江建新
普外
主任医师、博士生导师
主任医师、博士生导师
导师介绍
| 姓名 | 江建新 |
| 出生年月 | 1973年10月 |
| 单位 | 武汉大学人民医院肝胆外科 |
| 所属学科 | 临床医学-外科学 |
| 职务、职称及头衔 | 主任医师、博士生导师 |
| rm002979@whu.edu.cn | |
| 联系方式 | 15271821597 |
| 研究方向 |
1.胰腺癌侵袭转移的分子机制 2. 肝胆胰脾疾病的临床与基础研究 |
| 个人简介 | 主要从事肝胆胰脾疾病的诊治与科研工作，获国家自然科学基金3项、博士后基金1项，省科技厅、省卫生厅课题4项。参编书籍：《肝内外胆管扩张诊断治疗学》主编：吕云福，董家鸿-北 京：科学出版社 （第四章 病理生理）；以第一作者或通讯作者发表论文50余篇，其中SCI论文38篇，影响因子超过150。已培养硕士生17名，目前正在培养的5名。 |
| 学术任职与荣誉 |
中华医学会外科学分会第十六、十七、十八届中青年委员 中华医学会外科学分会第十七胰腺外科组委员 中国医疗保健国际交流促进会（医促会）胰腺疾病分会委员 中国医疗保健国际交流促进会（医促会）胰腺疾病分会，胰腺疾病微创治疗学组委员 中国研究型医院学会胰腺疾病专业委员会委员 中国研究型医院学会胰腺疾病专业委员会微创胰腺治疗学组委员 中国医师协会胰腺癌专业委员会委员 中国医师协会外科医师分会加速康复外科委员会 中国医学装备协会基础装备分会委员 中国抗癌协会肿瘤标志专业委员会非编码RNA与肿瘤研究专委会常委 湖北省抗癌协会胰腺癌专业委员常委 湖北省肝胆疾病学会理事 《中华内分泌外科杂志》编委，《中华肝胆外科杂志》通讯编委， 《世界华人消化杂志》编委、《Annals of surgery》(中文版)通讯编委、《医学参考报》编委 《中华临床医师杂志》 、 《中华实验外科杂志》 、 《 中德临床肿瘤杂志（英文版） 》 、《贵阳医学院学报》、《临床肝胆杂志》审稿人 |
| 教育履历 |
1992.09-1995.07三峡大学医学院医学系学习 2001.09-2004.07贵阳医学院，硕士学历，硕士学位，导师：孙诚谊教授 2006.09-2009.07华中科技大学同济医学院，博士学历，博士学位，导师：秦仁义教授 |
| 工作履历 |
1995.07-2001.07湖北省黄麦岭磷化工集团公司职工医院，外科住院医师。 2004.07-2006.09海南医学院附属医院肝胆外科，住院医师，主治医师。 2009.07-2013.12贵阳医学院附属医院肝胆外科，主治医师，副主任医师。 2013.12-2015.2贵阳医学院附属医院肝胆外科主任医师，教授，硕士生导师，曾任贵州省肝胆胰脾研究所副所长、贵阳医学院转化医学教研室副主任 2012.01-2015.5贵阳医学院基础医学院博士后流动站做博士后研究. 2015．2-2016．4湖北省肿瘤医院肝胆胰外科，主任医师，教授，硕士生导师 2016．4-至今武汉大学人民医院肝胆胰外科，主任医师，教授，博士生导师 2019.03-2019.05在川北医学院附属医院肝胆胰外科李敬东教授指导下，进行腹腔镜右半肝，腹腔镜肝门部胆管癌，腹腔镜胰十二指肠切除术。 |
| 成果获奖 |
腹腔镜、胆道镜及十二指肠镜“三镜”联合及术中激光碎石在胆道结石治疗中 的应用，一等奖，恩德思医学科学技术奖评奖委员会，2012年，排名第2 |
| 代表性论著 |
J.
