余锂镭
心内
医学博士，教授（三级），主任医师（一级），博士生导师
医学博士，教授（三级），主任医师（一级），博士生导师
导师介绍
| 姓名 | 余锂镭 |
| 出生年月 | 1982年12月 |
| 单位 | 武汉大学人民医院心血管内科 |
| 所属学科 | 临床医学-内科学 |
| 职务、职称及头衔 | 医学博士，教授（三级），主任医师（一级），博士生导师 |
| lileiyu@whu.edu.cn | |
| 联系方式 | 15827537180 |
| 研究方向 |
1.心血管创新临床技术研发 2.神经免疫代谢与心血管疾病机制研究 |
| 个人简介 | 长期致力于心血管疾病的临床及创新转化研究，入选国家“万人计划”，获评国家卫生健康委突出贡献中青年专家、国家教学名师（首届课程思政）、全国抗疫先进个人、全国优秀共产党员、全国向上向善好青年。任湖北省医师协会副会长、美国心脏病学会Fellow（FACC）、欧洲心脏病学会Fellow（FESC），近年以第一或通讯作者（含共同）发表高质量研究70余篇，IF大于10的研究16篇，被引大于5000。主持国家人才项目、国家自然科学基金（5项）、省杰青、省创新群体，省新世纪高层次人才等项目17项。获省科技进步一等奖两项（2018年、2022年）、中华医学科技奖、美国心脏病学院心脏介入“青年成就奖”（全球每年2人）等，研究入选年度心律失常领域全球十大研究进展，及年度全球心血管研究亮点。 |
| 学术任职与荣誉 | 入选国家“万人计划”、国家卫生健康委突出贡献中青年专家、国家教学名师（首届课程思政）、全国优秀共产党员、全国抗击新冠肺炎疫情先进个人、全国向上向善好青年，现担任湖北省医师协会副会长、美国心脏病学会Fellow（FACC）、欧洲心脏病学会Fellow（FESC），担任Cardiovasc Innov Appl副主编、PACE编委等 |
| 教育履历 |
2001.9-2006.6，华中科技大学同济医学院临床医学专业，获学士学位 2006.9-2011.6，武汉大学第一临床学院内科学专业，获博士学位 2008.3-2010.9，美国俄克拉荷马大学健康科学中心心律研究所，博士联合培养 2017.7-2017.7，澳大利亚帕斯皇家医院霍华德·弗洛里实验室，中澳青年科学家交流计划 2018.3-2018.3，英国皇家工程院，中英创新领军人才联合培养项目 |
| 工作履历 |
2017.11-至今，武汉大学人民医院，教授 2018.06-至今，武汉大学人民医院，博士生导师 2018.11-至今，武汉大学人民医院，主任医师 2020.11-至今武汉大学人民医院党委副书记 2023.06-至今武汉大学人民医院心血管医院副院长 |
| 成果获奖 |
2023年，国家卫生健康委突出贡献中青年专家 2022年，湖北省科学技术进步一等奖 2020年，国家“万人计划” 2020年，全国抗击新冠肺炎疫情先进个人 2020年，全国优秀共产党员 2020年，全国向上向善好青年 2021年，国家首批教育部课程思政教学团队和教学名师 2018年，湖北省科学技术进步奖一等奖 2021年，中华医学科技奖（心律失常唯一获奖） 2018年，美国心脏病学院介入专刊“青年作者成就奖”（全球每年2人） 2018年，第67届美国心脏病学院年会（ACC)中国原创研究一等奖 2017年，第66届美国心脏病学院年会（ACC)中国原创研究一等奖 2017年，中国介入心脏病学大会青年医师研究奖一等奖 2017年，东方心脏病学会议“东方新星奖” 2017年，“MedEngin”医学双创大赛一等奖 2017年，中国心血管医生创新俱乐部心血管技术与器械创新设计大赛一等奖 2014年，中华医学会心电生理和起搏分会“陈新心律学奖”一等奖 |
| 代表性论著 |
1.Yu
L(#), Scherlag BJ, Dormer K, Nguyen KT, Pope C, Fung KM, Sunny
Po(*).Autonomic denervation with magnetic nanoparticles. Circulation. 2010;
122（25）:2653~2659（IF39.918） 2. Zhang L(#), Guo F(#), Xu S, Deng Q, Xie M, Sun J, Kwok RTK, Lam JWY, Deng H(*), Jiang H(*), Yu L(*), Tang BZ(*). AIEgen-based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy. Adv Mater. 2023 Aug 2:e2304620.（IF32.086） 3.Yang Y(#), Wang J, Huang W, Wan G, Xia M, Chen D, Zhang Y, Wang Y, Guo F, Tan J, Liang H, Du B,Yu L(*), Tan W, Duan X, Yuan Q(*). Integrated Urinalysis Devices Based on Interface-Engineered Field Effect Transistor Biosensors Incorporated with Electronic Circuits. Advanced Materials. 