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科副主任，主任技师，副教授，博士生导师
科副主任，主任技师，副教授，博士生导师
导师介绍
| 姓名 | 祝成亮 |
| 出生年月 | 1980年1月 |
| 单位 | 武汉大学人民医院检验科 |
| 所属学科 | 临床医学-临床检验诊断学 |
| 职务、职称及头衔 | 科副主任，主任技师，副教授，博士生导师 |
| xinchengzhu@163.com | |
| 联系方式 | 027-88041911转88532或15327246066 |
| 研究方向 |
1.感染性疾病的实验室诊断 2.病毒感染与天然免疫 |
| 个人简介 | 主要从事感染性疾病的实验室诊断和病毒感染与天然免疫等相关研究工作。主持省部级课题10余项，其中国家自然科学基金2项，同时以骨干成员参与了国家重大专项和国家自然科学基金等多项课题。以第一/通讯作者（共）在Cell Res,Emerg Microbes Infect，Liver Int，J Infect，mSphere，Clin Chem Lab Med，Viruses等专业杂志发表SCI论文40余篇，其中高被引论文5篇，热点和封面论文各1篇，总引用次数达2000余次，单篇最高引用526次；目前正在培养的博士生2名，硕士生2名。2012-2021年全国检验医学领域学者论文学术影响力排名第45位。 |
| 学术任职与荣誉 |
武汉医学会第十八届理事会理事 湖北省生物工程学会理事 湖北省医学会微生物与免疫学分会第七届委员会常务委员 湖北省公共卫生青年拔尖人才 武汉市卫计委中青年医疗骨干人才 武汉大学“351人才计划”珞珈青年学者 武汉大学人民第四轮青年重点人才培养计划 |
| 教育履历 |
1997.09-2002.06武汉大学第二临床学院医学检验专业本科生获学士学位 2002.09-2005.06武汉大学第二临床学院临床检验诊断学硕士研究生获硕士学位 2005.09-2008.12武汉大学生命科学学院微生物学博士研究生获博士学位 |
| 工作履历 |
2009.07-2012.11武汉大学人民医院检验科主管技师 2017.07-2017.10美国印第安纳医学院访问学者 2012.12-2017.11武汉大学人民医院检验科副主任技师 2017.12-至今武汉大学人民医院检验科主任技师 2018.12-至今武汉大学人民医院检验科副教授 |
| 成果获奖 |
1.《原发性肝癌发生发展的机制及其精准治疗》；2021年湖北省科学技术奖一等奖； 2.《乙型肝炎病毒“正反馈调节”促进原发性肝癌的基础和临床研究》，2020年上海市浦东新区科学技术奖三等奖 |
| 代表性论著 |
1.Fan H(#), Zhou L(#), Lv J(#), Yang S(#), Chen G(#), Liu X,
Han C, Tan X, Qian S, Wu Z, Yu S, Guo M, Zhu C(*), Chen Y(*), Lan K(*).
Bacterial coinfections contribute to severe COVID-19 in
winter. Cell Res. 2023 May 23:1-3. 2.Wang G(#), Li Z(#), Tian M(#), Cui X, Ma J, Liu S, Ye C, Yuan L, Qudus M, Afaq U, Wu K, Liu X(*), Zhu C(*). β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1. Viruses. 2023 May 19;15(5):1204. 3.Li Z(#), Tian M(#), Wang G(#), Cui X(#), Ma J, Liu S, Shen B, Liu F, Wu K, Xiao X(*), Zhu C(*). Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly. Front Cell Infect Microbiol. 2023 Mar 29;13:1098712. 4.Liu Y(#), Li Z(#),Yuan L(#), Liu F, Wu K, Xiao X(*), Zhu C(*). Human papillomavirus genotypic characteristics of 60,685 subjects under age-expansion vaccination of the nine-valent human papillomavirus vaccine: A cross-sectional study. J Infect Public Health. 2023 Jul;16(7):989-995. 5.Xu Z(#), Zhao L(#), Zhong Y(#), Zhu C(#), Zhao K, Teng Y, Cheng X, Chen Q, Xia Y(*).A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA. Cell Mol Gastroenterol Hepatol. 2021 Dec 8:S2352-345X(21)00249-6. 6.Liu R#, Zhao L#, Cheng X#, Han H#, Li C, Li D, Liu A, Gao G, Zhou F, Liu F, Jiang Y*, Zhu C*, Xia Y*. Clinical characteristics of COVID-19 patients with hepatitis B virus infection - a retrospective study. Liver Int. 2021 Apr;41(4):720-730. 7.Luo Z(#), Zhu C(#), Ruan Z, Cui X, Shereen MA, Pan P, Huang J, Wang F, Su H, Xia Y(*), Wu J(*). Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage. Front Med (Lausanne). 2021 Sep 7;8:690523. 8.Han H(#), Yang L(#), Liu R, Liu F, Wu KL, Li J, Liu XH(*), Zhu CL(*). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection, Clin Chem Lab Med, 2020 Jun 25;58(7):1116-1120. 9.Liu R(#), Han H(#), Liu F, Lv Z, Wu K, Liu Y, Feng Y(*), Zhu C(*). Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020，Clin Chim Acta, 2020,7:172-175. 10.Han H(#), Ma Q(#), Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, Jiang Y, Cheng X, Zhu C(*), Xia Y(*). Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect. 2020 Dec;9(1):1123-1130. 