曾彬
心内
主任医师，副教授，硕士生导师
主任医师，副教授，硕士生导师
导师介绍
| 姓名 | 曾彬 |
| 出生年月 | 1978年11月 |
| 单位 | 武汉大学人民医院心血管内科 |
| 所属学科 | 临床医学-内科学 |
| 职务、职称及头衔 | 主任医师，副教授，硕士生导师 |
| zengbinwhu@163.com | |
| 联系方式 | 02788041911 |
| 研究方向 |
冠心病基础与临床 |
| 个人简介 | 主要从事冠心病及急性心肌梗死的临床介入诊断和治疗(冠状动脉造影术、经皮冠状动脉球囊成形术、经皮冠状动脉内支架置入术)；以及心绞痛、心力衰竭、高血压病、心肌病、心肌炎、早搏、高脂血症及心血管疾病急危重症的诊断与治疗。主持国家自然科学基金3项、中央高校基本科研业务费专项资金资助项目1项，参与国家自然科学基金2项。主编著作1部，参编2部，以第一作者发表SCI论文10余篇，核心或统计源期刊论著40余篇。已培养硕士生2名，目前正在培养硕士生3名。 |
| 学术任职与荣誉 |
湖北省预防医学会心血管疾病预防与控制专业委员会第一届委员会委员 中国医疗保健国际交流促进会心脏重症分会委员 湖北省医学会医疗事故技术鉴定专家库成员 湖北省职业病鉴定专家库成员 湖北省CTO俱乐部成员 |
| 教育履历 |
1998.09-2003.06湖北民族学院医学院临床医学专业本科生获学士学位 2003.09-2008.06武汉大学第一临床学院内科学硕博连读 获博士学位 2009.01-2011.01美国纽约大学西奈山医学院 完成博士后工作 |
| 工作履历 |
2008.07-2009.01 武汉大学人民医院心血管内科住院医师 2011.01-2011.11 武汉大学人民医院心血管内科主治医师 2011.11-2018.04 武汉大学人民医院心血管内科副主任医师 2012.11-至今 武汉大学人民医院心血管内科副教授 2018.04-至今 武汉大学人民医院心血管内科主任医师 |
| 成果获奖 | 《细胞移植治疗心血管疾病》2010年湖北省自然科学奖三等奖 |
| 代表性论著 |
1.
Bin Zeng, Lei Liu, Xiaoting Liao, Caixia Zhang.Cardiomyocyte protective
effects of thyroid hormone during hypoxia/reoxygenation injury through
activating of IGF-1-mediated PI3K/Akt signaling. Journal of Cellular and
Molecular Medicine(accept). 2. Zeng B, Liao X, Liu L, Zhang C, Ruan H, Yang B. Thyroid hormone mediates cardioprotection against postinfarction remodeling and dysfunction through the IGF-1/PI3K/AKT signaling pathway. Life Sci, 2021, 267:118977. 3. Bin Zeng, Xiaoting Liao,Lei Liu,Huaiyu Ruan,Caixia Zhang. Thyroid Hormone Diminishes Ca2+ Overload Induced by Hypoxia/Reoxygenation in Cardiomyocytes by Inhibiting Late Sodium Current and Reverse-Na+/Ca2+ Exchange Current.Pharmacology 2020,105(1-2):63-72. 4. Bin Zeng, Lei Liu, Xiaoting Liao, Caixia Zhang, Huaiyu Ruan.Thyroid hormone protects cardiomyocytes from H2O2-induced oxidative stress via the PI3K-AKT signaling pathway. Experimental Cell Research 2019,380(2): 205-215. 5. Bin Zeng, Lei Liu, Shaofeng Wang ,Zhiguo Dai. ILK regulates MSCs survival and angiogenesis partially through AKT and mTOR signaling pathways.Acta Histochemica 2017,119(4): 400-406. 6. Bin Zeng, Suiyang Tong, Xiaofeng Ren, Hao Xia. Cardiac cell proliferation assessed by EdU, a novel analysis of cardiac regeneration.Cytotechnology 2016,68(4): 763-770. 7. Bin Zeng, Xiaofeng Ren, Feng Cao, Xiaoyang Zhou, Jing Zhang. Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart. Journal of Biomedical Science 2011,18:67-72. 8. Bin Zeng, Guosheng Lin, Xiaofeng Ren, Yan Zhang ,Honglei Chen. Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. Journal of Biomedical Science 2010, 17:80-88. 9. Shu Tao, Zeng Bin, Ren Xiaofeng, Li Yanglin. HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium. Tissue Cell 2010,43(4):217-222. 10. Zeng Bin, Chen Honglei, Zhu Chengang, Ren Xiaofeng, Lin Guosheng, Cao Feng. Effects of combined mesenchymal stem cells and heme oxygenase-1 therapy on cardiac performance.European Journal of Cardio-Thoracic Surgery 2008,34(4):850-856. 