邓伟
心内
主任医师，副教授，博士生导师，心衰与心肌病科主任
主任医师，副教授，博士生导师，心衰与心肌病科主任
导师介绍
| 姓名 | 邓伟 |
| 出生年月 | 1982年10月 |
| 单位 | 武汉大学人民医院心血管医院 |
| 所属学科 | 临床医学-内科学-心力衰竭与心肌病 |
| 职务、职称及头衔 | 主任医师，副教授，博士生导师，心衰与心肌病科主任 |
| vivideng1982@whu.edu.cn | |
| 联系方式 | 18907128997 |
| 研究方向 |
1.心力衰竭的发病机制与临床干预 2.心肌病的发病机制与临床干预 |
| 个人简介 | |
| 主要从事心肌重构和心力衰竭的临床防治与基础科研工作，主持国家自然科学基金4项、国家教育部博士点基金项目和湖北省自然科学基金各1项。担任国家卫计委“重大疾病防治科技行动计划-心血管病专项”学术秘书。近五年在本领域发表SCI论文50余篇，其中通讯作者和共同第一作者20余篇，主要发表在EBiomedicine、Cell Death Dis、Free Radic Biol Med、J Mol Cell Cardiol等杂志。论文总被引次数超过2000，研究成果获得湖北省科技进步一等奖2项。担任中华医学会心血管病分会心衰学组委员、海峡两岸医药卫交流协会老年分会青年委员、中国医药教育协会重症分会委员，入选“武汉市中青年医学骨干人才培养工程”和“武汉大学珞珈青年学者”。 | |
| 学术任职与荣誉 | |
|
1.中华医学会心血管病分会心衰学组委员 2.中国医师协会心衰专委会青年委员 3.中国心衰中心联盟专家委员会委员 4.海峡两岸医药卫生协会老年分会青年委员 5.武汉市中青年医学骨干人才培养工程 6.武汉大学珞珈青年学者 7.武汉大学朱裕璧医学奖 |
|
| 教育履历 | |
|
2000-09至2005-06 武汉大学本科毕业医学学士学位 2006-09至2008-06 武汉大学硕士研究生医学硕士学位 2009-09至2012-06 武汉大学博士研究生医学博士学位 |
|
| 工作履历 | |
|
(1) 2015-12至今,武汉大学,人民医院心内科,副教授 (2) 2019-12至今,武汉大学,人民医院心内科,主任医师 (3) 2019-02至2019-11,武汉大学,人民医院心内科,副主任医师 (4) 2017-07至2019-01,新疆医科大学,第五附属医院心内科,副主任医师 (5) 2014-12至2015-11,武汉大学,人民医院心内科,副主任医师 (6) 2012-12至2014-11,武汉大学,人民医院心内科,主治医师 (7) 2012-07至2012-11,武汉大学,人民医院心内科,医师 |
|
| 成果获奖 | |
|
1. 2019年湖北省科技进步一等奖（排名第3） 2. 2013年湖北省科技进步一等奖（排名第10） |
|
| 代表性论著 | |
|
1. Xie S, Chen M, Fang W, Liu
S, Wu Q, Liu C, Xing Y, Shi W, Xu M, Zhang M, Chen S, Zeng X, Wang S, Deng W,
Tang Q. Diminished arachidonate 5-lipoxygenase perturbs phase separation and
transcriptional response of Runx2 to reverse pathological ventricular
remodeling. EBioMedicine. 2022 Dec;86:104359. doi:
10.1016/j.ebiom.2022.104359. Epub 2022 Nov 14. PMID: 36395739; PMCID:
PMC9672960.（通讯作者） 2. Shi W, Chen J, Zhao N, Xing Y, Liu S, Chen M, Fang W, Zhang T, Li L, Zhang H, Zhang M, Zeng X, Chen S, Wang S, Xie S, Deng W. Targeting heat shock protein 47 alleviated doxorubicin-induced cardiotoxicity and remodeling in mice through suppression of the NLRP3 inflammasome. J Mol Cell Cardiol. 2023 Nov 22;186:81-93. doi: 10.1016/j.yjmcc.2023.11.007. Epub ahead of print. PMID: 37995517.（通讯作者） 3. Xie S, Qi X, Wu Q, Wei L, Zhang M, Xing Y, Shi W, Chen S, Zeng X, Wang S, Guo H, Deng W. Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury. Free Radic Biol Med. 2021 Apr;166:348-357. doi: 10.1016/j.freeradbiomed.2021.02.034. Epub 2021 Mar 9. PMID: 33705958.（通讯作者） 4. Saiyang X, Qingqing W, Man X, Chen L, Min Z, Yun X, Wenke S, Haiming W, Xiaofeng Z, Si C, Haipeng G, Wei D, Qizhu T. Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction. Clin Transl Med. 2021 Jan;11(1):e266. doi: 10.1002/ctm2.266. PMID: 33463061; PMCID: PMC7775988.（通讯作者） 5. Fang W, Xie S, Deng W. Epicardial Adipose Tissue: a Potential Therapeutic Target for Cardiovascular Diseases. J Cardiovasc Transl Res. 2023 Oct 17. doi: 10.1007/s12265-023-10442-1. Epub ahead of print. PMID: 37848803.（通讯作者） 6. Saiyang X, Deng W, Qizhu T. Sirtuin 6: A potential therapeutic target for cardiovascular diseases. Pharmacol Res. 2021 Jan;163:105214. doi: 10.1016/j.phrs.2020.105214. Epub 2020 Sep 29. PMID: 33007414.（通讯作者） 7. Xie S, Deng W, Chen J, Wu QQ, Li H, Wang J, Wei L, Liu C, Duan M, Cai Z, Xie Q, Hu T, Zeng X, Tang Q. Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. Int J Biol Sci. 2020 Jan 1;16(1):12-26. doi: 10.7150/ijbs.37269. PMID: 31892842; PMCID: PMC6930369.