重治疗协助组委员;中华医学会消化病学分会第十一届委员会微创介入协作组委员;国家消化道早癌防治中心联盟理事;湖北省医学会消化内镜分会第七届委员会常务委员兼湖北省消化内镜分会静脉曲张和内痔学组组长;湖北省医师协会微无创医学专业委员会第一届委员会常务委员;湖北省消化内镜质量控制中心委员;中华消化内镜杂志、世界华人消化杂志、中国医药导报杂志等杂志编委;GUT中文版青年编委;The Lancet Gastroenterology & Hepatology、Didestion、Endoscopy、Regulatory peptides、Digestive Diseases、Transboundary and Emerging Diseases、中华消化内镜杂志、欧洲胃肠病与肝病、武汉大学学报(医学版)、临床肝病杂志等杂志审稿专家。
    2.荣誉:武汉大学人民医院医疗名家;武汉大学人民医院“突出贡献核心人才奖”;武汉大学人民医院优秀共产党称号;武汉大学优秀研究生导师;武汉大学人民医院医德医风先进个人;武汉大学人民医院“先进工作者”;江苏消化内镜2022年突出贡献奖;胃肠道肿瘤转移和化疗耐药的分子生物学特征及临床应用获2017年湖北省科学技术进步二等奖;微生物油脂生产关键技术及产业化获2105年中国粮油学会科学技术一等奖;微生物油脂加工关键技术与产业化应用获2014年湖北省科技进步一等奖;2017年第二届中国中日ESD高峰论坛手术视频大赛二等奖;2016年第16届全国消化年会手术视频比赛一等奖;2015年消化内镜手术视频甄选西区总决赛二等奖;2014年第5届全国食管胃静脉曲张年会手术视频比赛一等奖。
    教育履历
    1991.09-1996.06湖北医科大学临床医学专业本科生获学士学位
    1997.09-1999.06武汉大学第一临床学院内科学硕士研究生获硕士学位
    1999.09-2002.06武汉大学第一临床学院内科学博士研究生获博士学位
    工作履历
    1996.06-1997.06湖北省中医学院附属医院住院医师
    2002.06-2004.06武汉大学人民医院消化内科主治医师
    2004.06-2009.06武汉大学人民医院消化内科副教授、副主任医师
    2006.06至今武汉大学人民医院消化内科硕士生导师
    2009.06至今武汉大学人民医院消化内科主任医师
    2010.06至今武汉大学人民医院教授
    2021.06至今武汉大学人民医院博士生导师
    2023.07至今 武汉大学人民医院消化内Ⅱ科主任
    2013、2014年、2015年、2019年作为访问学者分别赴德国、美国、奥地利、意大利、日本学习
    成果获奖
    1.专利:陈明锴,肖勇,安萍,蔡江,一种基于光纤传感器的内科用消化道测压装置(2012,中国,CN201220057311.8);陈明锴,肖勇,高鹏,一种消化道取异物导管装置(2020,中国,ZL202020184632.9)
    2.《微生物油脂加工关键技术与产业化应用》2014年获湖北省科技进步奖一等奖
    3.《微生物油脂生产关键技术及产业化项目》2015年获中国粮油学会科学技术奖一等奖
    4.《胃肠道肿瘤转移和化疗耐药的分子生物学特征及临床应用》2017年获湖北省人民政府科技进步贰等奖
    5.主编专著:《微生物油脂发酵与加工技术》(何东平,陈明锴,闫子鹏主编2016,北京,中国亲工业出版社)
    代表性论著
    1.Xiao Y, Pan H, She Q, Wang F, Chen M. Prevention of SARS-CoV-2 infection in patients with decompensated cirrhosis. Lancet Gastroenterol Hepatol. 2020;5(6):528-529. ( IF: 35.7,1区)
    2.Chen L, Luo Z, Zhao C, Li Q, Geng Y, Xiao Y, Chen MK, Li L, Chen ZX, Wu M. Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer. Adv Sci (Weinh). 2022 Aug;9(23):e2200536. (IF: 15.1,1区)
    3.Han J, Wang B, Liu W, Wang S, Chen R, Chen M, Fu Z. Declining disease burden of HCC in the United States, 1992-2017: A population-based analysis. Hepatology. 2022 Sep;76(3):576-588. (IF: 13.5,1区)
    4.Chen M, Wang J, Xiao Y, Wu L, Hu S, Chen S, Yi G, Hu W, Xie X, Zhu Y, Chen Y, Yang Y, Yu H. Automated and real-time validation of gastroesophageal varices under esophagogastroduodenoscopy using a deep convolutional neural network: a multicenter retrospective study (with video). Gastrointest Endosc. 2021 Feb;93(2):422-432.e3. ( IF: 7.7,1区)
