折志刚
心内
心内科副主任，三级教授，博士生导师
心内科副主任，三级教授，博士生导师
导师介绍
| 姓名 | 折志刚 |
| 出生年月 | 1975年4月 |
| 单位 | 武汉大学人民医院心血管内科 |
| 所属学科 | 临床医学-内科学 |
| 职务、职称及头衔 | 心内科副主任，三级教授，博士生导师 |
| zgshe@whu.edu.cn | |
| 联系方式 | 027-68759885 |
| 研究方向 |
1.心血管代谢性疾病的机制研究 2.心血管代谢性疾病的靶向治疗 |
| 个人简介 | 主要从事心血管代谢性疾病的发病机制、靶向治疗和临床研究研究，获科技部及国家自然科学基金4项、省科技厅课题1项。在《Nature Medicine》、《Cell Metabolism》、《Circulation》、《Hepatology》及《Circulation Research》等杂志上发表SCI论文100余篇，其中第一作者或通讯作者发表论文30余篇，总引用次数近10000次。已经毕业和正在独立培养的博士生6名，硕士生6名。 |
| 学术任职与荣誉 |
中国医师协会临床精准医疗青委会委员 中国生物化学与分子生物学学会湖北省分会理事 中国病理生理学会血管分会会员 中国生物化学与分子生物学会会员 《Atherosclerosis》副主编 《Frontiers in Cardiovascular Medicine》编委 《Cell Metabolism》、《Nature Communications》、《Hepatology》、《Arteriosclerosis, Thrombosis, and Vascular Biology》、《Cardiovascular Research》等专业杂志特约审稿人， 美国心脏学会会员、特约基金评审人 |
| 教育履历 |
1993.09-1998.07包头医学院临床医学系本科生获学士学位 1998.09-2001.07包头医学院血红蛋白研究所&基因诊断研究所硕士研究生获硕士学位 2004.09-2007.09中国医学科学院/协和医科大学基础医学研究所博士研究生获博士学位 |
| 工作履历 |
2001.08-2004.08 北京亿利生物工程技术研究所研发主管 2007.11-2012.12 美国加州Sanford Burnham Prebys医学探索研究所博士后 2013.01-2016.04 美国加州Sanford Burnham Prebys医学探索研究所专任科学家 2016.04-至今 武汉大学人民医院心血管内科教授 |
| 成果获奖 |
1.STRIVE
创新性人类疾病研究奖 2.Fishman 职业发展奖 3.美国心脏协会研究奖 4.中国医学科学院中国协和医科大学年度优秀毕业论文奖: 5.优秀研究生 协和医科大学/中国医学科学院 |
| 代表性论著 |
1.
Wang Z, Shi W, Wu T, Peng T, Wang X, Liu S, Yang Z, Wang J, Li PL, Tian R,
Hong Y, Yang H, Bai L, Hu Y, Cheng X, Li H, Zhang XJ, She ZG. A
high-throughput drug screening identifies luteolin as a therapeutic candidate
for pathological cardiac hypertrophy and heart failure. Front Cardiovasc Med.
