武汉大学人民医院湖北省人民医院

院内导航

童强普外
主任医师；博士生导师；美国内布拉斯加大学医学中心（UNMC）博士后；胃肠外Ⅰ科副主任

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导师介绍

姓名	童强
出生年月	1978年10月
单位	武汉大学人民医院胃肠外Ⅰ科
所属学科	临床医学-外科学-普外科-胃肠外科
职务、职称及头衔	主任医师；博士生导师；美国内布拉斯加大学医学中心（UNMC）博士后；胃肠外Ⅰ科副主任
E-mail	qiangtong@whu.edu.cn
联系方式	027-88041911转82211
研究方向	1.胃肠道肿瘤侵袭转移的机制研究2.胃肠道肿瘤的早期诊断及筛查3.胃肠术后吻合口瘘的早期诊断及干预
个人简介	主要从事胃肠道肿瘤的临床和科研工作，主持国家自然科学基金两项，湖北省自然科学基金、省卫计委、武汉市科研项目十余项；参与美国NIH研究项目三项。《Oxidative Medicine and Cellular Longevity》及《Biomed Research International》首席客座主编；《Frontiers in Immunology》客座主编；《World Journal of Gastrointestinal Endoscopy》及《中华结直肠疾病电子杂志》编委；国家自然科学基金函评专家，国家卫生健康委员会专家库成员，湖北省医学会医学鉴定专家库成员。以第一作者和通讯作者发表论文60余篇，其中SCI论文近30篇，多篇影响因子均超过100。已培养研究生十余名，目前正在培养研究生5名。
学术任职与荣誉	湖北省医学青年拔尖人才第一层次人才华中科技大学“科技十佳” 武汉大学人民医院首届“医疗菁英” 国家自然科学基金函评专家国家卫生健康委员会专家库成员武汉医学会普通外科学分会青年委员会副主任委员湖北省临床肿瘤学会胃肠肿瘤专家委员会委员武汉大学人民医院临床研究伦理委员会委员湖北省医学会医学鉴定专家库成员
教育履历	09/2002—07/2007华中科技大学同济医学院外科学博士学位(硕博连读)
工作履历	09/2017—至今武汉大学人民医院胃肠外Ⅰ科主任医师、博士生导师、科室副主任 11/2010—08/2017 华中科技大学同济医学院附属协和医院胃肠外科副教授、副主任医师、硕士生导师； 12/2013—11/2016 美国内布拉斯加大学医学中心（University of Nebraska Medical Center）博士后研究员，师从美国著名的氧化还原生物学及医学领域的学术带头人Dr. Oberley-Deegan； 08/2010—07/2011 借调中华人民共和国卫生部医政司医疗处； 07/2007—10/2010 华中科技大学同济医学院附属协和医院胃肠外科讲师、主治医师；

代表性论著	1.Yuan J, Khan SU, Yan J, Lu J, Yang C, Tong Q. Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis. Biomed Pharmacother. Biomed Pharmacother. 2023 Aug;164:114986.（IF=7.4）(通讯作者) 2.Lu J, Guan S, Luo J, Yuan J, Yan J, Yang C, Tong Q. Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response. Front Oncol. 2023 May 18;13:1192192.（IF=6.2）(通讯作者) 3.Luo J, Yuan J, Yang Y, Jiang Y, Yan J, Tong Q. Special AT-rich sequence binding protein 1 promotes multidrug resistance in gastric cancer by regulation of Ezrin to alter subcellular localization of ATP-binding cassette transporters. Cancer Sci. 2023 Apr;114(4):1353-1364.（IF=6.5）(通讯作者) 4.Yuan J, Khan SU, Luo J, Jiang Y, Yang Y, Yan J, Tong Q. Biosynthetic Silver Nanoparticles Inhibit the Malignant Behavior of Gastric Cancer Cells and Enhance the Therapeutic Effect of 5-Fluorouracil by Promoting Intracellular ROS Generation and Apoptosis. Pharmaceutics. 2022 Oct 2;14(10):2109.（IF=6.5）(通讯作者) 5.Jiang Y, Li X, Yang Y, Luo J, Ren X, Yuan J, Tong Q. LncRNA HOXC-AS1 Sponges miR-99a-3p and Upregulates MMP8, Ultimately Promoting Gastric Cancer. Cancers (Basel). 2022 Jul 20;14(14):3534.（IF=6.6）(通讯作者) 6.Yang Y, Xiao Y, Jiang Y, Luo J, Yuan J, Yan J, Tong Q. Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways. Mediators Inflamm. 2022 Jun 7;2022:1894379.（IF=4.7）(通讯作者) 7.Jiang Y, Chen F, Ren X, Yang Y, Luo J, Yuan J, Yuan J, Tong Q. RNA-Binding Protein COL14A1, TNS1, NUSAP1 and YWHAE Are Valid Biomarkers to Predict Peritoneal Metastasis in Gastric Cancer. Front Oncol. 2022 Apr 19;12:830688.