（通讯作者） 8. Wu QQ, Deng W, Xiao Y, Chen JJ, Liu C, Wang J, Guo Y, Duan M, Cai Z, Xie S, Yuan Y, Tang Q. The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα. Oxid Med Cell Longev. 2019 Nov 3;2019:7536803. doi: 10.1155/2019/7536803. PMID: 31781348; PMCID: PMC6874937.（通讯作者） 9. Wu QQ, Xiao Y, Liu C, Duan M, Cai Z, Xie S, Yuan Y, Wu H, Deng W, Tang Q. The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling. J Mol Cell Cardiol. 2019 Mar;128:160-178. doi: 10.1016/j.yjmcc.2019.01.027. Epub 2019 Jan 31. PMID: 30711544.（通讯作者） 10. Liu C, Wu QQ, Cai ZL, Xie SY, Duan MX, Xie QW, Yuan Y, Deng W, Tang QZ. Zingerone attenuates aortic banding-induced cardiac remodelling via activating the eNOS/Nrf2 pathway. J Cell Mol Med. 2019 Sep;23(9):6466-6478. doi: 10.1111/jcmm.14540. Epub 2019 Jul 10. PMID: 31293067; PMCID: PMC6714175.（通讯作者） 11.Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W, Tang QZ. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2019 Dec 6;2019:6304058. doi: 10.1155/2019/6304058. PMID: 31885808; PMCID: PMC6925812.（通讯作者） 12. Duan MX, Zhou H, Wu QQ, Liu C, Xiao Y, Deng W, Tang QZ. Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs. Mediators Inflamm. 2019 Oct 7;2019:6168340. doi: 10.1155/2019/6168340. PMID: 31686985; PMCID: PMC6800917.（通讯作者） 13. Hu C, Zhang X, Wei W, Zhang N, Wu H, Ma Z, Li L, Deng W, Tang Q. Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway. Acta Pharm Sin B. 2019 Jul;9(4):690-701. doi: 10.1016/j.apsb.2019.03.003. Epub 2019 Mar 16. PMID: 31384530; PMCID: PMC6664099.（通讯作者） 14. Xu M, Wan CX, Huang SH, Wang HB, Fan D, Wu HM, Wu QQ, Ma ZG, Deng W, Tang QZ. Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy. Cell Death Dis. 2019 May 24;10(6):403. doi: 10.1038/s41419-019-1617-y. PMID: 31127082; PMCID: PMC6534559.（通讯作者） 15. Zhang X, Zhu JX, Ma ZG, Wu HM, Xu SC, Song P, Kong CY, Yuan YP, Deng W, Tang QZ. Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity. Int J Biol Sci. 2019 Jan 1;15(3):556-567. doi: 10.7150/ijbs.29907. PMID: 30745842; PMCID: PMC6367577.（通讯作者） 16. Zhang N, Wei WY, Liao HH, Yang Z, Hu C, Wang SS, Deng W, Tang QZ. AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload. J Mol Med (Berl). 2018 Dec;96(12):1345-1357. doi: 10.1007/s00109-018-1696-8. Epub 2018 Oct 19. PMID: 30341569.（通讯作者） 17. Liu XY, Liao HH, Feng H, Zhang N, Yang JJ, Li WJ, Chen S, Deng W, Tang QZ. Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro. J Pharmacol Sci. 2018 Sep;138(1):38-45. doi: 10.1016/j.jphs.2018.08.010. Epub 2018 Sep 4. PMID: 30241784.（通讯作者） 18. Li N, Zhou H, Ma ZG, Zhu JX, Liu C, Song P, Kong CY, Wu HM, Deng W, Tang QZ. Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro. Front Pharmacol. 2018 Aug 3;9:854. doi: 10.3389/fphar.2018.00854. PMID: 30123131; PMCID: PMC6086014.（通讯作者） 19. Zhang X, Ma ZG, Yuan YP, Xu SC, Wei WY, Song P, Kong CY, Deng W, Tang QZ. Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling. Cell Death Dis. 2018 Jan 24;9(2):102. doi: 10.1038/s41419-017-0123-3. PMID: 29367637; PMCID: PMC5833382.（通讯作者） |
| Name | Wei Deng |
| Date of birth | Oct, 1982 |
| Department | Department of Cardiology，Renmin Hospital,Wuhan University |
| Title | Chief physician, Associate professor, Doctoral supervisor |
| vivideng1982@whu.edu.cn | |
| TEL | 18907128997 |
| Research Direction | |
|
1. The pathophysiology and prevention of cardiac