11.Chengliang Zhu(#), Weiyong Liu(#), Hanwen Su(#), Sitong Li, Muhammad Adnan Shereen, Zhihua Lv, Zhili Niu, Dong Li, Fang Liu, Zhen Luo(*), Yuchen Xia(*). Breastfeeding Risk From Detectable Severe Acute Respiratory Syndrome Coronavirus 2 in Breastmilk . J Infect.2020 Jun 4; S0163-4453(20)30379-0. 12.Liu R(#), Ma Q(#), Han H, Su H, Liu F, Wu K, Wang W, Zhu C(*). The Value of Urine Biochemical Parameters in the Prediction of the Severity of Coronavirus Disease 2019. Clin Chem Lab Med, 2020 Jun 25;58(7):1121-1124. 13.Liu R(#), Yi S(#), Zhang J(#), Lv Z(#), Zhu C(#), Zhang Y(#). Viral Load Dynamics in Sputum and Nasopharyngeal Swab in Patients with COVID-19. J Dent Res. 2020 Aug 3;22034520946251. 14.Han H(#), Xu Z(#), Cheng X, Zhong Y, Yuan L, Wang F, Li Y, Liu F, Jiang Y(*), Zhu C(*), Xia Y(*). Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients. mSphere. 2020 Oct 7;5(5):e00922-20. 15.Liu R(#), Liu X(#), Yuan L(#), Han H, Shereen MA, Zhen J, Niu Z, Li D, Liu F, Wu K, Luo Z(*), Zhu C(*). Analysis of Adjunctive Serological Detection to Nucleic Acid Test for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Diagnosis Int Immunopharmacol. 2020 Jun 26;86:106746. 16.Liu R(#), Wang Y(#), Li J, Han H, Xia Z, Liu F, Wu K, Yang L, Liu X(*), Zhu C(*). Decreased T Cell Populations Contribute to the Increased Severity of COVID-19. Clin Chim Acta, 2020 May 13;508:110-114. 17.Han H(#), Xie L(#), Liu R, Yang J, Liu F, Wu K, Chen L, Hou W, Feng Y(*), Zhu C(*). Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China. J Med Virol. 2020, Jul;92(7):819-823. 18.Zhang B(#), Zhou X(#), Zhu C(#), Song Y, Feng F, Qiu Y, Feng J, Jiang Q, Song Q(*), Zhu B(*), Wang J(*). Immune phenotyping based on the Neutrophil-to-Lymphocyte ratio and IgG level predicts Disease severity and outcome for patients with COVID-19. Front Mol Biosci,2020 Jul 3;7:157. , https://doi.org/10.3389/fmolb.2020.00157. 19.Han H#, Yi J#, Cheng G, Jiang W, Brożek GM, Jiang Y*, Zhu C*, Xia Y*. SARS-CoV-2 Antibody Seroprevalence in Wuhan, China, from 23 April to 24 May 2020. mSphere. 2021 Apr 21;6(2):e01062-20. |
| Name | CHENGLIANG ZHU |
| Date of birth |
JAN，1980 |
| Department | CLINICAL LABORATORY DEPARTMENT，Renmin Hospital,Wuhan University. |
| Title | Deputy Director，Senior technician, doctoral tutor |
|
xinchengzhu@163.com |
|
| TEL |
027-88041911-88264 or 15327246066 |
| Research Direction |
1.
Laboratory diagnosis of infectious diseases 2. Viral infection and innate immunity. |
| Personal Profile | He is focuses primarily on laboratory diagnosis of infectious diseases and related research work on viral infection and innate immunity. He has presided 2 National Natural Science Foundation of China and 8 other provincial and ministerial projects, and participated in the National "973" Project, National Major Special Projects and 6 National Natural Science Foundation of China. He has published more than 40 papers in Cell Res, Emerge Microbes Infect, J Infect, Clin Chem Lab Med, viruses, among which 40 papers including 26 SCI papers are recognized as the first author/corresponding author. The total citation count exceeds 2000 times, with the highest single citation being 526 times. Currently, he is supervising 2 doctoral students and 2 master students. From 2012 to 2021, he ranked 45th in the academic influence of scholars' papers in the field of national laboratory medicine. |
| Selected Publications |
1.Fan H(#), Zhou L(#), Lv J(#), Yang S(#), Chen G(#), Liu X,
Han C, Tan X, Qian S, Wu Z, Yu S, Guo M, Zhu C(*), Chen Y(*), Lan K(*).