2022;e2203224.（IF32.086） 4.Yu L(#), Zhou L(#),Cao G(#),Sunny Po，Huang B，Zhou X，Wang M, Yuan S, Wang Z, Wang S, Jiang H(*),Optogenetic Modulation of Cardiac Sympathetic Never Activity to Protect Against Ventricular Arrhythmias. JACC. 2017;70（22）:2778-90（IF27.203） 5.Hu B(#), Liu R(#), Tang X(#), Pan Y(#), Wang M(#), Tong Y(#), Ye G(#), Shen G(#), Ying R(#), Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao M, Wang Y, Zhang H, Feng Z, Yu J, Chen J, Deng Z, Lu X, Zhang Y(*), Li Y(*), Liu B(*),Yu L(*), Li Y(*), Lu J(*), Liu T(*). The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants. National Science Review. 2021; nwab073.（IF23.178） 6. Ye T(#), Lai Y(#), Wang Z(#), Zhang X, Meng G, Zhou L, Zhang Y, Zhou, Z, Deng J, Wang M, Wang Y, Zhang Q, Zhou X,Yu L(*), Jiang H(*), Xiao X(*), Precise Modulation of Gold Nanorods for Protecting against Malignant Ventricular Arrhythmias via Near‐Infrared Neuromodulation. Adv. Funct. Mater. 2019;29,1902128.（IF19.924） 7.Zhang Y(#), Zhou L(#), Gao X, Liu C, Chen H, Zheng H, Gui J, Sun C,Yu L(*), Guo S(*). Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation. Nano Energy. 2021;106319.（IF19.069） 8.Zhang Y(#), Zhou L(#), Liu C, Gao X, Zhou Z, Duan S, Deng Q, Song L, Jiang H(*),Yu L(*), Guo S(*), Zheng H(*). Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation. Nano Energy. 2022;107420.（IF19.069） 9.Zhou L(#), Zhang Y(#), Cao G, Zhang C, Zheng C, Meng G, Lai Y, Zhou Z, Liu Z, Liu Z, Guo F, Dong X, Liang Z, Wang Y, Guo S, Zhou X(*), Jiang H(*), Yu L(*). Wireless Self-Powered Optogenetic System for Long-Term Cardiac Neuromodulation to Improve Post-MI Cardiac Remodeling and Malignant Arrhythmia. Adv Sci (Weinh). 2023;10(9):e2205551.（IF17.521） 10 .Zhou Z(#), Liu C(#), Xu S(#), Wang J, Guo F, Duan S, Deng, Q, Sun J, Yu F, Zhou Y, Wang M, Wang Y, Zhou L, Jiang H(*),Yu L(*). Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. Basic Res Cardiol. 2022;117(1):34.（IF17.165） 11. Lai Y(#), Zhou X(#), Guo F(#), Jin X, Meng G, Zhou L, Chen H, Liu Z,Yu L(*),Jiang H(*). Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2021;cvab209.（IF13.081） 12.Yu L (#),Huang B(#), Po SS, Tan T, Wang M, Zhou L, Meng G, Yuan S, Zhou X, Li X, Wang Z1, Wang S, Jiang H (*). Low-Level Tragus Stimulation for the Treatment of Ischemia and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Interv. 