remodeling and heart failure 2. The pathophysiology and prevention of cardiomyopathy |
|
| Personal Profile | |
| He is mainly engaged in clinical prevention and basic research on cardiac remodeling and heart failure, and he has taken charge 4 national natural science foundation projects, as well as one doctoral program funded by the Ministry of Education and one project funded by the Hubei Provincial Natural Science Foundation. He serves as the academic secretary of the "Major Disease Prevention and Control Technology Action Plan - Cardiovascular Disease Special Project" of the National Health and Family Planning Commission. In the past five years, more than 50 SCI papers have been published, including more than 20 corresponding authors and co-first authors, mainly in journals such as EBiomedicine, Cell Death Dis, Free Radio Biol Med, and J Mol Cell Cardiol. The total number of citations for all papers exceeds 2000, and the research results have won the first prize for scientific and technological progress in Hubei Province. He also serves as a young member of the Heart Failure Professional Committee of the Chinese Medical Association and a young member of the Cross Strait Medical and Health Exchange Association, and he has been selected for the "Wuhan Young Medical Backbone Talent Training Project" and "Wuhan University Luojia Young Scholar". | |
| Selected Publications | |
|
1. Xie S, Chen M, Fang W,
Liu S, Wu Q, Liu C, Xing Y, Shi W, Xu M, Zhang M, Chen S, Zeng X, Wang S,
Deng W, Tang Q. Diminished arachidonate 5-lipoxygenase perturbs phase
separation and transcriptional response of Runx2 to reverse pathological
ventricular remodeling. EBioMedicine. 2022 Dec;86:104359. doi:
10.1016/j.ebiom.2022.104359. Epub 2022 Nov 14. PMID: 36395739; PMCID:
PMC9672960.（通讯作者） 2. Shi W, Chen J, Zhao N, Xing Y, Liu S, Chen M, Fang W, Zhang T, Li L, Zhang H, Zhang M, Zeng X, Chen S, Wang S, Xie S, Deng W. Targeting heat shock protein 47 alleviated doxorubicin-induced cardiotoxicity and remodeling in mice through suppression of the NLRP3 inflammasome. J Mol Cell Cardiol. 2023 Nov 22;186:81-93. doi: 10.1016/j.yjmcc.2023.11.007. Epub ahead of print. PMID: 37995517.（通讯作者） 3. Xie S, Qi X, Wu Q, Wei L, Zhang M, Xing Y, Shi W, Chen S, Zeng X, Wang S, Guo H, Deng W. Inhibition of 5-lipoxygenase is associated with downregulation of the leukotriene B4 receptor 1/ Interleukin-12p35 pathway and ameliorates sepsis-induced myocardial injury. Free Radic Biol Med. 2021 Apr;166:348-357. doi: 10.1016/j.freeradbiomed.2021.02.034. Epub 2021 Mar 9. PMID: 33705958.（通讯作者） 4. Saiyang X, Qingqing W, Man X, Chen L, Min Z, Yun X, Wenke S, Haiming W, Xiaofeng Z, Si C, Haipeng G, Wei D, Qizhu T. Activation of Toll-like receptor 7 provides cardioprotection in septic cardiomyopathy-induced systolic dysfunction. Clin Transl Med. 2021 Jan;11(1):e266. doi: 10.1002/ctm2.266. PMID: 33463061; PMCID: PMC7775988.（通讯作者） 5. Fang W, Xie S, Deng W. Epicardial Adipose Tissue: a Potential Therapeutic Target for Cardiovascular Diseases. J Cardiovasc Transl Res. 2023 Oct 17. doi: 10.1007/s12265-023-10442-1. Epub ahead of print. PMID: 37848803.（通讯作者） 6. Saiyang X, Deng W, Qizhu T. Sirtuin 6: A potential therapeutic target for cardiovascular diseases. Pharmacol Res. 2021 Jan;163:105214. doi: 10.1016/j.phrs.2020.105214. Epub 2020 Sep 29. PMID: 33007414.