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    张兆辉 神经病学
    一级主任医师，三级教授，博士生导师，神经内Ⅰ科主任、神经病学教研室主任、神经内科医师规培基地主任
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    导师介绍

    姓名 张兆辉
    出生年月 1963年4月
    单位 武汉大学人民医院神经内科
    所属学科 神经病学
    职务、职称及头衔 一级主任医师，三级教授，博士生导师，神经内Ⅰ科主任、神经病学教研室主任、神经内科医师规培基地主任
    E-mail zhzhqing1990@163.com
    联系方式 027-88041911转82221
    研究方向 1. 脑血管病及相关疾病
    2. 认知功能障碍和神经变性疾病 
    个人简介 主要从事神经系统疾病的诊治与科研工作，主要研究方向是脑血管病及相关疾病的临床防治与基础研究，以及认知功能障碍和神经变性疾病。主持国家自然科学基金面上项目2项、湖北省科技厅重点项目1项、湖北省技术创新专项重大项目1项，其它省市级科研项目多项，在Science Advances、Nature Structural & Molecular Biology、Journal of Neurology、Experimental Neurology、eLife等杂志上发表SCI论文30余篇，统计源期刊论文200余篇。已培养研究生40余名。目前正在培养的硕士生7名。
    学术任职与荣誉 1. 《卒中与神经疾病》总编
    2. 中国医师协会神经内科医师分会委员
    3. 中国卒中学会血管性认知障碍分会常委
    4. 国家卫计委脑防委卒中中心管理指导委员会委员
    5. 中国中药协会眩晕专委会副主委
    6. 湖北省神经康复学会主委
    7. 湖北省预防医学会卒中预防与控制专业委员会副主委
    8. 湖北省卒中学会副会长
    9. 湖北省脑血管病防治学会副会长
    10. 湖北省脑卒中防治中心质量控制组组长
    11. 武汉市医学会神经内科分会副主委
    教育履历 1980.09-1985.06 武汉大学第一临床学院临床医学专业本科生 获学士学位
    1989.09-1992.06 武汉大学第一临床学院神经内科学硕士研究生 获硕士学位
    1999.09-2002.06 武汉大学第一临床学院内科学博士研究生 获博士学位
    工作履历 1985.07-1989.8  武汉大学人民医院神经内科住院医师
    1992.07-1999.08  武汉大学人民医院神经内科主治医师、副教授、副主任医师
    2002.07-至今 武汉大学人民医院神经内科教授、主任医师
    成果获奖 1. 作为第一完成人1992年获国家卫生部优秀论文二等奖
    2. 作为第一完成人1997年获湖北省卫生厅科技进步奖二等奖
    3. 1998年获武汉大学博士生万代奖
    4. 作为第一完成人2002年获湖北省科技进步奖二等奖
    5. 2001年获武汉大学优秀博士论文等称号
    代表性论著 1. Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z*, Ye K*. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Science Advances. 2021. 7(16):eabe4499.
    2. Zou L, Dai L, Zhang X, Zhang Z, Zhang Z. Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19. Arch Pharm Res. 2020, 43(8):765-772.
    3. Zhang ZH, Lin MT, Chen L. Editorial: Molecular Advances in Diagnosis and Treatment of CNS Tumors. Front Oncol. 2020, 10:590293.
    4. Zhaohong Kong#, Jingwei Wang, Tao Li, Zhaohui Zhang*, Jiang Jian*. 2019 novel coronavirus pneumonia with onset of dizziness: a case report. Annals of Translational Medicine. 2020, 8(7):506.
    5. Yiyi Li#, Xuan Niu#, Haitao Xu, Qingwen Li, Lanxia Meng, Mingyang He, Jie Zhang, Zhentao Zhang, Zhaohui Zhanga*. VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis. Experimental Cell Research. 2020, 389(1):11184.
    6. Jie Zhang#, Yiyi Li#, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, ZhaohuiZhang*. Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway. Frontiers in molecular neuroscience. 2020, 13:16.
    7. Zhaohong Kong#, Jian Jiang, Ming Deng, Zhaohui Zhang*, Gaohua Wang*. Edaravone reduces depression severity in patients with symptomatic intracranial stenosis and is associated with the serum expression of sex hormones. Medicine (Baltimore). 2020, 99:8.
    8. Zhaohong Kong#, Qinglin Shen, Jian Jiang, Min Deng, Zhaohui Zhang*, Gaohua Wang*. Wogonin improves functional neuroprotection for acute cerebral ischemia in rats by promoting angiogenesis via TGF-β1. Annals of Translational Medicine. 2019, 7(22):639.
    9. Xiangjun Tang#, Pengfei Xu#, Bin Wang, Jie Luo, Rui Fu, Kuanming Huang, Longjun Dai, Junti Lu, Gang Cao, Hao Peng, Li Zhang*, Zhaohui Zhang*, Qianxue Chen*. Identification of a Specific Gene Module for Predicting Prognosis in Glioblastoma Patients. Frontiers in oncology. 2019:9:812.