    5.Liu Y, Chen M. Letter: association between medication use and microscopic colitis-selection of controls matters. Aliment Pharmacol Ther. 2021;54(10):1363. ( IF: 7.6,1区)
    6.Liu Y, Chen M. Liver-adipose tissue crosstalk in nonalcoholic fatty liver disease: the emerging role of remnant cholesterol.J Hepatol. 2023 Jun 26:S0168-8278(23)00426-9. doi: 10.1016/j.jhep.2023.06.006. Epub ahead of print. PMID: 37380106. (IF: 25.7,1区)
    7.Liu Y, Chen M. Is nonalcoholic fatty liver disease a predictor of treatment response in chronic hepatitis B? J Med Virol. 2023 Mar;95(3):e28654. (IF: 12.7,1区)
    8.Liu Y, Chen M. Letter: association between the risk of microscopic colitis and use of proton pump inhibitors. Aliment Pharmacol Ther. 2021;54(4):526-527. doi:10.1111/apt.16523.( IF: 7.6,1区)
    9.Huang Z, Zhang W, Lv F, Ma L, Xiao Y, Gao S, Zhang M, Wang Y, Li P, Zhao H, Yu H, Cao J, Ke G, Wang Y, Chen M. Efficacy and safety of EUS-guided coil embolization combined with endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration for gastric varices with high-risk ectopic embolism: A multicenter and retrospective cohort study. Endosc Ultrasound. 2023 Jan-Feb;12(1):74-83. (IF:4.5,1区)
    10.Xiao Y, Huang Z, Cao J, Wang Z, Zhang F, Wang Y, Ke G, Liu J, Chen M. Balloon-occluded retrograde transvenous obliteration combined with EUS-guided coil embolization and endoscopic cyanoacrylate injection therapy of gastric varices with huge gastrorenal shunt (with videos). Endosc Ultrasound. 2023 Jan-Feb;12(1):157-159.  (IF:4.5,1区)
    11.Xiao Y, Shi X, She Q, Chen Q, Pan H, Zhang J, Liu X, Wu H, Jin W, Ke G, Liu S, Li J, Zhou J, Wu D, Wang F, Yu H, Chen M. Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study. Virulence. 2020 Dec;11(1):1250-1256. (IF:5.2,2区)
    12.Xiao Y, Wu D, Shi X, Liu S, Hu X, Zhou C, Tian X, Liu H, Long H, Li Z, Wang J, Tan T, Xu Y, Chen B, Liu T, Zhang H, Zheng S, Hu S, Song J, Tang J, Song J, Cheng Z, Xu W, Shen Y, Yu W, Xu Y, Li J, Zhou J, Wang F, Chen M. High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study. Virulence. 2021 Dec;12(1):1199-1208.( IF:5.2,2区)
    13.刘小娇,王政强,马超,郑世华,陈时,黄萍,刘苑斌,肖勇,陈明锴.肝硬化门静脉血栓形成风险预测列线图模型的建立与验证[J].中华消化内镜杂志, 2023,40(1): 47-52.
    14.黄子殷,操寄望,肖勇,汪洋,刘军,陈明锴.内镜超声引导弹簧圈栓塞联合内镜组织胶注射治疗胃底静脉曲张的回顾性研究[J].中华消化内镜杂志,2022,39(05):373-378.
    15.高欣,刘苑斌,肖勇,陈明锴.脾肾或胃肾分流型静脉曲张的临床特征与处置[J].中华消化内镜杂志,2022,39(05):352-357.
