王晞
心内
教授，主任医师
教授，主任医师
导师介绍
| 姓名 | 王晞 |
| 出生年月 | 1974年9月 |
| 单位 | 武汉大学人民医院心血管内科 |
| 所属学科 | 临床医学-内科学 |
| 职务、职称及头衔 | 教授，主任医师 |
| xiwangwhu@163.com; xi-wang@whu.edu.cn | |
| 联系方式 | 15994207265或027-88041911转88052 |
| 研究方向 |
心电生理与心律失常 |
| 个人简介 | 长期致力于心电生理心律失常研究，在以心脏为靶器官的光遗传技术的运用与研究中有较强优势，发表学术论文80余篇，SCI收录34篇，申请发明专利3项（实审期），获批专利1项，先后任高等教育出版社《内科学》、人民军医出版社电子书包《诊断学》学术秘书，先后主持国家自然科学基金项目1项，省自然科学基金项目3项，教育部留学回国人员科研启动基金项目1项；参与国家重点研发计划、国家重点基础研究发展计划（973计划）1项，卫生部科研卫生公益行业专项1项，省自然科学基金重点项目1项、科技攻关项目、创新群体项目各1项。获国家科技进二等奖1项，湖北省科技进步一等奖4项，教育部科技进步二等奖1项，武汉市科技进步一等奖2项。 |
| 学术任职与荣誉 |
中华医学会心电生理与起搏分会基础研究学组委员 中华医学会心电生理与起搏分会电生理女医师联盟委员 中华医学会心电生理与起搏分会心房颤动工作委员会委员 中华医学会心电生理与起搏分会室性心律失常工作委员会成员 中国医师协会心血管病学专科培训工作委员会秘书 中国中西医结合学会血管脉络病专业委员会青年委员 《医药导报》编委 湖北省实验动物学会理事 |
| 教育履历 |
1992.09-1997.06 同济医科大学（现华中科技大学同济医学院）临床医学专业本科生，获学士学位 1997.09-2002.06 武汉大学第一临床学院内科学硕博士研究生，获博士学位 |
| 工作履历 |
2002.07-2003.07 武汉大学人民医院心血管内科主治医师 2003.08-2004.08 澳大利亚阿德莱得大学生理系访问学者 2014.09-2005.12 武汉大学人民医院心血管内科主治医师 2006.01-2010.11 武汉大学人民医院心血管内科副主任医师，副教授 2010.12-2012.12 武汉大学人民医院心血管内科主任医师，副教授 2013.01-至今 武汉大学人民医院心血管内科主任医师，教授 |
| 成果获奖 |
1.《心律失常结构和神经重构的基础研究与临床防治》2011年国家科技进步二等奖 2.《心房颤动的防治策略研究与推广应用》2014年湖北省科技成果推广一等奖 3.《自主神经与心律失常相关性研究》2010年湖北省科技进步一等奖 4.《心房结构与房性心律失常关系的基础与临床研究》2007年湖北省科技进步一等奖 5.《心房颤动的基础与临床研究》2003年湖北省科技进步一等奖 |
| 代表性论著 |
1.Li
J, Wang L, Lou J, Li H, Rao P, Cheng Y, Wang X, Huang C. Optical capture and
defibrillation in rats with monocrotaline-induced myocardial fibrosis one
year after a single intravenous injection of adeno-associated
virus-channelrhodopsin-2. Heart Rythm,2020（in press） 2.Cheng Y, Li H, Wang L, Li J, Kang W, Rao P, Zhou F, Wang X, Huang C. Optogenetic approaches for termination of ventricular tachyarrhythmias after myocardial infarction in rats in vivo. J Biophotonics. 2020;13(7): e202000003 3.Rao P, Wang L, Cheng Y, Wang X, Li H, Zheng G, Li Z, Jiang C, Zhou Q, Huang C. Near-infrared light driven tissue-penetrating cardiac optogenetics via upconversion nanoparticles in vivo. Biomed Opt Express. 2020;11(3):1401-1416 4.Kang W, Cheng Y, Wang X, Zhou F, Zhou C, Wang L, Zhong L. Neuregulin-1:An underlying protective force of cardiac dysfunction in sepsis.Mol Med Rep. 2020;21(6):2311-2320 5.Pan X, Zhang K, Shen C, Wang X, Wang L, Huang YY. Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats. Chin Med J (Engl), 2020 Aug, 133(15):1786-1797 6.Wang X, Cheng Y. Optical manipulation of perfused mouse heart expressing Channelrhodopsin-2 in rhythm control. Channelrhodopsin: Methods and Protocols. Methods in Molecular Biology（in press） 7.Cheng Y, Li H, Lei H, Jiang C, Rao R, Wang L, Zhou F, Wang X. Flexible and precise control of cardiac rhythm with blue light. Biochem Biophys Res Commun. 2019,514(3):759-764 8.Wang X, Cheng Y, Rao P, Wang L. The optogenetic defibrillation of ventricular arrhythmia in myocardial infarction rats in vivo.Eur Heart J, 40(suppl1):4189 Abstract P6595 9.Wang X, Cheng Y, Rao P, Wang L. Near-Infrared photoactivation via upconversion nanoparticles promotes new advances in cardiac optogenetics toolbox. Eur Heart J, 40(suppl1):2115 Abstract P3504 10.Rao P, Liu Z, Duan H, Dang S, Li H, Zhong L, Wang X, Wang L, Wang X. Pretreatment with neuregulin-1 improves the cardiac electrophysiological properties in a rat model of myocardial infarction. Exp Ther Med.2019, 17(4): 3141-3149 11.Jiang C, Wang X, Dang S, Wang X, Deng Q, Hu J, Huang CX. Chinese Medicine Shensong Yangxin Capsule Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction.Chin J Integr Med. 2019 Jan 9. doi: 10.1007/s11655-018-2578-1. 