（通讯作者） 7. Xie S, Deng W, Chen J, Wu QQ, Li H, Wang J, Wei L, Liu C, Duan M, Cai Z, Xie Q, Hu T, Zeng X, Tang Q. Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. Int J Biol Sci. 2020 Jan 1;16(1):12-26. doi: 10.7150/ijbs.37269. PMID: 31892842; PMCID: PMC6930369.（通讯作者） 8. Wu QQ, Deng W, Xiao Y, Chen JJ, Liu C, Wang J, Guo Y, Duan M, Cai Z, Xie S, Yuan Y, Tang Q. The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα. Oxid Med Cell Longev. 2019 Nov 3;2019:7536803. doi: 10.1155/2019/7536803. PMID: 31781348; PMCID: PMC6874937.（通讯作者） 9. Wu QQ, Xiao Y, Liu C, Duan M, Cai Z, Xie S, Yuan Y, Wu H, Deng W, Tang Q. The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling. J Mol Cell Cardiol. 2019 Mar;128:160-178. doi: 10.1016/j.yjmcc.2019.01.027. Epub 2019 Jan 31. PMID: 30711544.（通讯作者） 10. Liu C, Wu QQ, Cai ZL, Xie SY, Duan MX, Xie QW, Yuan Y, Deng W, Tang QZ. Zingerone attenuates aortic banding-induced cardiac remodelling via activating the eNOS/Nrf2 pathway. J Cell Mol Med. 2019 Sep;23(9):6466-6478. doi: 10.1111/jcmm.14540. Epub 2019 Jul 10. PMID: 31293067; PMCID: PMC6714175.（通讯作者） 11.Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W, Tang QZ. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2019 Dec 6;2019:6304058. doi: 10.1155/2019/6304058. PMID: 31885808; PMCID: PMC6925812.（通讯作者） 12. Duan MX, Zhou H, Wu QQ, Liu C, Xiao Y, Deng W, Tang QZ. Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs. Mediators Inflamm. 2019 Oct 7;2019:6168340. doi: 10.1155/2019/6168340. PMID: 31686985; PMCID: PMC6800917.（通讯作者） 13. Hu C, Zhang X, Wei W, Zhang N, Wu H, Ma Z, Li L, Deng W, Tang Q. Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway. Acta Pharm Sin B. 2019 Jul;9(4):690-701. doi: 10.1016/j.apsb.2019.03.003. Epub 2019 Mar 16. PMID: 31384530; PMCID: PMC6664099.（通讯作者） 14. Xu M, Wan CX, Huang SH, Wang HB, Fan D, Wu HM, Wu QQ, Ma ZG, Deng W, Tang QZ. Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy. Cell Death Dis. 2019 May 24;10(6):403. doi: 10.1038/s41419-019-1617-y. PMID: 31127082; PMCID: PMC6534559.（通讯作者） 15. Zhang X, Zhu JX, Ma ZG, Wu HM, Xu SC, Song P, Kong CY, Yuan YP, Deng W, Tang QZ. Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity. Int J Biol Sci. 2019 Jan 1;15(3):556-567. doi: 10.7150/ijbs.29907. PMID: 30745842; PMCID: PMC6367577.（通讯作者） 16. Zhang N, Wei WY, Liao HH, Yang Z, Hu C, Wang SS, Deng W, Tang QZ. AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload. J Mol Med (Berl). 2018 Dec;96(12):1345-1357. doi: 10.1007/s00109-018-1696-8. Epub 2018 Oct 19. PMID: 30341569.（通讯作者） 17. Liu XY, Liao HH, Feng H, Zhang N, Yang JJ, Li WJ, Chen S, Deng W, Tang QZ. Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro. J Pharmacol Sci. 2018 Sep;138(1):38-45. doi: 10.1016/j.jphs.2018.08.010. Epub 2018 Sep 4. PMID: 30241784.（通讯作者） 18. Li N, Zhou H, Ma ZG, Zhu JX, Liu C, Song P, Kong CY, Wu HM, Deng W, Tang QZ. Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro. Front Pharmacol. 2018 Aug 3;9:854. doi: 10.3389/fphar.2018.00854. PMID: 30123131; PMCID: PMC6086014.（通讯作者） 19. Zhang X, Ma ZG, Yuan YP, Xu SC, Wei WY, Song P, Kong CY, Deng W, Tang QZ. Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling. Cell Death Dis. 2018 Jan 24;9(2):102. doi: 10.1038/s41419-017-0123-3. PMID: 29367637; PMCID: PMC5833382.（通讯作者） |
武汉大学人民医院
湖北省人民医院