    16.张腊英,陈明锴.瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制[J].临床肝胆病杂志,2022,38(01):224-227.
    17.张琎,肖勇,印安宁,曹卓,李娇,刘书中,黄子殷,刘小娇,邬海燕,陈明锴.乳果糖联合聚乙二醇方案对不同风险分层人群肠道准备效果的单中心随机对照研究[J].中华消化内镜杂志,2021,38(12):980-984.
    18.肖勇,刘书中,陈明锴.内痔的内镜下治疗进展[J].临床内科杂志,2021,38(10):659-661.
    19.刘书中,肖勇,李娇,曹卓,罗和生,陈明锴.不同内镜治疗策略对Ⅰ~Ⅲ度内痔疗效的单中心回顾性研究[J].中华消化内镜杂志,2021,38(09):702-706.
    20.张琎,陈明锴.乳果糖在结肠镜检查前肠道准备的应用及研究进展[J].中华消化内镜杂志,2021,38(04):333-336.
    Name Mingkai Chen
    Date of birth March,1974 
    Department Gastroenterology Department,Renmin Hospital,Wuhan University.
    Title Director of GastroenterologyⅡ, Party branch deputy secretary of Gastroenterology department and  Infection  Department, Archiater, Professor, Doctoral supervisor
    Email kaimingchen@163.com
    TEL 027-88041911转81396或13720330580
    Research Direction
    1.Endoscopic therapy of gastroesophageal varices caused by portal hypertension in liver cirrhosis, interventional therapy of portal hypertension.
    2.Early diagnosis and therapy of gastrointestinal tumors.
    3.Artificial intelligence diagnosis and digestive disease.
    4.Gastrointestinal kinetics and ion channels.
    Personal Profile
    He is mainly engaged in the interventional treatment and clinical study of portal hypertension in liver cirrhosis,proposing a novel treatment method for the insertion of spring coil under ultrasonic endoscope and establishing the MDT team of esophageal and gastric varices as the principal responsible persion;chairing (or undertaking)three national natural science funds ,one provincial health and family planning commission project,one project of technology and science of HuBei Province,two provincial natural science funds,one autonomous youth project of Wuhan University,one municipal chenguan plan and one seed fund of the medical department;editing《fermentation and processing technology of microbial grease》,publishing more than 10 sci papers and more than 70 papers have been published in Chinses journal of digestive endoscopy,Chinese journal of experimental surgery and Chinese joural of digestive science as the first author or corresponding author.By now,he has educated 30 masters. At present,there are 1 doctoral student and 8 master students studying with him.
    Selected Publications
    1.Xiao Y, Pan H, She Q, Wang F, Chen M. Prevention of SARS-CoV-2 infection in patients with decompensated cirrhosis. Lancet Gastroenterol Hepatol. 2020;5(6):528-529. ( IF: 35.7,1区)
    2.Chen L, Luo Z, Zhao C, Li Q, Geng Y, Xiao Y, Chen MK, Li L, Chen ZX, Wu M. Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer. Adv Sci (Weinh). 2022 Aug;9(23):e2200536. (IF: 15.1,1区)
    3.Han J, Wang B, Liu W, Wang S, Chen R, Chen M, Fu Z. Declining disease burden of HCC in the United States, 1992-2017: A population-based analysis. Hepatology. 2022 Sep;76(3):576-588. (IF: 13.5,1区)
