王志维
心胸外
科主任，基地主任，二级教授，一级主任医师，博士生导师
科主任，基地主任，二级教授，一级主任医师，博士生导师
导师介绍
| 姓名 | 王志维 |
| 出生年月 | 1962/8/20 |
| 单位 | 武汉大学人民医院心血管外科 |
| 所属学科 | 临床医学-外科学 |
| 职务、职称及头衔 | 科主任，基地主任，二级教授，一级主任医师，博士生导师 |
| wangzhiwei@whu.edu.cn | |
| 联系方式 | 027-88041911转82081或13995628899 |
| 研究方向 |
1.大血管疾病外科治疗和相关研究； 2.心脏移植基础和临床研究； 3.冠心病外科治疗和相关研究 |
| 个人简介 |
享受国务院政府特殊津贴专家、国家卫生计生委有突出贡献的中青年专家、中国医师协会心血管外科医师奖（金刀奖）得主、江城口碑医生。 主要从事心血管外科疾病的诊治与科研工作。擅长：心脏移植术治疗终末期心脏病、非体外循环心脏不停跳下冠状动脉搭桥术、深低温停循环下全弓替换术治疗A型主动脉夹层。各种复杂先心病及心脏瓣膜疾病、冠脉搭桥术、主动脉夹层及动脉瘤手术，手术成功率在98%以上，达到国际先进水平。 主持国家级及湖北省重大科研项目10余项，获得9项国家及省市科技进步奖，发表论文180余篇，其中SCI论文60余篇。已培养硕士生55名，博士生20名，目前正在培养的博士生5名，硕士生9名。 |
| 学术任职与荣誉 |
中华医学会胸心血管外科分会
委员 中国医师协会心血管外科医师分会 委员 中南六省胸心血管外科学会 常委 国家自然基金委项目评审 专家 湖北省医疗事故鉴定委员会 专家 武汉市医疗事故鉴定委员会 专家 湖北省医学会 理事 湖北省医师协会心血管外科医师分会 主任委员 湖北省医学会胸心血管外科学会 副主任委员 中华胸心血管外科杂志 通讯编委 武汉大学学报（医学版） 审稿专家 临床外科杂志 审稿专家 |
| 教育履历 |
1979.9-1984.7 同济医科大学医疗系，学士学位 1990.9-1993.7 武汉大学医学院心胸外科专业，硕士学位 2001.9-2004.7 华中科技大学同济医学院心血管外科专业，博士学位 |
| 工作履历 |
1984.8－1990.8 湖北省襄樊市中心医院心胸外科住院医师 1993.9-1997.9 武汉大学人民医院心胸外科主治医师 1997.10-2003.10 武汉大学人民医院心胸外科副教授、副主任医师 1999.2-2005.2 武汉大学人民医院心胸外科科副主任 2003.11-至今 武汉大学人民医院心胸外科主任医师、教授 2004.6-至今 武汉大学医学院心研所副所长、心血管外科研究室主任 2005.2-至今 武汉大学人民医院心血管外科科主任 2009.3-至今 武汉大学人民医院胸心外科科主任 |
| 成果获奖 |
1.《心脏移植关键技术体系创建与应用》2019年获教育部科技进步奖一等奖（第五完成人） 2.《主动脉夹层发病基础及复杂升弓部大血管手术技术创新》2015年获湖北省科技进步奖一等奖（第一完成人） 3.《复杂升弓部大血管手术技术创新与临床推广应用》2019年湖北省科技成果推广奖二等奖（第一完成人） 4.《主动脉夹层发病基础及复杂升弓部大血管手术技术创新》2015年获武汉市科技进步奖一等奖（第一完成人） 5.《深低温体外循环术中脑保护的系列研究》2010年获武汉市科技进步奖三等奖（第一完成人） 6.《微创冠状动脉搭桥术的临床研究与应用》2007年获湖北省科技进步奖二等奖（第一完成人） |
| 代表性论著 |
1.
Ren ZL, Hu R, Wang ZW*, et al. Epidemiologic and clinical characteristics of
heart transplant recipients during the 2019 coronavirus outbreak in Wuhan,
China: A descriptive survey report. J Heart Lung Transplant.