Jiang, Y. Zhang, Y. Guo, C. Yu, M. Chen, Z. Li, S. Tian, C. Sun,
MicroRNA-3127 promotes cell proliferation and tumorigenicity in
hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation,
Oncotarget. 2015. 6(2015)6359-6372. J. Jiang, C. Yu, M. Chen, H. Zhang, S. Tian, C. Sun, Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype, Oncotarget. 2015. 6(2015)2767-2778. J. Jiang, H. Chen, C. Yu, Y. Zhang, M. Chen, S. Tian, C. Sun, The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles, Nanomedicine (Lond). 2015. 10(2015)1863-1879. J. Jiang, Z. Li, C. Yu, M. Chen, S. Tian, C. Sun, MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer, Cancer Lett.. 2015. 356(2015)962-970. X. Guo, L. Zheng, J. Jiang, Y. Zhao, X. Wang, M. Shen, F. Zhu, R. Tian, C. Shi, M. Xu, X. Li, F. Peng, H. Zhang, Y. Feng, Y. Xie, X. Xu, W. Jia, R. He, C. Xie, J. Hu, D. Ye, M. Wang, R. Qin, Blocking NF-κB Is Essential for the Immunotherapeutic Effect of Recombinant IL18 in Pancreatic Cancer, Clin. Cancer Res.. 2016. 22(2016)5939-5950. X. Li, F. Zhu, J. Jiang, C. Sun, Q. Zhong, M. Shen, X. Wang, R. Tian, C. Shi, M. Xu, F. Peng, X. Guo, J. Hu, D. Ye, M. Wang, R. Qin, Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells, Autophagy. 2016. 12(2016)1521-1537. Jiang J, Yu C, Guo X, Zhang H, Tian S, Cai K, He Z, Sun C.G Protein-Coupled Receptor GPR87 Promotes the Expansion of PDA Stem Cells through Activating JAK2/STAT3.Mol Ther Oncolytics. 2020 Jan 28;17:384-393. doi: 10.1016/j.omto.2020.01.006. eCollection 2020 Jun 26.PMID: 32405536 Free PMC article. Xu J, Wang J, He Z, Chen P, Jiang X, Chen Y, Liu X, Jiang J.，LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer，Cell Death Dis. 2021 Jun 24;12(7):648. doi: 10.1038/s41419-021-03921-3. Jie Wang , Zhiwei He , Jian Xu , Peng Chen, Jianxin Jiang，Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling，Cell Death Dis. 2021 Jan 4;12(1):36. doi: 10.1038/s41419-020-03316-w. Shan Lei, Zhiwei He, Tengxiang Chen, Xingjun Guo, Zhirui Zeng, Yiyi Shen Jianxin Jiang. Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway [J]. J Exp Clin Cancer Res. 2019 Nov 20;38(1):470. doi: 10.1186/s13046-019-1388-4. M. Chen, M. Wang, S. Xu, X. Guo, J. Jiang, Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway, Oncotarget. 2015. 2015; 6:44466-44479. He Z, Guo X, Tian S, Zhu C, Chen S, Yu C, Jiang, J, Sun C.. MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12. [J]. J Exp Clin Cancer Res. 2019 Mar 12;38(1):126. doi: 10.1186/s13046-019-1105-3. Zhirui Zeng, Shan Lei , Zhiwei He, Tengxiang Chen, Jianxin Jiang，YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration；J Cell Physiol. 2021 Mar;236(3):2087-2098. doi: 10.1002/jcp.29995. Epub 2020 Aug 4. Wang J, Guo X, Xie C, Jiang J. KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway. Br J Cancer. 2017. 117(2): 245-255. 江建新,黎志鹏,喻超,肖杰,陈玲,孙诚谊, MicroRNA-100的表达对人胰腺癌细胞化疗药物敏感性的影响,中华肝胆外科杂志. 2015. 21(2015)50-52. 江建新,赖智文,刘勇,孙城谊, 14-3-3 sigma增强胰腺癌细胞株PANC-1的增殖能力,中华肝胆外科杂志. 2013. 19(2013)938-942. 龚江波,吴利达,金学林,赵士宇,徐继宗,江建新,再改良Sugiura术对肝硬化门静脉高压症患者门静脉血流动力学及肝功能的影响,中华肝胆外科杂志. 2017. 23(2017)90-94. 陈美源,孙诚谊,喻超,黎志鹏,江建新,微小RNA-100靶向成纤维生长因子受体调控胰腺癌细胞的增殖,中华肝胆外科杂志. 2016. 22(2016)116-120. 江建新,黎志鹏,喻超,肖杰,陈玲,孙诚谊,胰腺癌组织中微RNA-100的表达及意义,中华消化外科杂志. 2015. 14(2015)663-667. 江建新,詹磊,潘耀振,孙诚谊, shRNA干扰KAP-1基因表达对胰腺癌肿瘤干细胞自我更新的影响,中华肝胆外科杂志. 2013. 19(2013)520-525 |
| Name | Jianxin Jiang |
| Date of birth | October，1973 |
| Department | Hepatobiliary surgery，Renmin Hospital, Wuhan University. |
| Title | Professor, doctoral tutor |
| rm002979@whu.edu.cn | |
| TEL | 15271821597 |
| Research Direction |
1.
Molecular mechanism of invasion and metastasis of pancreatic cancer 2. Clinical and basic research on hepatobiliary, pancreatic and spleen diseases |
| Personal Profile | He is mainly engaged in the diagnosis and treatment of diagnosis, treatment and research of hepatobiliary, pancreatic and spleen diseases, and has been awarded 3 items for the National Natural Science Foundation, 4 items from the provincial science and technology departments and provincial health department projects. He has also Participated in the book : "Diagnosis and Therapy of Intrahepatic and Extrahepatic Bile Ducts", Editor-in-Chief: Lu Yunfu, Dong Jiahong-Beijing: Science Press (Chapter 4 Pathophysiology); Besides, there are more than 50 articles published including 38 SCI papers and the impact factor is over 150. By now, he has educated 17 masters. At present, there are 5 Masters studying with him. |