2017;10(15):1511-1520.（IF11.3） 13. Meng G(#), Zhou X(#), Wang M, Zhou L, Wang Z, Wang M, Deng J, Wang Y, Zhou Z, Zhang Y, Lai Y, Zhang Q, Yang X,Yu L(*), Jiang H(*). Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways. EBioMedicine. 2019;44:656-664.（IF11.205） 14. Wang Z(#),Yu L(#), Wang S, Huang B, Liao K, Saren G, Tan T, Jiang H(*). Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction. Circ Heart Fail. 2014;7(6):1014-21.（IF10.447） 15.Han J(#), Zhang Y(#), Wang X, Zhang G, Yu Z, Wang C, Xu T, Zhou Z, Yang X, Jin X, Liu C, Zhou L, Wang Y, Tang B, Guo S(*), Jiang H(*), Yu L(*). Ultrasound-mediated piezoelectric nanoparticle modulation of intrinsic cardiac autonomic nervous system for rate control in atrial fibrillation. Biomater Sci. 2023;11(2):655-665.（IF7.59） 16. Yu L(#), Scherlag BS, Dormer K, Rutel I, Huang B, Zhou X, Kuriakose AE, Nguyen KK, Sunny Po(*). Targeted Ganglionated Plexi Denervation Using Magnetic Nanoparticles Carrying Calcium Chloride Payload. JACC Clin Electrophysiol. 2018;4(10):1347-1358.（IF7.0） 17.Yu L(#)，Wang Y(#)，Zhou X，Huang B，Wang M，Li X，Meng G，Yuan S，Xia H(*)，Jiang H(*)，Leptin injection into the left stellate ganglion augments ischemia related ventricular arrhythmias via sympathetic nerve activation. Heart Rhythm.2018;15(4):597-606.（IF6.779） 18.Yu L(#)，Huang B(#)，Zhou X，Wang S，Wang M，Li X，Zhou L，Meng G，Yuan S，Wang Y，Jiang Hong(*)，Renal sympathetic stimulation and ablation affect ventricular arrhythmia by modulating autonomic activity in a cesium-induced long QT canine model. Heart Rhythm. 2017;14(6):912-919（IF6.779） 19. Wang S(#)，Zhou X(#)，Huang B，Wang Z，Zhou L，Chen M，Yu L(*)，Jiang H(*)，Spinal cord stimulation suppresses atrial fibrillation by inhibiting autonomic remodeling. Heart Rhythm. 2016;13(1):274-81.（IF6.779） 20. Wang S(#), Zhou X(#), Huang B, Wang Z, Liao K, Saren G, Lu Z, Chen M,Yu L(*), Jiang H(*).Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model. Heart Rhythm. 2015;12(7):1628-35.（IF6.779） |
| Name | LILEI YU |
| Date of birth | Dec, 1982 |
| Department | Department of Cardiology, Renmin Hospital of Wuhan University |
| Title | Director, Professor, doctoral supervisor |
| lileiyu@whu.edu.cn | |
| TEL | 15827537180 |
| Research Direction |
1.