    4.Chen M, Wang J, Xiao Y, Wu L, Hu S, Chen S, Yi G, Hu W, Xie X, Zhu Y, Chen Y, Yang Y, Yu H. Automated and real-time validation of gastroesophageal varices under esophagogastroduodenoscopy using a deep convolutional neural network: a multicenter retrospective study (with video). Gastrointest Endosc. 2021 Feb;93(2):422-432.e3. ( IF: 7.7,1区)
    5.Liu Y, Chen M. Letter: association between medication use and microscopic colitis-selection of controls matters. Aliment Pharmacol Ther. 2021;54(10):1363. ( IF: 7.6,1区)
    6.Liu Y, Chen M. Liver-adipose tissue crosstalk in nonalcoholic fatty liver disease: the emerging role of remnant cholesterol.J Hepatol. 2023 Jun 26:S0168-8278(23)00426-9. doi: 10.1016/j.jhep.2023.06.006. Epub ahead of print. PMID: 37380106. (IF: 25.7,1区)
    7.Liu Y, Chen M. Is nonalcoholic fatty liver disease a predictor of treatment response in chronic hepatitis B? J Med Virol. 2023 Mar;95(3):e28654. (IF: 12.7,1区)
    8.Liu Y, Chen M. Letter: association between the risk of microscopic colitis and use of proton pump inhibitors. Aliment Pharmacol Ther. 2021;54(4):526-527. doi:10.1111/apt.16523.( IF: 7.6,1区)
    9.Huang Z, Zhang W, Lv F, Ma L, Xiao Y, Gao S, Zhang M, Wang Y, Li P, Zhao H, Yu H, Cao J, Ke G, Wang Y, Chen M. Efficacy and safety of EUS-guided coil embolization combined with endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration for gastric varices with high-risk ectopic embolism: A multicenter and retrospective cohort study. Endosc Ultrasound. 2023 Jan-Feb;12(1):74-83. (IF:4.5,1区)
    10.Xiao Y, Huang Z, Cao J, Wang Z, Zhang F, Wang Y, Ke G, Liu J, Chen M. Balloon-occluded retrograde transvenous obliteration combined with EUS-guided coil embolization and endoscopic cyanoacrylate injection therapy of gastric varices with huge gastrorenal shunt (with videos). Endosc Ultrasound. 2023 Jan-Feb;12(1):157-159.  (IF:4.5,1区)
    11.Xiao Y, Shi X, She Q, Chen Q, Pan H, Zhang J, Liu X, Wu H, Jin W, Ke G, Liu S, Li J, Zhou J, Wu D, Wang F, Yu H, Chen M. Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study. Virulence. 2020 Dec;11(1):1250-1256. (IF:5.2,2区)
    12.Xiao Y, Wu D, Shi X, Liu S, Hu X, Zhou C, Tian X, Liu H, Long H, Li Z, Wang J, Tan T, Xu Y, Chen B, Liu T, Zhang H, Zheng S, Hu S, Song J, Tang J, Song J, Cheng Z, Xu W, Shen Y, Yu W, Xu Y, Li J, Zhou J, Wang F, Chen M. High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study. Virulence. 2021 Dec;12(1):1199-1208.( IF:5.2,2区)
    13.刘小娇,王政强,马超,郑世华,陈时,黄萍,刘苑斌,肖勇,陈明锴.肝硬化门静脉血栓形成风险预测列线图模型的建立与验证[J].中华消化内镜杂志, 2023,40(1): 47-52.
    14.黄子殷,操寄望,肖勇,汪洋,刘军,陈明锴.内镜超声引导弹簧圈栓塞联合内镜组织胶注射治疗胃底静脉曲张的回顾性研究[J].中华消化内镜杂志,2022,39(05):373-378.
    15.高欣,刘苑斌,肖勇,陈明锴.脾肾或胃肾分流型静脉曲张的临床特征与处置[J].中华消化内镜杂志,2022,39(05):352-357.
    16.张腊英,陈明锴.瞬时感受器电位离子通道蛋白V4在肝脏疾病中的作用机制[J].临床肝胆病杂志,2022,38(01):224-227.
    17.张琎,肖勇,印安宁,曹卓,李娇,刘书中,黄子殷,刘小娇,邬海燕,陈明锴.乳果糖联合聚乙二醇方案对不同风险分层人群肠道准备效果的单中心随机对照研究[J].中华消化内镜杂志,2021,38(12):980-984.
    18.肖勇,刘书中,陈明锴.内痔的内镜下治疗进展[J].临床内科杂志,2021,38(10):659-661.
    19.刘书中,肖勇,李娇,曹卓,罗和生,陈明锴.不同内镜治疗策略对Ⅰ~Ⅲ度内痔疗效的单中心回顾性研究[J].中华消化内镜杂志,2021,38(09):702-706.
    20.张琎,陈明锴.乳果糖在结肠镜检查前肠道准备的应用及研究进展[J].中华消化内镜杂志,2021,38(04):333-336.