武汉大学人民医院湖北省人民医院

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丁国华肾内
研究所所长，二级教授，一级主任医师，博士生导师

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导师介绍

姓名	丁国华
出生年月	1953年8月
单位	武汉大学人民医院肾病内科
所属学科	临床医学-内科学
职务、职称及头衔	研究所所长，二级教授，一级主任医师，博士生导师
E-mail	ghxding@qq.com
联系方式	027-88041911转82144 或13554023015
研究方向	1.肾小球足细胞病理生物学与肾小球硬化 2.糖尿病肾病的分子机制 3.肾脏免疫与肾间质炎症
个人简介	主要从事肾脏疾病的诊治与研究工作。获奖成果省级5项，出版专著10部，发表论文共500余篇（其中SCI收录100余篇），承担课题项目共13项（国家级8项，省级5项）。已培养博士生44名、硕士生73名，目前正在培养的博士生13名、硕士生4名。
学术任职与荣誉	学术任职：国家肾病学专业医疗质量控制中心专家委员会委员中国病理生理学会肾脏病专业委员会副主任委员亚太医学免疫学会肾脏病分会副主任委员中国初级卫生保健基金会肾病专业委员会副会长中华医学会肾脏病分会第九、第十届常委中国肾脏病医师协会第一、第二、第三、第四届常委/副会长湖北省肾病内科医师协会名誉主任委员湖北省肾脏病学会前任主任委员湖北省透析学会主任委员湖北省肾脏病临床医学研究中心主任湖北省肾脏病学专业医疗质量控制中心主任湖北省中西医结合学会副会长湖北省生物工程学会常务理事湖北省医学会常务理事中华肾脏病杂志编委美国肾脏病学会杂志中文版编委肾脏病与透析肾移植杂志编委临床内科杂志编委个人荣誉：国务院特殊津贴专家、湖北省突出贡献中青年专家、武汉大学“珞珈杰出学者”、国家科学技术奖励评审委员、国家自然科学基金一审和二审评委、湖北省科学技术奖励评审委员、武汉市科技成果评价专家，获2019年度“国之名医-卓越建树”称号。
教育履历	1971.02-1974.07 武汉大学医学院（原湖北医学院） 1984.09-1990.12 美国纽约爱因斯坦医学院研究生院，获硕士、博士学位 1991.09-1993.06 美国宾西伐尼亚州立大学医学院，博士后
工作履历	1974.07-1984.09 武汉大学人民医院任内科住院医师 1993.07-1997.06 美国宾西伐尼亚州立大学医学院内科助教授 1997.07-2001.06 肾内科副主任、内科副主任 2001.07-2018.06 肾内科主任、内科副主任 1997.07-至今武汉大学人民医院内科学教授、博士生导师 2001.07-至今武汉大学泌尿系疾病研究所所长
成果获奖	《高胆固醇－转化生长因子β与进展性肾硬化》2002年获湖北省自然科学二等奖《血小板相关物质在慢性肾脏疾病进程中的作用研究》2004年湖北省科技进步三等奖《炎性细胞因子与氧化应激在糖尿病肾病中的作用》2006年湖北省科技进步二等奖《肾小球足细胞损伤机制及诊治策略研究》2011年湖北省科技进步一等奖《急性肾损伤的分子机制及防治策略》2019年湖北省科技进步二等奖
代表性论著	1. Chen Z, Zhu Z, Liang W, Ding G. Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. Kidney Int. 2023;103(4):735-748. 2. Huang X, Chen Z, Ding G.. PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment. Ren Fail. 2023;45(1):2230318. 3. Yang X, Chen Z, Ding G. STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease. Cell Signal. 2023;109:110777. 4. Feng J, Chen Z, Ding G. AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease. Int J Biol Sci. 2022;18(10):4026-4042. 5. Luo Z, Chen Z, Ding G. Angiotensin II induces podocyte metabolic reprogramming from glycolysis to glycerol-3-phosphate biosynthesis. Cell Signal. 2022;99:110443. 6. Chen Z, Liang W, Ding G. Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway. Cell Prolif. 2022;55(10):e13296. 7. Feng J, Chen Z, Ding G. Roles of Mitochondrial DNA Damage in Kidney Diseases: A New Biomarker. Int J Mol Sci. 2022;23(23):15166. 8. Cao Y, Chen Z, Ding G. Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway. Front Cell Dev Biol. 2021;9:769213. 9. Zhang Z, Liang W, Ding G. PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2022;12:797025. 10. Yang X, Feng J, Ding G. Roles of SIRT6 in kidney disease: a novel therapeutic target. Cell Mol Life Sci. 2021;79(1):53.

Name	Guohua Ding
Date of birth	August, 1953
Department	Nephrology, Renmin Hospital, Wuhan University.
Title	Director, Professor
Email	ghxding@qq.com
TEL	027-88041911-82144 or 13554023015
Research Direction	1. Pathobiology of glomerular podocyte and glomerular sclerosis 2. Molecular mechanism of diabetic nephropathy 3. Nephro-immunology and interstitial inflammation
Personal Profile	He is mainly engaged in the diagnosis and treatment of kidney diseases, focus on the physiology and pathophysiology of podocytes, the molecular mechanisms of glomerulosclerosis and diabetic kidney disease, and has been awarded 8 items for the National Natural Science Foundation, 5 items from the provincial science and Technology Department, the Provincial Education Commission and the Provincial Health Department. More than 500 papers published by the first or corresponding author, including nearly 100 SCI papers with more than 200 influencing factors (IF). By now, he has educated 73 masters and 44 doctors. At present, there are 13 doctors and 4 masters studying with him.
Selected Publications	1. Chen Z, Zhu Z, Liang W, Ding G. Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. Kidney Int. 2023;103(4):735-748. 2. Huang X, Chen Z, Ding G.. PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment. Ren Fail. 2023;45(1):2230318. 3. Yang X, Chen Z, Ding G. STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease. Cell Signal. 2023;109:110777. 4. Feng J, Chen Z, Ding G. AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease. Int J Biol Sci. 2022;18(10):4026-4042. 5. Luo Z, Chen Z, Ding G. Angiotensin II induces podocyte metabolic reprogramming from glycolysis to glycerol-3-phosphate biosynthesis. Cell Signal. 2022;99:110443. 6. Chen Z, Liang W, Ding G. Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway. Cell Prolif. 2022;55(10):e13296. 7. Feng J, Chen Z, Ding G. Roles of Mitochondrial DNA Damage in Kidney Diseases: A New Biomarker. Int J Mol Sci. 2022;23(23):15166. 8. Cao Y, Chen Z, Ding G. Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway. Front Cell Dev Biol. 2021;9:769213. 9. Zhang Z, Liang W, Ding G. PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2022;12:797025. 10. Yang X, Feng J, Ding G. Roles of SIRT6 in kidney disease: a novel therapeutic target. Cell Mol Life Sci. 2021;79(1):53.