| Selected Publications |
J. Jiang, Y. Zhang, Y. Guo, C. Yu, M. Chen, Z. Li, S. Tian, C.
Sun, MicroRNA-3127 promotes cell proliferation and tumorigenicity in
hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation,
Oncotarget. 2015. 6(2015)6359-6372. J. Jiang, C. Yu, M. Chen, H. Zhang, S. Tian, C. Sun, Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype, Oncotarget. 2015. 6(2015)2767-2778. J. Jiang, H. Chen, C. Yu, Y. Zhang, M. Chen, S. Tian, C. Sun, The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles, Nanomedicine (Lond). 2015. 10(2015)1863-1879. J. Jiang, Z. Li, C. Yu, M. Chen, S. Tian, C. Sun, MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer, Cancer Lett.. 2015. 356(2015)962-970. X. Guo, L. Zheng, J. Jiang, Y. Zhao, X. Wang, M. Shen, F. Zhu, R. Tian, C. Shi, M. Xu, X. Li, F. Peng, H. Zhang, Y. Feng, Y. Xie, X. Xu, W. Jia, R. He, C. Xie, J. Hu, D. Ye, M. Wang, R. Qin, Blocking NF-κB Is Essential for the Immunotherapeutic Effect of Recombinant IL18 in Pancreatic Cancer, Clin. Cancer Res.. 2016. 22(2016)5939-5950. X. Li, F. Zhu, J. Jiang, C. Sun, Q. Zhong, M. Shen, X. Wang, R. Tian, C. Shi, M. Xu, F. Peng, X. Guo, J. Hu, D. Ye, M. Wang, R. Qin, Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells, Autophagy. 2016. 12(2016)1521-1537. Jiang J, Yu C, Guo X, Zhang H, Tian S, Cai K, He Z, Sun C.G Protein-Coupled Receptor GPR87 Promotes the Expansion of PDA Stem Cells through Activating JAK2/STAT3.Mol Ther Oncolytics. 2020 Jan 28;17:384-393. doi: 10.1016/j.omto.2020.01.006. eCollection 2020 Jun 26.PMID: 32405536 Free PMC article. Xu J, Wang J, He Z, Chen P, Jiang X, Chen Y, Liu X, Jiang J.，LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer，Cell Death Dis. 2021 Jun 24;12(7):648. doi: 10.1038/s41419-021-03921-3. Jie Wang , Zhiwei He , Jian Xu , Peng Chen, Jianxin Jiang，Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling，Cell Death Dis. 2021 Jan 4;12(1):36. doi: 10.1038/s41419-020-03316-w. Shan Lei, Zhiwei He, Tengxiang Chen, Xingjun Guo, Zhirui Zeng, Yiyi Shen Jianxin Jiang. Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway [J]. J Exp Clin Cancer Res. 2019 Nov 20;38(1):470. doi: 10.1186/s13046-019-1388-4. M. Chen, M. Wang, S. Xu, X. Guo, J. Jiang, Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway, Oncotarget. 2015. 2015; 6:44466-44479. He Z, Guo X, Tian S, Zhu C, Chen S, Yu C, Jiang, J, Sun C.. MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12. [J]. J Exp Clin Cancer Res. 2019 Mar 12;38(1):126. doi: 10.1186/s13046-019-1105-3. Zhirui Zeng, Shan Lei , Zhiwei He, Tengxiang Chen, Jianxin Jiang，YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration；J Cell Physiol. 2021 Mar;236(3):2087-2098. doi: 10.1002/jcp.29995. Epub 2020 Aug 4. Wang J, Guo X, Xie C, Jiang J. KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway. Br J Cancer. 2017. 117(2): 245-255. 江建新,黎志鹏,喻超,肖杰,陈玲,孙诚谊, MicroRNA-100的表达对人胰腺癌细胞化疗药物敏感性的影响,中华肝胆外科杂志. 2015. 21(2015)50-52. 江建新,赖智文,刘勇,孙城谊, 14-3-3 sigma增强胰腺癌细胞株PANC-1的增殖能力,中华肝胆外科杂志. 2013. 19(2013)938-942. 龚江波,吴利达,金学林,赵士宇,徐继宗,江建新,再改良Sugiura术对肝硬化门静脉高压症患者门静脉血流动力学及肝功能的影响,中华肝胆外科杂志. 2017. 23(2017)90-94. 陈美源,孙诚谊,喻超,黎志鹏,江建新,微小RNA-100靶向成纤维生长因子受体调控胰腺癌细胞的增殖,中华肝胆外科杂志. 2016. 22(2016)116-120. 江建新,黎志鹏,喻超,肖杰,陈玲,孙诚谊,胰腺癌组织中微RNA-100的表达及意义,中华消化外科杂志. 2015. 14(2015)663-667. 江建新,詹磊,潘耀振,孙诚谊, shRNA干扰KAP-1基因表达对胰腺癌肿瘤干细胞自我更新的影响,中华肝胆外科杂志. 2013. 19(2013)520-525 |
武汉大学人民医院
湖北省人民医院