2023 Mar 14;10:1130635. doi: 10.3389/fcvm.2023.1130635. 2. Qu W, Chen Z, Hu X, Zou T, Huang Y, Zhang Y, Hu Y, Tian S, Wan J, Liao R, Bai L, Xue J, Ding Y, Hu M, Zhang XJ, Zhang X, Zhao J, Cheng X, She ZG§, Li H§. Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model. Front Endocrinol (Lausanne). 2022 Apr 19;13:849060. doi: 10.3389/fendo.2022.849060. (§:并列通讯作者) 3. Zhang XJ*, She ZG*, Wang J*, Sun D*, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H. Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. Sci Transl Med. 2021 Dec 15;13(624) (*:并列一作) 4. Ji YX, Wang Y, Li PL, Cai L, Wang XM, Bai L, Liu Z, Tian H, Tian S, Zhang P, Zhang XJ, Cheng X, Yuan Y, She ZG§, Hu Y§, Li H§. A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis. Cell Metab. 2021 Jun 1;33(6):1171-1186. (§:并列通讯作者) 5. Yang X, Sun D, Xiang H, Wang S, Huang Y, Li L, Cheng X, Liu H, Hu F, Cheng Y, Ma T, Hu M, Tian H, Tian S, Zhou Y, Zhang P, Zhang XJ, Ji YX, Hu Y§, Li H§, She ZG§. Hepatocyte SH3RF2 Deficiency is a Key Aggravator for Nonalcoholic Fatty Liver Disease. Hepatology. 2021 Apr 24. doi: 10.1002/hep.31863. Online ahead of print. (§:并列通讯作者) 6. Liu YM, Xie J, Chen MM, Zhang X, Cheng X, Li H, Zhou F, Qin JJ, Lei F, Chen Z, Lin L, Yang C, Mao W, Chen G, Lu H, Xia X, Wang D, Liao X, Yang J, Huang X, Zhang BH, Yuan Y, Cai J, Zhang XJ, Wang Y, Zhang X, She ZG§ Li H§. Kidney Function Indicators Predict Adverse Outcomes of COVID-19. Med (N Y). 2021 Jan 15;2(1):38-48.e2. (§:并列通讯作者)（IF：17） 7. Cheng X, Liu YM, Li H, Zhang X, Lei F, Qin JJ, Chen Z, Deng KQ, Lin L, Chen MM, Song X, Xia M, Huang X, Liu W, Cai J, Zhang XJ, Zhou F, Zhang P, Wang Y, Ma X, Xu Q, Yang J, Ye P, Mao W, Huang X, Xia J, Zhang BH, Guo J, Zhu L, Lu Z, Yuan Y§, Wei X§, She ZG§, Ji YX§, Li H§. Metformin Use Is Associated with Increased Incidence of Acidosis but not Mortality in Individuals with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020 Oct 6;32(4):537-547.e3.. (§:并列通讯作者)（IF：21.567） 8. Zhu L*, She ZG*, Cheng X*, Qin JJ*, Zhang XJ*, Cai J, Lei F, Wang H, Xie J, Wang W, Li H, Zhang P, Song X, Chen X, Xiang M, Zhang C, Bai L, Xiang D, Chen MM, Liu Y, Yan Y, Liu M, Mao W, Zou J, Liu L, Chen G, Luo P, Xiao B, Zhang C, Zhang Z, Lu Z, Wang J, Lu H, Xia X, Wang D, Liao X, Peng G, Ye P, Yang J, Yuan Y, Huang X, Guo J, Zhang BH, Li H. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020 Jun 2;31(6):1068-1077.e3. (*:并列一作)（IF：21.567） 9. Wu X, Lin L, Qin JJ, Wang L, Wang H, Zou Y, Zhu X, Hong Y, Zhang Y, Liu Y, Xin C, Xu S, Ye S, Zhang J, Xiong Z, Zhu L, Li H§, Chen J§, She ZG§. CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. J Am Heart Assoc. 2020 May 5;9(9):e014920. (§:并列通讯作者)（IF：4.605） 10. Liu D, Zhang P, Zhou J, Liao R, Che Y, Gao MM, Sun J, Cai J, Cheng X, Huang Y, Chen G, Nie H, Ji YX, Zhang XJ, Huang Z, Xu H, She ZG§, Li H§. TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation. Cell Metab. 2020 Apr 7;31(4):726-740. (§:并列通讯作者)（IF：21.567） 11. Jun Gong,Chun Fang,Peng Zhang,Pi‐Xiao Wang,Yixing Qiu,Li‐Jun Shen,Li Zhang,Xue‐Yong Zhu,Song Tian,Feng Li,Zhihua Wang,Zan Huang,Aibing Wang§,Xiao‐Dong Zhang§,She ZG§. Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disease in Mice. Hepatology. 2019 Feb;69(2):524-544.（IF：14.679）(§:并列通讯作者) 12. Liu X, Yang Q, Zhu LH, Liu J, Deng KQ, Zhu XY, Liu Y, Gong J, Zhang P, Li S, Xia H, She ZG. Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway. J Am Heart Assoc. 