（IF=6.2）(通讯作者) 8.Luo J, Wu H, Jiang Y, Yang Y, Yuan J, Tong Q. The Role of Heart Rate, Body Temperature, and Respiratory Rate in Predicting Anastomotic Leakage following Surgery for Rectal Cancer. Mediators Inflamm. 2021 Aug 19;2021:8698923.（IF=4.7）(通讯作者) 9.Luo J, Wu H, Yang Y, Jiang Y, Yuan J, Tong Q. Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery. Mediators Inflamm. 2021 Jun 28;2021:9968642.（IF=4.7）(通讯作者) 10.Yang Y, Wang Q, Luo J, Jiang Y, Zhou R, Tong S, Wang Z, Tong Q. Superoxide Dismutase Mimic, MnTE-2-PyP Enhances Rectal Anastomotic Strength in Rats after Preoperative Chemoradiotherapy. Oxid Med Cell Longev. 2020 Apr 13;2020:3509859.（IF=5.1）(通讯作者) 11.Yang Y, Fang E, Luo J, Wu H, Jiang Y, Liu Y, Tong S, Wang Z, Zhou R, Tong Q. The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression. Oxid Med Cell Longev. 2019 Dec 13;2019:3643715.（IF=5.1）(通讯作者) 12.Yang Y, Zhang P, Yan RC, Wang Q, Fang EH, Wu HX, Li SJ, Tan HY, Zhou X, Ma XX, Tang Y, Huang YM, Deng R, Liu Y, Tong SL, Wang ZH, Oberley-Deegan RE, Tong Q. MnTE-2-PyP attenuates TGF-β-induced epithelial-mesenchymal transition of colorectal cancer cells by inhibiting Smad2/3 signaling pathway. Oxid Med Cell Longev. 2019 Feb 25;2019:8639791.（IF=5.1）(通讯作者) 13.Tong Q, Zhu Y, Galaske JW, Kosmacek EA, Chatterjee A, Dickinson BC, Oberley-Deegan RE. MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell. Free Radic Biol Med. 2016 Dec;101:32-43.（IF=5.8） 14.Tong Q, Weaver MR, Kosmacek EA, O'Connor BP, Harmacek L, Venkataraman S, Oberley-Deegan RE. MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene. Free Radic Biol Med. 2016 May;94:185-94.（IF=5.8） 15.Tong Q, Gong AY, Zhang XT, Lin C, Ma S, Chen J, Hu G, Chen XM. LincRNA-Cox2 modulates TNF-α-induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi-2/NuRD-mediated epigenetic histone modifications. FASEB J. 2016 Mar;30(3):1187-97.（IF=5.3） 16.Peng Z, Fang E, Wang C, Lu X, Wang G, Tong Q. Construction of Novel Thermosensitive Magnetic Cationic Liposomes as a Drug and Gene Co-Delivery System. J Nanosci Nanotechnol. 2015 May;15(5):3823-33.（IF=1.6）(通讯作者) 17.Peng Z, Wang CX, Fang EH, Wang GB,Tong Q. Role of epithelial-mesenchymal transition in gastric cancer initiation and progression. World J Gastroenterol. 2014 May 14;20(18):5403-10.（IF=2.4）(通讯作者) 18.Peng Z, Wang C, Fang E, Lu X, Wang G,Tong Q. Co-delivery of doxorubicin and SATB1 shRNA by thermosensitive magnetic cationic liposomes for gastric cancer therapy. PLoS One. 2014 Mar 27;9(3):e92924.（IF=3.5）(通讯作者) 19.Lu X, Cheng C, Wang G, Shu X, Ma J, Tong Q. Synergistic enhancement of cancer therapy using a combination of fusion protein MG7-scFv/SEB and tumor necrosis factor alpha. Protein Pept Lett. 2013 Apr;20(4):467-472.（IF=2.0）(通讯作者) 20.Sun F, Lu X, Li H, Peng Z, Wu K, Wang G, Tong Q. Special AT-rich sequence binding protein 1 regulates the multidrug resistance and invasion of human gastric cancer cells. Oncol Lett. 2012 Jul;4(1):156-162.（IF=1.5）(通讯作者)