Innovative research and development of clinical technology for cardiovascular
diseases 2. Neuroimmune metabolism mechanism research of cardiovascular disease |
| Personal Profile | Prof. Yu has long been committed to clinical and translational research on cardiovascular diseases. He has been selected for the National "Ten Thousand People Program", and has been honored as a young and middle-aged expert with outstanding contributions by the National Health Commission, a National Master Teacher (the first course of Civics and Politics), a National Advanced Individual in Epidemic Resistance, a National Outstanding Communist Party Member, and a National Upwardly Mobile Young Person. He is the Vice President of Hubei Provincial Physicians Association, Young Member of the Cardiovascular Disease Branch of the Chinese Medical Association, Fellow of the American College of Cardiology (FACC), Fellow of the European Society of Cardiology (FESC). He has presided over 17 projects, including the "Ten Thousand People Program" of the central government and the National Natural Science Foundation of China. He published over 70 research, with 16 research’s IF >10. His research has been cited more than 5000 times by Cell, JAMA, Nat Rev Cardiol, Nature Reviews Materials and other journals. His research has been honored with two first prizes of Provincial Scientific and Technological Progress (2018 and 2022), Chinese Medical Science and Technology Award, American College of Cardiology Cardiac Intervention "Young Achiever Award" (2 persons per year globally), and First Prize for Original Research in China at the 66th and 67th Annual Meetings of the American College of Cardiology, etc. His research has been honored as one of the top ten global research advances in the field of cardiac arrhythmia by the Chinese Journal of Arrhythmology, and selected into the "Review of the 70th Anniversary of Cardiovascular Cause" by Chinese Society of Cardiovascular Disease. |
| Selected Publications |
1.Yu
L(#), Scherlag BJ, Dormer K, Nguyen KT, Pope C, Fung KM, Sunny
Po(*).Autonomic denervation with magnetic nanoparticles. Circulation. 2010;
122（25）:2653~2659（IF39.918） 2. Zhang L(#), Guo F(#), Xu S, Deng Q, Xie M, Sun J, Kwok RTK, Lam JWY, Deng H(*), Jiang H(*), Yu L(*), Tang BZ(*). AIEgen-based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy. Adv Mater. 2023 Aug 2:e2304620.（IF32.086） 3.Yang Y(#), Wang J, Huang W, Wan G, Xia M, Chen D, Zhang Y, Wang Y, Guo F, Tan J, Liang H, Du B,Yu L(*), Tan W, Duan X, Yuan Q(*). Integrated Urinalysis Devices Based on Interface-Engineered Field Effect Transistor Biosensors Incorporated with Electronic Circuits. Advanced Materials. 2022;e2203224.（IF32.086） 4.Yu L(#), Zhou L(#),Cao G(#),Sunny Po，Huang B，Zhou X，Wang M, Yuan S, Wang Z, Wang S, Jiang H(*),Optogenetic Modulation of Cardiac Sympathetic Never Activity to Protect Against Ventricular Arrhythmias. JACC. 2017;70（22）:2778-90（IF27.203） 5.Hu B(#), Liu R(#), Tang X(#), Pan Y(#), Wang M(#), Tong Y(#), Ye G(#), Shen G(#), Ying R(#), Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao M, Wang Y, Zhang H, Feng Z, Yu J, Chen J, Deng Z, Lu X, Zhang Y(*), Li Y(*), Liu B(*),Yu L(*), Li Y(*), Lu J(*), Liu T(*). The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants. National Science Review. 2021; nwab073.（IF23.178） 6. Ye T(#), Lai Y(#), Wang Z(#), Zhang X, Meng G, Zhou L, Zhang Y, Zhou, Z, Deng J, Wang M, Wang Y, Zhang Q, Zhou X,Yu L(*), Jiang H(*), Xiao X(*), Precise Modulation of Gold Nanorods for Protecting against Malignant Ventricular Arrhythmias via Near‐Infrared Neuromodulation. Adv. Funct. Mater. 