    10. Dan Hu#, Jing Xiong, Yunfei Zha, Zhaohui Zhang*. Posterior reversible encephalopathy syndrome complicated with subarachnoid hemorrhage in an eclamptic pregnant patient: case report. BMC Neurology. 2018, 18(1):182.
    11. Xuan Niu#, Guang Ou Yang#, Peng fei Yan, Shu lan Huang, Zhentao Zhang, Zhaohui Zhang*. Closure of patent foramen ovale for cryptogenic stroke patients: an updated systematic review and meta‑analysis of randomized trials. Journal of Nuerology. 2018, 1259-1268.
    12. Chao Wang#, Jie Zhang, Junchun Tang, Yi-yi Li, YanXia Gu, Ying Yu, Jing Xiong, Xueqing Zhao, Zheng Zhang, Ting-ting Li, Jutao Chen, Qi Wan, Zhaohui Zhang*. Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury. Experimental Neurology. 2018, 1-9.
    13. Shuke Nie#, Yang Tan#, Zhentao Zhang, Guiqin Chen, Jing Xiong, Dan Hu, Keqiang Ye, Yunjian Zhang, Xuebing Cao, Liam Chen*, Zhaohui Zhang*. Bilateral Implantation of Shear Stress Modififier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities. Frontiers in Aging neuroscience. 2018, 10:303.
    14. Zhaohui Zhang#, Shuke Nie, Liam Chen*. Targeting prion-like protein spreading in neurodegenerative diseases. Neural Regeneration Research. 2018, 2159-2159).
    15. Dan HU#, Jian-yi NIU#, Jing XIONG, Shu-ke NIE, Fei ZENG, Zhao-hui ZHANG*. LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease. Current Medical science. 2018, 1012-1017).
    16. Liting Wang#, Zhaohui Zhang*. Simultaneous neurosyphilis and tuberculous meningitis in a patient with systemic lupus erythematosus: a case report. International Journal of Clinical and Experimental Medicine. 2018, 8766-8769.
    17. Zou L, Dai L, Zhang Y, Fu W, Gao Y, Zhang Z, Zhang Z. Clinical Characteristics and Risk Factors for Disease Severity and Death in Patients With Coronavirus Disease 2019 in Wuhan, China. Front Med (Lausanne). 2020, 7:532.
    18. Laiwei Cao#, Zhentao Zhang, Zhaohui Zhang*. Myasthenia gravis and dyspnea associated with Castleman's disease. International Journal of Clinical and Experimental Medicine. 2018, 7491-7494.
    19. Jianyi Niu#, Jing Xiong#, Dan Hu, Fei Zeng, Shuke Nie, Shanping Mao, TaoWang, ZhentaoZhang, ZhaohuiZhang*. 2', 3'-Dideoxycytidine Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease. Neurochemical Research. 2017, 2996-3004.
    20. YING YU#, JUN QIN, MEIZHEN LIU, QINGYUAN RUAN , YILIANG LI, ZHAOHUI ZHANG*. Role of Rho kinase in lysophosphatidic acid-induced altering of blood-brain barrier permeability. International Journal of Molecular Medicine. 2017, 661-669. 
    Name Zhaohui Zhang
    Date of birth APR, 1963
    Department Department of Neurology, Renmin Hospital of Wuhan University
    Title Professor, Chief physician
    Email zhzhqing1990@163.com
    TEL 027-88041911-82221
    Research Direction 1. Cerebral vascular disease and related diseases
    2. Cognitive impairment and neurodegenerative diseases
    Personal Profile He is engaged in the diagnosis and treatment of neurology disease and mainly focused on the prevention and pathological mechanisms of cerebral vascular diseases, cognitive impairment, and neurodegenerative diseases. He has been awarded 2 grants from the National Natural Science Foundation, 1 item from the Science and Technology Department of Hu Bei province and another 1 item from the Special Major Technological Innovation Projects of Hu Bei province, The total funds of which accounts for about one million yuan. Besides, there are more than 200 articles published in journals of statistical resources and another more than 30 papers published in leading SCI journals such as Science Advances, Nature Structural & Molecular Biology, Journal of Neurology and Experimental Neurology et al. By now, he has trained more than 40 postgraduates and 7 postgraduates are being guided by him at present.
    Selected Publications 1. Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z*, Ye K*. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Science Advances. 2021. 7(16):eabe4499.
    2. Zou L, Dai L, Zhang X, Zhang Z, Zhang Z. Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19. Arch Pharm Res. 2020, 43(8):765-772.
    3. Zhang ZH, Lin MT, Chen L. Editorial: Molecular Advances in Diagnosis and Treatment of CNS Tumors. Front Oncol. 2020, 10:590293.