11. Zeng Bin, Ren Xiaofeng, Lin Guosheng, Zhu Chengang ,Chen Honglei, Yin Jiechao, Jiang Hong , Yang Bo, Ding Danhua. Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement. Cell Biology International 2008,32(10):1256-1264. 12. Bin Zeng, Sheng Lin-Guo,Gang Zhu-Chen, Hong Jiang, Jun Cai,Bo Yang,Hui Shen.Efficient cardiomyocyte differentiation of embryonic stem cells by bone morphogenetic protein-2 combined with visceral endoderm-like cells. Cell Biology International 2006,30(10):768-776. 13. Fu J, Lin G, Zeng B, Wu Z, Wu Y, Chu H, Qin G, Liang G, Li J, Gan X, Yu X, Li C, Liu D. Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Biochem Biophys Res Commun 2006,350(1):162-168. 14. Li XY, Xu L, Lin GS, Li XY, Jiang XJ, Wang T, Lü JJ, Zeng B. Protective effect of caffeine administration on myocardial ischemia/reperfusion injury in rats. Shock 2011,36(3):289-294. 15.Zhang C, Lin G, Wan W, Li X, Zeng B, Yang B, Huang C. Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway. Int J Mol Med 2012,29(4):557-563. 16. Lei Liu,Bin Zeng. Risk Factor Differences in Acute Myocardial Infarction between Young and Older People: A Systematic Review and Meta-Analysis. International Journal of Cardiovascular Sciences 2019,32(2):163-176. 17.阮怀玉,廖小婷,曾彬.miR-19b对H2O2诱导的大鼠心肌细胞H9c2氧化应激损伤的保护作用及机制研究.心血管病学进展,2021,42(2):177-182. 18.张彩霞,曾彬,廖小婷.三碘甲状腺原氨酸预处理对小鼠心肌梗死后心室重构的影响.中国心血管病研究. 2021,19(3):35-39. 19.张彩霞,曾彬,廖小婷.心肌梗死模型中三碘甲状腺原氨酸对心肌的保护作用研究.心血管病学进展,2020,41(11):1209-1214. 20.廖小婷,曾彬,刘磊,张彩霞,阮怀玉.T3通过激活PI3K/AKT信号通路减轻心肌细胞缺氧复氧损伤.武汉大学学报(医学版).2020,41(03):392-397. |
| Name | BIN ZENG |
| Date of birth | November，1978 |
| Department | Cardiovascular Department，Renmin Hospital,Wuhan University. |
| Title | Chief physician，Associate professor, Master's tutor |
| zengbinwhu@163.com | |
| TEL | 02788041911 |
| Research Direction | The basis and clinical of coronary heart disease |
| Personal Profile | He is mainly engaged in the clinical intervention diagnosis and treatment of coronary heart disease and acute myocardial infarction (coronary angiography, percutaneous coronary balloon angioplasty, percutaneous coronary stent placement), and angina pectoris, heart failure, hypertension, myocarditis, premature beats and hyperlipidemia. He has presided 3 items for the National Natural Science Foundation, 1 special funded project for basic scientific research operation fees of central universities, participated in 2 National Natural Science Foundation .Editor-in-chief of one book, participated in the editing of 2 titles, published more than 10 SCI papers as the first author, and more than 40 papers in core or statistical source journals. By now, he has educated 2 doctors. At present, there are 3 doctors studying with him. |
| Selected Publications |
1.