2019;29,1902128.（IF19.924） 7.Zhang Y(#), Zhou L(#), Gao X, Liu C, Chen H, Zheng H, Gui J, Sun C,Yu L(*), Guo S(*). Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation. Nano Energy. 2021;106319.（IF19.069） 8.Zhang Y(#), Zhou L(#), Liu C, Gao X, Zhou Z, Duan S, Deng Q, Song L, Jiang H(*),Yu L(*), Guo S(*), Zheng H(*). Performance-enhanced flexible piezoelectric nanogenerator via layer-by-layer assembly for self-powered vagal neuromodulation. Nano Energy. 2022;107420.（IF19.069） 9.Zhou L(#), Zhang Y(#), Cao G, Zhang C, Zheng C, Meng G, Lai Y, Zhou Z, Liu Z, Liu Z, Guo F, Dong X, Liang Z, Wang Y, Guo S, Zhou X(*), Jiang H(*), Yu L(*). Wireless Self-Powered Optogenetic System for Long-Term Cardiac Neuromodulation to Improve Post-MI Cardiac Remodeling and Malignant Arrhythmia. Adv Sci (Weinh). 2023;10(9):e2205551.（IF17.521） 10 .Zhou Z(#), Liu C(#), Xu S(#), Wang J, Guo F, Duan S, Deng, Q, Sun J, Yu F, Zhou Y, Wang M, Wang Y, Zhou L, Jiang H(*),Yu L(*). Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. Basic Res Cardiol. 2022;117(1):34.（IF17.165） 11. Lai Y(#), Zhou X(#), Guo F(#), Jin X, Meng G, Zhou L, Chen H, Liu Z,Yu L(*),Jiang H(*). Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2021;cvab209.（IF13.081） 12.Yu L (#),Huang B(#), Po SS, Tan T, Wang M, Zhou L, Meng G, Yuan S, Zhou X, Li X, Wang Z1, Wang S, Jiang H (*). Low-Level Tragus Stimulation for the Treatment of Ischemia and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Interv. 2017;10(15):1511-1520.（IF11.3） 13. Meng G(#), Zhou X(#), Wang M, Zhou L, Wang Z, Wang M, Deng J, Wang Y, Zhou Z, Zhang Y, Lai Y, Zhang Q, Yang X,Yu L(*), Jiang H(*). Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways. EBioMedicine. 2019;44:656-664.（IF11.205） 14. Wang Z(#),Yu L(#), Wang S, Huang B, Liao K, Saren G, Tan T, Jiang H(*). Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction. Circ Heart Fail. 2014;7(6):1014-21.（IF10.447） 15.Han J(#), Zhang Y(#), Wang X, Zhang G, Yu Z, Wang C, Xu T, Zhou Z, Yang X, Jin X, Liu C, Zhou L, Wang Y, Tang B, Guo S(*), Jiang H(*), Yu L(*). Ultrasound-mediated piezoelectric nanoparticle modulation of intrinsic cardiac autonomic nervous system for rate control in atrial fibrillation. Biomater Sci. 2023;11(2):655-665.（IF7.59） 16. Yu L(#), Scherlag BS, Dormer K, Rutel I, Huang B, Zhou X, Kuriakose AE, Nguyen KK, Sunny Po(*). Targeted Ganglionated Plexi Denervation Using Magnetic Nanoparticles Carrying Calcium Chloride Payload. JACC Clin Electrophysiol. 2018;4(10):1347-1358.（IF7.0） 17.Yu L(#)，Wang Y(#)，Zhou X，Huang B，Wang M，Li X，Meng G，Yuan S，Xia H(*)，Jiang H(*)，Leptin injection into the left stellate ganglion augments ischemia related ventricular arrhythmias via sympathetic nerve activation. Heart Rhythm.2018;15(4):597-606.（IF6.779） 18.Yu L(#)，Huang B(#)，Zhou X，Wang S，Wang M，Li X，Zhou L，Meng G，Yuan S，Wang Y，Jiang Hong(*)，Renal sympathetic stimulation and ablation affect ventricular arrhythmia by modulating autonomic activity in a cesium-induced long QT canine model. Heart Rhythm. 2017;14(6):912-919（IF6.779） 19. Wang S(#)，Zhou X(#)，Huang B，Wang Z，Zhou L，Chen M，Yu L(*)，Jiang H(*)，Spinal cord stimulation suppresses atrial fibrillation by inhibiting autonomic remodeling. Heart Rhythm. 2016;13(1):274-81.（IF6.779） 20. Wang S(#), Zhou X(#), Huang B, Wang Z, Liao K, Saren G, Lu Z, Chen M,Yu L(*), Jiang H(*).Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model. Heart Rhythm. 2015;12(7):1628-35.（IF6.779） |
武汉大学人民医院
湖北省人民医院