2018 Jun 26;7(13). pii: e008654. doi: 10.1161/JAHA.118.008654.（IF：4.605） 13. Gong FH, Cheng WL, Wang H, Gao M, Qin JJ, Zhang Y, Li X, Zhu X, Xia H, She ZG. Reduced atherosclerosis lesion size, inflammatory response in miR-150 knockout mice via macrophage effects.J Lipid Res. 2018 Apr; 59(4):658-669.（IF：4.483） 14. Zhang P，Wang PX, Zhao LP, Zhang Xi, Ji YX, Zhang XJ, Fang C, Lu YX, Yang X, Gao MM, Zhang Y, Tian S, Zhu XY, Gong J, Ma XL, Li F, Wang Zh, Huang Z, She ZG§, Li H§. The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Nature Medicine. 2018 Feb;24(2):213-223. (§:并列通讯作者)（IF：36.13） 15. Cheng WL*, She ZG*, Qin JJ*, Guo JH, Gong FH, Zhang P, Fang C, Tian S, Zhu XY, Gong J, Wang ZH, Huang Z, Li H., Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging KLF4 Signaling. Circulation. 2017 Oct 10;136(15):1412-1433. (*:并列一作)（IF：23.603） 16. She ZG, Hamzah J, Kotamraju VR, Hong-Bo Pang HB, Jansen S and Ruoslahti E. Plaque-penetrating peptide inhibits development of hypoxic atherosclerotic plaque. Journal of Controlled Release. 2016; 238:212-20.（IF：7.727） 17. She ZG, Chang Y, Pang HB, Han W, Chen HZ, Smith JW and Stallcup WB. NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2016;36:49-59. (唯一通讯作者). (同期特别评论文章).（IF：6.604） 18. She ZG, Liu X, Kotamraju VR, Ruoslahti E. Clot-targeted Micellar Formulation Improves Anticoagulation Efficacy of Bivalirudin. ACS Nano. 2014 Oct 28;8(10):10139-49（IF：14.588） 19. She ZG, Zheng W, Wei YS, Chen HZ, Wang AB, Li HL, Liu G, Zhang R, Liu JJ, Stallcup WB, Zhou Z, Liu DP, Liang CC. Human Paraoxonase Gene Cluster Transgenic Overexpression Represses Atherogenesis and Promotes Atherosclerotic Plaque Stability in ApoE Null Mice. Circulation Research. 2009; 104 (10):1160-1168.（IF：14.467） 20. Li HL*, She ZG*, Li TB*, Yang QL, Wang YG, Liu DP. Overexpression of Myofibrillogenesis Regulator-1 Aggravates Cardiac Hypertrophy in Response to Chronic Angiotensin II Infusion in Mice. Hypertension. 2007; 49 (6):1399-408.(*:并列一作). (同期特别评论文章).（IF：7.713） |
| Name | ZHIGANG SHE |
| Date of birth | April，1975 |
| Department | Cardiovascular Department，Renmin Hospital,Wuhan University. |
| Title | Vice Director, Professor, doctoral tutor |
| zgshe@whu.edu.cn | |
| TEL | 027-68759885 |
| Research Direction |
1.
Mechanism of cardiometabolic diseases. 2. Targeted therapy of cardiometabolic diseases. |
| Personal Profile | Professor She is interested in exploring the mechanism of cardiometabolic diseases and developing targeted therapy of cardiometabolic diseases accordingly. He has been awarded 4 grants from Ministry of Science and technology and the National Natural Science Foundation, 1 grant from the science and Technology Department of Hubei province. He has published more than 100 SCI papers onNature Medicine, Cell Metabolism, Circulation, Hepatology, Circulation Researchand other top journals, including more than 30 papers have been published as the first author or corresponding author papers. The total citation of professor She’s paper is nearly 10,000 times. He has trained and is training 6 doctor and 6 master degree candidate. |
| Selected Publications |
1.
Wang Z, Shi W, Wu T, Peng T, Wang X, Liu S, Yang Z, Wang J, Li PL, Tian R,
Hong Y, Yang H, Bai L, Hu Y, Cheng X, Li H, Zhang XJ, She ZG. A
high-throughput drug screening identifies luteolin as a therapeutic candidate
for pathological cardiac hypertrophy and heart failure. Front Cardiovasc Med.