Bin Zeng, Lei Liu, Xiaoting Liao, Caixia Zhang.Cardiomyocyte protective
effects of thyroid hormone during hypoxia/reoxygenation injury through
activating of IGF-1-mediated PI3K/Akt signaling. Journal of Cellular and
Molecular Medicine(accept). 2. Zeng B, Liao X, Liu L, Zhang C, Ruan H, Yang B. Thyroid hormone mediates cardioprotection against postinfarction remodeling and dysfunction through the IGF-1/PI3K/AKT signaling pathway. Life Sci, 2021, 267:118977. 3. Bin Zeng, Xiaoting Liao,Lei Liu,Huaiyu Ruan,Caixia Zhang. Thyroid Hormone Diminishes Ca2+ Overload Induced by Hypoxia/Reoxygenation in Cardiomyocytes by Inhibiting Late Sodium Current and Reverse-Na+/Ca2+ Exchange Current.Pharmacology 2020,105(1-2):63-72. 4. Bin Zeng, Lei Liu, Xiaoting Liao, Caixia Zhang, Huaiyu Ruan.Thyroid hormone protects cardiomyocytes from H2O2-induced oxidative stress via the PI3K-AKT signaling pathway. Experimental Cell Research 2019,380(2): 205-215. 5. Bin Zeng, Lei Liu, Shaofeng Wang ,Zhiguo Dai. ILK regulates MSCs survival and angiogenesis partially through AKT and mTOR signaling pathways.Acta Histochemica 2017,119(4): 400-406. 6. Bin Zeng, Suiyang Tong, Xiaofeng Ren, Hao Xia. Cardiac cell proliferation assessed by EdU, a novel analysis of cardiac regeneration.Cytotechnology 2016,68(4): 763-770. 7. Bin Zeng, Xiaofeng Ren, Feng Cao, Xiaoyang Zhou, Jing Zhang. Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart. Journal of Biomedical Science 2011,18:67-72. 8. Bin Zeng, Guosheng Lin, Xiaofeng Ren, Yan Zhang ,Honglei Chen. Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. Journal of Biomedical Science 2010, 17:80-88. 9. Shu Tao, Zeng Bin, Ren Xiaofeng, Li Yanglin. HO-1 modified mesenchymal stem cells modulate MMPs/TIMPs system and adverse remodeling in infarcted myocardium. Tissue Cell 2010,43(4):217-222. 10. Zeng Bin, Chen Honglei, Zhu Chengang, Ren Xiaofeng, Lin Guosheng, Cao Feng. Effects of combined mesenchymal stem cells and heme oxygenase-1 therapy on cardiac performance.European Journal of Cardio-Thoracic Surgery 2008,34(4):850-856. 11. Zeng Bin, Ren Xiaofeng, Lin Guosheng, Zhu Chengang ,Chen Honglei, Yin Jiechao, Jiang Hong , Yang Bo, Ding Danhua. Paracrine action of HO-1-modified mesenchymal stem cells mediates cardiac protection and functional improvement. Cell Biology International 2008,32(10):1256-1264. 12. Bin Zeng, Sheng Lin-Guo,Gang Zhu-Chen, Hong Jiang, Jun Cai,Bo Yang,Hui Shen.Efficient cardiomyocyte differentiation of embryonic stem cells by bone morphogenetic protein-2 combined with visceral endoderm-like cells. Cell Biology International 2006,30(10):768-776. 13. Fu J, Lin G, Zeng B, Wu Z, Wu Y, Chu H, Qin G, Liang G, Li J, Gan X, Yu X, Li C, Liu D. Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Biochem Biophys Res Commun 2006,350(1):162-168. 14. Li XY, Xu L, Lin GS, Li XY, Jiang XJ, Wang T, Lü JJ, Zeng B. Protective effect of caffeine administration on myocardial ischemia/reperfusion injury in rats. Shock 2011,36(3):289-294. 15.Zhang C, Lin G, Wan W, Li X, Zeng B, Yang B, Huang C. Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway. Int J Mol Med 2012,29(4):557-563. 16. Lei Liu, Bin Zeng. Risk Factor Differences in Acute Myocardial Infarction between Young and Older People: A Systematic Review and Meta-Analysis. International Journal of Cardiovascular Sciences 2019,32(2):163-176. 17.阮怀玉,廖小婷,曾彬.miR-19b对H2O2诱导的大鼠心肌细胞H9c2氧化应激损伤的保护作用及机制研究.心血管病学进展,2021,42(2):177-182. 18.张彩霞,曾彬,廖小婷.三碘甲状腺原氨酸预处理对小鼠心肌梗死后心室重构的影响.中国心血管病研究. 2021,19(3):35-39. 19.张彩霞,曾彬,廖小婷.心肌梗死模型中三碘甲状腺原氨酸对心肌的保护作用研究.心血管病学进展,2020,41(11):1209-1214. 20.廖小婷,曾彬,刘磊,张彩霞,阮怀玉.T3通过激活PI3K/AKT信号通路减轻心肌细胞缺氧复氧损伤.武汉大学学报(医学版).2020,41(03):392-397. |
武汉大学人民医院
湖北省人民医院