肿瘤中心主任兼肿瘤学教研室主任、学科带头人
1、肺癌的多学科精准诊疗
2、各种实体肿瘤的精准诊疗
国家第五届“国之名医”——卓越建树专家; 国家自然基金和科技奖评审专家;国家教育部学位评审专家;中国科协科技人才奖项评审专家; 国家卫健委医政医管局《肺癌诊疗指南》专家组成员; 国家癌症中心肺癌质控专家; 国家抗肿瘤药物临床应用监测委员会委员 国家新型抗肿瘤药物合理应用专家委员会委员; 中华医学会继续医学教育教材《肺癌》分册副主编、人民卫生出版社《肿瘤学》教材编委; 中华放射肿瘤学杂志 编委; 中华肿瘤防治杂志 编委; 肿瘤学杂志 副主编; 国际肿瘤学杂志 编委; 武汉大学学报医学版 编委; 中国医师协会肿瘤多学科诊疗专业委员会 副主任委员兼总干事; 世界华人肿瘤医师协会常委兼胸部肿瘤分会 副主任委员; 中国医促会胸部肿瘤分会 副主任委员; 吴阶平医学基金会肿瘤多学科诊疗专委会 副主任委员; 中国临床肿瘤学会(CSCO) 常务理事; CSCO老年肿瘤专委会副主委,肺癌、大数据专委会 常委; 中国抗癌协会肺癌、科普、肿瘤多学科诊疗专委会 常委; 湖北省“323”肺癌质控专家委员会 主任委员; 湖北省临床肿瘤学会(ESCO)理事长兼肺癌专委员会主任委员; 武汉医学会放射肿瘤治疗学分会 主任委员。
部分科研论文:
[1] Chen, L., Q. Zhou, P. Zhang, et al., Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation[J]. Nat Chem Biol, 2023.DOI: 10.1038/s41589-023-01354-x.
[2] Li, Y., J. Chen, B. Wang, et al., FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis[J]. Drug Resist Updat, 2023. 67: p. 100926.DOI: 10.1016/j.drup.2023.100926.
[3] Cheng, Y., Z. Gao, T. Zhang, et al., Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance[J]. Cell Stem Cell, 2023. 30(1): p. 69-85.e7.DOI: 10.1016/j.stem.2022.12.003.
[4] Chu, Y., Y. Yao, Q. Hu, et al., Riskscore Model Based on Oxidative Stress-Related Genes May Facilitate the Prognosis Evaluation for Patients With Colon Cancer[J]. Clin Transl Gastroenterol, 2023. 14(6): p. e00582.DOI: 10.14309/ctg.0000000000000582.
[5] Ran, Z., L. Zhang, M. Dong, et al., O-GlcNAcylation: A Crucial Regulator in Cancer-Associated Biological Events[J]. Cell Biochem Biophys, 2023.DOI: 10.1007/s12013-023-01146-z.
[6] Zhao, C., T. Xu, Y. Yao, et al., Comparison of case-based learning using Watson for oncology and traditional method in teaching undergraduate medical students[J]. Int J Med Inform, 2023. 177: p. 105117.DOI: 10.1016/j.ijmedinf.2023.105117.
[7] Chen, L., Y. Weng, X. Cui, et al., Comprehensive analyses of a CD8(+) T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma[J]. BMC Bioinformatics, 2023. 24(1): p. 238.DOI: 10.1186/s12859-023-05302-3.
[8] Liu, Z., J. Wang, F. Liao, et al., Tumor-Educated Platelets Facilitate Thrombus Formation Through Migration[J]. Front Oncol, 2022. 12: p. 857865.DOI: 10.3389/fonc.2022.857865.
[9] Fu, X., W. Tan, Q. Song, et al., BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies[J]. Front Cell Dev Biol, 2022. 10: p. 813457.DOI: 10.3389/fcell.2022.813457.
[10] Ren, X., W. Wen, X. Fan, et al., COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas[J]. Cell, 2021. 184(23): p. 5838.DOI: 10.1016/j.cell.2021.10.023. [11] Zheng, S., Q. Song,P. Zhang, Metabolic Modifications, Inflammation, and Cancer Immunotherapy[J]. Front Oncol, 2021. 11: p. 703681.DOI: 10.3389/fonc.2021.703681.
[12] Yu, L., H. Gong, Q. Li, et al., Survival Analysis of Radiation Therapy in Ovarian Cancer: A SEER Database Analysis[J]. J Oncol, 2021. 2021: p. 8849039.DOI: 10.1155/2021/8849039.