Bacterial coinfections contribute to severe COVID-19 in
winter. Cell Res. 2023 May 23:1-3. 2.Wang G(#), Li Z(#), Tian M(#), Cui X, Ma J, Liu S, Ye C, Yuan L, Qudus M, Afaq U, Wu K, Liu X(*), Zhu C(*). β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1. Viruses. 2023 May 19;15(5):1204. 3.Li Z(#), Tian M(#), Wang G(#), Cui X(#), Ma J, Liu S, Shen B, Liu F, Wu K, Xiao X(*), Zhu C(*). Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly. Front Cell Infect Microbiol. 2023 Mar 29;13:1098712. 4.Liu Y(#), Li Z(#),Yuan L(#), Liu F, Wu K, Xiao X(*), Zhu C(*). Human papillomavirus genotypic characteristics of 60,685 subjects under age-expansion vaccination of the nine-valent human papillomavirus vaccine: A cross-sectional study. J Infect Public Health. 2023 Jul;16(7):989-995. 5.Xu Z(#), Zhao L(#), Zhong Y(#), Zhu C(#), Zhao K, Teng Y, Cheng X, Chen Q, Xia Y(*).A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA. Cell Mol Gastroenterol Hepatol. 2021 Dec 8:S2352-345X(21)00249-6. 6.Liu R#, Zhao L#, Cheng X#, Han H#, Li C, Li D, Liu A, Gao G, Zhou F, Liu F, Jiang Y*, Zhu C*, Xia Y*. Clinical characteristics of COVID-19 patients with hepatitis B virus infection - a retrospective study. Liver Int. 2021 Apr;41(4):720-730. 7.Luo Z(#), Zhu C(#), Ruan Z, Cui X, Shereen MA, Pan P, Huang J, Wang F, Su H, Xia Y(*), Wu J(*). Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage. Front Med (Lausanne). 2021 Sep 7;8:690523. 8.Han H(#), Yang L(#), Liu R, Liu F, Wu KL, Li J, Liu XH(*), Zhu CL(*). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection, Clin Chem Lab Med, 2020 Jun 25;58(7):1116-1120. 9.Liu R(#), Han H(#), Liu F, Lv Z, Wu K, Liu Y, Feng Y(*), Zhu C(*). Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020，Clin Chim Acta, 2020,7:172-175. 10.Han H(#), Ma Q(#), Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, Jiang Y, Cheng X, Zhu C(*), Xia Y(*). Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect. 2020 Dec;9(1):1123-1130. 11.Chengliang Zhu(#), Weiyong Liu(#), Hanwen Su(#), Sitong Li, Muhammad Adnan Shereen, Zhihua Lv, Zhili Niu, Dong Li, Fang Liu, Zhen Luo(*), Yuchen Xia(*). Breastfeeding Risk From Detectable Severe Acute Respiratory Syndrome Coronavirus 2 in Breastmilk . J Infect.2020 Jun 4; S0163-4453(20)30379-0. 12.Liu R(#), Ma Q(#), Han H, Su H, Liu F, Wu K, Wang W, Zhu C(*). The Value of Urine Biochemical Parameters in the Prediction of the Severity of Coronavirus Disease 2019. Clin Chem Lab Med, 2020 Jun 25;58(7):1121-1124. 13.Liu R(#), Yi S(#), Zhang J(#), Lv Z(#), Zhu C(#), Zhang Y(#). Viral Load Dynamics in Sputum and Nasopharyngeal Swab in Patients with COVID-19. J Dent Res. 2020 Aug 3;22034520946251. 14.Han H(#), Xu Z(#), Cheng X, Zhong Y, Yuan L, Wang F, Li Y, Liu F, Jiang Y(*), Zhu C(*), Xia Y(*). Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients. mSphere. 2020 Oct 7;5(5):e00922-20. 15.Liu R(#), Liu X(#), Yuan L(#), Han H, Shereen MA, Zhen J, Niu Z, Li D, Liu F, Wu K, Luo Z(*), Zhu C(*). Analysis of Adjunctive Serological Detection to Nucleic Acid Test for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Diagnosis Int Immunopharmacol. 2020 Jun 26;86:106746. 16.Liu R(#), Wang Y(#), Li J, Han H, Xia Z, Liu F, Wu K, Yang L, Liu X(*), Zhu C(*). Decreased T Cell Populations Contribute to the Increased Severity of COVID-19. Clin Chim Acta, 2020 May 13;508:110-114. 17.Han H(#), Xie L(#), Liu R, Yang J, Liu F, Wu K, Chen L, Hou W, Feng Y(*), Zhu C(*). Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China. J Med Virol. 2020, Jul;92(7):819-823. 18.Zhang B(#), Zhou X(#), Zhu C(#), Song Y, Feng F, Qiu Y, Feng J, Jiang Q, Song Q(*), Zhu B(*), Wang J(*). Immune phenotyping based on the Neutrophil-to-Lymphocyte ratio and IgG level predicts Disease severity and outcome for patients with COVID-19. Front Mol Biosci,2020 Jul 3;7:157. , https://doi.org/10.3389/fmolb.2020.00157. 19.Han H#, Yi J#, Cheng G, Jiang W, Brożek GM, Jiang Y*, Zhu C*, Xia Y*. SARS-CoV-2 Antibody Seroprevalence in Wuhan, China, from 23 April to 24 May 2020. mSphere. 2021 Apr 21;6(2):e01062-20. |
武汉大学人民医院
湖北省人民医院