12.Kang W, Cheng Y, Zhou F, Wang L, Zhong L, Li HT, Wang X, Dang S, Wang X. Neuregulin-1 protects cardiac function in septic rats through multiple targets based on endothelial cells. Int J Mol Med. 2019,44(4): 1255-1266. 13.Wang X , Rao P, Wang L,Cheng Y,Jiang C,Huang C. Cardiac Optogenetics in Intact Rat Heart for Optical Pacing and Defibrillation in Vivo. Circulation,2018, 138(Suppl 1) Abstract14695 14.Jiang C, Li HT, Zhou YM, Wang X, Wang L, Liu ZQ. Cardiac optogenetics: a novel approach to cardiovascular disease therapy. Europace, 2018, 20(11):1741-1749 15.Lai X, Zhong L, Fu HX, Dang S, Wang X, Zhang N, Feng GK, Liu ZQ, Wang X, Wang L. Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model. Neural Regen Res,2017,12(11):1905-1910 16.Wang X, Hu D, Dang S, Huang H, Huang CX, Yuan MJ, Tang YH, Zheng QS, Yin F, Zhang S, Zhang BL, Gao RL, Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes: A Randomized, Double-blind, Multicenter Clinical Trial.. Chin Med J (Engl),2017, 130(14):1639-1647 17.Zhou Q, Pan X, Wang L, Wang X, Xiong D. The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy. Eur J Pharmacol,2016,788:234-240. 18.Wang X, Liu Z, Duan H, Wang L. Therapeutic potential of Neuregulin in cardiovascular system: can we ignore the effects of Neuregulin on electrophysiology? Mini Rev Med Chem,2016,16(11):867-871 19.Hu J, Wang X, Wei SM, Tang YH1, Zhou Q, Huang CX. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Eur J Pharmacol,2016,789:319-27 20.程玥,李剑怡,绕盼盼,刘华芬,王晞.利用光遗传学技术实施终止室性心律失常的实验研究.中国心脏起搏与心电生理研究,2020 21.饶盼盼,王晞,程玥,姜婵,黄从新.可见光起搏心脏的在体实验研究.中国心脏起搏与心电生理研究,2019,33(2):133-137 22.程玥,王晞.光遗传学工具蛋白紫红质通道蛋白-2（channelrhodopsin 2, ChR2）的结构与特性介绍.中国心脏起搏与心电生理研究,2019,33(1):51-54 23.姜婵,王晞,刘自强,饶盼盼,黄从新.利用光遗传学技术实现光起搏的实验研究.中国心脏起搏与心电生理研究,2017,31(3):255-259 24.饶盼盼,王晞. KillerRed在光遗传学中的研究进展.中国心脏起搏与心电生理研究,2017,31(4):283-286 25.姜婵,王晞.光敏蛋白——心电生理研究的新工具.中国心脏起搏与心电生理研究,2016,30(5):381-384 26.刘自强,王晞.光遗传学技术与应用.医学综述,2016,22(14):2270-2274 27.王晞,来欣.光遗传学技术与光起搏-心电生理研究中的新手段.中国心脏起搏与心电生理杂志,2014,28(4):283-285 28.实用新型专利：一种可共享智能药盒系统，专利号201820843740.5，申请人：武汉大学人民医院，发明人：王晞，王龙 29.发明专利（实审阶段）：一种基于上转化发光技术的心脏节律与功能的光控制系统，申请号：201810909121.6，申请人：武汉大学人民医院，发明人：王晞，程玥，王龙，饶盼盼 30.发明专利（实审阶段）：一种可共享智能药盒系统及其应用方法，申请号：201810555854.4，申请人：武汉大学人民医院，发明人：王晞，王龙 31.发明专利（实审阶段）：一种中药组合物在制备抑制心肌梗死后神经重构药物中的应用。申请人：河北以岭医药研究院有限公司，发明人：黄从新，王晞，党松，周家蓬，申请号：201410086105.3 |
| Name | XI WANG |
| Date of birth | September，1974 |
| Department | Cardiovascular Department，Renmin Hospital,Wuhan University. |
| Title | Professor |
| xiwangwhu@163.com; xi-wang@whu.edu.cn | |
| TEL | 15994207265 or 027-88041911-88052 |
| Research Direction |
1.Electrocardio
physiology and arrhythmia 2.Optogenetics and cardiovascular disease |
| Personal Profile | She is mainly engaged in the researches of mechanism and treatment of arrhythmia and has been awarded 1 items for the National Natural Science Foundation, 3 items from the provincial science and Technology Department. She has also involved in “973” Program, projects from Ministry of health or Hubei Province. Besides, there are more than 80 articles published. |
| Selected Publications |
1.Li
J, Wang L, Lou J, Li H, Rao P, Cheng Y, Wang X, Huang C. Optical capture and
defibrillation in rats with monocrotaline-induced myocardial fibrosis one
year after a single intravenous injection of adeno-associated