2020;39(5):412-417. （IF=7.865，一区，TOP期刊） 2. Li B, Wang Z*, Hong J, et al. Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells. Clin Transl Med. 2021;11(1):e276. （IF=11.492） 3. Jia F, Wu Q, Wang Z*, et al. BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. Oxid Med Cell Longev. 2021;2021:5986260. （IF=6.544，二区） 4. Hu Z, Wang Z*, Chang J, et al. Application of prosthesis eversion method for ascending aorta replacement guarantees better clinical outcomes of type A acute aortic dissection surgery. J Thorac Dis. 2021;13(2):533-540. （IF=2.894，四区） 5. Wang P, Wang Z*, Zhang M, et al. Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p. Life Sci. 2021;271:119199. （IF=5.030，三区） 6. Yu A, Zhang M, Wang Z*, et al. Elephant trunk stent fenestration for acute type A aortic dissection. Ann Thorac Surg. 2020;S0003-4975(20)32176-7. （IF=4.334，二区） 7. Wu H, Xu Z, Wang Z*, et al. Exosomes from dendritic cells with Mettl3 gene knockdown prevent immune rejection in a mouse cardiac allograft model. Immunogenetics. 2020;72(8):423-430. （IF=2.840，四区） 8. Ren W, Shi F, Wang Z*, et al. Two Cases Treated by Different Strategies for Common Carotid Artery Dissection with Thrombosis Due to a Type A Aortic Dissection. Braz J Cardiovasc Surg. 2020;35(3):387-391. （IF=1.311，四区） 9. Wu H, Xu Z, Wang Z*, et al. Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival. Genes Immun. 2020;21(3):193-202. （IF=2.674，四区） 10. Hu Z, Li B, Wang Z*, et al. The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFβ by suppressing the expression of the TGFβ receptor ALK5 in aorta remodeling. Mol Med Rep. 2020;22(1):387-397. （IF=2.1，四区） 11. Ren W, Li B, Wang Z* , et al. When Behcet's disease meets Stanford type A aortic dissection, heart transplantation is a reliable treatment. Ann Transl Med. 2020;8(5):251.（IF=3.297，二区） 12. Wu HB, Wang ZW*, Shi F, et al. Avβ3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway. Cardiovasc Ther. 2020;2020:6869856. （IF=2.538，三区） 13. Ruan Y, Wang Z*, Wu Z, et al. Painless retrograde type A aortic dissection followed conservative treatment of type B aortic dissection: a case report. BMC Cardiovasc Disord. 2020;20(1):17. （IF=2.078，四区） 14. Shi F, Wang Z*. Acute Aortic Dissection Surgery: Hybrid Debranching Versus Total Arch Replacement. J Cardiothorac Vasc Anesth. 2020;34(6):1487-1493. （IF=2.258，四区） 15. Wu HB, Wang ZW*, Shi F, et al. Avβ3 single-stranded DNA aptamer attenuates vascular restenosis via Ras-PI3K/MAPK pathway in rats after percutaneous transluminal coronary angioplasty. Artif Organs. 2020;44(6):611-619. （IF=2.259，四区） 16. Ren W, Wang Z*, Wang J, et al. IL-5 overexpression attenuates aortic dissection by reducing inflammation and smooth muscle cell apoptosis. Life Sci. 2020;241:117144. （IF=3.647，三区） 17. Hu X, Liu H, Wang Z*, et al. miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice. Oxid Med Cell Longev. 2019;2019:1512326. （IF=5.076，二区） 18. Hu J, Wu Q, Wang Z*, et al. Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress. Biomed Pharmacother. 2019;120:109475. （IF=4.545，三区） 19. Wu Q, Hong J, Wang Z*, et al. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2019;2019:7064319. （IF=5.076，二区） 20. Li B, Wang Z*, Chen R, et al. Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. Life Sci. 2019;224:51-57. （IF=3.647，三区） |
| Name | Zhiwei Wang |
| Date of birth | 20-Aug-62 |
| Department | Cardiovascular Surgery, Renmin Hospital, Wuhan University. |
| Title | Director, Professor, doctoral tutor |
| wangzhiwei@whu.edu.cn | |
| TEL | 027-88041911-82081 or 13995628899 |
| Research Direction |
1.
Surgical treatment and related study of aortic diseases 2. Basic and clinical study of heart transplantation 3. Surgical treatment and related study of coronary heart diseases |
| Personal Profile |
Professor
Wang enjoys the special allowance of the State Council government, and wins a
long list of academic accolades. He has been granted as a young and
middle-aged expert with outstanding contributions by the National Health and
Family Planning Commission. Awarded as excellent doctor in cardiovascular
surgery by Chinese Medical Doctor Association, as well as doctor with public
praise of Jiangcheng city. Professor Wang is mainly interested in clinical treatment and basic study of cardiovascular disease. He is good at a variety of cardiovascular surgeries, main include: heart transplantation for end-stage heart disease, off pump coronary artery bypass grafting (OPCABG), total arch replacement for type A aortic dissection under deep hypothermia, various complex congenital heart disease and heart valve disease, coronary artery bypass grafting (CABG), aortic dissection and aneurysm surgery. The operative successful rate is over 98%, reaching the international advanced level. Professor Wang has presided over 10 national and provincial major scientific research projects. Received 9 national and provincial science and technology progress awards. Published more than 180 scientific papers, with more than 60 papers cited by SCI database. He has supervised 55 master students and 20 doctoral students, and currently there are 5 doctoral students and 9 master students engaged in scientific research and clinical work in school. |
| Selected Publications |
1.