Name	Qiang Tong
Date of birth	October，1978
Department	Department of Gastrointestinal Surgery，Renmin Hospital,Wuhan University
Title	Deputy Director, Director Doctor, Doctor tutor
Email	qiangtong@whu.edu.cn
TEL	027-88041911-82211
Research Direction	1. Early screening of gastrointestinal tumors 2. Invasion and metastasis of gastrointestinal tumors 3. Mechanism and intervention of anastomotic leakage after gastrointestinal surgery
Personal Profile	He is mainly engaged in the basic and clinical work of gastrointestinal tumors. He has presided over more than ten scientific research projects of the National Natural Science Foundation of China and provincial level, participated in three NIH research projects in the United States, and published more than 60 articles in the field of gastrointestinal oncology as the first author and corresponding author. He has trained more than 10 students and is currently training 5 graduate students.
Selected Publications	1.Yuan J, Khan SU, Yan J, Lu J, Yang C,Tong Q. Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis. Biomed Pharmacother. Biomed Pharmacother. 2023 Aug;164:114986.（IF=7.4）(Corresponding author) 2.Lu J, Guan S, Luo J, Yuan J, Yan J, Yang C,Tong Q. Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response. Front Oncol. 2023 May 18;13:1192192.（IF=6.2）(Corresponding author) 3.Luo J, Yuan J, Yang Y, Jiang Y, Yan J,Tong Q. Special AT-rich sequence binding protein 1 promotes multidrug resistance in gastric cancer by regulation of Ezrin to alter subcellular localization of ATP-binding cassette transporters. Cancer Sci. 2023 Apr;114(4):1353-1364.（IF=6.5）(Corresponding author) 4.Yuan J, Khan SU, Luo J, Jiang Y, Yang Y, Yan J,Tong Q. Biosynthetic Silver Nanoparticles Inhibit the Malignant Behavior of Gastric Cancer Cells and Enhance the Therapeutic Effect of 5-Fluorouracil by Promoting Intracellular ROS Generation and Apoptosis. Pharmaceutics. 2022 Oct 2;14(10):2109.（IF=6.5）(Corresponding author) 5.Jiang Y, Li X, Yang Y, Luo J, Ren X, Yuan J,Tong Q. LncRNA HOXC-AS1 Sponges miR-99a-3p and Upregulates MMP8, Ultimately Promoting Gastric Cancer. Cancers (Basel). 2022 Jul 20;14(14):3534.（IF=6.6）(Corresponding author) 6.Yang Y, Xiao Y, Jiang Y, Luo J, Yuan J, Yan J,Tong Q. Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways. Mediators Inflamm. 2022 Jun 7;2022:1894379.（IF=4.7）(Corresponding author) 7.Jiang Y, Chen F, Ren X, Yang Y, Luo J, Yuan J, Yuan J,Tong Q. RNA-Binding Protein COL14A1, TNS1, NUSAP1 and YWHAE Are Valid Biomarkers to Predict Peritoneal Metastasis in Gastric Cancer. Front Oncol. 2022 Apr 19;12:830688.（IF=6.2）(Corresponding author) 8.Luo J, Wu H, Jiang Y, Yang Y, Yuan J,Tong Q. The Role of Heart Rate, Body Temperature, and Respiratory Rate in Predicting Anastomotic Leakage following Surgery for Rectal Cancer. Mediators Inflamm. 2021 Aug 19;2021:8698923.