virus-channelrhodopsin-2. Heart Rythm,2020（in press） 2.Cheng Y, Li H, Wang L, Li J, Kang W, Rao P, Zhou F, Wang X, Huang C. Optogenetic approaches for termination of ventricular tachyarrhythmias after myocardial infarction in rats in vivo. J Biophotonics. 2020;13(7): e202000003 3.Rao P, Wang L, Cheng Y, Wang X, Li H, Zheng G, Li Z, Jiang C, Zhou Q, Huang C. Near-infrared light driven tissue-penetrating cardiac optogenetics via upconversion nanoparticles in vivo. Biomed Opt Express. 2020;11(3):1401-1416 4.Kang W, Cheng Y, Wang X, Zhou F, Zhou C, Wang L, Zhong L. Neuregulin-1:An underlying protective force of cardiac dysfunction in sepsis.Mol Med Rep. 2020;21(6):2311-2320 5.Pan X, Zhang K, Shen C, Wang X, Wang L, Huang YY. Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats. Chin Med J (Engl), 2020 Aug, 133(15):1786-1797 6.Wang X, Cheng Y. Optical manipulation of perfused mouse heart expressing Channelrhodopsin-2 in rhythm control. Channelrhodopsin: Methods and Protocols. Methods in Molecular Biology（in press） 7.Cheng Y, Li H, Lei H, Jiang C, Rao R, Wang L, Zhou F, Wang X. Flexible and precise control of cardiac rhythm with blue light. Biochem Biophys Res Commun. 2019,514(3):759-764 8.Wang X, Cheng Y, Rao P, Wang L. The optogenetic defibrillation of ventricular arrhythmia in myocardial infarction rats in vivo.Eur Heart J, 40(suppl1):4189 Abstract P6595 9.Wang X, Cheng Y, Rao P, Wang L. Near-Infrared photoactivation via upconversion nanoparticles promotes new advances in cardiac optogenetics toolbox. Eur Heart J, 40(suppl1):2115 Abstract P3504 10.Rao P, Liu Z, Duan H, Dang S, Li H, Zhong L, Wang X, Wang L, Wang X. Pretreatment with neuregulin-1 improves the cardiac electrophysiological properties in a rat model of myocardial infarction. Exp Ther Med.2019, 17(4): 3141-3149 11.Jiang C, Wang X, Dang S, Wang X, Deng Q, Hu J, Huang CX. Chinese Medicine Shensong Yangxin Capsule Ameliorates Myocardial Microcirculation Dysfunction in Rabbits with Chronic Myocardial Infarction.Chin J Integr Med. 2019 Jan 9. doi: 10.1007/s11655-018-2578-1. 12.Kang W, Cheng Y, Zhou F, Wang L, Zhong L, Li HT, Wang X, Dang S, Wang X. Neuregulin-1 protects cardiac function in septic rats through multiple targets based on endothelial cells. Int J Mol Med. 2019,44(4): 1255-1266. 13.Wang X , Rao P, Wang L,Cheng Y,Jiang C,Huang C. Cardiac Optogenetics in Intact Rat Heart for Optical Pacing and Defibrillation in Vivo. Circulation,2018, 138(Suppl 1) Abstract14695 14.Jiang C, Li HT, Zhou YM, Wang X, Wang L, Liu ZQ. Cardiac optogenetics: a novel approach to cardiovascular disease therapy. Europace, 2018, 20(11):1741-1749 15.Lai X, Zhong L, Fu HX, Dang S, Wang X, Zhang N, Feng GK, Liu ZQ, Wang X, Wang L. Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model. Neural Regen Res,2017,12(11):1905-1910 16.Wang X, Hu D, Dang S, Huang H, Huang CX, Yuan MJ, Tang YH, Zheng QS, Yin F, Zhang S, Zhang BL, Gao RL, Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes: A Randomized, Double-blind, Multicenter Clinical Trial.. Chin Med J (Engl),2017, 130(14):1639-1647 17.Zhou Q, Pan X, Wang L, Wang X, Xiong D. The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy. Eur J Pharmacol,2016,788:234-240. 18.Wang X, Liu Z, Duan H, Wang L. Therapeutic potential of Neuregulin in cardiovascular system: can we ignore the effects of Neuregulin on electrophysiology? Mini Rev Med Chem,2016,16(11):867-871 Hu J, Wang X, Wei SM, Tang YH1, Zhou Q, Huang CX. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Eur J Pharmacol,2016,789:319-27 |
武汉大学人民医院
湖北省人民医院