[13] Yu, D., W. Hu, L. Chen, et al., Effect of radiotherapy interruption due to COVID-19 outbreak[J]. Radiother Oncol, 2021. 155: p. 1-2.DOI: 10.1016/j.radonc.2020.09.055.
[14] Yang, S., Y. Yao, Y. Dong, et al., Prediction of Radiation Pneumonitis Using Genome-Scale Flux Analysis of RNA-Seq Derived From Peripheral Blood[J]. Front Med (Lausanne), 2021. 8: p. 715961.DOI: 10.3389/fmed.2021.715961.
[15] Tan, W., P. Jiang, W. Zhang, et al., Posttranscriptional regulation of de novo lipogenesis by glucose-induced O-GlcNAcylation[J]. Mol Cell, 2021. 81(9): p. 1890-1904.e7.DOI: 10.1016/j.molcel.2021.02.009.
[16] Liu, C., K. Song, Q. Hu, et al., Having gastroesophageal cancer is associated with increased risk of severe COVID-19-related events in patients with digestive tract cancer: A multicenter, retrospective, cohort study[J]. Int J Cancer, 2021. 148(7): p. 1789-1793.DOI: 10.1002/ijc.33452.
[17] Lei, T., J. Li, H. Zhong, et al., Postoperative Radiotherapy for Patients With Resectable Stage III-N2 Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis[J]. Front Oncol, 2021. 11: p. 680615.DOI: 10.3389/fonc.2021.680615. [18] He, H., T. Xu, P. Li, et al., Anti-PD-1 Immunotherapy Combined With Stereotactic Body Radiation Therapy and GM-CSF as Salvage Therapy in a PD-L1-Positive Patient With Refractory Metastatic Thyroid Hürthle Cell Carcinoma: A Case Report and Literature Review[J]. Front Oncol, 2021. 11: p. 782646.DOI: 10.3389/fonc.2021.782646.
[19] Zuo, H., L. Chen, N. Li, et al., Identification of a Ubiquitination-Related Gene Risk Model for Predicting Survival in Patients With Pancreatic Cancer[J]. Front Genet, 2020. 11: p. 612196.DOI: 10.3389/fgene.2020.612196.
[20] Wu, J., H. Zhang, L. Li, et al., A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis[J]. Cancer Commun (Lond), 2020. 40(7): p. 301-312.DOI: 10.1002/cac2.12067.
[21] Liu, C., L. Li, K. Song, et al., A nomogram for predicting mortality in patients with COVID-19 and solid tumors: a multicenter retrospective cohort study[J]. J Immunother Cancer, 2020. 8(2).DOI: 10.1136/jitc-2020-001314.
[22] Hu, Z., S. Mi, T. Zhao, et al., BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites[J]. Embo j, 2020. 39(12): p. e104133.DOI: 10.15252/embj.2019104133.
[23] Gong, H., H. Feng, L. Yu, et al., Coronavirus Disease 2019 Infection Among Medical Staff in Wuhan: A Retrospective Study From a Single Center[J]. Chest, 2020. 158(4): p. 1409-1412.DOI: 10.1016/j.chest.2020.05.529.
[24] Peng, Y., Q. Liao, W. Tan, et al., The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors[J]. Nat Commun, 2019. 10(1): p. 1224.DOI: 10.1038/s41467-019-09232-8.
[25] Yao, Y., Z. Zheng,Q. Song, Mesenchymal stem cells: A double-edged sword in radiation-induced lung injury[J]. Thorac Cancer, 2018. 9(2): p. 208-217.DOI: 10.1111/1759-7714.12573.
部分科研项目及成果:
1、国家自然科学基金,AIM2炎症小体在放射性肺炎发生中的调控机制,81372407,主持
2、国家自然科学基金,TMCC2在骨髓增殖性肿瘤中的功能和机制研究,81670123,主持
3、国家自然科学基金,精氨酸甲基化修饰抑制NADP合成的分子机制及生物学功能研究,82273094,主持
4、获湖北省科技进步二等奖,第一完成人
5、《肺癌诊疗指南》,中华医学会,专家组成员
6、《临床肿瘤规范化诊疗实践与进展--肺癌分册》,人民卫生出版社,副主编
7、《肿瘤精准放射治疗学临床要点》,湖北科学技术出版社,主编
8、《肿瘤精准放疗靶区勾画图谱》,湖北科学技术出版社,主编
9、《精准肿瘤学解析—进展及案例》科学出版社,副主译
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宋启斌 |