（IF=4.7）(Corresponding author) 9.Luo J, Wu H, Yang Y, Jiang Y, Yuan J,Tong Q. Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery. Mediators Inflamm. 2021 Jun 28;2021:9968642.（IF=4.7）(Corresponding author) 10.Yang Y, Wang Q, Luo J, Jiang Y, Zhou R, Tong S, Wang Z,Tong Q. Superoxide Dismutase Mimic, MnTE-2-PyP Enhances Rectal Anastomotic Strength in Rats after Preoperative Chemoradiotherapy. Oxid Med Cell Longev. 2020 Apr 13;2020:3509859.（IF=5.1）(Corresponding author) 11.Yang Y, Fang E, Luo J, Wu H, Jiang Y, Liu Y, Tong S, Wang Z, Zhou R,Tong Q. The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression. Oxid Med Cell Longev. 2019 Dec 13;2019:3643715.（IF=5.1）(Corresponding author) 12.Yang Y, Zhang P, Yan RC, Wang Q, Fang EH, Wu HX, Li SJ, Tan HY, Zhou X, Ma XX, Tang Y, Huang YM, Deng R, Liu Y, Tong SL, Wang ZH, Oberley-Deegan RE,Tong Q. MnTE-2-PyP attenuates TGF-β-induced epithelial-mesenchymal transition of colorectal cancer cells by inhibiting Smad2/3 signaling pathway. Oxid Med Cell Longev. 2019 Feb 25;2019:8639791.（IF=5.1）(Corresponding author) 13.Tong Q, Zhu Y, Galaske JW, Kosmacek EA, Chatterjee A, Dickinson BC, Oberley-Deegan RE. MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell. Free Radic Biol Med. 2016 Dec;101:32-43.（IF=5.8） 14.Tong Q, Weaver MR, Kosmacek EA, O'Connor BP, Harmacek L, Venkataraman S, Oberley-Deegan RE. MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene. Free Radic Biol Med. 2016 May;94:185-94.（IF=5.8） 15.Tong Q, Gong AY, Zhang XT, Lin C, Ma S, Chen J, Hu G, Chen XM. LincRNA-Cox2 modulates TNF-α-induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi-2/NuRD-mediated epigenetic histone modifications. FASEB J. 2016 Mar;30(3):1187-97.（IF=5.3） 16.Peng Z, Fang E, Wang C, Lu X, Wang G,Tong Q. Construction of Novel Thermosensitive Magnetic Cationic Liposomes as a Drug and Gene Co-Delivery System. J Nanosci Nanotechnol. 2015 May;15(5):3823-33.（IF=1.6）(Corresponding author) 17.Peng Z, Wang CX, Fang EH, Wang GB,Tong Q. Role of epithelial-mesenchymal transition in gastric cancer initiation and progression. World J Gastroenterol. 2014 May 14;20(18):5403-10.（IF=2.4）(Corresponding author) 18.Peng Z, Wang C, Fang E, Lu X, Wang G,Tong Q. Co-delivery of doxorubicin and SATB1 shRNA by thermosensitive magnetic cationic liposomes for gastric cancer therapy. PLoS One. 2014 Mar 27;9(3):e92924.（IF=3.5）(Corresponding author) 19.Lu X, Cheng C, Wang G, Shu X, Ma J,Tong Q. Synergistic enhancement of cancer therapy using a combination of fusion protein MG7-scFv/SEB and tumor necrosis factor alpha. Protein Pept Lett. 2013 Apr;20(4):467-472.（IF=2.0）(Corresponding author) 20.Sun F, Lu X, Li H, Peng Z, Wu K, Wang G,Tong Q. Special AT-rich sequence binding protein 1 regulates the multidrug resistance and invasion of human gastric cancer cells. Oncol Lett. 2012 Jul;4(1):156-162.（IF=1.5）(Corresponding author)