Ren ZL, Hu R, Wang ZW*, et al. Epidemiologic and clinical characteristics of
heart transplant recipients during the 2019 coronavirus outbreak in Wuhan,
China: A descriptive survey report. J Heart Lung Transplant.
2020;39(5):412-417. （IF=7.865，Q1） 2. Li B, Wang Z*, Hong J, et al. Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells. Clin Transl Med. 2021;11(1):e276. （IF=11.492） 3. Jia F, Wu Q, Wang Z*, et al. BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. Oxid Med Cell Longev. 2021;2021:5986260. （IF=6.544，Q2） 4. Hu Z, Wang Z*, Chang J, et al. Application of prosthesis eversion method for ascending aorta replacement guarantees better clinical outcomes of type A acute aortic dissection surgery. J Thorac Dis. 2021;13(2):533-540. （IF=2.894，Q4） 5. Wang P, Wang Z*, Zhang M, et al. Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p. Life Sci. 2021;271:119199. （IF=5.030，Q3） 6. Yu A, Zhang M, Wang Z*, et al. Elephant trunk stent fenestration for acute type A aortic dissection. Ann Thorac Surg. 2020;S0003-4975(20)32176-7. （IF=4.334，Q2） 7. Wu H, Xu Z, Wang Z*, et al. Exosomes from dendritic cells with Mettl3 gene knockdown prevent immune rejection in a mouse cardiac allograft model. Immunogenetics. 2020;72(8):423-430. （IF=2.840，Q4） 8. Ren W, Shi F, Wang Z*, et al. Two Cases Treated by Different Strategies for Common Carotid Artery Dissection with Thrombosis Due to a Type A Aortic Dissection. Braz J Cardiovasc Surg. 2020;35(3):387-391. （IF=1.311，Q4） 9. Wu H, Xu Z, Wang Z*, et al. Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival. Genes Immun. 2020;21(3):193-202. （IF=2.674，Q4） 10. Hu Z, Li B, Wang Z*, et al. The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFβ by suppressing the expression of the TGFβ receptor ALK5 in aorta remodeling. Mol Med Rep. 2020;22(1):387-397. （IF=2.1，Q4） 11. Ren W, Li B, Wang Z* , et al. When Behcet's disease meets Stanford type A aortic dissection, heart transplantation is a reliable treatment. Ann Transl Med. 2020;8(5):251.（IF=3.297，Q2） 12. Wu HB, Wang ZW*, Shi F, et al. Avβ3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway. Cardiovasc Ther. 2020;2020:6869856. （IF=2.538，Q3） 13. Ruan Y, Wang Z*, Wu Z, et al. Painless retrograde type A aortic dissection followed conservative treatment of type B aortic dissection: a case report. BMC Cardiovasc Disord. 2020;20(1):17. （IF=2.078，Q4） 14. Shi F, Wang Z*. Acute Aortic Dissection Surgery: Hybrid Debranching Versus Total Arch Replacement. J Cardiothorac Vasc Anesth. 2020;34(6):1487-1493. （IF=2.258，Q4） 15. Wu HB, Wang ZW*, Shi F, et al. Avβ3 single-stranded DNA aptamer attenuates vascular restenosis via Ras-PI3K/MAPK pathway in rats after percutaneous transluminal coronary angioplasty. Artif Organs. 2020;44(6):611-619. （IF=2.259，Q4） 16. Ren W, Wang Z*, Wang J, et al. IL-5 overexpression attenuates aortic dissection by reducing inflammation and smooth muscle cell apoptosis. Life Sci. 2020;241:117144. （IF=3.647，Q3） 17. Hu X, Liu H, Wang Z*, et al. miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice. Oxid Med Cell Longev. 2019;2019:1512326. （IF=5.076，Q2） 18. Hu J, Wu Q, Wang Z*, et al. Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress. Biomed Pharmacother. 2019;120:109475. （IF=4.545，Q3） 19. Wu Q, Hong J, Wang Z*, et al. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2019;2019:7064319. （IF=5.076，Q2） 20. Li B, Wang Z*, Chen R, et al. Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. Life Sci. 2019;224:51-57. （IF=3.647，Q3） |
武汉大学人民医院
湖北省人民医院