2023 Mar 14;10:1130635. doi: 10.3389/fcvm.2023.1130635. 2. Qu W, Chen Z, Hu X, Zou T, Huang Y, Zhang Y, Hu Y, Tian S, Wan J, Liao R, Bai L, Xue J, Ding Y, Hu M, Zhang XJ, Zhang X, Zhao J, Cheng X, She ZG§, Li H§. Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model. Front Endocrinol (Lausanne). 2022 Apr 19;13:849060. doi: 10.3389/fendo.2022.849060. (§:并列通讯作者) 3. Zhang XJ*, She ZG*, Wang J*, Sun D*, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H. Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. Sci Transl Med. 2021 Dec 15;13(624) (*:并列一作) 4. Ji YX, Wang Y, Li PL, Cai L, Wang XM, Bai L, Liu Z, Tian H, Tian S, Zhang P, Zhang XJ, Cheng X, Yuan Y, She ZG§, Hu Y§, Li H§. A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis. Cell Metab. 2021 Jun 1;33(6):1171-1186. (§:并列通讯作者) 5. Yang X, Sun D, Xiang H, Wang S, Huang Y, Li L, Cheng X, Liu H, Hu F, Cheng Y, Ma T, Hu M, Tian H, Tian S, Zhou Y, Zhang P, Zhang XJ, Ji YX, Hu Y§, Li H§, She ZG§. Hepatocyte SH3RF2 Deficiency is a Key Aggravator for Nonalcoholic Fatty Liver Disease. Hepatology. 2021 Apr 24. doi: 10.1002/hep.31863. Online ahead of print. (§:并列通讯作者) 6. Liu YM, Xie J, Chen MM, Zhang X, Cheng X, Li H, Zhou F, Qin JJ, Lei F, Chen Z, Lin L, Yang C, Mao W, Chen G, Lu H, Xia X, Wang D, Liao X, Yang J, Huang X, Zhang BH, Yuan Y, Cai J, Zhang XJ, Wang Y, Zhang X, She ZG§ Li H§. Kidney Function Indicators Predict Adverse Outcomes of COVID-19. Med (N Y). 2021 Jan 15;2(1):38-48.e2. (§:并列通讯作者)（IF：17） 7. Cheng X, Liu YM, Li H, Zhang X, Lei F, Qin JJ, Chen Z, Deng KQ, Lin L, Chen MM, Song X, Xia M, Huang X, Liu W, Cai J, Zhang XJ, Zhou F, Zhang P, Wang Y, Ma X, Xu Q, Yang J, Ye P, Mao W, Huang X, Xia J, Zhang BH, Guo J, Zhu L, Lu Z, Yuan Y§, Wei X§, She ZG§, Ji YX§, Li H§. Metformin Use Is Associated with Increased Incidence of Acidosis but not Mortality in Individuals with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020 Oct 6;32(4):537-547.e3.. (§:并列通讯作者)（IF：21.567） 8. Zhu L*, She ZG*, Cheng X*, Qin JJ*, Zhang XJ*, Cai J, Lei F, Wang H, Xie J, Wang W, Li H, Zhang P, Song X, Chen X, Xiang M, Zhang C, Bai L, Xiang D, Chen MM, Liu Y, Yan Y, Liu M, Mao W, Zou J, Liu L, Chen G, Luo P, Xiao B, Zhang C, Zhang Z, Lu Z, Wang J, Lu H, Xia X, Wang D, Liao X, Peng G, Ye P, Yang J, Yuan Y, Huang X, Guo J, Zhang BH, Li H. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020 Jun 2;31(6):1068-1077.e3. (*:并列一作)（IF：21.567） 9. Wu X, Lin L, Qin JJ, Wang L, Wang H, Zou Y, Zhu X, Hong Y, Zhang Y, Liu Y, Xin C, Xu S, Ye S, Zhang J, Xiong Z, Zhu L, Li H§, Chen J§, She ZG§. CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. J Am Heart Assoc. 