    4. Zhaohong Kong#, Jingwei Wang, Tao Li, Zhaohui Zhang*, Jiang Jian*. 2019 novel coronavirus pneumonia with onset of dizziness: a case report. Annals of Translational Medicine. 2020, 8(7):506.
    5. Yiyi Li#, Xuan Niu#, Haitao Xu, Qingwen Li, Lanxia Meng, Mingyang He, Jie Zhang, Zhentao Zhang, Zhaohui Zhanga*. VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis. Experimental Cell Research. 2020, 389(1):11184.
    6. Jie Zhang#, Yiyi Li#, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, ZhaohuiZhang*. Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway. Frontiers in molecular neuroscience. 2020, 13:16.
    7. Zhaohong Kong#, Jian Jiang, Ming Deng, Zhaohui Zhang*, Gaohua Wang*. Edaravone reduces depression severity in patients with symptomatic intracranial stenosis and is associated with the serum expression of sex hormones. Medicine (Baltimore). 2020, 99:8.
    8. Zhaohong Kong#, Qinglin Shen, Jian Jiang, Min Deng, Zhaohui Zhang*, Gaohua Wang*. Wogonin improves functional neuroprotection for acute cerebral ischemia in rats by promoting angiogenesis via TGF-β1. Annals of Translational Medicine. 2019, 7(22):639.
    9. Xiangjun Tang#, Pengfei Xu#, Bin Wang, Jie Luo, Rui Fu, Kuanming Huang, Longjun Dai, Junti Lu, Gang Cao, Hao Peng, Li Zhang*, Zhaohui Zhang*, Qianxue Chen*. Identification of a Specific Gene Module for Predicting Prognosis in Glioblastoma Patients. Frontiers in oncology. 2019:9:812.
    10. Dan Hu#, Jing Xiong, Yunfei Zha, Zhaohui Zhang*. Posterior reversible encephalopathy syndrome complicated with subarachnoid hemorrhage in an eclamptic pregnant patient: case report. BMC Neurology. 2018, 18(1):182.
    11. Xuan Niu#, Guang Ou Yang#, Peng fei Yan, Shu lan Huang, Zhentao Zhang, Zhaohui Zhang*. Closure of patent foramen ovale for cryptogenic stroke patients: an updated systematic review and meta‑analysis of randomized trials. Journal of Nuerology. 2018, 1259-1268.
    12. Chao Wang#, Jie Zhang, Junchun Tang, Yi-yi Li, YanXia Gu, Ying Yu, Jing Xiong, Xueqing Zhao, Zheng Zhang, Ting-ting Li, Jutao Chen, Qi Wan, Zhaohui Zhang*. Lysophosphatidic acid induces neuronal cell death via activation of asparagine endopeptidase in cerebral ischemia-reperfusion injury. Experimental Neurology. 2018, 1-9.
    13. Shuke Nie#, Yang Tan#, Zhentao Zhang, Guiqin Chen, Jing Xiong, Dan Hu, Keqiang Ye, Yunjian Zhang, Xuebing Cao, Liam Chen*, Zhaohui Zhang*. Bilateral Implantation of Shear Stress Modififier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities. Frontiers in Aging neuroscience. 2018, 10:303.
    14. Zhaohui Zhang#, Shuke Nie, Liam Chen*. Targeting prion-like protein spreading in neurodegenerative diseases. Neural Regeneration Research. 2018, 2159-2159).
    15. Dan HU#, Jian-yi NIU#, Jing XIONG, Shu-ke NIE, Fei ZENG, Zhao-hui ZHANG*. LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease. Current Medical science. 2018, 1012-1017).
    16. Liting Wang#, Zhaohui Zhang*. Simultaneous neurosyphilis and tuberculous meningitis in a patient with systemic lupus erythematosus: a case report. International Journal of Clinical and Experimental Medicine. 2018, 8766-8769.
    17. Zou L, Dai L, Zhang Y, Fu W, Gao Y, Zhang Z, Zhang Z. Clinical Characteristics and Risk Factors for Disease Severity and Death in Patients With Coronavirus Disease 2019 in Wuhan, China. Front Med (Lausanne). 2020, 7:532.
    18. Laiwei Cao#, Zhentao Zhang, Zhaohui Zhang*. Myasthenia gravis and dyspnea associated with Castleman's disease. International Journal of Clinical and Experimental Medicine. 2018, 7491-7494.
    19. Jianyi Niu#, Jing Xiong#, Dan Hu, Fei Zeng, Shuke Nie, Shanping Mao, TaoWang, ZhentaoZhang, ZhaohuiZhang*. 2', 3'-Dideoxycytidine Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease. Neurochemical Research. 2017, 2996-3004.
    20. YING YU#, JUN QIN, MEIZHEN LIU, QINGYUAN RUAN , YILIANG LI, ZHAOHUI ZHANG*. Role of Rho kinase in lysophosphatidic acid-induced altering of blood-brain barrier permeability. International Journal of Molecular Medicine. 2017, 661-669. 



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