心血管外科-成人与小儿心脏外科中心

在大血管疾病尤其是主动脉夹层或主动脉瘤的开放及微创手术治疗方面有丰富的临床经验；所在手术团队常规开展成人及儿童瓣膜病成形术，冠状动脉搭桥术、大血管疾病手术治疗以及先心病微创治疗等，均取得良好的临床治疗效果，在国内处于领先水平。

以第一作者在Advance Material（IF:32）等国际顶级期刊发表SCI文章10余篇，主持中央高校自主科研青年教师项目1项，参与国家自然科学基金面上项目2项，湖北省卫健委重点支持项目1项，湖北省科技厅重点项目1项。

1.Che YJ, Ren XH, Wang ZW, Wu Q, Xing K, Zhang M, Xu C, Han D, Yuan S, Zheng SH, Chen YY, Liao XR, Shi F, Zhong XH, Cai X, Cheng SX. Lymph-Node-Targeted Drug Delivery for Effective Immunomodulation to Prolong the Long-Term Survival After Heart Transplantation. Adv Mater. 2023 Apr;35(16):e2207227. doi: 10.1002/adma.202207227. Epub 2022 Dec 22. PMID: 36314402.

2.Wu QI, Hu Z, Wang Z, Che Y, Zhang M, Zheng S, Xing K, Zhong X, Chen Y, Shi F, Yuan S. Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function. Transl Res. 2023 May 21:S1931-5244(23)00083-X. doi: 10.1016/j.trsl.2023.05.001. Epub ahead of print. PMID: 37220836.

3.Shi F, Wang Z, Wu Q, Zhong X, Zhang M, Li B, Ren W, Yuan S, Chen Y. Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway. Pharmacol Res. 2022 Sep;183:106366. doi: 10.1016/j.phrs.2022.106366. Epub 2022 Jul 23. PMID: 35882294.

4.Zhong X, Wu Q, Wang Z, Zhang M, Zheng S, Shi F, Chen Y, Che Y, Yuan S, Xing K. Iron deficiency exacerbates aortic medial degeneration by inducing excessive mitochondrial fission. Food Funct. 2022 Jul 18;13(14):7666-7683. doi: 10.1039/d2fo01084d. PMID: 35735054.

5.Wu Q, Chen Y, Wang Z, Cai X, Che Y, Zheng S, Yuan S, Zhong X. Mangiferin Inhibits PDGF-BB-Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells and Alleviates Neointimal Formation in Mice through the AMPK/Drp1 Axis. Oxid Med Cell Longev. 2021 Dec 3;2021:3119953. doi: 10.1155/2021/3119953. PMID: 34900084; PMCID: PMC8664531.

6.Wu Q, Hong J, Wang Z, Hu J, Chen R, Hu Z, Li B, Hu X, Zhang Z, Ruan Y. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2019 May 9;2019:7064319. doi: 10.1155/2019/7064319. PMID: 31210846; PMCID: PMC6532287.