2020 May 5;9(9):e014920. (§:并列通讯作者)（IF：4.605） 10. Liu D, Zhang P, Zhou J, Liao R, Che Y, Gao MM, Sun J, Cai J, Cheng X, Huang Y, Chen G, Nie H, Ji YX, Zhang XJ, Huang Z, Xu H, She ZG§, Li H§. TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation. Cell Metab. 2020 Apr 7;31(4):726-740. (§:并列通讯作者)（IF：21.567） 11. Jun Gong,Chun Fang,Peng Zhang,Pi‐Xiao Wang,Yixing Qiu,Li‐Jun Shen,Li Zhang,Xue‐Yong Zhu,Song Tian,Feng Li,Zhihua Wang,Zan Huang,Aibing Wang§,Xiao‐Dong Zhang§,She ZG§. Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disease in Mice. Hepatology. 2019 Feb;69(2):524-544.（IF：14.679）(§:并列通讯作者) 12. Liu X, Yang Q, Zhu LH, Liu J, Deng KQ, Zhu XY, Liu Y, Gong J, Zhang P, Li S, Xia H, She ZG. Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway. J Am Heart Assoc. 2018 Jun 26;7(13). pii: e008654. doi: 10.1161/JAHA.118.008654.（IF：4.605） 13. Gong FH, Cheng WL, Wang H, Gao M, Qin JJ, Zhang Y, Li X, Zhu X, Xia H, She ZG. Reduced atherosclerosis lesion size, inflammatory response in miR-150 knockout mice via macrophage effects.J Lipid Res. 2018 Apr; 59(4):658-669.（IF：4.483） 14. Zhang P，Wang PX, Zhao LP, Zhang Xi, Ji YX, Zhang XJ, Fang C, Lu YX, Yang X, Gao MM, Zhang Y, Tian S, Zhu XY, Gong J, Ma XL, Li F, Wang Zh, Huang Z, She ZG§, Li H§. The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Nature Medicine. 2018 Feb;24(2):213-223. (§:并列通讯作者)（IF：36.13） 15. Cheng WL*, She ZG*, Qin JJ*, Guo JH, Gong FH, Zhang P, Fang C, Tian S, Zhu XY, Gong J, Wang ZH, Huang Z, Li H., Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging KLF4 Signaling. Circulation. 2017 Oct 10;136(15):1412-1433. (*:并列一作)（IF：23.603） 16. She ZG, Hamzah J, Kotamraju VR, Hong-Bo Pang HB, Jansen S and Ruoslahti E. Plaque-penetrating peptide inhibits development of hypoxic atherosclerotic plaque. Journal of Controlled Release. 2016; 238:212-20.（IF：7.727） 17. She ZG, Chang Y, Pang HB, Han W, Chen HZ, Smith JW and Stallcup WB. NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2016;36:49-59. (唯一通讯作者). (同期特别评论文章).（IF：6.604） 18. She ZG, Liu X, Kotamraju VR, Ruoslahti E. Clot-targeted Micellar Formulation Improves Anticoagulation Efficacy of Bivalirudin. ACS Nano. 2014 Oct 28;8(10):10139-49（IF：14.588） 19. She ZG, Zheng W, Wei YS, Chen HZ, Wang AB, Li HL, Liu G, Zhang R, Liu JJ, Stallcup WB, Zhou Z, Liu DP, Liang CC. Human Paraoxonase Gene Cluster Transgenic Overexpression Represses Atherogenesis and Promotes Atherosclerotic Plaque Stability in ApoE Null Mice. Circulation Research. 2009; 104 (10):1160-1168.（IF：14.467） 20. Li HL*, She ZG*, Li TB*, Yang QL, Wang YG, Liu DP. Overexpression of Myofibrillogenesis Regulator-1 Aggravates Cardiac Hypertrophy in Response to Chronic Angiotensin II Infusion in Mice. Hypertension. 2007; 49 (6):1399-408.(*:并列一作). (同期特别评论文章).（IF：7.713） |
武汉大学人民医院
湖北省人民医院